#slidearchiveseries urothelial carcinoma in situ colonizing prostatic urethra #gupath
July 11, 2025 at 2:15 AM
#slidearchiveseries urothelial carcinoma in situ colonizing prostatic urethra #gupath
#slidearchiveseries signet-ring cell-like prostatic acinar adenocarcinoma 💍 #gupath
December 11, 2024 at 3:24 AM
#slidearchiveseries signet-ring cell-like prostatic acinar adenocarcinoma 💍 #gupath
#slidearchiveseries history of radical orchiectomy with pure teratoma, serum tumor markers (post-orchiectomy): AFP 537, increased to 469, HCG 2; status post chemotherapy x 4 cycles ➡️ retroperitoneal lymph node dissection #gupath #pathsky
January 12, 2025 at 2:32 PM
#slidearchiveseries history of radical orchiectomy with pure teratoma, serum tumor markers (post-orchiectomy): AFP 537, increased to 469, HCG 2; status post chemotherapy x 4 cycles ➡️ retroperitoneal lymph node dissection #gupath #pathsky
#slidearchiveseries history of DLBCL s/p chemotherapy with residual retroperitoneal lymphadenopathy, s/p radiation therapy for bulky cauda equina leptomeningeal disease, now for management of prostate abscess #gupath #malakoplakia
March 29, 2025 at 2:35 PM
#slidearchiveseries history of DLBCL s/p chemotherapy with residual retroperitoneal lymphadenopathy, s/p radiation therapy for bulky cauda equina leptomeningeal disease, now for management of prostate abscess #gupath #malakoplakia
#slidearchiveseries embryonal carcinoma #gupath #pathsky
🔬 pseudoendodermal sinus-like
🎨 OCT4
📑 pubmed.ncbi.nlm.nih.gov/29129333/
🏥 history of epididymo-orchitis; enlarged testicle with a heterogeneous mass-like area (increasing in size), serum tumor markers not known
🔬 pseudoendodermal sinus-like
🎨 OCT4
📑 pubmed.ncbi.nlm.nih.gov/29129333/
🏥 history of epididymo-orchitis; enlarged testicle with a heterogeneous mass-like area (increasing in size), serum tumor markers not known
December 12, 2024 at 11:17 PM
#slidearchiveseries embryonal carcinoma #gupath #pathsky
🔬 pseudoendodermal sinus-like
🎨 OCT4
📑 pubmed.ncbi.nlm.nih.gov/29129333/
🏥 history of epididymo-orchitis; enlarged testicle with a heterogeneous mass-like area (increasing in size), serum tumor markers not known
🔬 pseudoendodermal sinus-like
🎨 OCT4
📑 pubmed.ncbi.nlm.nih.gov/29129333/
🏥 history of epididymo-orchitis; enlarged testicle with a heterogeneous mass-like area (increasing in size), serum tumor markers not known
#slidearchiveseries urothelial carcinoma, clear cell (glycogen-rich) #gupath
🎨 IHC profile similar to conventional urothelial carcinoma (GATA3, p63)
⚠️ distinguish from metastatic CCRCC and clear cell adenocarcinoma
🎨 IHC profile similar to conventional urothelial carcinoma (GATA3, p63)
⚠️ distinguish from metastatic CCRCC and clear cell adenocarcinoma
March 29, 2025 at 3:38 PM
#slidearchiveseries urothelial carcinoma, clear cell (glycogen-rich) #gupath
🎨 IHC profile similar to conventional urothelial carcinoma (GATA3, p63)
⚠️ distinguish from metastatic CCRCC and clear cell adenocarcinoma
🎨 IHC profile similar to conventional urothelial carcinoma (GATA3, p63)
⚠️ distinguish from metastatic CCRCC and clear cell adenocarcinoma
December 12, 2024 at 11:00 PM
#slidearchiveseries urothelial carcinoma, plasmacytoid variant #gupath #pathsky #pathoutpic
