Palette of the Day:
8-Bit RGBM by A.J. Otero
#lospecdailies #8bitrgbm #palette
Download: https://lospec.com/palette-list/8-bit-rgbm
8-Bit RGBM by A.J. Otero
#lospecdailies #8bitrgbm #palette
Download: https://lospec.com/palette-list/8-bit-rgbm
October 15, 2025 at 7:00 AM
Palette of the Day:
8-Bit RGBM by A.J. Otero
#lospecdailies #8bitrgbm #palette
Download: https://lospec.com/palette-list/8-bit-rgbm
8-Bit RGBM by A.J. Otero
#lospecdailies #8bitrgbm #palette
Download: https://lospec.com/palette-list/8-bit-rgbm
After 6 years of being involved in early phase clinical trials, I was honored to present data from our Phase 0/2 study exploring CDK4/6i +ERKi in rGBM patients. Grateful to the collaborative team, patients and their families #SNO2024
November 23, 2024 at 8:12 PM
After 6 years of being involved in early phase clinical trials, I was honored to present data from our Phase 0/2 study exploring CDK4/6i +ERKi in rGBM patients. Grateful to the collaborative team, patients and their families #SNO2024
se o papa fosse hermafrodita
se o papa fosse hermafrodita
o aborto seria legal ♫⋆｡♪ ₊˚♬ ﾟ.
se o papa fosse hermafrodita
o aborto seria legal ♫⋆｡♪ ₊˚♬ ﾟ.
February 12, 2025 at 4:14 PM
Very excited to have this collaborative work on evaluating PK/PD and single-cell responses for Ribociclib+Everolimus in #rGBM published. It was such a great experience working with @kevin-johnson.bsky.social and @roelverhaak.bsky.social. @ivycenter.bsky.social @anchitien.bsky.social
Delighted to share this new collaborative paper with the Ivy BTC where we performed deep characterization of glioma patients enrolled on a CDK4/6i Phase 0 trial academic.oup.com/neuro-oncolo... with @kevin-johnson.bsky.social @shwetalm.bsky.social @nadersanai.bsky.social
Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade glioma
AbstractBackground. Outcomes for adult patients with high-grade glioma (HGG) remain poor, necessitating new treatment strategies. Key challenges include po
academic.oup.com
November 8, 2025 at 6:04 PM
Very excited to have this collaborative work on evaluating PK/PD and single-cell responses for Ribociclib+Everolimus in #rGBM published. It was such a great experience working with @kevin-johnson.bsky.social and @roelverhaak.bsky.social. @ivycenter.bsky.social @anchitien.bsky.social
Oooh, I see, one reason to use octahedral environment maps is that it simplifies doing something like RGBM encoding where you might implement your own bilinear filtering in the shader
Also enables packing them into texture arrays (which have much wider hw support than cube arrays)
Also enables packing them into texture arrays (which have much wider hw support than cube arrays)
Oh. Huh. Today I learned about octahedral environment maps :O
December 7, 2025 at 12:12 AM
Oooh, I see, one reason to use octahedral environment maps is that it simplifies doing something like RGBM encoding where you might implement your own bilinear filtering in the shader
Also enables packing them into texture arrays (which have much wider hw support than cube arrays)
Also enables packing them into texture arrays (which have much wider hw support than cube arrays)
alright it's bed time. I misread a post about RGBM encoding and was just ready to accept that Ranked Competitive Breast Growth had octahedral environment maps
I'm a couple months behind, Katherine could've done anything by now
I'm a couple months behind, Katherine could've done anything by now
December 7, 2025 at 12:26 AM
alright it's bed time. I misread a post about RGBM encoding and was just ready to accept that Ranked Competitive Breast Growth had octahedral environment maps
I'm a couple months behind, Katherine could've done anything by now
I'm a couple months behind, Katherine could've done anything by now
A isenção do Imposto de Renda atinge diretamente os brasileiros que estarão no centro da disputa em 2026. O Planalto sabe disso. O Congresso também.
