#organosodium
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newcrystle.bsky.social
Includes four lovely organosodium structures from the Service
chemicalscience.rsc.org Chemical Science @chemicalscience.rsc.org · 7d
HOT in Chemical Science! 🔥

"Ligand-induced ortho-Selective C(sp²)‒H Metalation in a Neophylsodium complex via an Regioselective Intramolecular C(sp3)-to-C(sp2) Rearrangement: Ligand- and Metal Identity-Effects" by Roly J. Armstrong, Erli Lu and colleagues.

🔗doi.org/10.1039/d6sc...
Schematic illustrating ligand-controlled ortho-metalation of a sodium alkyl reagent. A sodium–carbon(sp³) complex on the left is converted to a sodium–carbon(sp²) aryl species through ortho-metalation directed by a diamine ligand. Two inset traffic-light-style diagrams indicate tunable reaction outcomes based on metal identity (Li or Na) and ligand denticity (mono-, bi-, or tridentate). The central structure shows a dinuclear sodium complex coordinated by bidentate amine ligands and tert-butyl-substituted aryl groups. Subsequent reaction with electrophiles (E⁺) gives a functionalized aromatic product bearing a new substituent (E) at the ortho position relative to the tert-butyl group.
October 5, 2026 at 10:01 AM
avncorp.bsky.social
AVN partnered with a client to develop an #organosodium catalyst for a critical process application. AVN’s Environmental, Health & Safety (EH&S) team worked closely with pilot plant personnel to implement safety protocols and ensure safe operations....Read more here! avncorp.com/blogs/the-av...
THE AVN BLOG: Catalyst Development
AVN partnered with a client to develop and manufacture an organosodium catalyst for a critical process application. The project involved the pilot-scale use of sodium metal…
avncorp.com
September 11, 2026 at 1:24 PM
natsynth.nature.com
Now online:

News & Views on the Article by Roly J. Armstrong, Erli Lu, Koji Kubota, Hajime Ito & co-workers

www.nature.com/articles/s44...

A mechanochemical route to organosodium by Sobi Asako

www.nature.com/articles/s44... ($)
#Chemsky
A mechanochemical route to organosodium - Nature Synthesis
A simple mechanochemical setup enables the rapid, solvent-free preparation of organosodium compounds directly from sodium lumps without the need for strictly inert conditions, rendering these previous...
www.nature.com
April 21, 2026 at 12:02 PM
newcrystle.bsky.social
Pleased to see this study by Erli Lu at @unibirmingham.bsky.social on the reactivity of C-Si bonds in print. Some really cool structures in this one, including two from the Service: onlinelibrary.wiley.com/doi/10.1002/...
#chemsky #organometallics
Tandem Reactivity of Metal−Carbon and Carbon−Silicon Bonds in Mononuclear α‐Silyl Organolithium or Organosodium Complexes Towards CO, CO2 and Heteroallenes
Anionic α-silyl alkyl is one of the most used organometallic building blocks and funtional groups. Traditionally, the C─Si bond in these complexes is considered as inert. In this work, we report a se....
onlinelibrary.wiley.com
April 21, 2026 at 8:40 AM
chemistryworld.com
With alternative organometallics becoming increasingly sought after, this straightforward mechanochemical procedure avoids the need for problematic solvents and offers potential.
Ball-milled sodium provides easy access to organometallic reagent
Solvent-free organosodium is a promising alternative to lithium reagents
www.chemistryworld.com
January 11, 2026 at 12:30 PM
hajito1.bsky.social
Our research has been higlighted in Chemistry World!
Ball-milled sodium provides easy access to organometallic reagent
www.chemistryworld.com/news/ball-mi...
Ball-milled sodium provides easy access to organometallic reagent
Solvent-free organosodium is a promising alternative to lithium reagents
www.chemistryworld.com
January 8, 2026 at 12:42 AM
newcrystle.bsky.social
A really nice report on our recent @natsynth.nature.com article.
#chemsky #organosodium
chemistryworld.com Chemistry World @chemistryworld.com · Jan 7
As the cost of lithium rises, chemists have developed a simple mechanochemical way to make organosodium reagents – alternatives to ubiquitous organolithium ones.
Ball-milled sodium provides easy access to organometallic reagent
Solvent-free organosodium is a promising alternative to lithium reagents
www.chemistryworld.com
January 7, 2026 at 10:37 AM
chemistryworld.com
As the cost of lithium rises, chemists have developed a simple mechanochemical way to make organosodium reagents – alternatives to ubiquitous organolithium ones.
Ball-milled sodium provides easy access to organometallic reagent
Solvent-free organosodium is a promising alternative to lithium reagents
www.chemistryworld.com
January 7, 2026 at 10:20 AM
natsynth.nature.com
Now online and open access:

