DNA polymerase but it just like makes you into a clone of me or something
November 1, 2026 at 2:35 AM
DNA polymerase but it just like makes you into a clone of me or something
Things We Do for No Reason – Polymerase Chain Reaction for Lyme Disease Diagnostic Testing
✅ Just Accepted
🔗 https://bit.ly/3UjrPsu
✅ Just Accepted
🔗 https://bit.ly/3UjrPsu
November 4, 2026 at 6:54 PM
Things We Do for No Reason – Polymerase Chain Reaction for Lyme Disease Diagnostic Testing
✅ Just Accepted
🔗 https://bit.ly/3UjrPsu
✅ Just Accepted
🔗 https://bit.ly/3UjrPsu
Happy to share our preprint with @chaocheng.bsky.social "Single-molecule nascent RNA profiling reveals multiple layers of co-transcriptional splicing and their reprogramming by cold in Arabidopsis"
Thanks to all co-authors!
www.biorxiv.org/content/10.6...
Thanks to all co-authors!
www.biorxiv.org/content/10.6...
Single-molecule nascent RNA profiling reveals multiple layers of co-transcriptional splicing and their reprogramming by cold in Arabidopsis
In eukaryotes, RNA polymerase II (Pol II) transcription is closely coupled to RNA processing, yet how polymerase progression coordinates multiple processing events within individual nascent transcript...
www.biorxiv.org
November 3, 2026 at 2:07 PM
Happy to share our preprint with @chaocheng.bsky.social "Single-molecule nascent RNA profiling reveals multiple layers of co-transcriptional splicing and their reprogramming by cold in Arabidopsis"
Thanks to all co-authors!
www.biorxiv.org/content/10.6...
Thanks to all co-authors!
www.biorxiv.org/content/10.6...
And it's a ring-shaped peptide, which is why cooking, freezing or drying a death cap doesn't make it safe. Amanitin shuts down RNA polymerase II, so liver cells can't make proteins. The cruel part is the lull after the first gut symptoms, before the liver fails.
November 1, 2026 at 8:29 PM
And it's a ring-shaped peptide, which is why cooking, freezing or drying a death cap doesn't make it safe. Amanitin shuts down RNA polymerase II, so liver cells can't make proteins. The cruel part is the lull after the first gut symptoms, before the liver fails.
So how is the @asbmb.bsky.social transcription meeting @triggerloop.bsky.social @lucas.farnunglab.com ?
www.asbmb.org/meetings-eve...
www.asbmb.org/meetings-eve...
Transcriptional regulation by chromatin and RNA polymerase
Oct. 29 – Nov. 1, 2026 | Alexandria, VA
www.asbmb.org
October 31, 2026 at 5:54 PM
So how is the @asbmb.bsky.social transcription meeting @triggerloop.bsky.social @lucas.farnunglab.com ?
www.asbmb.org/meetings-eve...
www.asbmb.org/meetings-eve...
In the latest #Yeast research article, Lucía Ramos-Alonso, Sara Martín Villanueva, Jesus de la Cruz, Sebastian Chavez & José E. Pérez Ortín investigate the regulation of #RNA polymerase I #transcription elongation in a yeast mutant with a large cell volume.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Decoupling of Cell Volume From the Number of Ribosomal DNA Repeat Copies Through Regulation of RNA Polymerase I Transcription Elongation in a Large‐Cell Yeast Mutant
Although most studies in the regulation of gene transcription in eukaryotes have focused on protein-coding genes transcribed into mRNA by RNA polymerase II, the regulation of RNA polymerase I (RNA Po...
onlinelibrary.wiley.com
October 29, 2026 at 5:03 PM
In the latest #Yeast research article, Lucía Ramos-Alonso, Sara Martín Villanueva, Jesus de la Cruz, Sebastian Chavez & José E. Pérez Ortín investigate the regulation of #RNA polymerase I #transcription elongation in a yeast mutant with a large cell volume.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Yes, and I used alpha amanitin in my PhD research in the early 70s in studies of RNA polymerase II transcription of Herpes Simplex virus. It was also the toxin of choice in my sci-fi novel “DomainShifters” (written under a pseudonym). Hasn’t been a best seller, but hope springs eternal.
