It’s FINALLY out!
We investigated the natural variations for endodermal suberin and identified SUBER GENE1 (SBG1)- Type One Protein Phosphatases (TOPPs) as a novel module that regulates endodermal suberization.
@mariebarberon.bsky.social
rdcu.be/fgU6g
#PlantScience
We investigated the natural variations for endodermal suberin and identified SUBER GENE1 (SBG1)- Type One Protein Phosphatases (TOPPs) as a novel module that regulates endodermal suberization.
@mariebarberon.bsky.social
rdcu.be/fgU6g
#PlantScience
GWAS reveal SUBER GENE1-mediated suberization via type one phosphatases
Nature Plants - A genetic screen across Arabidopsis accessions identifies SBG1 as a regulator of root abscisic acid response and endodermal suberin deposition via type 1 protein phosphatases,...
rdcu.be
May 5, 2026 at 7:58 AM
It’s FINALLY out!
We investigated the natural variations for endodermal suberin and identified SUBER GENE1 (SBG1)- Type One Protein Phosphatases (TOPPs) as a novel module that regulates endodermal suberization.
@mariebarberon.bsky.social
rdcu.be/fgU6g
#PlantScience
We investigated the natural variations for endodermal suberin and identified SUBER GENE1 (SBG1)- Type One Protein Phosphatases (TOPPs) as a novel module that regulates endodermal suberization.
@mariebarberon.bsky.social
rdcu.be/fgU6g
#PlantScience
Our new year starts of course with new preprint on brassinosteroid signaling tinyurl.com/nhzcfkxd. We re-analyzed the function of Kelch phosphatases, which were previously characterized as protein tyrosine phosphatases that dephosphorylate the critical pTyr200 in the GSK3 kinase BIN2. (1/6)
Plant Kelch phosphatases are Ser/Thr phosphatases involved in cell cycle regulation
Brassinosteroids (BRs) are plant steroid hormones sensed at the cell surface by the membrane receptor kinase BRI1. Activation of BRI1 leads to the dephosphorylation of BZR1/BES1 transcription factors ...
tinyurl.com
January 7, 2026 at 7:48 AM
Our new year starts of course with new preprint on brassinosteroid signaling tinyurl.com/nhzcfkxd. We re-analyzed the function of Kelch phosphatases, which were previously characterized as protein tyrosine phosphatases that dephosphorylate the critical pTyr200 in the GSK3 kinase BIN2. (1/6)
Join us in Würzburg, Germany, for the EMBO workshop “Phosphatases: From basic research to translation”! July 27-31 2025. Newest developments in the field, from academia and industry. Great networking opportunities! Short talk slots available. Hope to see you there! meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
December 11, 2024 at 5:13 AM
Join us in Würzburg, Germany, for the EMBO workshop “Phosphatases: From basic research to translation”! July 27-31 2025. Newest developments in the field, from academia and industry. Great networking opportunities! Short talk slots available. Hope to see you there! meetings.embo.org/event/25-pho...
New Article: "GWAS reveal SUBER GENE1-mediated suberization via type one phosphatases" rdcu.be/fgVkV
A genetic screen across Arabidopsis accessions identifies SBG1 as a regulator of root abscisic acid response and endodermal suberin deposition via type 1 phosphatases.
#PlantScience
A genetic screen across Arabidopsis accessions identifies SBG1 as a regulator of root abscisic acid response and endodermal suberin deposition via type 1 phosphatases.
#PlantScience
May 5, 2026 at 6:51 PM
New Article: "GWAS reveal SUBER GENE1-mediated suberization via type one phosphatases" rdcu.be/fgVkV
A genetic screen across Arabidopsis accessions identifies SBG1 as a regulator of root abscisic acid response and endodermal suberin deposition via type 1 phosphatases.
#PlantScience
A genetic screen across Arabidopsis accessions identifies SBG1 as a regulator of root abscisic acid response and endodermal suberin deposition via type 1 phosphatases.
#PlantScience
A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience https://www.biorxiv.org/content/10.64898/2026.09.29.755255v1
September 29, 2026 at 4:01 PM
A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience https://www.biorxiv.org/content/10.64898/2026.09.29.755255v1
The book I wrote 12 years ago vs the most recent book I wrote. 📕
May 22, 2026 at 1:53 PM
The book I wrote 12 years ago vs the most recent book I wrote. 📕
That's a perfect description. It's phosphatases and kinases all the way down.
