#multidrug
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samillingworth.com
💊 New antibiotic class

Scientists have developed Novltex, a new antibiotic with strong activity against multidrug-resistant bacteria like MRSA. It’s cheaper to make and highly effective in lab tests.

🔗 pubs.acs.org/doi/10.1021/...

#SciComm #Antibiotics #AMR 🧪
Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation
Increasing spread of multidrug-resistant (MDR) bacteria demands antibiotics that combine potent activity with scalable synthesis. Novo29 (clovibactin) is promising but suffers from low yield (1%), dep...
pubs.acs.org
September 20, 2025 at 6:21 PM
crof.bsky.social
mRNA vaccines for multidrug-resistant bacteria: promise, challenges, and microbiome-informed strategies - The Lancet Microbe www.thelancet.com/journals/lan...
mRNA vaccines for multidrug-resistant bacteria: promise, challenges, and microbiome-informed strategies
Antimicrobial resistance (AMR) has made multidrug-resistant organisms (MDROs), particularly ESKAPE-E pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobac...
www.thelancet.com
July 27, 2026 at 2:43 PM
sailorrooscout.bsky.social
THIS IS HUGE! Researchers at the University of Illinois have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections (MORE THAN 130 multidrug-resistant bacterial strains, in fact) while sparing the gut microbiome!

Let’s talk about that! 🧪🧵⬇️
June 11, 2024 at 4:00 PM
fangferric.bsky.social
Merck discontinues imipenem-cilastatin plus relebactam, a combination agent primarily used to target multidrug-resistant Pseudomonas aeruginosa.
bachynski.bsky.social Kathleen Bachynski @bachynski.bsky.social · 2d
Apparently Merck is no longer supplying Recarbrio. “In an unexpected move, Merck discontinued an important antibiotic from the U.S. market earlier this month, underscoring concerns about the commitment large pharmaceutical companies are willing to make to a field that is crucial to public health”
Merck discontinues a crucial antibiotic despite concerns over superbug resistance
Merck discontinued Recarbio, an important antibiotic in the U.S., despite concerns over resistance to superbugs.
www.statnews.com
September 28, 2026 at 11:51 PM
nizet.bsky.social
Will Ferrell as multidrug-resistant bacterial pathogen threats #AMR #MicroSky #IDSky
October 6, 2025 at 2:50 PM
craigmaclean.bsky.social
Excited to share this new paper from the lab:
academic.oup.com/ismej/articl...!
See thread below
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug-resistance plasmids
Abstract. Phage therapy offers an alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are promising the
academic.oup.com
June 3, 2026 at 8:25 PM
kwardvancouver.bsky.social
housing prevents this.

www.emjreviews.com/microbiology...
December 30, 2025 at 6:19 AM
cidrap.bsky.social
Analysis highlights bacterial contamination, multidrug-resistance, in retail meat samples

FDA data show over 1/3rd of US retail meat samples tested positive for potentially harmful bacteria, and nearly 1 in 4 bacterial isolates were multidrug-resistant.

www.cidrap.umn.edu/f...
June 18, 2025 at 9:16 PM
danielcazares.bsky.social
Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme...

Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug resistance plasmids
Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part
doi.org
May 11, 2026 at 11:24 AM
boghuma.bsky.social
Very nice review on multi-drug resistant bacterial infections of the #IDSky Crew. some fantastic summary figures it there. Please tag the authors if they are on here :)
www.thelancet.com/journals/lan...
Multidrug-resistant Gram-negative bacterial infections
Multidrug-resistant Gram-negative bacterial infections cause significant morbidity and mortality globally. These pathogens easily acquire antimicrobial resistance (AMR), further highlighting their cli...
www.thelancet.com
January 20, 2025 at 9:11 PM
wvschaik.bsky.social
New manuscript from the group

'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'

www.biorxiv.org/content/10.1...

/1
IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium , but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of t...
www.biorxiv.org
July 17, 2025 at 8:39 AM
cidrap.bsky.social
High rates of multidrug-resistant bacteria found in West Bank hospitals

More than one third of the 10,007 bacterial isolates collected from 13 West Bank hospitals were classified as multidrug-resistant.

www.cidrap.umn.edu/a...
November 6, 2025 at 9:47 PM
who.int
Did you know that if tuberculosis (TB) medicines are used incorrectly or if the treatment is stopped too soon, the antibiotics can lose their power?

