#multiplexing
Standard Kubernetes pod scheduling for AI agents instead of custom control planes, using Agent Substrate for sub-second agent resume and high-density multiplexing.
Up 653 stars over seven days.

https://github.com/agent-substrate/substrate
September 26, 2026 at 8:31 AM
The big bottleneck is running 4x gpus on a pcie 3.0 system but it has a multiplexing chip that mitigates it a bit. I’ve got a hard cap of 32 gb and I’m gpu bound but that should be plenty for what I’m doing.
September 26, 2026 at 2:15 AM
Roman’s article in Laborpraxis explores microfluidics for multiplexed super-resolution imaging and its potential integration with Flamingo (in German): tinyurl.com/laborpraxis

@romantsukanov.bsky.social

#Flamingo #microfluidics #SuperResolution #microscopy #DNAPAINT #multiplexing
September 25, 2026 at 1:37 PM
Cytek to demo Full Spectrum Profiling for MRD monitoring at ESCCA and ICCS this autumn. Spectral cytometry gaining traction in minimal residual disease applications as labs seek higher-parameter detection without multiplexing complexity.
Cytek Biosciences to showcase spectral cytometry at ESCCA and ICCS
Cytek will present Full Spectrum Profiling technology at two clinical cytometry conferences in September and October, with a focus on MRD monitoring.
biotech.disruptsmedia.com
September 24, 2026 at 4:00 PM
Bei einer neuen Markierungsmethode werden fluoreszierenden Marker nicht anhand ihrer Farbe, sondern ihrer Leuchtdauer unterschieden. Dadurch lassen sich mit Standardmikroskopen acht verschiedene Proteine in einer Zelle gleichzeitig sichtbar machen.

@opazo.bsky.social

pubs.acs.org/ancac3/artic...
Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing
Abstract. Fluorescence lifetime (FL) is a robust strategy for multiplexed imaging; however, variability in fluorophores’ local microenvironment when used o
pubs.acs.org
September 24, 2026 at 7:38 AM
ЕСО | Ограничение на стойностите на трансграничните преносни капацитети: GovAlert.eu/2HhT
ESO.BG - Електроенергиен Системен Оператор
The Electricity System Operator performs the general operational planning, coordination and control of the electrical power system of the Republic of Bulgaria, as well as its common operation with the electrical power systems of other countries. DWDM Lambda λ. huge bandwidth demands. Point-to-point wavelength division multiplexing data transmission service
www.eso.bg
September 24, 2026 at 7:01 AM
Goood morning wiki.php.net/rfc/poll_api it's time to have some fun with you 🎉 😎 🌪️
PHP: rfc:poll_api
I/O polling (also called I/O multiplexing) is a mechanism that allows a program to efficiently monitor multiple I/O resources (like network sockets, pipes, or files) simultaneously and be notified…
wiki.php.net
September 24, 2026 at 5:39 AM
Efficient differential expression analysis of large-scale single-cell transcriptomics data using Dreamlet
Dreamlet applies a pseudobulk approach and fits a regression model for each gene and cell cluster to test for differential expression associated with trait variation across subjects. Use of precision-weighted linear mixed models enables accounting for repeated measures study designs, including technical or biological replicates, high-dimensional batch effects due to sample multiplexing, and variation in sequencing depth and cell number23 (Fig. 1). Dreamlet incorporates precision weights at two levels to account for uncertainty in the observed gene expression measurements. Dreamlet first initializes the precision weights using a Poisson count model of the observed data that considers the fact that observing more cells and reads from a sample increases the measurement precision of the underlying expression state18 (Supplementary Methods). Incorporating these weights does not affect computational time. These initial weights are then used to estimate an empirical mean-variance trend that estimates a second round of weights without assuming a parametric model for the counting error24. Dreamlet also extends the use of empirical Bayes moderated t-statistics, which borrow information across genes to increase power and control of false positive rate25, to the case of precision-weighted linear mixed models (Supplementary Methods). Finally, the dreamlet workflow is designed for large-scale data and is substantially...
www.nature.com
September 24, 2026 at 5:13 AM
Today I am trying to get my head around wavelength division multiplexing and all I can say is hats off to the nerds who figured this stuff out
September 23, 2026 at 11:21 PM
Yotsuya station has two announcements running simultaneously over the tannoy: one in a deep man’s voice and another in a high-pitched woman’s; weirdly you can tune in to one or the other, which I guess is a sort of ingenious frequency-division multiplexing.
September 23, 2026 at 12:08 AM
the sustained multiplexing of parallel thought streams—narrative, analytical, contextual, simulated, metacognitive—held simultaneously available for recursive cross-reference and higher-order compression
September 22, 2026 at 6:38 PM
Internal monologue stacking is temporal multiplexing of cognition:

multiple persistent thought trajectories remain simultaneously addressable, allowing the mind to recursively cross-reference, compress, and recombine them rather than processing experience as a strictly serial stream.
September 22, 2026 at 6:37 PM
Stacking, chunking, task-switching, and incubation form a recursive cognitive multiplexing process in which multiple thought–voice streams evolve without continuous working-memory maintenance, while conscious attention selectively accesses, recombines, and re-chunks their emergent outputs.
September 22, 2026 at 3:30 PM
cognitive multiplexing: one conscious channel interfacing with many partially independent processes.
September 22, 2026 at 3:29 PM
📝 Summary:

Agent Substrate is a secure, high-density runtime for running millions of sandboxed agents by multiplexing actors onto a smaller pool of workers, with fast suspend/resume, persistent state, and Kubernetes-based orchestration. It is framework-agnostic, supports multiple sandbox (1/2)
September 22, 2026 at 1:17 PM
A new AI review! mmatczuk/go-http-tunnel ⭐3.7/5.0
go-http-tunnel is a pragmatic reverse-tunneling solution built around HTTP/2 multiplexing over a single TLS connection.
https://gitrated.com/mmatczuk/go-http-tunnel
September 21, 2026 at 6:46 PM
In a new review in "Current Opinion in Chemical Biology", Vivek Sanjay Belapurkar, Mette Galsgaard Malle, Jørgen Kjems and Chao Sun explore the latest approaches to multiplexed molecular imaging, looking at how different techniques balance multiplexing capacity with spatial resolution:
www.sciencedirect.com
September 21, 2026 at 11:49 AM
Valerii Radchenkov, Peter J. Reece, Stephen P. Bremner, Nicholas J. Ekins-Daukes, Michael P. Nielsen: Multiplexing approaches to thermoradiative signatureless communications https://arxiv.org/abs/2609.21353 https://arxiv.org/pdf/2609.21353 https://arxiv.org/html/2609.21353
September 21, 2026 at 6:56 AM
Yes and you're giving up the significant multiplexing efficiency from shared resource pooling. (It's called "batch size".)

Also given "personal use" prompting is not continuous, you're then paying for lots of idle GPU*minutes to keep the model loaded.

Thus why AWS et al offer MTok-based metering.
September 20, 2026 at 8:07 PM
Serving full-resolution frontier models with meaningful context buffer length and acceptable tok/sec, eg what Anthropic does with Sonnet, takes a GPU cluster.

There is some efficiency gains by multiplexing of users sharing the resource at the same time, but the upfront capex is still what it is.
September 20, 2026 at 7:40 PM