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Introduction In Microsoft Word and PowerPoint, there are many types of non-text content that can be given alternative text. We tested the alternative text of everything that we could think of in Word and PowerPoint and then converted these files to PDFs using Adobe’s Acrobat PDFMaker (the Acrobat Tab on Windows), Adobe’s Create PDF cloud […]

Author summary To exert toxicity, Vip3 tetrameric protoxins are activated by larval gut proteases facilitating the formation of lytic pores that destroy the midgut epithelium cells killing the susceptible larvae. Here, we demonstrate that the proteolytic activation of Vip3Aa protoxin is necessary for triggering receptor binding. Binding analysis of Vip3Aa protoxin and activated toxin to S. frugiperda midguts and toxicity assays against Sf9 cells, confirmed that proteolytic activation is necessary for an efficient binding to the insect midgut membranes and for toxicity. The analysis of residues from domains III, IV and V, that become exposed after Vip3Aa activation by proteolysis, allowed us to identify a structural binding epitope which plays an important role in receptor binding and toxicity. Our results indicate that the structural change that Vip3Aa undergoes after activation by larval midgut proteases, besides being important for membrane insertion and pore formation, also triggers receptor binding important for toxicity.

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Introduction In Microsoft Word and PowerPoint, there are many types of non-text content that can be given alternative text. We tested the alternative text of everything that we could think of in Word and PowerPoint and then converted these files to PDFs using Adobe’s Acrobat PDFMaker (the Acrobat Tab on Windows), Adobe’s Create PDF cloud […]

If you work with Markdown, you know the struggle: it's great for writing, but turning it into a polished, professional PDF usually involves a clunky mix of browser "Print to PDF" tricks, CSS hacks,...