Neuropixels + Optogenetics = Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors.
Today in @natmethods.nature.com
doi.org/10.1038/s415...
Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.
Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors.
Today in @natmethods.nature.com
doi.org/10.1038/s415...
Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.
June 1, 2026 at 11:20 AM
Neuropixels + Optogenetics = Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors.
Today in @natmethods.nature.com
doi.org/10.1038/s415...
Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.
Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors.
Today in @natmethods.nature.com
doi.org/10.1038/s415...
Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.
Neuropixels and Optogenetics are delighted to announce the birth of
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
February 7, 2025 at 9:16 AM
Neuropixels and Optogenetics are delighted to announce the birth of
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
New Toettchlab paper alert!
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
July 24, 2026 at 2:47 PM
New Toettchlab paper alert!
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
🔬 Calibrating the DMD for optogenetics. Project light on your cells by drawing in napari-pymmcore!
November 27, 2024 at 3:57 PM
🔬 Calibrating the DMD for optogenetics. Project light on your cells by drawing in napari-pymmcore!
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Heard an established successful neuroscientist dismissing junior scientists as "people at the bottom" 🤦♀️
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
November 23, 2025 at 3:27 PM
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Happy to announce that the #VierockLab is moving to #Goettingen joining the new #Else-Kröner-Fresensius-Center-for-Optogenetic-Therapies and a vibrant Optogenetics Community in their goal to bring Optogenetics to the clinic! In the #OpsinEngineeringLab we have Openings - please share and apply! 🚀☺️🎊
September 11, 2026 at 5:14 PM
Happy to announce that the #VierockLab is moving to #Goettingen joining the new #Else-Kröner-Fresensius-Center-for-Optogenetic-Therapies and a vibrant Optogenetics Community in their goal to bring Optogenetics to the clinic! In the #OpsinEngineeringLab we have Openings - please share and apply! 🚀☺️🎊
#introduction 🦋!! My lab studies how cell types & circuits of the hippocampus generates activity (theta, gamma and ripples) and their role in memory function 👉🏼https://hippo-circuitlab.es/. We use #ephys #optogenetics #computational-neurosc #machinelearning. We love #openscience & #neurotechnologies
November 18, 2024 at 7:03 AM
#introduction 🦋!! My lab studies how cell types & circuits of the hippocampus generates activity (theta, gamma and ripples) and their role in memory function 👉🏼https://hippo-circuitlab.es/. We use #ephys #optogenetics #computational-neurosc #machinelearning. We love #openscience & #neurotechnologies
"optogenetics" is a cute word that doesn't quite convey "we infect mice with viruses that make them grow photoreceptors on their brains, and then mind control them by shining light through their skulls"
Induction of cortical on/off periods in awake mice fulfills sleep functions www.nature.com/articles/s41... A new, artificial form of "local sleep" in mammals?
June 23, 2026 at 8:29 PM
"optogenetics" is a cute word that doesn't quite convey "we infect mice with viruses that make them grow photoreceptors on their brains, and then mind control them by shining light through their skulls"
By studying a unique, light-activated protein in dragonflies, researchers may have unlocked new opportunities for deep-tissue optogenetics.
Read the OPN story: https://bit.ly/4mzOB8T
#optogenetics #proteins 💡 ⚛️ 🧪
Read the OPN story: https://bit.ly/4mzOB8T
#optogenetics #proteins 💡 ⚛️ 🧪
April 16, 2026 at 7:14 PM
By studying a unique, light-activated protein in dragonflies, researchers may have unlocked new opportunities for deep-tissue optogenetics.
Read the OPN story: https://bit.ly/4mzOB8T
#optogenetics #proteins 💡 ⚛️ 🧪
Read the OPN story: https://bit.ly/4mzOB8T
#optogenetics #proteins 💡 ⚛️ 🧪
Optogenetics is poised to move from a research tool to new therapies—if scientists can show it’s safe. https://scim.ag/48VQ7gt
Can adding light sensors to nerve cells switch off pain, epilepsy, and other disorders?
Optogenetics is poised to move from a research tool to new therapies—if scientists can show it’s safe
scim.ag
December 10, 2025 at 5:51 PM
Optogenetics is poised to move from a research tool to new therapies—if scientists can show it’s safe. https://scim.ag/48VQ7gt
The rise and shine of yeast optogenetics
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
February 27, 2025 at 9:39 PM
The rise and shine of yeast optogenetics
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed by multiplexed optogenetics and biosensor imaging by Klaus M. Hahn and team: www.biorxiv.org/content/10.6...
May 18, 2026 at 11:59 AM
RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed by multiplexed optogenetics and biosensor imaging by Klaus M. Hahn and team: www.biorxiv.org/content/10.6...
We are hiring a postdoc! We study neural activity and movement using holographic optogenetics, imaging, and recordings in awake mice.
My first postdoc, Masashi, is starting his own lab, so now we have an opening.
Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com
My first postdoc, Masashi, is starting his own lab, so now we have an opening.
Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com
Oldenburg Lab
Decoding the motor system through the use of multiphoton holographic optogenetics.
oldenburglab.com
May 19, 2026 at 1:44 PM
We are hiring a postdoc! We study neural activity and movement using holographic optogenetics, imaging, and recordings in awake mice.
My first postdoc, Masashi, is starting his own lab, so now we have an opening.
Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com
My first postdoc, Masashi, is starting his own lab, so now we have an opening.
Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com
Excited to share the lab’s first publication, co-led by talented postdoc Chuyi Su @chuyisu.bsky.social
We leveraged cell type-specific optogenetics in the macaque cerebral cortex to elucidate the role of excitatory and inhibitory neurons in visual form processing.
www.nature.com/articles/s41...