November 1, 2026 at 9:15 PM
Yes, and I used alpha amanitin in my PhD research in the early 70s in studies of RNA polymerase II transcription of Herpes Simplex virus. It was also the toxin of choice in my sci-fi novel “DomainShifters” (written under a pseudonym). Hasn’t been a best seller, but hope springs eternal.
Molecular and Structural Characterisation of the MERS-Coronavirus Polymerase https://www.biorxiv.org/content/10.64898/2026.11.01.763422v1
November 3, 2026 at 2:17 AM
Molecular and Structural Characterisation of the MERS-Coronavirus Polymerase https://www.biorxiv.org/content/10.64898/2026.11.01.763422v1
Molecular and Structural Characterisation of the MERS-Coronavirus Polymerase https://www.biorxiv.org/content/10.64898/2026.11.01.763422v1
November 3, 2026 at 2:17 AM
Molecular and Structural Characterisation of the MERS-Coronavirus Polymerase https://www.biorxiv.org/content/10.64898/2026.11.01.763422v1
CRV Science Labs ⚗️
🧬 Tier 3 Synthesis: How Heimdallarchaeia Cellular Machinery, RNA Polymerase Regulatory Markers, and Accretive Ribosome Evolution Bridge the Archaeal-to-Eukaryotic Transition — Which eukaryotic cellular system…
https://crvscience.com/labs/discoveries/heimdall-eukaryogenesis-tier3
🧬 Tier 3 Synthesis: How Heimdallarchaeia Cellular Machinery, RNA Polymerase Regulatory Markers, and Accretive Ribosome Evolution Bridge the Archaeal-to-Eukaryotic Transition — Which eukaryotic cellular system…
https://crvscience.com/labs/discoveries/heimdall-eukaryogenesis-tier3
CRV Science Labs ⚗️
🧬 Tier 3 Synthesis: How Heimdallarchaeia Cellular Machinery, RNA Polymerase Regulatory Markers, and Accretive Ribosome Evolution Bridge the Archaeal-to-Eukaryotic Transition — Which eukaryotic cellular systems already existed in the Asgard archaeal ancestor (Candidatus Heimdalla…
crvscience.com
November 3, 2026 at 6:10 AM
CRV Science Labs ⚗️
🧬 Tier 3 Synthesis: How Heimdallarchaeia Cellular Machinery, RNA Polymerase Regulatory Markers, and Accretive Ribosome Evolution Bridge the Archaeal-to-Eukaryotic Transition — Which eukaryotic cellular system…
https://crvscience.com/labs/discoveries/heimdall-eukaryogenesis-tier3
🧬 Tier 3 Synthesis: How Heimdallarchaeia Cellular Machinery, RNA Polymerase Regulatory Markers, and Accretive Ribosome Evolution Bridge the Archaeal-to-Eukaryotic Transition — Which eukaryotic cellular system…
https://crvscience.com/labs/discoveries/heimdall-eukaryogenesis-tier3
cmon baby lemme do some polymerase chain reaction itll really amplify our sex life
October 29, 2026 at 3:51 PM
cmon baby lemme do some polymerase chain reaction itll really amplify our sex life
Human senataxin uses distinct peripheral elements to unwind R-loops and act on RNA polymerase II www.biorxiv.org/content/10.64898/2026.11.01.763451v1 #cryoem
November 4, 2026 at 9:31 AM
Human senataxin uses distinct peripheral elements to unwind R-loops and act on RNA polymerase II www.biorxiv.org/content/10.64898/2026.11.01.763451v1 #cryoem
🧬A hidden genetic fingerprint in wetlands!🌿
A study of 1,222 DNA polymerase gene sequences reveals distinct genetic patterns in China's Napahai plateau wetland.
