#rqc
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fscavone.bsky.social
New paper from our lab! 🥳🎉 "UFMylation orchestrates spatiotemporal coordination of RQC at the ER"
@Science Advances
www.science.org/doi/10.1126/...
UFMylation orchestrates spatiotemporal coordination of RQC at the ER
Structures of stalled ER-bound 60S ribosomal subunits identify cooperative interaction between UFMylation and RQC machineries.
www.science.org
May 2, 2025 at 6:52 PM
plantophagy.bsky.social
Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
March 25, 2026 at 12:51 PM
rebex.bsky.social
Good morning 👋🏼
I’m still continuing with the theme #MadMarch25 🤪
Yes I’m afraid so…
I love The Carpenters but they had several extremely cheesy tracks! 🧀
I’ve gone with ‘Jambalaya’ today! youtu.be/t5ImncN-rQc
Enjoy 🎶
#RoseWednesday
March 12, 2025 at 8:13 AM
plantophagy.bsky.social
🆕 #preprint by @gekaragoz.bsky.social lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) www.biorxiv.org/content/10.1... As always let us know what you think!
January 20, 2025 at 6:04 PM
doublefantasyqueer.bsky.social
Happy transID unity & community day! #radqueer #transid #radqueerpleaseinteract #rqc🌈🍓 #radqueer🌈🍓 #transidpleaseinteract
September 1, 2024 at 1:54 AM
embojournal.org
What are the roles of UFMylation during ribosome-associated quality control?
@gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
March 26, 2026 at 2:00 PM
radq-loser.bsky.social
Hiiii new to bsky as an alter but not as a system!!
Pro endo, proship, pro systravel radqueer system
Here to join the RQC on bsky !!
#radqueer #rq #rqc #🌈🍓
September 18, 2024 at 4:49 AM
merveyigit.bsky.social
I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 We discovered a novel role for eIF2A in ribosome-associated quality control (RQC), challenging decades-old assumptions about its enigmatic function in translation initiation.

Check it out to learn more! ⭐️
#RNA
May 26, 2025 at 10:23 PM
trentini-lab.bsky.social
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
August 1, 2025 at 10:36 AM
handle.invalid
PRESTEM ATENÇÃO NA LETRA

youtu.be/Rqc-sPxHktc?...
September 6, 2024 at 6:02 PM
lockedboys.bsky.social
Daily Chaster Link Share
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10% off cages:
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Code: THAVGSYT

📸⬇️ @pupsarang.bsky.social
March 7, 2025 at 10:52 AM
wikipedia.org
Not-so-fun fact: A 2007 study analyzing paintings created between 1500 and 1900 around the times of notable volcanic events found a correlation between volcanic activity and the amount of red used in the painting ➡️ w.wiki/rqc
July 17, 2026 at 2:09 PM
hydroblade.bsky.social
this but with the rqc as well
June 18, 2025 at 11:09 AM
hydroblade.bsky.social
the rqc
June 16, 2025 at 8:51 PM
bobbyscocks.bsky.social
#Laurel24

Day 15 - Morass

Jambalaya (On The Bayou) - The Carpenters
youtu.be/t5ImncN-rQc?...
The Carpenters - Jambalaya (On The Bayou) (Live in 1974) • TopPop
YouTube video by TopPop
youtu.be
December 14, 2024 at 10:34 PM
plosbiology.org
Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0
Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,
November 18, 2025 at 5:35 PM
rocqueercomics.bsky.social
Some #eldenring art for my #RQC buddies!
May 6, 2026 at 6:15 AM
report-rqs.bsky.social
#radqueer #rqc #transid #transabled #transrace #xenosatanist #map #paraphilia #paraphile #propara #radpara #radfreak #🍓🌈 #🌈🍓 #🌈🍓rqc #🍓🌈rqc #radqueerspleaseinteract
Text that says: "To all radqueers who are considering leaving the community: There is a safe space for you in the anti-radqueer community - yes, even if you disagree with what I just said, even if you <insert thing here>. Radqueers are not the only ones who will accept you. You can find a place to feel safe that isn't rife with predators and racists. There are safe spaces for you. You can send me an instant message with genuine questions."
October 21, 2024 at 9:57 PM
hydroblade.bsky.social
What the fuck is up with the tumblr rqc
July 18, 2025 at 10:52 AM
rocqueercomics.bsky.social
One of the many talented artists who hang out with RQC <3

Liz's work is vibrant, expressive, and very often personal and vulnerable! <3

#comics #art
paperbagcomic.bsky.social Liz Pritchard @paperbagcomic.bsky.social · Mar 1
Stay tuned…… more art coming soon!!
Slash forward. F@ck the sunshine, these lines are bullets that pierce through skin. Slash forward: Leaving fractures, the world turns colder. Love is bolder. Slash forward: Mantric phantom. We’re all haunted by something, a deadly venom.
September 25, 2025 at 8:48 PM
fscavone.bsky.social
Cool preprint on UFMylation & ER-RQC here: www.biorxiv.org/content/10.1... by @Karagoz & @PlantoPhagy labs!
The coordinated action of UFMylation and ribosome-associated quality control pathway clears arrested nascent chains at the endoplasmic reticulum
Clearance of incomplete nascent polypeptides resulting from ribosomal stalling is essential for protein homeostasis. While ribosome-associated quality control (RQC) mechanisms that degrade these polyp...
www.biorxiv.org
January 20, 2025 at 7:58 PM
cp-trendsmicrobiol.bsky.social
Viruses and RQC: a molecular arms race at the heart of translation
Viruses and RQC: a molecular arms race at the heart of translation
Viruses rely exclusively on host ribosomes for protein synthesis, but the translation of viral mRNA depletes host resources and imposes structural constraints that trigger translational stress. Translational stress activates cellular surveillance responses, including the ribosome-associated quality control (RQC), which safeguards translation fidelity by degrading aberrant translation products and mRNAs, with potential antiviral effects. Here, I review emerging evidence detailing the complex interplay between viral infections and the RQC, highlight its antiviral properties, and discuss how viruses have evolved RQC-reprogramming strategies to optimize viral protein production and evade immune detection. The evidence points to the RQC as a critical regulatory hub in host–pathogen dynamics. This insight may inform novel antiviral strategies targeting translational control mechanisms, offering potential new avenues to combat viral diseases.
dlvr.it
March 25, 2026 at 7:23 PM