We leveraged cell type-specific optogenetics in the macaque cerebral cortex to elucidate the role of excitatory and inhibitory neurons in visual form processing.
www.nature.com/articles/s41...
Optotagging in primate cortex uncovers excitatory and inhibitory neuron specializations in form vision - Nature Communications
This study leverages cell type-specific optogenetics in the monkey cerebral cortex to elucidate the unique functional contributions of excitatory and inhibitory neurons in visual form processing. The ...
www.nature.com
August 26, 2026 at 6:24 PM
Excited to share the lab’s first publication, co-led by talented postdoc Chuyi Su @chuyisu.bsky.social
We leveraged cell type-specific optogenetics in the macaque cerebral cortex to elucidate the role of excitatory and inhibitory neurons in visual form processing.
www.nature.com/articles/s41...
We leveraged cell type-specific optogenetics in the macaque cerebral cortex to elucidate the role of excitatory and inhibitory neurons in visual form processing.
www.nature.com/articles/s41...
It was fun writing this essay, about bottom-up neuroscience and how we might simulate entire brains, using data collected via new technologies (expansion microscopy, optogenetics, whole brain voltage imaging, and more), with @kordinglab.bsky.social!
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology, and how neurons generate behavior, write @kordinglab.bsky.social and @eboyden3.bsky.social.
#neuroskyence
bit.ly/48EzEO8
#neuroskyence
bit.ly/48EzEO8
Whole-brain, bottom-up neuroscience: The time for it is now
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate…
bit.ly
October 21, 2025 at 12:38 AM
It was fun writing this essay, about bottom-up neuroscience and how we might simulate entire brains, using data collected via new technologies (expansion microscopy, optogenetics, whole brain voltage imaging, and more), with @kordinglab.bsky.social!
This paper was a LONG time coming! We functionally mapped excitatory and inhibitory inputs onto dopamine neuron dendrites using spatial optogenetics.
Dendrite-specific synaptic inputs onto dopaminergic SNc neurons https://www.biorxiv.org/content/10.64898/2026.08.02.742307v1
August 5, 2026 at 8:13 PM
This paper was a LONG time coming! We functionally mapped excitatory and inhibitory inputs onto dopamine neuron dendrites using spatial optogenetics.
Just saw the new Captain America - bit meh, tbh. BUT… optogenetics, FTW! 😅
March 22, 2025 at 9:26 PM
Just saw the new Captain America - bit meh, tbh. BUT… optogenetics, FTW! 😅
Job alert!
Postdoc position in auditory neuroscience.
Funded by the Fondation Bettencourt Schueller.
Work in Paris (France) at @pasteur.fr / @cnrs.fr / Institut de l'Audition.
#neuroscience #hearing #optogenetics
Postdoc position in auditory neuroscience.
Funded by the Fondation Bettencourt Schueller.
Work in Paris (France) at @pasteur.fr / @cnrs.fr / Institut de l'Audition.
#neuroscience #hearing #optogenetics
March 10, 2025 at 9:49 AM
Job alert!
Postdoc position in auditory neuroscience.
Funded by the Fondation Bettencourt Schueller.
Work in Paris (France) at @pasteur.fr / @cnrs.fr / Institut de l'Audition.
#neuroscience #hearing #optogenetics
Postdoc position in auditory neuroscience.
Funded by the Fondation Bettencourt Schueller.
Work in Paris (France) at @pasteur.fr / @cnrs.fr / Institut de l'Audition.
#neuroscience #hearing #optogenetics
And
High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing
www.nature.com/articles/s41...
High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing
www.nature.com/articles/s41...
High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing - Nature Neuroscience
Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.
www.nature.com
September 19, 2025 at 4:15 AM
And
High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing
www.nature.com/articles/s41...
High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing
www.nature.com/articles/s41...
Can light build centrosome-like activity? 💡🔬
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
September 15, 2026 at 2:34 PM
Can light build centrosome-like activity? 💡🔬
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Happy to share that my lab received an NIH R01 award focused on studying how norepinephrine from the locus coeruleus shapes cortical taste coding, using imaging, optogenetics, fiber photometry, & behavior.
Excited to explore how neuromodulatory dynamics shape hedonic regulation & decision-making.
Excited to explore how neuromodulatory dynamics shape hedonic regulation & decision-making.
May 27, 2026 at 9:59 PM
Happy to share that my lab received an NIH R01 award focused on studying how norepinephrine from the locus coeruleus shapes cortical taste coding, using imaging, optogenetics, fiber photometry, & behavior.
Excited to explore how neuromodulatory dynamics shape hedonic regulation & decision-making.
Excited to explore how neuromodulatory dynamics shape hedonic regulation & decision-making.
How does signalling control cortical tension?
Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.
More here:
www.biorxiv.org/content/10.6...
Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social
Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.
More here:
www.biorxiv.org/content/10.6...
Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social
December 18, 2025 at 5:22 PM
How does signalling control cortical tension?
Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.
More here:
www.biorxiv.org/content/10.6...
Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social
Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.
More here:
www.biorxiv.org/content/10.6...
Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social
A pair of papers on using holographic optogenetics and compressed sensing for connectomics:
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing - Nature Neuroscience
The authors develop a new computational system for high-throughput mapping of synaptic connectivity using two-photon holographic optogenetics and intracellular recordings.
www.nature.com
September 19, 2025 at 4:15 AM
A pair of papers on using holographic optogenetics and compressed sensing for connectomics:
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
December 23, 2024 at 3:14 PM