prion disease, that's the next step here
by Thanksgiving
by Thanksgiving
September 29, 2026 at 1:21 PM
prion disease, that's the next step here
by Thanksgiving
by Thanksgiving
Astrocytic Stat3 is dispensable for prion disease progression despite its role in neuroinflammation #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02445-1
https://link.springer.com/10.1186/s40478-026-02445-1
September 29, 2026 at 1:03 PM
Astrocytic Stat3 is dispensable for prion disease progression despite its role in neuroinflammation #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02445-1
https://link.springer.com/10.1186/s40478-026-02445-1
Infecting people with the "being inflatable is hot actually" brainworm like the humble prion
September 29, 2026 at 7:08 AM
Infecting people with the "being inflatable is hot actually" brainworm like the humble prion
you know that a person with technical expertise still needs to like make those, right? and that prions are recognizably different in structure from regular proteins? and that prion diseases aren't contagious in the first place, making their use as a bioweapon extremely questionable?
September 29, 2026 at 3:02 AM
you know that a person with technical expertise still needs to like make those, right? and that prions are recognizably different in structure from regular proteins? and that prion diseases aren't contagious in the first place, making their use as a bioweapon extremely questionable?
There are also plans that are basically one-step, but next to impossible for a human. Like it should in theory be possible to design an extremely dangerous prion with AI technology close to what we already have.
September 29, 2026 at 2:17 AM
There are also plans that are basically one-step, but next to impossible for a human. Like it should in theory be possible to design an extremely dangerous prion with AI technology close to what we already have.
prion disease
September 28, 2026 at 9:44 PM
prion disease
Prion: A Proteína Malfalada que Desafia o Destino do Cérebro Humano e Animal
Prion é uma proteína mal dobrada capaz de infectar outras proteínas normais, causando doenças neurodegenerativas fatais sem envolver DNA ou RNA. Foi encontrado em animais como ovel
Prion é uma proteína mal dobrada capaz de infectar outras proteínas normais, causando doenças neurodegenerativas fatais sem envolver DNA ou RNA. Foi encontrado em animais como ovel
Prion: A Proteína Malfalada que Desafia o Destino do Cérebro Humano e Animal
Prion é uma proteína mal dobrada capaz de infectar outras proteínas normais, causando doenças neurodegenerativas fatais sem envolver DNA ou RNA. Foi encontrado em animais como ovelhas (scrapie), bois (doença da vaca louca) e cervos (doença crônica de wasting), e também causa a doença de Creutzfeldt-
khatulistiwa.org
September 28, 2026 at 9:22 PM
Prion: A Proteína Malfalada que Desafia o Destino do Cérebro Humano e Animal
Prion é uma proteína mal dobrada capaz de infectar outras proteínas normais, causando doenças neurodegenerativas fatais sem envolver DNA ou RNA. Foi encontrado em animais como ovel
Prion é uma proteína mal dobrada capaz de infectar outras proteínas normais, causando doenças neurodegenerativas fatais sem envolver DNA ou RNA. Foi encontrado em animais como ovel
PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
September 28, 2026 at 7:02 PM
PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
I'm so annoyed when ppl think prion disease is the reason they shouldn't eat people
September 28, 2026 at 6:20 PM
I'm so annoyed when ppl think prion disease is the reason they shouldn't eat people
PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
September 28, 2026 at 6:15 PM
PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
September 28, 2026 at 6:15 PM
PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication https://www.biorxiv.org/content/10.64898/2026.09.22.753491v1
dug out some expired store bought panéed chicken that I'd left in the back of the fridge until it burst open and breaded chicken goo started leaking out. I'm surprised I don't have prion disease.
September 28, 2026 at 3:19 PM
dug out some expired store bought panéed chicken that I'd left in the back of the fridge until it burst open and breaded chicken goo started leaking out. I'm surprised I don't have prion disease.
I'm always amused that sweetmeats are not what you think. Prion disease like BSE, CJD, CWD, etc. Did Elvis die from brain rot contracted from eating fried squirrel? Anyway, don't eat animal (or human) brains.
September 28, 2026 at 3:02 PM
I'm always amused that sweetmeats are not what you think. Prion disease like BSE, CJD, CWD, etc. Did Elvis die from brain rot contracted from eating fried squirrel? Anyway, don't eat animal (or human) brains.
I like the part of disco elysium where its implied that the coalition against revachol was at least partly influenced by a prion outbreak giving everyone some kind of Transmissible Spongiform Encephalopathy
September 28, 2026 at 12:51 PM
I like the part of disco elysium where its implied that the coalition against revachol was at least partly influenced by a prion outbreak giving everyone some kind of Transmissible Spongiform Encephalopathy
I don't know what a prion is but congratulations!
September 28, 2026 at 9:36 AM
I don't know what a prion is but congratulations!
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
September 28, 2026 at 7:01 AM
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
September 28, 2026 at 4:15 AM
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
September 28, 2026 at 4:15 AM
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
Monitoring intramolecular dynamics across two regions of the mouse prion protein during misfolding and oligomerization using fluorescence correlation spectroscopy #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
September 28, 2026 at 4:02 AM
Monitoring intramolecular dynamics across two regions of the mouse prion protein during misfolding and oligomerization using fluorescence correlation spectroscopy #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
Monitoring intramolecular dynamics across two regions of the mouse prion protein during misfolding and oligomerization using fluorescence correlation spectroscopy https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
September 28, 2026 at 3:47 AM
Monitoring intramolecular dynamics across two regions of the mouse prion protein during misfolding and oligomerization using fluorescence correlation spectroscopy https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
Monitoring intramolecular dynamics across two regions of the mouse prion protein during misfolding and oligomerization using fluorescence correlation spectroscopy https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
September 28, 2026 at 3:47 AM
Monitoring intramolecular dynamics across two regions of the mouse prion protein during misfolding and oligomerization using fluorescence correlation spectroscopy https://www.biorxiv.org/content/10.64898/2026.09.25.753467v1
when the dev has prion disease
Games Will Never Be Coherent Like They Used To Be
September 28, 2026 at 2:11 AM
when the dev has prion disease
Prion-like Protein TDP-43: Mechanisms, Diagnosis, and Therapeutic Prospects pubmed.ncbi.nlm.nih.gov/42796657/ #cryoem
September 28, 2026 at 12:25 AM
Prion-like Protein TDP-43: Mechanisms, Diagnosis, and Therapeutic Prospects pubmed.ncbi.nlm.nih.gov/42796657/ #cryoem
This is scary, but the extremely cool thing about CWD is that being a prion disease, it is a mistake in the replication in proteins. CWD folds proteins in such a way that makes them very hard to destroy. Not even exposure sun and air brakes them down easily.
More advice for hunters. Prevent chronic wasting disease (a type of spongiform encephalopathy like “mad cow” or CJD in humans.) Dear hunters, stop dumping the damned carcasses
September 27, 2026 at 11:38 PM
This is scary, but the extremely cool thing about CWD is that being a prion disease, it is a mistake in the replication in proteins. CWD folds proteins in such a way that makes them very hard to destroy. Not even exposure sun and air brakes them down easily.