Article by Roly J. Armstrong, Erli Lu, Koji Kubota, Hajime Ito & co-workers

Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides

www.nature.com/articles/s44...
#Chemsky
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides - Nature Synthesis
A mechanochemical protocol for the direct synthesis of organosodium compounds is developed using cheap and shelf-stable sodium lumps and readily available organic halides under bulk, solvent-free cond...
www.nature.com
December 15, 2025 at 10:25 AM
newcrystle.bsky.social
Very pleased to share this new article in @natsynth.nature.com with the structure of a short-lived organosodium complex provided by the Service. Well done to all involved at @chemistryncl.bsky.social and Hokkaido University: www.nature.com/articles/s44...
#chemsky #crystallography
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides - Nature Synthesis
A mechanochemical protocol for the direct synthesis of organosodium compounds is developed using cheap and shelf-stable sodium lumps and readily available organic halides under bulk, solvent-free cond...
www.nature.com
December 11, 2025 at 9:17 AM
zimmermanv66.bsky.social
search.app/oBS2x
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides - Nature Synthesis
A mechanochemical protocol for the direct synthesis of organosodium compounds is developed using cheap and shelf-stable sodium lumps and readily available organic halides under bulk, solvent-free cond...
search.app
December 9, 2025 at 4:47 PM
sciencex.bsky.social
A new mechanochemical approach enables efficient, environmentally friendly synthesis of organosodium reagents, offering a sustainable alternative to lithium-based methods in organic chemistry. doi.org/hbdwrj
Towards sustainable organic synthesis—mechanochemistry replaces lithium with sodium in organic reactions
Highly reactive organometallic reagents, like organolithiums (molecules with a carbon–lithium bond) are essential reagents in organic synthesis because of their applications from polymer synthesis to pharmaceuticals, and more.
phys.org
December 8, 2025 at 4:02 PM
bigearthdata.ai
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides
->Nature | #organic #sustainable agriculture | More from Lil Dr Glen EcoChat at BigEarthData.ai
Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides
We initially attempted the generation of organosodium species through the reaction of bromobenzene (1a) with sodium lumps using a Retsch MM400 mixer mill (5 ml stainless-steel milling jar with one stainless-steel ball; ball diameter: 10 mm). The mineral oil on...
www.nature.com
December 8, 2025 at 3:46 PM
synthesis1969.bsky.social
#Organosodium reagents are emerging as greener, more reactive alternatives to lithium🧪 Benzyl sodium shows divergent reactivity with #pyridines, unlocking access to #dihydropyridines 🔍 New mechanistic insights revealed by Eva Hevia & co-workers @evaheviagroup.bsky.social

👉 buff.ly/DThXVcG
November 7, 2025 at 8:01 AM
newmacdonald.bsky.social
Really upsetting that I share so many interests with stupid assholes
Research interests: Milk, Cheese, Infrared Milk Analysis, Microfiltration, Milk Quality Cornell University https://chemistry.cornell.edu David B. Collum | Department of Chemistry and Chemical Biology The Collum group studies how aggregation and solvation dictate the reactivity and selectivity of organolithium and organosodium compounds.
September 3, 2025 at 8:44 PM
evaheviagroup.bsky.social
Excited to share the latest work from David Anderson just accepted @angewandtechemie.bsky.social on the structure and applications of #sodium #neopentyl a donor free #organosodium #reagent soluble in #hydrocarbon solvents @unibe.ch