🔬discohesive single tumor cells, eccentrically placed nuclei, eosinophilic cytoplasm
💥high grade, poor prognosis
🙅🏻♀️do not use CD138 in isolation to distinguish from plasma cells
🔬discohesive single tumor cells, eccentrically placed nuclei, eosinophilic cytoplasm
💥high grade, poor prognosis
🙅🏻♀️do not use CD138 in isolation to distinguish from plasma cells
December 12, 2024 at 8:11 PM
#slidearchiveseries urothelial carcinoma, plasmacytoid variant #gupath #pathsky #pathoutpic
🔬discohesive single tumor cells, eccentrically placed nuclei, eosinophilic cytoplasm
💥high grade, poor prognosis
🙅🏻♀️do not use CD138 in isolation to distinguish from plasma cells
🔬discohesive single tumor cells, eccentrically placed nuclei, eosinophilic cytoplasm
💥high grade, poor prognosis
🙅🏻♀️do not use CD138 in isolation to distinguish from plasma cells
#slidearchiveseries urinary bladder, inflammatory myofibroblastic tumor #gupath #pathsky #pathoutpic
🔬 Diverse patterns: myxoid, fascicular, hyalinized
🎨 ALK IHC (diffuse cytoplasmic) in 40-60%
🧬 50-60% ALK fusions (EML4, TPM3/4, CARS, RANBP2, IGFBP5…)
🔬 Diverse patterns: myxoid, fascicular, hyalinized
🎨 ALK IHC (diffuse cytoplasmic) in 40-60%
🧬 50-60% ALK fusions (EML4, TPM3/4, CARS, RANBP2, IGFBP5…)
March 29, 2025 at 4:19 PM
#slidearchiveseries urinary bladder, inflammatory myofibroblastic tumor #gupath #pathsky #pathoutpic
🔬 Diverse patterns: myxoid, fascicular, hyalinized
🎨 ALK IHC (diffuse cytoplasmic) in 40-60%
🧬 50-60% ALK fusions (EML4, TPM3/4, CARS, RANBP2, IGFBP5…)
🔬 Diverse patterns: myxoid, fascicular, hyalinized
🎨 ALK IHC (diffuse cytoplasmic) in 40-60%
🧬 50-60% ALK fusions (EML4, TPM3/4, CARS, RANBP2, IGFBP5…)
#slidearchiveseries scrotal calcinosis
#gupath #dermpath #pathsky #pathoutpic
🔬intradermal nodules varying in size and number, foreign body giant cell reaction in surrounding tissue
📊 differentials include calcification of epidermal or pilar cyst
🤔 idiopathic or dystrophic
#gupath #dermpath #pathsky #pathoutpic
🔬intradermal nodules varying in size and number, foreign body giant cell reaction in surrounding tissue
📊 differentials include calcification of epidermal or pilar cyst
🤔 idiopathic or dystrophic
December 12, 2024 at 3:30 AM
#slidearchiveseries scrotal calcinosis
#gupath #dermpath #pathsky #pathoutpic
🔬intradermal nodules varying in size and number, foreign body giant cell reaction in surrounding tissue
📊 differentials include calcification of epidermal or pilar cyst
🤔 idiopathic or dystrophic
#gupath #dermpath #pathsky #pathoutpic
🔬intradermal nodules varying in size and number, foreign body giant cell reaction in surrounding tissue
📊 differentials include calcification of epidermal or pilar cyst
🤔 idiopathic or dystrophic
#slidearchiveseries chromophobe carcinoma with sarcomatoid differentiation #gupath #pathsky #pathoutpic
⚠️ sarcomatoid component may overrun the epithelial component, extensive sampling may be needed to identify recognizable carcinoma
⚠️ sarcomatoid component may overrun the epithelial component, extensive sampling may be needed to identify recognizable carcinoma
February 22, 2025 at 1:52 AM
#slidearchiveseries chromophobe carcinoma with sarcomatoid differentiation #gupath #pathsky #pathoutpic
