'Unlike typical gene therapy, which alters a person’s genes to treat a genetic disease, antisense oligonucleotide [RNA] therapy, uses short strands of genetic material to target RNA produced by the gene and reduce how much protein is made.'
Looking for good news. Advances in RNA science & med.
Looking for good news. Advances in RNA science & med.
First for RNA therapy: man with rare motor-neuron disease improves after treatment
Gene-targeting treatments could be used to treat other people with rare forms of amyotrophic lateral sclerosis (ALS).
www.nature.com
September 19, 2026 at 9:48 AM
'Unlike typical gene therapy, which alters a person’s genes to treat a genetic disease, antisense oligonucleotide [RNA] therapy, uses short strands of genetic material to target RNA produced by the gene and reduce how much protein is made.'
Looking for good news. Advances in RNA science & med.
Looking for good news. Advances in RNA science & med.
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
January 6, 2026 at 8:05 AM
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
April 25, 2025 at 5:19 AM
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation.
That’s going to lead to better cancer therapies.
That’s going to lead to better cancer therapies.
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering
Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...
www.nature.com
March 5, 2025 at 8:58 PM
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation.
That’s going to lead to better cancer therapies.
That’s going to lead to better cancer therapies.
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
Cellular RNA interacts with MAVS to promote antiviral signaling
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...
www.science.org
December 19, 2024 at 8:13 PM
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
Predicting 3D structures for proteins with A.I. is a lot easier than for RNA
www.nature.com/articles/d41... @nature.com feature by @dianakwon.bsky.social
www.nature.com/articles/d41... @nature.com feature by @dianakwon.bsky.social
RNA function follows form – why is it so hard to predict?
AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.
www.nature.com
March 24, 2025 at 3:19 PM
Predicting 3D structures for proteins with A.I. is a lot easier than for RNA
www.nature.com/articles/d41... @nature.com feature by @dianakwon.bsky.social
www.nature.com/articles/d41... @nature.com feature by @dianakwon.bsky.social
A Japanese research team has developed a drug that uses RNA to target the USAG-1 protein to help regrow teeth.
December 13, 2024 at 5:10 PM
A Japanese research team has developed a drug that uses RNA to target the USAG-1 protein to help regrow teeth.
AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
RNA function follows form – why is it so hard to predict?
AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.
go.nature.com
April 5, 2025 at 1:22 AM
AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
Why understanding biology matters in bioinformatics
One big lesson: RNA and protein levels aren’t always correlated. If you don’t know this, you might draw the wrong conclusions. 🧵👇
One big lesson: RNA and protein levels aren’t always correlated. If you don’t know this, you might draw the wrong conclusions. 🧵👇
January 21, 2025 at 2:45 PM
Why understanding biology matters in bioinformatics
One big lesson: RNA and protein levels aren’t always correlated. If you don’t know this, you might draw the wrong conclusions. 🧵👇
One big lesson: RNA and protein levels aren’t always correlated. If you don’t know this, you might draw the wrong conclusions. 🧵👇
What explains the divergence between RNA and protein levels ?
Protein degradation is a HUGE factor.
It accounts for up to 50 % of protein variation across proteins & tissue types.
www.biorxiv.org/content/10.1...
🧵
Protein degradation is a HUGE factor.
It accounts for up to 50 % of protein variation across proteins & tissue types.
www.biorxiv.org/content/10.1...
🧵
February 13, 2025 at 1:03 PM
What explains the divergence between RNA and protein levels ?
Protein degradation is a HUGE factor.
It accounts for up to 50 % of protein variation across proteins & tissue types.
www.biorxiv.org/content/10.1...
🧵
Protein degradation is a HUGE factor.
It accounts for up to 50 % of protein variation across proteins & tissue types.
www.biorxiv.org/content/10.1...
🧵
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
July 25, 2025 at 3:46 PM
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
RNA function follows form – why is it so hard to predict?
AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.
go.nature.com
March 30, 2025 at 1:36 PM
AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
CALVADOS-RNA is now published
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
February 26, 2025 at 7:09 PM
CALVADOS-RNA is now published
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
In this evaluation of AlphaFold3 (and other methods), we show that (i) accurate predictions are limited to RNA structures/complexes with structural similarity to PDB and (ii) that current methods are bad at estimating the accuracy of the predictions. www.biorxiv.org/content/10.1...
Limits of deep-learning-based RNA prediction methods
Motivation: In recent years, tremendous advances have been made in predicting protein structures and protein-protein interactions. However, progress in predicting the structure of RNA, either alone or...
www.biorxiv.org
May 5, 2025 at 1:01 PM
In this evaluation of AlphaFold3 (and other methods), we show that (i) accurate predictions are limited to RNA structures/complexes with structural similarity to PDB and (ii) that current methods are bad at estimating the accuracy of the predictions. www.biorxiv.org/content/10.1...
Advances in CLIP-derived methods have enabled high-resolution mapping of individual RNA binding protein-RNA interactions as well as RNA binding protein-associated RNA–RNA interactions #RNA #CLIP @evannostrandlab.bsky.social bit.ly/4bYjAsg
February 17, 2026 at 4:25 PM
Advances in CLIP-derived methods have enabled high-resolution mapping of individual RNA binding protein-RNA interactions as well as RNA binding protein-associated RNA–RNA interactions #RNA #CLIP @evannostrandlab.bsky.social bit.ly/4bYjAsg
AlphaFold’s highly accurate structural models transformed protein biology, but RNA lags behind
https://go.nature.com/41UEulj
https://go.nature.com/41UEulj
RNA function follows form – why is it so hard to predict?
AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.
go.nature.com
March 24, 2025 at 2:49 PM
AlphaFold’s highly accurate structural models transformed protein biology, but RNA lags behind
https://go.nature.com/41UEulj
https://go.nature.com/41UEulj
Novavax is protein (not DNA or RNA). Just spike protein and an adjuvant
December 26, 2024 at 11:02 PM
Novavax is protein (not DNA or RNA). Just spike protein and an adjuvant
The average American has three friends:
May 2, 2025 at 1:40 PM
The average American has three friends:
Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
February 26, 2025 at 11:21 PM
Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
January 8, 2025 at 12:29 PM
5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
www.nature.com
February 21, 2026 at 11:32 PM
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii
Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology
A resource of human RNA-protein associations is produced using a sequencing-based method.
go.nature.com
September 10, 2025 at 3:42 PM
Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions - PubMed
RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-R …
pubmed.ncbi.nlm.nih.gov
January 18, 2026 at 3:29 AM
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
🚨 I am super happy to announce that our analysis of how the structure of protein-RNA interfaces evolves is now published (early access) at @plos.bsky.social Computational Biology:
doi.org/10.1371/jour...
🧬🧶
doi.org/10.1371/jour...
🧬🧶
December 3, 2024 at 10:03 PM
🚨 I am super happy to announce that our analysis of how the structure of protein-RNA interfaces evolves is now published (early access) at @plos.bsky.social Computational Biology:
doi.org/10.1371/jour...
🧬🧶
doi.org/10.1371/jour...
🧬🧶