.In a stunning turn of events, Canada has decided to pause its $17 billion deal for the F-35 fighter jets from the United States, opting instead to review its options, including a compelling offer fro...

Chromosomal rearrangements and gene fusions are the initial events in the development of many cancers. Astroblastoma (ABM), a brain cancer of unknown cellular origin and challenging to treat, is associated with diverse in-frame gene fusions, including MN1-BEND2 and MN1-CXXC5 (refs. 1,2). However, it remains unclear whether these gene fusions contribute to tumorigenesis. Here we show in mice that these two ABM-associated fusions converge on similar molecular activities and initiate malignancy specifically in ventral telencephalon neural progenitors. BEND2 and CXXC5 recognize similar DNA motifs, which indicates a convergence on downstream gene regulation. Expression of MN1-BEND2 in ventral telencephalon neural progenitors results in aberrant cell proliferation, impaired differentiation, a perivascular occupancy pattern of cells reminiscent of ABM and acquisition of an ABM-associated transcriptional signature. By contrast, MN1-BEND2 expression in dorsal telencephalon neural progenitors le

Get more from crittheoryworkgroup on Patreon

The molecular mechanisms of astroblastoma development are identified, whereby distinct gene fusions upregulate shared transcriptional networks to disrupt the normal development of ventral telencephalo...

DCA-AVTALET Peter Hultqvists ”förtydligande” saknar betydelse, skriver Mikael Nyberg

YouTube video by Finstad for Congress

Critique of the Podcast Form · Episode