The USDA says the pseudorabies detection does not pose a risk to consumer health or affect the safety of the commercial pork supply.

Russia’s federal veterinary watchdog, Rosselkhoznadzor, detected live Aujeszky’s disease virus in samples from batch No. 20 of the Multikan-8 vaccine, according to TASS.

The CFIA states that American shipments that have already been certified 'will be permitted to enter Canada' following reports of outbreaks of pseudorabies in commercial swine.

The pseudorabies virus found in a swine herd in central Iowa this week was an isolated incident, Agriculture Secretary Mike Naig said Friday.

PANoptosis is a newly described type of cell death that can be triggered upon microbial infection, autoinflammatory diseases, and cytokine storms, and involves the coordinated activation of pyroptosis, apoptosis, and necroptosis. Pseudorabies virus (PRV) infection has been reported to trigger excessive inflammatory responses in mice, swine, and in rare cases in humans, leading to acute viral encephalitis. However, the precise mechanisms by which PRV exacerbates host inflammation responses remain incompletely understood, and the potential role of PANoptosis in this pathogenic process has yet to be elucidated. Here, we demonstrate that PRV infection in different cell lines, murine primary macrophages and mice all results in activation of the PANoptotic signaling pathway and drives the formation of the core scaffold (caspase-8/ASC/RIPK3) within the PANoptosome. We observe that innate sensor proteins AIM2, Pyrin, and ZBP1 interact with the core scaffold protein ASC in PRV-infected THP-1 Mφ and co-localize with ASC. We further identify that IRF1 serves as the key transcription factor that is upregulated during PRV infection. Increased IRF1 translocates to the nucleus and binds directly to the promoter regions of innate sensor genes ZBP1 and AIM2, thereby elevating their gene expression. Ultimately, we discover that the genetic suppression of IRF1 expression and...

Current APHIS Veterinary Services (VS) disease eradication programs include cooperative State-Federal efforts directed at cattle and swine brucellosis, bovine and cervid tuberculosis, and pseudorabies...

Author summary Gap junctional intercellular communication (GJIC) is a key feature of multicellular organisms, that allows individual cells to coordinate their functions. Connexin-43 (Cx43) is the most...

Pseudorabies, a highly contagious disease affecting swine, has been found in Iowa after being eradicated from the U.S. over 20 years ago, and the Iowa Department of Agriculture and Land Stewardship…

A livestock disease that the United States spent two decades and significant public resources eradicating has returned. The USDA Animal and Plant Health Inspection Service (APHIS) confirmed on April 30, 2026 that pseudorabies virus (PRV) had been detected in a small commercial swine facility in Iowa — traced to five boars that originated from an outdoor farm in Texas, where the same disease was also confirmed. This marks the first known case of pseudorabies in U.S. commercial pigs since 2004, when a coordinated state-federal-industry program declared the disease eliminated from the commercial swine industry. Both the Iowa and Texas operations have been depopulated under disease control protocols. A two-mile quarantine zone around the Iowa facility is undergoing its final round of testing scheduled between June 12 and July 11, 2026 — a window that encompasses the coming days and the next month. The outcome of that testing will determine whether the outbreak has been contained to the two confirmed premises or has silently spread into the broader swine population. "Based on the confirmation of the pseudorabies virus in a small commercial swine herd in Iowa, we are moving decisively to eliminate the disease," said Iowa Secretary of Agriculture Mike Naig...

Pseudorabies is again considered eradicated in Iowa, after IDALS confirmed a spring outbreak did not spread to other farms.

Scientific Reports - 2’-5’ Oligoadenylate Synthetase-Like 1- (OASL1-) deficient mice promote antiviral protection against pseudorabies virus infection associated with enhanced...

Pseudorabies virus (PRV), a pathogen that induces different disease symptoms and is often fatal in domestic animals and wildlife, has caused great economic losses to the swine industry. Since 2011, di...

Macroautophagy/autophagy is a biological process that sequesters and degrades cytoplasmic material, damaged organelles, and infectious pathogens in eukaryotic cells via lysosomes. Autophagy is invo...

Pseudorabies virus (PRV) belongs to the alpha herpesvirus family and is responsible for Aujeszky’s disease in pigs. Similar to other alpha herpesviruses, PRV establishes a lifelong latent infection ...