Explore the hidden diversity of wetland ecosystems!
#Wetlands #Genetics
Read more🔗:
www.maxapress.com/article/doi/...
A study of 1,222 DNA polymerase gene sequences reveals distinct genetic patterns in China's Napahai plateau wetland.
Explore the hidden diversity of wetland ecosystems!
#Wetlands #Genetics
Read more🔗:
www.maxapress.com/article/doi/...
November 3, 2026 at 7:05 AM
🧬A hidden genetic fingerprint in wetlands!🌿
A study of 1,222 DNA polymerase gene sequences reveals distinct genetic patterns in China's Napahai plateau wetland.
Explore the hidden diversity of wetland ecosystems!
#Wetlands #Genetics
Read more🔗:
www.maxapress.com/article/doi/...
A study of 1,222 DNA polymerase gene sequences reveals distinct genetic patterns in China's Napahai plateau wetland.
Explore the hidden diversity of wetland ecosystems!
#Wetlands #Genetics
Read more🔗:
www.maxapress.com/article/doi/...
Human senataxin uses distinct peripheral elements to unwind R-loops and act on RNA polymerase II https://www.biorxiv.org/content/10.64898/2026.11.01.763451v1
November 3, 2026 at 8:45 AM
Human senataxin uses distinct peripheral elements to unwind R-loops and act on RNA polymerase II https://www.biorxiv.org/content/10.64898/2026.11.01.763451v1
Human senataxin uses distinct peripheral elements to unwind R-loops and act on RNA polymerase II https://www.biorxiv.org/content/10.64898/2026.11.01.763451v1
November 3, 2026 at 8:45 AM
Human senataxin uses distinct peripheral elements to unwind R-loops and act on RNA polymerase II https://www.biorxiv.org/content/10.64898/2026.11.01.763451v1
APR-246 and DNA polymerase theta inhibitor Novobiocinsynergize to eliminate TP53 mutant AML cells https://www.biorxiv.org/content/10.64898/2026.10.30.763043v1
November 2, 2026 at 6:46 PM
APR-246 and DNA polymerase theta inhibitor Novobiocinsynergize to eliminate TP53 mutant AML cells https://www.biorxiv.org/content/10.64898/2026.10.30.763043v1
APR-246 and DNA polymerase theta inhibitor Novobiocinsynergize to eliminate TP53 mutant AML cells https://www.biorxiv.org/content/10.64898/2026.10.30.763043v1
November 2, 2026 at 6:46 PM
APR-246 and DNA polymerase theta inhibitor Novobiocinsynergize to eliminate TP53 mutant AML cells https://www.biorxiv.org/content/10.64898/2026.10.30.763043v1
Making PCR
_Making PCR_ is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time--the polymerase chain reaction.
View Book #Subteron #Science #AdvancedTech
_Making PCR_ is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time--the polymerase chain reaction.
View Book #Subteron #Science #AdvancedTech
Making PCR
_Making PCR_ is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time--the polymerase chain reaction.
bookshop.org
November 3, 2026 at 9:25 PM
Making PCR
_Making PCR_ is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time--the polymerase chain reaction.
View Book #Subteron #Science #AdvancedTech
_Making PCR_ is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time--the polymerase chain reaction.
View Book #Subteron #Science #AdvancedTech
🔬 Abstract highlights · In-cell structures visualize human pre-ribosome…
We further show how pre-ribosome assembly landscapes are altered upon RNA polymerase I inhibition.
Science
https://doi.org/10.1126/science.aej0483
We further show how pre-ribosome assembly landscapes are altered upon RNA polymerase I inhibition.