⚠️ sarcomatoid component may overrun the epithelial component, extensive sampling may be needed to identify recognizable carcinoma
⚠️ sarcomatoid component may overrun the epithelial component, extensive sampling may be needed to identify recognizable carcinoma
#slidearchiveseries urothelial carcinoma, micropapillary subtype #gupath #pathsky #pathoutpic
☝🏼distinguish from retraction artifact
✅ multiple small nests floating within single lacunae
✅ back-to-back lacunae
✅ presence of ring formations
☝🏼distinguish from retraction artifact
✅ multiple small nests floating within single lacunae
✅ back-to-back lacunae
✅ presence of ring formations
December 12, 2024 at 3:19 AM
#slidearchiveseries urothelial carcinoma, micropapillary subtype #gupath #pathsky #pathoutpic
☝🏼distinguish from retraction artifact
✅ multiple small nests floating within single lacunae
✅ back-to-back lacunae
✅ presence of ring formations
☝🏼distinguish from retraction artifact
✅ multiple small nests floating within single lacunae
✅ back-to-back lacunae
✅ presence of ring formations
#slidearchiveseries paraganglioma of urinary bladder #gupath #pathsky
🔬 polygonal cells with granular cytoplasm in Zellballen pattern
🎨 SYN/CG/often GATA3 (pitfall)
🧬assoc with germline SDH mutation
🤔confused with urothelial ca, granular cell tumor, melanoma
🔬 polygonal cells with granular cytoplasm in Zellballen pattern
🎨 SYN/CG/often GATA3 (pitfall)
🧬assoc with germline SDH mutation
🤔confused with urothelial ca, granular cell tumor, melanoma
February 15, 2025 at 1:50 PM
#slidearchiveseries paraganglioma of urinary bladder #gupath #pathsky
🔬 polygonal cells with granular cytoplasm in Zellballen pattern
🎨 SYN/CG/often GATA3 (pitfall)
🧬assoc with germline SDH mutation
🤔confused with urothelial ca, granular cell tumor, melanoma
🔬 polygonal cells with granular cytoplasm in Zellballen pattern
🎨 SYN/CG/often GATA3 (pitfall)
🧬assoc with germline SDH mutation
🤔confused with urothelial ca, granular cell tumor, melanoma
#slidearchiveseries urothelial carcinoma, high grade, muscle invasive, pT2 #gupath #bladdertumor #pathsky
December 11, 2024 at 11:23 AM
#slidearchiveseries urothelial carcinoma, high grade, muscle invasive, pT2 #gupath #bladdertumor #pathsky
#slidearchiveseries SMARCB1 deficient renal medullary carcinoma
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
December 12, 2024 at 10:54 PM
#slidearchiveseries SMARCB1 deficient renal medullary carcinoma
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
#slidearchiveseries metastatic mixed germ cell tumor (teratoma and choriocarcinoma) involving lymph node #gupath #pathsky
🏥 h/o testicular mixed germ cell tumor (teratoma, choriocarcinoma, seminoma) s/p chemotherapy and RPLND with growing mediastinal mass and increasing HCG
🏥 h/o testicular mixed germ cell tumor (teratoma, choriocarcinoma, seminoma) s/p chemotherapy and RPLND with growing mediastinal mass and increasing HCG
December 12, 2024 at 11:28 PM
#slidearchiveseries metastatic mixed germ cell tumor (teratoma and choriocarcinoma) involving lymph node #gupath #pathsky
🏥 h/o testicular mixed germ cell tumor (teratoma, choriocarcinoma, seminoma) s/p chemotherapy and RPLND with growing mediastinal mass and increasing HCG
🏥 h/o testicular mixed germ cell tumor (teratoma, choriocarcinoma, seminoma) s/p chemotherapy and RPLND with growing mediastinal mass and increasing HCG