Learn more about fighting multidrug-resistant TB.

Remember, TB is curable!
March 24, 2026 at 8:25 AM
danielcazares.bsky.social
Phage constrain multidrug resistance spread
#Phage #Plasmid #AMR #EvolutionaryBiology #CraigMacLeanLab
The final version of our paper is out in @isme-microbes.bsky.social

academic.oup.com/ismej/articl...

bsky.app/profile/dani...

More exciting phage and plasmid research coming soon!
June 3, 2026 at 10:59 AM
drericding.bsky.social
3) A USAID memo estimated that cases of multidrug-resistant tuberculosis will rise by ~30%⬆️ in the next few years, an unprecedented regression in the history of humankind’s fight against the disease.
March 16, 2025 at 5:08 PM
natbiotech.nature.com
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - @yizhoudonglab.bsky.social @icahngenomics.bsky.social go.nature.com/3LZS6HD
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
go.nature.com
November 26, 2025 at 3:11 PM
cenmag.bsky.social
Researchers have found that multidrug-resistant bacteria from hospitals are also highly resistant to the common herbicide glyphosate. The study sparks concerns that exposure to the common chemical could be allowing drug-resistant bacteria to thrive.

#chemsky 🧪
Glyphosate could be boosting spread of multidrug-resistant bacteria
Extensive application of the weed killer in Argentina may be unintentionally selecting for bacteria already resistant to many antibiotics
cen.acs.org
March 28, 2026 at 4:28 PM
csabapallab.bsky.social
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
www.science.org
January 13, 2025 at 11:52 AM
evolvedbiofilm.bsky.social
Bacterial heterozygosity promotes survival under multidrug selection

@currentbiology.bsky.social by @shetoot.bsky.social et al from Danny Rozen and Dennis Claessen at #LeidenBiology #IBL @unileiden.bsky.social

doi.org/10.1016/j.cu...
Bacterial heterozygosity promotes survival under multidrug selection
Shitut et al. show how bacterial heterozygosity affects evolution and resistance using an experimental L-form model. Polyploid cells with varied chromosome types survive better across antibiotic gradi...
www.cell.com
March 4, 2025 at 6:44 PM
germhuntermd.bsky.social
#IDSky #MedSky required reading:

Multidrug-resistant Gram-negative bacterial infections

Nenad Macesic, Anne-Catrin Uhlemann, Anton Peleg

Review in @thelancet.bsky.social

doi.org/10.1016/S014...
Figure 1 Mechanisms of action of key antibiotics for the treatment of multidrug-resistant Gram-negative bacterial infections Several classes of antibiotics are available for the treatment of multidrug-resistant Gram-negative bacterial infections. Their mechanisms of action focus on key aspects of bacterial cell function, such as inhibiting cell wall synthesis (ie, β-lactams and fosfomycin) and function (ie, polymyxins), protein synthesis (ie, aminoglycosides and tetracyclines), folic acid synthesis (ie, trimethoprim and sulphonamides), and DNA replication (ie, fluoroquinolones). Because of increasing antimicrobial resistance, novel antibiotics have been developed to overcome some of these mechanisms; for example, by inhibiting antibiotic modification (ie, β-lactamase inhibitors) or by altering entry pathways (ie, cefiderocol, which enters via iron transporters). DHF=dihydrofolic acid. PABA=para-aminobenzoic acid. THF=tetrahydrofolate. Figure 2 Diagnostic testing of multidrug-resistant Gram-negative bacteria Diagnosis of multidrug-resistant Gram-negative bacterial infections involves both species identification and antibiotic susceptibility testing. Although clinical microbiology laboratories have undergone automation of these processes and have seen the introduction of proteomic methods, such as MALDI-TOF, delays in turnaround time remain and might affect patient outcomes. New biochemical, molecular (eg, PCR), automated microscopy, and hybridisation-based rapid diagnostics now allow faster detection of antimicrobial resistance, including by testing clinical samples directly. Emerging technologies are seeking to improve both the speed of testing and provide more detailed information regarding the underlying mechanisms of antimicrobial resistance. MALDI-TOF=matrix-assisted laser desorption/ionisation time-of-flight. Figure 3 Summary of new antibiotic agents for the treatment of multidrug-resistant Gram-negative bacterial infections Green=antibiotic is reliably active in vitro and guideline recommended. Yellow=variable activity; antibiotic might be effective if in vitro susceptibility is shown, clinical data might be lacking to support routine use. Red=not recommended, likely absence of in vitro susceptibility. IV=intravenously. *Administered simultaneously via Y-site administration. †Administration was studied in combination with imipenem–cilastatin. Figure 4 Summary of IDSA and ESCMID guidelines for the treatment of multidrug-resistant Gram-negative bacterial infections 3GCephR-E=third-generation cephalosporin-resistant Enterobacterales. AmpC-E=β-lactamase producing Enterobacterales. CRAB=carbapenem-resistant Acinetobacter baumannii. CRE=carbapenem-resistant Enterobacterales. DTR-P aeruginosa=difficult-to-treat resistant-Pseudomonas aeruginosa. ESBL-E=extended-spectrum β-lactamase-producing Enterobacterales. ESCMID=European Society for Clinical Microbiology and Infectious Diseases. IDSA=Infectious Diseases Society of America. MBL=metallo-β-lactamase. UTI=urinary tract infection.
January 17, 2025 at 2:21 PM
adapalmer.bsky.social
Last month the WHO recommended three new regimens for multidrug-resistant tuberculosis. It's a big breakthrough—the new regimens allow patients to be cured in nine months with all-oral treatments.
https://buff.ly/4dpP5bz
#ShareGoodNewsToo
Major advance in the fight against MDR-TB: four new short and effective treatments from recent clinical trials approved by the WHO
Boston, 19 August 2024 – Today, in a rapid communication, the World Health Organization (WHO) recommended 3 new regimens for multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB), which were…
buff.ly
October 3, 2024 at 1:50 PM
chercheurjuteux.com
34ème rétractation pour l'IHU et toujours 29ème pour Raoult.

RETRACTED ARTICLE: Pulmonary Isolation of Multidrug resistant “Mycobacterium simulans” and Mycobacterium tuberculosis from a patient in the Horn of Africa

www.nature.com/articles/s41...
RETRACTED ARTICLE: Pulmonary Isolation of Multidrug resistant “Mycobacterium simulans” and Mycobacterium tuberculosis from a patient in the Horn of Africa - Scientific Reports
Scientific Reports - RETRACTED ARTICLE: Pulmonary Isolation of Multidrug resistant “Mycobacterium simulans” and Mycobacterium tuberculosis from a patient in the Horn of Africa
www.nature.com
December 28, 2024 at 12:02 AM
bioturbonick.net
Top 4 infectious disease fears:

Prions
Hantavirus
Rabies
Multidrug-resistant bacteria
monarchdiaries.bsky.social The Monarch Diaries @monarchdiaries.bsky.social · May 3
Hantavirus is no joke. A friend I was visiting in Nevada had just spring cleaned a shed on her ranch and complained about feeling a little ill. We said goodbye. Three days later she was dead.
carlquintanilla.bsky.social Carl Quintanilla @carlquintanilla.bsky.social · May 3
(AFP) - Three people have died on a cruise ship in the Atlantic, the WHO said Sunday, one a confirmed case of hantavirus -- an illness usually transmitted to humans from rodents.

www.yahoo.com/news/article...
May 3, 2026 at 8:32 PM
adapalmer.bsky.social
Also this year, the WHO recommended three new oral regimens for multidrug-resistant TB - allowing patients to be cured in nine months compared to the current, conventional 18-month regimen, which includes daily painful injections. https://buff.ly/4dpP5bz
#ShareGoodNewsToo
Major advance in the fight against MDR-TB: four new short and effective treatments from recent clinical trials approved by the WHO
Boston, 19 August 2024 – Today, in a rapid communication, the World Health Organization (WHO) recommended 3 new regimens for multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB), which were…
buff.ly
January 11, 2025 at 2:50 PM
cidrap.bsky.social
Study shows high rate of multidrug-resistant bacteria in hospitalized Ukrainian refugees

Among Ukrainian refugees treated at a Finnish hospital, 79% of those treated for war wounds carried multidrug-resistant bacteria.

www.cidrap.umn.edu/a...
July 21, 2025 at 7:55 PM