Science
https://doi.org/10.1126/science.aej0483
November 3, 2026 at 9:08 PM
🔬 Abstract highlights · In-cell structures visualize human pre-ribosome…
We further show how pre-ribosome assembly landscapes are altered upon RNA polymerase I inhibition.
Science
https://doi.org/10.1126/science.aej0483
We further show how pre-ribosome assembly landscapes are altered upon RNA polymerase I inhibition.
Science
https://doi.org/10.1126/science.aej0483
Eloi Vincent, Clément Lopez, Rémi Sieskind, Isciane Commenge, Rafael Navaza, Ahmed Haouz, Marc Delarue: Directed evolution of a thermostable family-A DNA polymerase into a reverse transcriptase for 2’-modified RNA https://pasteur.hal.science/pasteur-05849084v1 [sdv]
November 4, 2026 at 3:01 AM
Eloi Vincent, Clément Lopez, Rémi Sieskind, Isciane Commenge, Rafael Navaza, Ahmed Haouz, Marc Delarue: Directed evolution of a thermostable family-A DNA polymerase into a reverse transcriptase for 2’-modified RNA https://pasteur.hal.science/pasteur-05849084v1 [sdv]
PXD072041 🚨
GTSF-1 is an essential activating cofactor for PIWI proteins in many metazoans and is associated with the RNA-dependent RNA polymerase RRF-3
🚨 New dataset alert! 🚨
GTSF-1 is an essential activating cofactor for PIWI proteins in many metazoans and is associated with the RNA-dependent RNA polymerase RRF-3
🚨 New dataset alert! 🚨
November 1, 2026 at 11:00 PM
PXD072041 🚨
GTSF-1 is an essential activating cofactor for PIWI proteins in many metazoans and is associated with the RNA-dependent RNA polymerase RRF-3
🚨 New dataset alert! 🚨
GTSF-1 is an essential activating cofactor for PIWI proteins in many metazoans and is associated with the RNA-dependent RNA polymerase RRF-3
🚨 New dataset alert! 🚨
CRV Science Labs ⚗️
🔬 How Sub-Domain Partitioning of RNA Polymerase II, Chitin Synthase, and Hsp70 Resolves the Microsporidia Long-Branch Attraction Puzzle at the Base of Fungi — Synthesizing 1.68 Mb across 32 Developm…
https://crvscience.com/labs/discoveries/microsporidia-fungi-subdomain-lba-tier3
🔬 How Sub-Domain Partitioning of RNA Polymerase II, Chitin Synthase, and Hsp70 Resolves the Microsporidia Long-Branch Attraction Puzzle at the Base of Fungi — Synthesizing 1.68 Mb across 32 Developm…
https://crvscience.com/labs/discoveries/microsporidia-fungi-subdomain-lba-tier3
CRV Science Labs ⚗️
🔬 How Sub-Domain Partitioning of RNA Polymerase II, Chitin Synthase, and Hsp70 Resolves the Microsporidia Long-Branch Attraction Puzzle at the Base of Fungi — Synthesizing 1.68 Mb across 32 Development and Untouched Reserve cohorts (64 eukaryotic taxa) validates CANDIDATE-LAW-00…
crvscience.com
November 3, 2026 at 1:41 PM
CRV Science Labs ⚗️
🔬 How Sub-Domain Partitioning of RNA Polymerase II, Chitin Synthase, and Hsp70 Resolves the Microsporidia Long-Branch Attraction Puzzle at the Base of Fungi — Synthesizing 1.68 Mb across 32 Developm…
https://crvscience.com/labs/discoveries/microsporidia-fungi-subdomain-lba-tier3
🔬 How Sub-Domain Partitioning of RNA Polymerase II, Chitin Synthase, and Hsp70 Resolves the Microsporidia Long-Branch Attraction Puzzle at the Base of Fungi — Synthesizing 1.68 Mb across 32 Developm…
https://crvscience.com/labs/discoveries/microsporidia-fungi-subdomain-lba-tier3
CRV Science Labs ⚗️
