Cutaneous leishmaniasis is a significant challenge to public health. This new paper examined the efficacy of ivermectin, moxidectin, afoxolaner, and permethrin against Leishmania tropica.🧪
Moxidectin was found a promising candidate for the treatment of leishmaniasis.
doi.org/10.1051/para...
Moxidectin was found a promising candidate for the treatment of leishmaniasis.
doi.org/10.1051/para...
July 15, 2025 at 7:25 AM
Cutaneous leishmaniasis is a significant challenge to public health. This new paper examined the efficacy of ivermectin, moxidectin, afoxolaner, and permethrin against Leishmania tropica.🧪
Moxidectin was found a promising candidate for the treatment of leishmaniasis.
doi.org/10.1051/para...
Moxidectin was found a promising candidate for the treatment of leishmaniasis.
doi.org/10.1051/para...
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#leishmania
#openaccess paper: doi.org/10.1051/para...
#leishmania
#openaccess paper: doi.org/10.1051/para...
August 16, 2025 at 5:51 PM
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#leishmania
#openaccess paper: doi.org/10.1051/para...
#leishmania
#openaccess paper: doi.org/10.1051/para...
Read our October issue!
Featuring a trial testing moxidectin for lymphatic filariasis, bedaquiline resistance and tuberculosis outcomes, and a recombinant influenza vaccine for children.
www.thelancet.com/issue/S1473-...
Featuring a trial testing moxidectin for lymphatic filariasis, bedaquiline resistance and tuberculosis outcomes, and a recombinant influenza vaccine for children.
www.thelancet.com/issue/S1473-...
September 25, 2025 at 1:22 PM
Read our October issue!
Featuring a trial testing moxidectin for lymphatic filariasis, bedaquiline resistance and tuberculosis outcomes, and a recombinant influenza vaccine for children.
www.thelancet.com/issue/S1473-...
Featuring a trial testing moxidectin for lymphatic filariasis, bedaquiline resistance and tuberculosis outcomes, and a recombinant influenza vaccine for children.
www.thelancet.com/issue/S1473-...
Related to my last post -- feeding deer with drug-laced corn to control ticks 🧪 (bonus ivermectin/covid snark) https://entomologytoday.org/2023/06/05/feeding-deer-tick-control-moxidectin-new-study/
Feeding Deer Corn With Tick-Control Drug Shows Promise in New Study
A proof-of-concept study shows the potential of feeding white-tailed deer corn treated with moxidectin, a derivative of ivermectin that eliminates ticks.
entomologytoday.org
June 6, 2023 at 2:24 PM
Related to my last post -- feeding deer with drug-laced corn to control ticks 🧪 (bonus ivermectin/covid snark) https://entomologytoday.org/2023/06/05/feeding-deer-tick-control-moxidectin-new-study/
Exactly. It's a miracle! Never mind the surgery, radiation, and chemo they did on the side. It was the Moxidectin and Nitenpyram! Bonus! They no longer have fleas!
January 10, 2025 at 8:58 PM
Exactly. It's a miracle! Never mind the surgery, radiation, and chemo they did on the side. It was the Moxidectin and Nitenpyram! Bonus! They no longer have fleas!
Moxidectin, for example, went untested for human diseases for decades; we now know that it can cure ~70% of whipworm infections in kids.
Aspirin was used for over a century before we found it had cardiovascular benefits.
Aspirin was used for over a century before we found it had cardiovascular benefits.
July 24, 2026 at 12:38 PM
Moxidectin, for example, went untested for human diseases for decades; we now know that it can cure ~70% of whipworm infections in kids.
Aspirin was used for over a century before we found it had cardiovascular benefits.
Aspirin was used for over a century before we found it had cardiovascular benefits.
Moxidectin, a better treatment for river #blindness, has been rescued by non-profit funders after the pharmaceutical industry walked away.
A better treatment for river blindness is available, but its rollout is complicated
A novel financing model rescued moxidectin from abandonment. The path to getting the drug manufactured and distributed exposes deeper faultlines in global health systems
www.nature.com
June 8, 2026 at 7:55 PM
Moxidectin, a better treatment for river #blindness, has been rescued by non-profit funders after the pharmaceutical industry walked away.
