www.biorxiv.org/content/10.6...
Conserved tyrosine Y16 acts as a phosphorylation switch controlling Ena/VASP recruitment to sites of actin assembly
Conserved tyrosine Y16 acts as a phosphorylation switch controlling Ena/VASP recruitment to sites of actin assembly
October 31, 2026 at 12:12 PM
www.biorxiv.org/content/10.6...
Conserved tyrosine Y16 acts as a phosphorylation switch controlling Ena/VASP recruitment to sites of actin assembly
Conserved tyrosine Y16 acts as a phosphorylation switch controlling Ena/VASP recruitment to sites of actin assembly
We also looked at the canonical NF-κB pathway. Phosphorylation of IκBα and the NF-κB subunit p65 is completely abrogated in E750Q macrophages.
November 3, 2026 at 11:41 AM
We also looked at the canonical NF-κB pathway. Phosphorylation of IκBα and the NF-κB subunit p65 is completely abrogated in E750Q macrophages.
#Arabidopsis cyclin-dependent kinases and MAP65 #phosphorylation link #microtubule dynamics with #salt stress adaptation
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @newphyt.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @newphyt.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
Arabidopsis cyclin‐dependent kinases and <fc>MAP65</fc> phosphorylation link microtubule dynamics with salt stress adaptation
Working model illustrating the CDK-MAP65-microtubule module mediating salt stress adaptation in Arabidopsis.
nph.onlinelibrary.wiley.com
October 30, 2026 at 12:09 PM
#Arabidopsis cyclin-dependent kinases and MAP65 #phosphorylation link #microtubule dynamics with #salt stress adaptation
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @newphyt.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @newphyt.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
Never Say Never...!😶
Takatani et al. show that NEK 'Never-in-mitosis A'-related kinases redundantly regulate vegetative & reproductive development in #Arabidopsis through phosphorylation-dependent control of #microtubules & the FT #flowering pathway
🆓 doi.org/10.1093/pcp/...
#PlantScience
Takatani et al. show that NEK 'Never-in-mitosis A'-related kinases redundantly regulate vegetative & reproductive development in #Arabidopsis through phosphorylation-dependent control of #microtubules & the FT #flowering pathway
🆓 doi.org/10.1093/pcp/...
#PlantScience
November 5, 2026 at 12:57 PM
Never Say Never...!😶
Takatani et al. show that NEK 'Never-in-mitosis A'-related kinases redundantly regulate vegetative & reproductive development in #Arabidopsis through phosphorylation-dependent control of #microtubules & the FT #flowering pathway
🆓 doi.org/10.1093/pcp/...
#PlantScience
Takatani et al. show that NEK 'Never-in-mitosis A'-related kinases redundantly regulate vegetative & reproductive development in #Arabidopsis through phosphorylation-dependent control of #microtubules & the FT #flowering pathway
🆓 doi.org/10.1093/pcp/...
#PlantScience
Correction: The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence SciReports
Correction: The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence
Scientific Reports, Published online: 04 November 2026; doi:10.1038/s41598-026-77080-wCorrection: The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence
dlvr.it
November 4, 2026 at 10:09 PM
Correction: The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence SciReports
An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury https://www.biorxiv.org/content/10.64898/2026.11.03.763957v1
November 4, 2026 at 10:19 AM
An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury https://www.biorxiv.org/content/10.64898/2026.11.03.763957v1
An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury https://www.biorxiv.org/content/10.64898/2026.11.03.763957v1
November 4, 2026 at 10:19 AM
An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury https://www.biorxiv.org/content/10.64898/2026.11.03.763957v1
The Global Phosphorylation Landscape of Acute Heat Stress in Reef-Building Corals https://www.biorxiv.org/content/10.64898/2026.10.29.762943v1
November 2, 2026 at 6:03 PM
The Global Phosphorylation Landscape of Acute Heat Stress in Reef-Building Corals https://www.biorxiv.org/content/10.64898/2026.10.29.762943v1
The Global Phosphorylation Landscape of Acute Heat Stress in Reef-Building Corals https://www.biorxiv.org/content/10.64898/2026.10.29.762943v1
November 2, 2026 at 6:03 PM
The Global Phosphorylation Landscape of Acute Heat Stress in Reef-Building Corals https://www.biorxiv.org/content/10.64898/2026.10.29.762943v1
Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions https://www.biorxiv.org/content/10.64898/2026.10.27.762205v1
October 30, 2026 at 11:47 PM
Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions https://www.biorxiv.org/content/10.64898/2026.10.27.762205v1
Accumulating evidence implicates mitochondrial dysfunction and impaired oxidative phosphorylation as contributors to migraine pathophysiology, linking cellular energy deficits to cortical spreading depression, trigeminovascular activation, and oxidative stress. (🧵 2/9)
November 5, 2026 at 4:42 AM
Accumulating evidence implicates mitochondrial dysfunction and impaired oxidative phosphorylation as contributors to migraine pathophysiology, linking cellular energy deficits to cortical spreading depression, trigeminovascular activation, and oxidative stress. (🧵 2/9)
Surprising non-transcriptional function for mediator kinase CDK8 in human DNA replication:
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
CDC7 and CDK8 kinases cooperate to support DNA replication origin firing in human cells - The EMBO Journal
The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin-dependent kinases (CDKs), together with CDC7 kinase, are essential f...
