The potato (Solanum tuberosum L.) has become one of the most widely farmed crops worldwide, noted for its adaptability in consumption as both a cooked vegetable and a fundamental component in several processed items, such as starch and chips. In Egypt, approximately 649,000 feddans are dedicated to potato cultivation1. Despite this substantial agricultural commitment, there remains a pressing need for the importation of virus-free minitubers to ensure healthy yields. Farmers often resort to the application of chemical fertilizers to optimize productivity; however, such practices can result in harmful chemical residues that pose significant health risks to consumers. Considering these challenges, chitosan—a natural polysaccharide derived from chitin found in crustacean exoskeletons and fungal cell walls—has garnered attention as a viable organic alternative in agricultural practices2,3. Chitosan has demonstrated the ability to promote plant development, displaying biocompatibility, antibacterial and antifungal characteristics, and functioning as an efficient biodegradable chelating agent. Its zero-pre-harvest interval (PHI) and lack of residues make it an attractive option for integration into organic fertilizers, pesticides, and post-harvest applications. Efforts to overcome the inherent limitations of chitosan have led to the development of its derivatives, such as chitosan acetate, chitosan lactate, and N, O-carboxymethyl chitosan (N, O-CMC), which exhibit improved...