November 21, 2023 at 3:34 PM
That's a perfect description. It's phosphatases and kinases all the way down.
Very excited that the EMBO workshop on #phosphatases is about to start in the beautiful Juliusspital venue in Würzburg!
July 27, 2025 at 2:00 PM
Very excited that the EMBO workshop on #phosphatases is about to start in the beautiful Juliusspital venue in Würzburg!
Congratulations @mariebarberon.bsky.social 's group for your latest publication in @natplants.nature.com : GWAS reveal SUBER GENE1-mediated #suberization via type one phosphatases
🌱 How do plants cope with climate stress? Our Department of Plant Science discovered how roots adapt to environmental stress, advancing plant resilience knowledge.
Read more 👇
https://www.unige.ch/medias/en/2026/les-plantes-adaptent-leurs-racines-face-aux-stress-climatiques
#ClimateChange
Read more 👇
https://www.unige.ch/medias/en/2026/les-plantes-adaptent-leurs-racines-face-aux-stress-climatiques
#ClimateChange
May 13, 2026 at 9:29 AM
Congratulations @mariebarberon.bsky.social 's group for your latest publication in @natplants.nature.com : GWAS reveal SUBER GENE1-mediated #suberization via type one phosphatases
Proteomic and biogeochemical perspectives on cyanobacteria nutrient acquisition – Part 2: quantitative contributions of cyanobacterial alkaline phosphatases to bulk enzymatic rates in the subtropical North Atlantic bg.copernicus.org/articles/23/... #jcampubs 🌊
Proteomic and biogeochemical perspectives on cyanobacteria nutrient acquisition – Part 2: quantitative contributions of cyanobacterial alkaline phosphatases to bulk enzymatic rates in the subtropical ...
Abstract. Microbial enzymes alter marine biogeochemical cycles by catalyzing chemical transformations that bring elements into and out of particulate organic pools. These processes are often studied t...
bg.copernicus.org
February 3, 2026 at 2:25 PM
Proteomic and biogeochemical perspectives on cyanobacteria nutrient acquisition – Part 2: quantitative contributions of cyanobacterial alkaline phosphatases to bulk enzymatic rates in the subtropical North Atlantic bg.copernicus.org/articles/23/... #jcampubs 🌊
If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
January 17, 2025 at 6:58 PM
If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...
New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...
August 13, 2025 at 5:20 PM
New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...
Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean
www.nature.com/articles/s41... #jcampubs 🌊
www.nature.com/articles/s41... #jcampubs 🌊
Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean - Nature Communications
This study shows that Alteromonas is a key driver of phosphorus recycling in the ocean and that its alkaline phosphatases are multifunctional—with different families coexisting in one genome by adopti...
www.nature.com
November 7, 2025 at 3:18 PM
Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean
www.nature.com/articles/s41... #jcampubs 🌊
www.nature.com/articles/s41... #jcampubs 🌊
My office and laboratory used to be the office and lab of Professor Eddie Fischer. Eddie (right) and his dear friend Ed Krebs, together discovered protein phosphorylation, protein kinases, and protein phosphatases.
Eddie was an immigrant.
www.nobelprize.org/prizes/medic...
Eddie was an immigrant.
www.nobelprize.org/prizes/medic...
September 27, 2025 at 3:06 PM
My office and laboratory used to be the office and lab of Professor Eddie Fischer. Eddie (right) and his dear friend Ed Krebs, together discovered protein phosphorylation, protein kinases, and protein phosphatases.
Eddie was an immigrant.
www.nobelprize.org/prizes/medic...
Eddie was an immigrant.
www.nobelprize.org/prizes/medic...
Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization www.pnas.org/doi/abs/10.1... #jcampubs
December 5, 2025 at 6:40 PM
Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization www.pnas.org/doi/abs/10.1... #jcampubs
Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases www.biorxiv.org/content/10.6...
February 19, 2026 at 11:20 AM
Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases www.biorxiv.org/content/10.6...
🚨New preprint🚨
How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle?
We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times.
📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵
How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle?
We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times.
📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵
February 24, 2025 at 5:09 PM
🚨New preprint🚨
How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle?
We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times.
📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵
How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle?
We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times.
📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵
G0 or no-G0, if you’re interested in learning the role of phosphatases in regulating quiescence and cell cycle entry read this new review by Robinson & Barr published in #BiochemSocTrans https://doi.org/10.1042/BST20250091 🧪
June 2, 2026 at 1:01 PM
G0 or no-G0, if you’re interested in learning the role of phosphatases in regulating quiescence and cell cycle entry read this new review by Robinson & Barr published in #BiochemSocTrans https://doi.org/10.1042/BST20250091 🧪
Arrived in Wurzburg to get the latest om phosphatases!
July 27, 2025 at 4:31 PM
Arrived in Wurzburg to get the latest om phosphatases!
This is one of (the?) best papers of my career to date. The work in it wouldn't have been possible #WithoutNSF
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase
Protein tyrosine phosphatases (PTPs) are a family of enzymes that play important roles in regulating cellular signaling pathways. Due to the unusual role of loo
papers.ssrn.com
May 3, 2025 at 12:42 AM
This is one of (the?) best papers of my career to date. The work in it wouldn't have been possible #WithoutNSF
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
🚨 Out now! The Leonard lab reveals in @pnas.org that phosphatases PHLPP1/2, once thought to dephosphorylate Akt and suppress tumors, are actually catalytically inactive. Instead, they have a non-catalytic role, reshaping our understanding of Akt regulation ➡️ tinyurl.com/hf28b3mu
@univie.ac.at
@univie.ac.at
April 2, 2025 at 6:55 AM
🚨 Out now! The Leonard lab reveals in @pnas.org that phosphatases PHLPP1/2, once thought to dephosphorylate Akt and suppress tumors, are actually catalytically inactive. Instead, they have a non-catalytic role, reshaping our understanding of Akt regulation ➡️ tinyurl.com/hf28b3mu
@univie.ac.at
@univie.ac.at
Join scientists, biotech start-ups and pharmaceutical companies to discuss #phosphatase research at the EMBO Workshop "Phosphatases: From basic research to translation" in Würzburg, Germany, 27–31 July
Deadline: 11 April
meetings.embo.org/event/25-pho...
#EMBOphosphatases #EMBOevents 🧪
Deadline: 11 April
meetings.embo.org/event/25-pho...
#EMBOphosphatases #EMBOevents 🧪
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
April 8, 2025 at 9:47 AM
Join scientists, biotech start-ups and pharmaceutical companies to discuss #phosphatase research at the EMBO Workshop "Phosphatases: From basic research to translation" in Würzburg, Germany, 27–31 July
Deadline: 11 April
meetings.embo.org/event/25-pho...
#EMBOphosphatases #EMBOevents 🧪
Deadline: 11 April
meetings.embo.org/event/25-pho...
#EMBOphosphatases #EMBOevents 🧪
In our new work, we identified 2 phosphatases, PP1 & PP5, to dephosphorylate the co-chaperone BAG3 regulating the process of chaperone-assisted selective autophagy to maintain cellular proteostasis: www.life-science-alliance.org/content/8/2/... Thanks everyone involved for this great collaboration!
Identification of phosphatases that dephosphorylate the co-chaperone BAG3
The co-chaperone BAG3 plays critical roles in maintaining cellular proteostasis. It associates with 14-3-3 proteins during the trafficking of aggregation-prone proteins and facilitates their degradati...
www.life-science-alliance.org
November 23, 2024 at 9:03 AM
In our new work, we identified 2 phosphatases, PP1 & PP5, to dephosphorylate the co-chaperone BAG3 regulating the process of chaperone-assisted selective autophagy to maintain cellular proteostasis: www.life-science-alliance.org/content/8/2/... Thanks everyone involved for this great collaboration!
A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience https://www.biorxiv.org/content/10.64898/2026.09.29.755255v1
September 29, 2026 at 4:01 PM
A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience https://www.biorxiv.org/content/10.64898/2026.09.29.755255v1
Does this make phosphatases and kinases the little devils and angels on the shoulders of our soul?
July 30, 2025 at 2:14 AM
Does this make phosphatases and kinases the little devils and angels on the shoulders of our soul?