Assista à análise de Pedro Doria no Ponto de Partida: www.youtube.com/watch?v=rGBM...
#meio #pontodepartida #impostoderenda #eleicoes2026 #politica
Assista à análise de Pedro Doria no Ponto de Partida: www.youtube.com/watch?v=rGBM...
#meio #pontodepartida #impostoderenda #eleicoes2026 #politica
October 1, 2025 at 9:48 PM
A isenção do Imposto de Renda atinge diretamente os brasileiros que estarão no centro da disputa em 2026. O Planalto sabe disso. O Congresso também.
Assista à análise de Pedro Doria no Ponto de Partida: www.youtube.com/watch?v=rGBM...
#meio #pontodepartida #impostoderenda #eleicoes2026 #politica
Assista à análise de Pedro Doria no Ponto de Partida: www.youtube.com/watch?v=rGBM...
#meio #pontodepartida #impostoderenda #eleicoes2026 #politica
Tak pro velky uspech - takhle se to da cele rozdelat a slozit, kdybyste nahodou potrebovali. www.youtube.com/watch?v=Rgbm...
March 29, 2026 at 7:39 PM
Tak pro velky uspech - takhle se to da cele rozdelat a slozit, kdybyste nahodou potrebovali. www.youtube.com/watch?v=Rgbm...
To learn more about this ministry, go here: riograndeborderland.org
Rio Grande Borderland Ministries
Rio Grande Borderland Ministries (RGBM) is a ministry of the Episcopal Diocese of the Rio Grande serving in the borderlands of New Mexico and far west Texas. RGBM has been engaging with long-term syst...
riograndeborderland.org
March 15, 2025 at 12:08 AM
To learn more about this ministry, go here: riograndeborderland.org
Unraveling the functional complexity of the tumor microenvironment via #spatialbiology. The 2 images show rGBM tissue with cell signaling cell plot (left) & cell-type mIHC (right). Neoplastic, vascular & immune cells show distinct signals which correlate with cell clustering & proximity to ECM
December 18, 2024 at 9:31 AM
Unraveling the functional complexity of the tumor microenvironment via #spatialbiology. The 2 images show rGBM tissue with cell signaling cell plot (left) & cell-type mIHC (right). Neoplastic, vascular & immune cells show distinct signals which correlate with cell clustering & proximity to ECM
URJANET 🚨 com 17 votos, Janet Jackson foi eleita melhor cantora da história em votação realizada pelo blogspot especializado "♡Janet Jackson Lovers♡"
September 2, 2024 at 4:34 AM
GÊNIO: você tem 3 desejos
Janet: faça que todas as palavras tenham 5
letras
Gênio: okayy
Janet: façaa todas aasss plvrs terem NET nnooo
final
Gênet: oknet
Janet: fanet tonet asnet pinet tenet JA nonet
conet
Janet: Janet
Janet: Janet
Janet: faça que todas as palavras tenham 5
letras
Gênio: okayy
Janet: façaa todas aasss plvrs terem NET nnooo
final
Gênet: oknet
Janet: fanet tonet asnet pinet tenet JA nonet
conet
Janet: Janet
Janet: Janet
September 2, 2024 at 2:32 PM
Comment écrire plusieurs romans en même temps
YouTube video by Catherine Loiseau
www.youtube.com
April 1, 2025 at 8:42 AM
One of two dippers seen in the Seven Arches (Balmossie) Viaduct area of the Dighty Burn in Monifieth/Broughty Ferry, Dundee on a Friday walk on a bright chilly afternoon. A 5yo male RGBM/CL97968. 📷📸🎞️🪶 #birds #ukwildlife
March 29, 2025 at 12:37 AM
One of two dippers seen in the Seven Arches (Balmossie) Viaduct area of the Dighty Burn in Monifieth/Broughty Ferry, Dundee on a Friday walk on a bright chilly afternoon. A 5yo male RGBM/CL97968. 📷📸🎞️🪶 #birds #ukwildlife
www.youtube.com/watch?v=rGBM... You wanted to know about this, so here you go.
