Aspirin reduces dementia risk 3.5-fold in high platelet polygenic score carriers while raising bleeding risk. Read more here.

How are genomic researchers transforming human health?

WHAT IS ALREADY KNOWN ON THIS TOPIC * Most evidence on polygenic risk scores for myopia comes from populations of European ancestry, while evidence in East Asian children, particularly those from mainland China, remains limited.WHAT THIS STUDY ADDS * A polygenic risk score derived from an East Asian ancestry genome-wide association study was associated with spherical equivalent, axial length and myopia, and identified children with higher genetic susceptibility. However, it provided only modest additional predictive information, while parental myopia contributed more and the combination of both achieved the best predictive performance.HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY * These findings support further evaluation of ancestry-matched polygenic risk scores for childhood myopia risk assessment, although their limited incremental predictive value and the need for external validation currently restrict clinical application.Introduction Myopia is one of the most common ocular disorders and has become a major public health concern as its prevalence has...

Adolescence is a key developmental period characterized by continued brain and bodily development alongside significant life transitions and growing independence. The incidence of depression also rises during adolescence; 47% of people with depressive disorders begin experiencing symptoms by age 25 [1, 2]. Depression during adolescence is associated with poorer health, educational attainment and life satisfaction in adulthood, particularly with younger age of onset [3,4,5]. Such research highlights the need for prevention and early intervention in at-risk youth, and the need for effective methods of quantifying depression risk. Depression, like other mental health disorders, is highly heritable and polygenic, with many hundreds of genetic variations contributing small amounts to overall risk [6,7,8]. However, genetic risk alone is likely to always be insufficient for accurate prediction given the complexity and heterogenous nature of depression [7, 9]; current polygenic risk scores (PRS) representing cumulative genetic risk explain ~6% of variance in adult depression [8]. Additional sources of variance are environmental factors – the individual, family, peer, community and population-level influences on a young person’s life – and gene-environment interaction effects [5]. Incorporating these alongside PRS could improve prediction and future risk stratification of depression [5, 7]. Unlike genetic variants, environmental factors can be...

Although anonymized genomes can in principle be re-identified by predicting traits through Polygenic Scores, the authors show that in realistic settings the risk is negligible, alleviating privacy con...

A genome-wide study of more than 140,000 UK Biobank surgery patients identified a PITX2 risk locus for postoperative atrial fibrillation and linked polygenic risk scores for chronic diseases to the

Intelligence is correlated with a range of left-wing and liberal political beliefs. This may suggest intelligence directly alters our political views. Alternatively, the association may be confounded ...

Exploring the Behavioral and Emotional Manifestation of Polygenic Risk for Psychiatric Disorders Among Schoolchildren