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#openaccess paper: doi.org/10.1051/para...
#openaccess paper: doi.org/10.1051/para...
July 6, 2025 at 6:11 PM
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#openaccess paper: doi.org/10.1051/para...
#openaccess paper: doi.org/10.1051/para...
New study:
NexGard® Plus shows strong field efficacy against canine sarcoptic mange.
Afoxolaner + moxidectin + pyrantel eliminated Sarcoptes scabiei (100%) after 2 treatments, with rapid clinical improvement. 🐶🔬🧪
doi.org/10.1051/para...
NexGard® Plus shows strong field efficacy against canine sarcoptic mange.
Afoxolaner + moxidectin + pyrantel eliminated Sarcoptes scabiei (100%) after 2 treatments, with rapid clinical improvement. 🐶🔬🧪
doi.org/10.1051/para...
January 23, 2026 at 9:56 AM
New study:
NexGard® Plus shows strong field efficacy against canine sarcoptic mange.
Afoxolaner + moxidectin + pyrantel eliminated Sarcoptes scabiei (100%) after 2 treatments, with rapid clinical improvement. 🐶🔬🧪
doi.org/10.1051/para...
NexGard® Plus shows strong field efficacy against canine sarcoptic mange.
Afoxolaner + moxidectin + pyrantel eliminated Sarcoptes scabiei (100%) after 2 treatments, with rapid clinical improvement. 🐶🔬🧪
doi.org/10.1051/para...
Not-for-profit pharmaceutical company MDGH receives first endemic country approval for a new river blindness treatment www.medicinesdevelopment.com/news/ghana-b...
Ghana becomes first river blindness-endemic country to approve moxidectin | News | Medicines Development for Global Health
Medicines Development for Global Health (MDGH) announced today that the Ghana Food and Drugs Authority (FDA) approved moxidectin 2 mg oral tables for the treatment of river blindness (onchocerciasis) ...
www.medicinesdevelopment.com
December 9, 2024 at 10:47 AM
Not-for-profit pharmaceutical company MDGH receives first endemic country approval for a new river blindness treatment www.medicinesdevelopment.com/news/ghana-b...
Can’t count how many border collies presenting for sudden blindness whose owners were puzzled by: do you have horses? Did you deworm recently?
But they got it soon enough. A few bags of intralipid later, most did ok.
Oh, and resistant heartworms are a thing. Moxidectin, etc, are gaining favor.
But they got it soon enough. A few bags of intralipid later, most did ok.
Oh, and resistant heartworms are a thing. Moxidectin, etc, are gaining favor.
February 11, 2026 at 6:53 AM
Can’t count how many border collies presenting for sudden blindness whose owners were puzzled by: do you have horses? Did you deworm recently?
But they got it soon enough. A few bags of intralipid later, most did ok.
Oh, and resistant heartworms are a thing. Moxidectin, etc, are gaining favor.
But they got it soon enough. A few bags of intralipid later, most did ok.
Oh, and resistant heartworms are a thing. Moxidectin, etc, are gaining favor.
𝗡𝗲𝘄 𝗽𝗮𝗽𝗲𝗿 𝘁𝗼𝗱𝗮𝘆:
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#openaccess 🔗: doi.org/10.1051/para...
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#openaccess 🔗: doi.org/10.1051/para...
July 4, 2025 at 1:33 PM
𝗡𝗲𝘄 𝗽𝗮𝗽𝗲𝗿 𝘁𝗼𝗱𝗮𝘆:
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#openaccess 🔗: doi.org/10.1051/para...
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
#openaccess 🔗: doi.org/10.1051/para...
Amidst the chaos, a good news story
www.australianphilanthropicservices.com.au/impact-inves...
www.australianphilanthropicservices.com.au/impact-inves...
Impact investment advances the treatment of river blindness — Australian Philanthropic Services
Impact investment helps Medicines Development for Global Health develop Moxidectin to treat river blindness
www.australianphilanthropicservices.com.au
February 7, 2025 at 2:49 AM
Amidst the chaos, a good news story
www.australianphilanthropicservices.com.au/impact-inves...
www.australianphilanthropicservices.com.au/impact-inves...
