Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.

Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche in which to engraft eng...

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.

Berg, G. et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome 8, 103 (2020). Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021). De Vos, W. M., Tilg, H., Van Hul, M. & Cani, P. D. Gut microbiome and health: mechanistic insights. Gut 71, 1020–1032 (2022). Ferretti, P., Johnson, K., Priya, S. & Blekhman, R. Genomics of host–microbiome interactions in humans. Nat. Rev. Genet. 27, 62–80 (2026). Zhernakova, D. V. et al. Host genetic regulation of human gut microbial structural variation. Nature 625, 813–821 (2024). David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559–563 (2014). Ross, F. C. et al. The interplay between diet and the gut microbiome: implications for health and disease. Nat. Rev. Microbiol. 22, 671–686 (2024). Sanz, Y. et al. The gut microbiome connects nutrition and human health. Nat. Rev. Gastroenterol. Hepatol. 22, 534–555 (2025). Schumacher, J. et al. Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model. Gut Microbes 17, 2519697 (2025). Brinck, J. E. et al. Intestinal pH: a major driver of...

Fungal infections cause millions of deaths annually, yet no vaccines are approved despite growing drug resistance and limited treatment options. NXT-2 is a pan-fungal vaccine that protects against mul...

The Microbiome Drug Market is expected to grow from 4,900 USD Million in 2025 to 10.8 USD Billion by 2035. The Microbiome Drug Market CAGR (growth rate) is expected to be around 8.1% | Wiseguy Reports

On top of all the other things we need to be aware of in terms of staying healthy — like keeping fit, looking after our mental health and minimising drug use, smoking and alcohol — gut health is…

Mice with diet-induced fatty liver disease improved after a drug blocked a bacterial enzyme in their gut, never entering the bloodstream. The findings point to the gut microbiome as a drug target for ...

International leaders in drug delivery, protein design and microbiome sciences will strengthen health discovery, training and innovation in Canada.

Traditional pharmacological models typically posit drug effects within an acute or sub-acute timeframe, assuming a return to baseline microbial states upon cessation, particularly for non-antibiotic t

## Seerave & MVIF Symposium: The Microbiome in Cancer Immunotherapy ## The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors, yet it remains one of the most underr...

The findings suggest that a person's prescription history may help explain differences in the gut microbiome years later. The gut microbiome includes the vast community of bacteria and other microorganisms that live in the digestive tract and can influence digestion, metabolism, immune function, and other aspects of health. Drug Effects May Persist for Years Researchers analyzed stool samples and prescription records from more than 2,500 participants in the Estonian Biobank who were part of the Estonian Microbiome cohort. They found that most of the medications examined were associated with differences in the gut microbiome. For a substantial number of drugs, those differences could still be detected years after people had stopped taking the medication. The lasting effects were not limited to antibiotics, which are already well known for their ability to disrupt populations of gut bacteria. Antidepressants, beta-blockers, proton pump inhibitors, and benzodiazepines were also associated with distinctive microbial "fingerprints." Beta-blockers are commonly used to treat conditions such as high blood pressure and certain heart problems. Proton pump inhibitors reduce stomach acid and are often prescribed for acid reflux and related conditions. Benzodiazepines are medications commonly used for anxiety and other disorders. "Most microbiome studies only consider current medications, but...

What if the most controversial part of this ivermectin story isn’t the drug, it’s the question it raised about the microbiome? In this clip, Dr. Sabine Hazan says she observed bifidobacteria increase...

The rising demand for novel therapeutics, including antimicrobial, anticancer, and anti-inflammatory agents, underscores the need for new drug discovery strategies. Microbial communities represent ric...