onlinelibrary.wiley.com/doi/epdf/10....
July 29, 2025 at 5:12 PM
nathandavison.bsky.social
Honoured to receive the 2025 RSC Dalton Emerging Researcher Prize for my work on organolithium and organosodium chemistry.
www.rsc.org/standards-and-recognition/prizes/winners/dr-nathan-davison
June 25, 2025 at 10:09 AM
jppierce.bsky.social
Go ask Dave.
Collum appears to be the spokesperson for all things libertarian within the Academy. Given that the current administration's agenda is a libertarian's dream, he might be a good place to start if you're trying to establish a beachhead.

chemistry.cornell.edu/david-b-collum
David B. Collum
The Collum group studies how aggregation and solvation dictate the reactivity and selectivity of organolithium and organosodium compounds commonly used by synthetic chemists in both academia and the p...
chemistry.cornell.edu
April 18, 2025 at 2:45 PM
natsynth.nature.com
Now online:

News & Views on the Article by Laurean Ilies, Eva Hevia, Sobi Asako & co-workers

www.nature.com/articles/s44...

Coupling reactions using iron–sodium pairs by by Jos Briggs-Pritchard & Michael Neidig

www.nature.com/articles/s44... ($)
#Chemsky
Coupling reactions using iron–sodium pairs - Nature Synthesis
Organosodium reagents have long been considered too reactive for application in organic synthesis. Now, sodium-based nucleophiles can be used with iron catalysis to enable C(sp2) homo-coupling and C(s...
www.nature.com
March 26, 2025 at 6:31 PM
evaheviagroup.bsky.social
Pushing the boundaries of #organosodium reagents, we are incredibly excited to report their applications in #iron #catalysed #crosscouplings with Sobi Asako and Laurean Ilies at RIKEN 🇯🇵 @naturesynthesis.bsky.social
@unibe.ch #openaccess #TeamWorkMakestheDreamWork

www.nature.com/articles/s44...
March 25, 2025 at 12:38 PM
antorna.bsky.social
Our latest work in Bern, in collaboration with RIKEN, now open access! Check how organosodium can be paired with iron catalysis, for more sustainable cross-coupling reactions

www.nature.com/articles/s44...
March 25, 2025 at 12:35 PM
natsynth.nature.com
Now online & open access:

Article by Ikko Takahashi, Andreu Tortajada, David E. Anderson, Laurean Ilies, Eva Hevia & Sobi Asako

Iron-catalysed direct coupling of organosodium compounds

www.nature.com/articles/s44...
#ChemSky
Iron-catalysed direct coupling of organosodium compounds - Nature Synthesis
Despite the abundance and non-toxic nature of sodium, organosodium reagents have rarely been used in organic synthesis. Now iron-catalysed homocoupling and C(sp2)–C(sp3) cross-coupling reactions of ar...
www.nature.com
March 25, 2025 at 12:05 PM
chemrxivbot.bsky.social
Gram-scale Synthesis of Dibenzo[a,e]pentalenes from Trialkyl(phenylethynyl)silanes via Organosodium Intermediates

Authors: Ayane Sato, Takuya Kuwabara
DOI: 10.26434/chemrxiv-2025-8dmvw
February 27, 2025 at 10:52 AM
chemrxivbot.bsky.social
Gram-scale Synthesis of Dibenzo[a,e]pentalenes from Trialkyl(phenylethynyl)silanes via Organosodium Intermediates

Authors: Ayane Sato, Takuya Kuwabara
DOI: 10.26434/chemrxiv-2025-8dmvw
February 27, 2025 at 9:43 AM
chemrxivbot.bsky.social
Gram-scale Synthesis of Dibenzo[a,e]pentalenes from Trialkyl(phenylethynyl)silanes via Organosodium Intermediates

Authors: Ayane Sato, Takuya Kuwabara
DOI: 10.26434/chemrxiv-2025-8dmvw
February 27, 2025 at 9:10 AM