link.springer.com
November 2, 2026 at 8:24 PM
Surprising non-transcriptional function for mediator kinase CDK8 in human DNA replication:
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
The Parkinson's disease-associated A53E mutation decreases alpha-synuclein aggregation and phosphorylation in vivo https://www.biorxiv.org/content/10.64898/2026.10.29.762882v1
October 30, 2026 at 10:16 PM
The Parkinson's disease-associated A53E mutation decreases alpha-synuclein aggregation and phosphorylation in vivo https://www.biorxiv.org/content/10.64898/2026.10.29.762882v1
The authors included RRIDs in their in Protein Science paper! Thanks for making your methods matter! #BetterScience #methodsmatter #ReproducibleResearch
Phosphorylation event changes the RNA binding mode of EZH2 disordered segment
Read the full paper: Phosphorylation event changes the RNA binding mode of EZH2 disordered segment
doi.org
November 1, 2026 at 7:00 AM
The authors included RRIDs in their in Protein Science paper! Thanks for making your methods matter! #BetterScience #methodsmatter #ReproducibleResearch
RRIDs were included in this in Physiologia Plantarum paper. Thanks for making your methods matter! #accelerateopenscience #RRID #OpenScience
Dual Phosphorylation of Thr175 and Ser176 Is Essential for SnRK1α1 Activation
Read the full paper: Dual Phosphorylation of Thr175 and Ser176 Is Essential for SnRK1α1 Activation
doi.org
November 1, 2026 at 7:00 AM
RRIDs were included in this in Physiologia Plantarum paper. Thanks for making your methods matter! #accelerateopenscience #RRID #OpenScience
📢 Paper highlight: How might PPARγ help limit liver fibrosis?
PPARγ increased senescence markers and reduced fibrosis-associated markers in hepatic stellate cells, via LIFR and reduced STAT3 phosphorylation. Rosiglitazone also reduced fibrosis-associated changes in mice.
Paper in reply ↓
PPARγ increased senescence markers and reduced fibrosis-associated markers in hepatic stellate cells, via LIFR and reduced STAT3 phosphorylation. Rosiglitazone also reduced fibrosis-associated changes in mice.
Paper in reply ↓
November 3, 2026 at 11:37 AM
📢 Paper highlight: How might PPARγ help limit liver fibrosis?
PPARγ increased senescence markers and reduced fibrosis-associated markers in hepatic stellate cells, via LIFR and reduced STAT3 phosphorylation. Rosiglitazone also reduced fibrosis-associated changes in mice.
Paper in reply ↓
PPARγ increased senescence markers and reduced fibrosis-associated markers in hepatic stellate cells, via LIFR and reduced STAT3 phosphorylation. Rosiglitazone also reduced fibrosis-associated changes in mice.
Paper in reply ↓
CRV Science Labs ⚗️
🧬 Protein Normal-Mode Allostery and Circadian Phosphorylation Limit-Cycle Benchmark Against SciPy Spectral and RK45 Solvers — We benchmark a self-contained Rust normal-mode allostery and circadian oscillator module …
https://crvscience.com/labs/discoveries/kaiabc-allostery-scipy
🧬 Protein Normal-Mode Allostery and Circadian Phosphorylation Limit-Cycle Benchmark Against SciPy Spectral and RK45 Solvers — We benchmark a self-contained Rust normal-mode allostery and circadian oscillator module …
https://crvscience.com/labs/discoveries/kaiabc-allostery-scipy
CRV Science Labs ⚗️
🧬 Protein Normal-Mode Allostery and Circadian Phosphorylation Limit-Cycle Benchmark Against SciPy Spectral and RK45 Solvers — We benchmark a self-contained Rust normal-mode allostery and circadian oscillator module against SciPy v1.18.1 (scipy.linalg.eigh and scipy.integrate.sol…
crvscience.com
November 2, 2026 at 10:36 AM
CRV Science Labs ⚗️
🧬 Protein Normal-Mode Allostery and Circadian Phosphorylation Limit-Cycle Benchmark Against SciPy Spectral and RK45 Solvers — We benchmark a self-contained Rust normal-mode allostery and circadian oscillator module …
https://crvscience.com/labs/discoveries/kaiabc-allostery-scipy
🧬 Protein Normal-Mode Allostery and Circadian Phosphorylation Limit-Cycle Benchmark Against SciPy Spectral and RK45 Solvers — We benchmark a self-contained Rust normal-mode allostery and circadian oscillator module …
https://crvscience.com/labs/discoveries/kaiabc-allostery-scipy
The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures https://www.biorxiv.org/content/10.64898/2026.10.26.761842v1
October 30, 2026 at 8:31 AM
The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures https://www.biorxiv.org/content/10.64898/2026.10.26.761842v1
Our latest work from Macurek’s lab is now out in NAR! Following our favorite phosphatase PPM1D/WIP1 took us down an unexpected path into the nucleolus.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Dynamic phosphorylation of TCOF1 controlled by CK2 and PPM1D regulates nucleolar condensation and RNA polymerase I activity
Abstract. The nucleolus is a membrane-less organelle essential for ribosomal DNA (rDNA) transcription and ribosome biogenesis, yet the mechanisms regulatin
academic.oup.com
November 1, 2026 at 7:17 PM
Our latest work from Macurek’s lab is now out in NAR! Following our favorite phosphatase PPM1D/WIP1 took us down an unexpected path into the nucleolus.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions https://www.biorxiv.org/content/10.64898/2026.10.27.762205v1
October 30, 2026 at 11:47 PM
Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions https://www.biorxiv.org/content/10.64898/2026.10.27.762205v1