FinCEN withdrew a 2020 proposal to track transactions with self-custodial crypto wallets and a 2023 plan to designate crypto mixing as a primary money laundering concern.

The Civic Engagement Strategist leads all planning, logistics, and coordination efforts for the Native American Youth and Family Center (NAYA) and the NAYA Action Fund s policy and advocacy programming. A primary focus is the Leadership, Entrepreneurship, and Advocacy Development (LEAD) program and our annual Legislative Days of Action in Salem, Oregon and Olympia, Washington. The LEAD Program is an annual cohort model that nurtures relationships and develops leadership and advocacy skills wi...

To assess CMA activity during senescence in aging cells, we isolated mouse ear fibroblasts (mEFs), a reliable primary cell model for the study of aging in vitro39,40, as, at early passages, they allow analyzing aging separately from replicative senescence. We confirmed, as reported previously39, that mEFs from aged mice (23-month-old; 23 m) were not more senescent than those from young mice (4-month-old; 4 m) using senescence-associated β-galactosidase (SA-β-gal) staining or p16INK4A messenger RNA, but could still be induced into senescence 7 days after initial treatment with palbociclib (Palbo) (Extended Data Fig. 1a,b). ProteoSTAT staining confirmed the characteristic loss of proteostasis and increased protein aggregation in aged mEFs (Extended Data Fig. 1c), which could be directly attributed to the CMA decline with age29, as we found comparable protein aggregation in mEFs from 4 m CMA-deficient (L2AKO) mice32 (Extended Data Fig. 1c). To monitor CMA activity upon senescence induction, we used mEFs from transgenic KFERQDendra mice, which systemically express a fluorescent CMA reporter41,42 consisting of the CMA-targeting motif KFERQ fused to Dendra2. KFERQDendra is recognized by Hsc70 and delivered to LAMP2A, generating fluorescent lysosomal puncta42. Following LAMP2A binding and unfolding, KFERQDendra is translocated for degradation in the lysosomal lumen42. The number of...

The article explores the complex relationship between elderly patients and their pets, particularly focusing on the emotional and practical challenges that arise when an elderly person is hospitalized and unable to return home. Ranjana Srivastava, an Australian oncologist and author, shares a poignant case study of an elderly woman who has been waiting for residential care after a fall, but whose primary concern is her dog. The patient, despite cognitive impairment, vividly describes her dog as her constant companion, curling up on her lap while she knits and following her around her apartment. The hospital staff are aware of her attachment to her dog but face practical barriers: the hospital won't allow the dog inside, and the neighbor who offered to take the dog can't bring it into the facility. The article highlights how concern for a pet's welfare can become a significant barrier to healthcare, with patients delaying treatment, worrying about hospitalization, or even discharging themselves early to care for their pets. Srivastava notes that while our relationships with pets matter to wellbeing, providing physical activity, psychological comfort, and social connection, the healthcare system often fails to address this aspect of patient care. She references a recent essay in the New England Journal of Medicine that recognizes the intertwined wellbeing of humans and their pets. The author argues that hospitals should work more effectively with community services and animal welfare agencies to care for the whole patient, rather than treating pets as a peripheral issue. The article concludes with the poignant observation that for as long as they cared for the patient, the medical team would sit with her and hear her retell the story about her dog, a ritual they hoped would continue with the next team. The piece underscores the need for healthcare systems to recognize and address the social determinants of health, including the role of pets in the lives of elderly patients.