They name the drug for treating screwworm in dogs here.
www.aphis.usda.gov/news/agency-...
www.aphis.usda.gov/news/agency-...
FDA Conditionally Approves Drug To Treat New World Screwworm in Dogs | Animal and Plant Health Inspection Service
Washington, D.C., December 17, 2025—Today, the U.S. Food and Drug Administration conditionally approved Credelio Quattro-CA1 (lotilaner, moxidectin, praziquantel, pyrantel) chewable tablets for the tr...
www.aphis.usda.gov
June 12, 2026 at 8:35 PM
They name the drug for treating screwworm in dogs here.
www.aphis.usda.gov/news/agency-...
www.aphis.usda.gov/news/agency-...
Credelio Quattro, Simparica Trio both have Moxidectin & Pyrantel but, as name suggests, Quattro has one more API; and supposedly kills ticks, heartworms faster
Zenrelia obviously different from Apoquel (remember black box warning)
Befrena, Cytopoint both monoclonal antibodies
Zenrelia obviously different from Apoquel (remember black box warning)
Befrena, Cytopoint both monoclonal antibodies
July 7, 2026 at 4:01 PM
Credelio Quattro, Simparica Trio both have Moxidectin & Pyrantel but, as name suggests, Quattro has one more API; and supposedly kills ticks, heartworms faster
Zenrelia obviously different from Apoquel (remember black box warning)
Befrena, Cytopoint both monoclonal antibodies
Zenrelia obviously different from Apoquel (remember black box warning)
Befrena, Cytopoint both monoclonal antibodies
New paper in press:
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
Soon... www.parasite-journal.org
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
Soon... www.parasite-journal.org
June 9, 2025 at 9:25 AM
New paper in press:
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
Soon... www.parasite-journal.org
Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy 🧪
Soon... www.parasite-journal.org
Parasites survive by controlling their muscles & movement, but what happens when that system suddenly shuts down? Moxidectin interrupts the signals parasites need to function, stopping them in their tracks. See the chemistry behind this drug in my short educational video.
youtu.be/E4Z_jVNwp9k
youtu.be/E4Z_jVNwp9k
How does Moxidectin Work for Parasites?
YouTube video by Dr. Rob Swanda
youtu.be
March 26, 2026 at 8:59 PM
Parasites survive by controlling their muscles & movement, but what happens when that system suddenly shuts down? Moxidectin interrupts the signals parasites need to function, stopping them in their tracks. See the chemistry behind this drug in my short educational video.
youtu.be/E4Z_jVNwp9k
youtu.be/E4Z_jVNwp9k
So it turns out that ivermectin is no longer the best medicine to fight parasitic worms. It is inferior to moxidectin. No word on how successful either of these medicines are in treatment of a COVID-19 infection. Lol.
Efficacy and safety of moxidectin compared with ivermectin against Strongyloides stercoralis infection in adults in Laos and Cambodia: a randomised, double-blind, non-inferiority, phase 2b/3 trial
Infection with the soil-transmitted helminth Strongyloides stercoralis affects up to 600 million people globally, most of whom live in rural areas wit…
www.sciencedirect.com
May 8, 2025 at 4:52 PM
So it turns out that ivermectin is no longer the best medicine to fight parasitic worms. It is inferior to moxidectin. No word on how successful either of these medicines are in treatment of a COVID-19 infection. Lol.
Cutaneous leishmaniasis presents a significant challenge to public health. 🧪
In this paper, the authors examined the efficacy of ivermectin, 𝗺𝗼𝘅𝗶𝗱𝗲𝗰𝘁𝗶𝗻, afoxolaner, and permethrin against all stages of Leishmania tropica and THP-1 cells.
doi.org/10.1051/para...
In this paper, the authors examined the efficacy of ivermectin, 𝗺𝗼𝘅𝗶𝗱𝗲𝗰𝘁𝗶𝗻, afoxolaner, and permethrin against all stages of Leishmania tropica and THP-1 cells.
doi.org/10.1051/para...