🔬 Testing the Sub-Domain LBA Law on Microsporidia and Rozellomycota Across RNA Polymerase II, Chitin Synthase, and Hsp70 — Evaluating 328 kb across 8 exploratory cohorts (18 opisthokont, amoebozoan, and e…
https://crvscience.com/labs/discoveries/microsporidia-subdomain-lba-tier1
🔬 Testing the Sub-Domain LBA Law on Microsporidia and Rozellomycota Across RNA Polymerase II, Chitin Synthase, and Hsp70 — Evaluating 328 kb across 8 exploratory cohorts (18 opisthokont, amoebozoan, and e…
https://crvscience.com/labs/discoveries/microsporidia-subdomain-lba-tier1
CRV Science Labs ⚗️
🔬 Testing the Sub-Domain LBA Law on Microsporidia and Rozellomycota Across RNA Polymerase II, Chitin Synthase, and Hsp70 — Evaluating 328 kb across 8 exploratory cohorts (18 opisthokont, amoebozoan, and excavate taxa) shows that quarantining degenerated C-terminal repeat tails w…
crvscience.com
November 3, 2026 at 12:40 PM
CRV Science Labs ⚗️
🔬 Testing the Sub-Domain LBA Law on Microsporidia and Rozellomycota Across RNA Polymerase II, Chitin Synthase, and Hsp70 — Evaluating 328 kb across 8 exploratory cohorts (18 opisthokont, amoebozoan, and e…
https://crvscience.com/labs/discoveries/microsporidia-subdomain-lba-tier1
🔬 Testing the Sub-Domain LBA Law on Microsporidia and Rozellomycota Across RNA Polymerase II, Chitin Synthase, and Hsp70 — Evaluating 328 kb across 8 exploratory cohorts (18 opisthokont, amoebozoan, and e…
https://crvscience.com/labs/discoveries/microsporidia-subdomain-lba-tier1
Our latest work from Macurek’s lab is now out in NAR! Following our favorite phosphatase PPM1D/WIP1 took us down an unexpected path into the nucleolus.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Dynamic phosphorylation of TCOF1 controlled by CK2 and PPM1D regulates nucleolar condensation and RNA polymerase I activity
Abstract. The nucleolus is a membrane-less organelle essential for ribosomal DNA (rDNA) transcription and ribosome biogenesis, yet the mechanisms regulatin
academic.oup.com
November 1, 2026 at 7:17 PM
Our latest work from Macurek’s lab is now out in NAR! Following our favorite phosphatase PPM1D/WIP1 took us down an unexpected path into the nucleolus.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
In many labs, CE dictates casework.
The 8-dye Spectrum CE System, 24-Capillary completes a family of three CE options and runs kits from multiple vendors. Paradyme™ 27GY, the first and only Reduced-Stutter Polymerase STR kit, is QC-tested on Spectrum.
Not For Medical Diagnostic Use #ForensicDNA
The 8-dye Spectrum CE System, 24-Capillary completes a family of three CE options and runs kits from multiple vendors. Paradyme™ 27GY, the first and only Reduced-Stutter Polymerase STR kit, is QC-tested on Spectrum.
Not For Medical Diagnostic Use #ForensicDNA
November 4, 2026 at 4:00 PM
In many labs, CE dictates casework.
The 8-dye Spectrum CE System, 24-Capillary completes a family of three CE options and runs kits from multiple vendors. Paradyme™ 27GY, the first and only Reduced-Stutter Polymerase STR kit, is QC-tested on Spectrum.
Not For Medical Diagnostic Use #ForensicDNA
The 8-dye Spectrum CE System, 24-Capillary completes a family of three CE options and runs kits from multiple vendors. Paradyme™ 27GY, the first and only Reduced-Stutter Polymerase STR kit, is QC-tested on Spectrum.
Not For Medical Diagnostic Use #ForensicDNA