NIOD Annual Lecture 2026: Omer Bartov
YouTube video by NIODFilm
www.youtube.com
June 4, 2026 at 2:50 PM
www.youtube.com/watch?v=rGBM... You wanted to know about this, so here you go.
Sept 29, 2025:
DCVax-L increased the 4-year survival rate to 15.7% in the nGBM cohort v 9.9% in controls. In the rGBM cohort the #DCVax-L group showed a significantly higher mOS (13.2 m vs. 7.8 m).
💪
#FreezeYourTumor
#GetDCVax
$nwbo #glioblastoma #gbm
cancerbiomed.org/content/cbm/...
DCVax-L increased the 4-year survival rate to 15.7% in the nGBM cohort v 9.9% in controls. In the rGBM cohort the #DCVax-L group showed a significantly higher mOS (13.2 m vs. 7.8 m).
💪
#FreezeYourTumor
#GetDCVax
$nwbo #glioblastoma #gbm
cancerbiomed.org/content/cbm/...
October 2, 2025 at 4:54 PM
Sept 29, 2025:
DCVax-L increased the 4-year survival rate to 15.7% in the nGBM cohort v 9.9% in controls. In the rGBM cohort the #DCVax-L group showed a significantly higher mOS (13.2 m vs. 7.8 m).
💪
#FreezeYourTumor
#GetDCVax
$nwbo #glioblastoma #gbm
cancerbiomed.org/content/cbm/...
DCVax-L increased the 4-year survival rate to 15.7% in the nGBM cohort v 9.9% in controls. In the rGBM cohort the #DCVax-L group showed a significantly higher mOS (13.2 m vs. 7.8 m).
💪
#FreezeYourTumor
#GetDCVax
$nwbo #glioblastoma #gbm
cancerbiomed.org/content/cbm/...
The mOS for 64 rGBM patients who underwent #DCVax-L and control patients were 13.2 mos and 7.8 mos, respectively. The mOS for 232 nGBM patients who underwent DCVax-L and control patients were 19.3 mos and 16.5 mos, respectively.
💪
$nwbo #glioblastoma #gbm
pmc.ncbi.nlm.nih.gov/articles/PMC...
💪
$nwbo #glioblastoma #gbm
pmc.ncbi.nlm.nih.gov/articles/PMC...
June 10, 2025 at 3:24 PM
The mOS for 64 rGBM patients who underwent #DCVax-L and control patients were 13.2 mos and 7.8 mos, respectively. The mOS for 232 nGBM patients who underwent DCVax-L and control patients were 19.3 mos and 16.5 mos, respectively.
💪
$nwbo #glioblastoma #gbm
pmc.ncbi.nlm.nih.gov/articles/PMC...
💪
$nwbo #glioblastoma #gbm
pmc.ncbi.nlm.nih.gov/articles/PMC...
Can recurrent #Glioblastoma be overcome by targeting several #Oncogenic nodes at once? LiPBAE-delivered miR-590-3p nanomiRs inhibit the TGFBR2–SMAD network, suppress orthotopic rGBM growth, and prolong survival in mice. @jhu.edu
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 3, 2026 at 2:45 AM
Can recurrent #Glioblastoma be overcome by targeting several #Oncogenic nodes at once? LiPBAE-delivered miR-590-3p nanomiRs inhibit the TGFBR2–SMAD network, suppress orthotopic rGBM growth, and prolong survival in mice. @jhu.edu
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
The skybox is a 2K x 1K webp image and comes in at just 250KB.
It is a lossy encoded medium dynamic range image using our own "rgbp" format, which is similar to rgbm, but better suited to the way older browsers handle image alpha.
The scene: t.co/8hpbxikar9
The skybox: t.co/13SNzhG4Qf
It is a lossy encoded medium dynamic range image using our own "rgbp" format, which is similar to rgbm, but better suited to the way older browsers handle image alpha.