September 19, 2025 at 9:44 AM
Cutaneous leishmaniasis presents a significant challenge to public health. 🧪
In this paper, the authors examined the efficacy of ivermectin, 𝗺𝗼𝘅𝗶𝗱𝗲𝗰𝘁𝗶𝗻, afoxolaner, and permethrin against all stages of Leishmania tropica and THP-1 cells.
doi.org/10.1051/para...
In this paper, the authors examined the efficacy of ivermectin, 𝗺𝗼𝘅𝗶𝗱𝗲𝗰𝘁𝗶𝗻, afoxolaner, and permethrin against all stages of Leishmania tropica and THP-1 cells.
doi.org/10.1051/para...
New paper today: 🧪
Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with Sarcoptes scabiei
doi.org/10.1051/para...
Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with Sarcoptes scabiei
doi.org/10.1051/para...
January 22, 2026 at 9:14 AM
New paper today: 🧪
Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with Sarcoptes scabiei
doi.org/10.1051/para...
Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with Sarcoptes scabiei
doi.org/10.1051/para...
OHRG PhD student Eliza stott recently published a paper describing the pharmacokinetics of moxidectin in bare-nosed wombats, comparing intravenous, subcutaneous and transdermal application. You can find a non-expert summary here: wildlifehealth.blog/2026/04/22/c....
Comparing Moxidectin Administration Routes in Wombats
Stott, E. K., Skerratt, L. F., Whittem, T., Leeming, M., Pillay, K., Doran, G. S., Gardner, B., Lynch, M., Klein, M., Holz, P., Chen, T., Hufschmid, J., and Woodward, A. P. (2026). Pharmacokinetics…
wildlifehealth.blog
April 29, 2026 at 2:38 AM
OHRG PhD student Eliza stott recently published a paper describing the pharmacokinetics of moxidectin in bare-nosed wombats, comparing intravenous, subcutaneous and transdermal application. You can find a non-expert summary here: wildlifehealth.blog/2026/04/22/c....
A new clinical trial led by Swiss TPH & partners on Pemba Island has shown that combining moxidectin with albendazole is more effective than current standard treatment for whipworm infections in school-aged children.
The results might inform future guide-lines for soil-transmitted helminth control.
The results might inform future guide-lines for soil-transmitted helminth control.
Combination Therapy Improves Treatment of Whipworm in Children
A new clinical trial led by Swiss TPH and partners on Pemba Island, Tanzania, has shown that combining moxidectin with albendazole is far more effective than current standard...
www.swisstph.ch
July 17, 2025 at 12:38 PM
A new clinical trial led by Swiss TPH & partners on Pemba Island has shown that combining moxidectin with albendazole is more effective than current standard treatment for whipworm infections in school-aged children.
The results might inform future guide-lines for soil-transmitted helminth control.
The results might inform future guide-lines for soil-transmitted helminth control.
$ELAN's own Credelio Plus refers to ability to "prevents flea tapeworm infestations"
Newer Credelio Quattro actually lacks one indication that Plus has, demodex mites
Both contain lotilaner
Plus also has milbemycin oxime, while Quattro has moxidectin, praziquantel, and pyrantel
Newer Credelio Quattro actually lacks one indication that Plus has, demodex mites
Both contain lotilaner
Plus also has milbemycin oxime, while Quattro has moxidectin, praziquantel, and pyrantel
September 20, 2025 at 8:35 PM
$ELAN's own Credelio Plus refers to ability to "prevents flea tapeworm infestations"
Newer Credelio Quattro actually lacks one indication that Plus has, demodex mites
Both contain lotilaner
Plus also has milbemycin oxime, while Quattro has moxidectin, praziquantel, and pyrantel
Newer Credelio Quattro actually lacks one indication that Plus has, demodex mites
Both contain lotilaner
Plus also has milbemycin oxime, while Quattro has moxidectin, praziquantel, and pyrantel
Ghana rolls out moxidectin, a new treatment for river blindness www.medicinesdevelopment.com/news/momentum
January 29, 2025 at 8:12 AM
Ghana rolls out moxidectin, a new treatment for river blindness www.medicinesdevelopment.com/news/momentum