The scene: t.co/8hpbxikar9
The skybox: t.co/13SNzhG4Qf
March 1, 2025 at 8:30 PM
The skybox is a 2K x 1K webp image and comes in at just 250KB.
It is a lossy encoded medium dynamic range image using our own "rgbp" format, which is similar to rgbm, but better suited to the way older browsers handle image alpha.
The scene: t.co/8hpbxikar9
The skybox: t.co/13SNzhG4Qf
It is a lossy encoded medium dynamic range image using our own "rgbp" format, which is similar to rgbm, but better suited to the way older browsers handle image alpha.
The scene: t.co/8hpbxikar9
The skybox: t.co/13SNzhG4Qf
Full results of this first-in-class phase 1 clinical trial for recurrent glioblastoma now available online first ahead of print in Clinical Cancer Research -- aacrjournals.org/clincancerre...
A genomically-tailored multi-agent precision medicine clinical trial for adults with recurrent glioblastoma
Abstract. Purpose: Existing salvage therapies for recurrent glioblastoma (rGBM) have limited efficacy, with median survival of approximately 9 months. Given the complex molecular heterogeneity of GBM,...
aacrjournals.org
February 8, 2026 at 12:19 AM
Full results of this first-in-class phase 1 clinical trial for recurrent glioblastoma now available online first ahead of print in Clinical Cancer Research -- aacrjournals.org/clincancerre...
Three of eight dippers seen (likely 3 pairs) in the Seven Arches (Balmossie) Viaduct area of the Dighty Burn in Monifieth/Broughty Ferry, Dundee on my Saturday walk on a dingy grey day. 1st/2nd pic: 5yo male RGBM/CL97968, 3rd pic: metal-ringed, 4th pic: colour-ringed RGLM. 📷📸🎞️🪶 #birds #ukwildlife
March 23, 2025 at 1:36 AM
Three of eight dippers seen (likely 3 pairs) in the Seven Arches (Balmossie) Viaduct area of the Dighty Burn in Monifieth/Broughty Ferry, Dundee on my Saturday walk on a dingy grey day. 1st/2nd pic: 5yo male RGBM/CL97968, 3rd pic: metal-ringed, 4th pic: colour-ringed RGLM. 📷📸🎞️🪶 #birds #ukwildlife
Intracranial delivery of B7-H3-targeting CAR-T cells for recurrent glioblastoma: a phase 1 trial
->Nature | More info at BigEarthData.ai
->Nature | More info at BigEarthData.ai
Intracranial delivery of B7-H3-targeting CAR-T cells for recurrent glioblastoma: a phase 1 trial
Recurrent glioblastoma (rGBM) is a leading brain malignancy with few therapeutic options. Here we present the complete results of a phase 1 trial investigating the safety and efficacy of autologous B7-H3-targeting chimeric antigen receptor T (CAR-T) cell (TX103) therapy for the treatment of rGBM. In this open-label, 3 + 3 dose-escalation trial, patients aged 18–75 years with B7-H3-positive (≥30%) rGBM received intracranial infusion of TX103 at three dose levels (DLs—2 × 107, 6 × 107 and 1.5 × 108 cells per infusion). Primary endpoints were safety, maximum tolerated dose (MTD), and recommended phase 2 dose (RP2D). Secondary endpoints included survival, pharmacokinetics and immunological response. Fifteen patients received a total of 72 intracranial infusions and 13 underwent repeated infusions. TX103 therapy was well tolerated, with no dose-limiting toxicities or MTD identified. Treatment-related adverse events (TRAEs) included low-grade cytokine release syndrome (86.7%), sinus tachycardia (53.3%), vomiting (53.3%), hypertension (53.3%) and elevated intracranial pressure (46.7%). Three grade 3 TRAEs considered serious adverse events occurred (elevated intracranial pressure, epilepsy and depressed consciousness), two at DL3. The 12-month overall survival (OS) rate was 66.7% and median OS was 19.1 months (95% confidence interval = 8.93, not reached) from first infusion. Disease control (stable disease or...
www.nature.com
August 7, 2026 at 5:07 AM