#slidearchiveseries urothelial carcinoma, micropapillary subtype
#gupath #pathsky #pathoutpic
🔬 small tumor cell clusters without fibrovascular cores, floating in lacunar spaces
⚠️ may resemble vascular invasion
#gupath #pathsky #pathoutpic
🔬 small tumor cell clusters without fibrovascular cores, floating in lacunar spaces
⚠️ may resemble vascular invasion
December 12, 2024 at 3:18 AM
#slidearchiveseries urothelial carcinoma, micropapillary subtype
#gupath #pathsky #pathoutpic
🔬 small tumor cell clusters without fibrovascular cores, floating in lacunar spaces
⚠️ may resemble vascular invasion
#gupath #pathsky #pathoutpic
🔬 small tumor cell clusters without fibrovascular cores, floating in lacunar spaces
⚠️ may resemble vascular invasion
#slidearchiveseries urothelial carcinoma with extensive squamous differentiation #gupath #pathsky #pathoutpic
☝🏼 identifiable urothelial component (may only be carcinoma in situ)
✌🏼 recommended to report percentage of squamous component
☝🏼 identifiable urothelial component (may only be carcinoma in situ)
✌🏼 recommended to report percentage of squamous component
December 12, 2024 at 3:13 AM
#slidearchiveseries urothelial carcinoma with extensive squamous differentiation #gupath #pathsky #pathoutpic
☝🏼 identifiable urothelial component (may only be carcinoma in situ)
✌🏼 recommended to report percentage of squamous component
☝🏼 identifiable urothelial component (may only be carcinoma in situ)
✌🏼 recommended to report percentage of squamous component
#slidearchiveseries papillary renal neoplasm with reverse polarity #gupath #pathsky #pathoutpic
🕵🏻♀️ usually asymptomatic, incidentally found, clinically indolent
🔬 thin papillary/tubulopapillary growth, apically located, low grade nuclei
🎨 CK7, GATA3, L1CAM
🧬 KRAS mutation
🕵🏻♀️ usually asymptomatic, incidentally found, clinically indolent
🔬 thin papillary/tubulopapillary growth, apically located, low grade nuclei
🎨 CK7, GATA3, L1CAM
🧬 KRAS mutation
December 12, 2024 at 3:22 AM
#slidearchiveseries papillary renal neoplasm with reverse polarity #gupath #pathsky #pathoutpic
🕵🏻♀️ usually asymptomatic, incidentally found, clinically indolent
🔬 thin papillary/tubulopapillary growth, apically located, low grade nuclei
🎨 CK7, GATA3, L1CAM
🧬 KRAS mutation
🕵🏻♀️ usually asymptomatic, incidentally found, clinically indolent
🔬 thin papillary/tubulopapillary growth, apically located, low grade nuclei
🎨 CK7, GATA3, L1CAM
🧬 KRAS mutation
#slidearchiveseries clear cell adenocarcinoma of urinary bladder #gupath #pathsky
🔬solid, tubulocystic, and papillary growth patterns; hobnail cells with eosinophilic or clear cytoplasm
➕ CK7, PAX8, HNF1β, p53, Napsin
➖ GATA3, p63, ER, PR, WT1
🔬solid, tubulocystic, and papillary growth patterns; hobnail cells with eosinophilic or clear cytoplasm
➕ CK7, PAX8, HNF1β, p53, Napsin
➖ GATA3, p63, ER, PR, WT1
December 12, 2024 at 11:25 PM
#slidearchiveseries clear cell adenocarcinoma of urinary bladder #gupath #pathsky
🔬solid, tubulocystic, and papillary growth patterns; hobnail cells with eosinophilic or clear cytoplasm
➕ CK7, PAX8, HNF1β, p53, Napsin
➖ GATA3, p63, ER, PR, WT1
🔬solid, tubulocystic, and papillary growth patterns; hobnail cells with eosinophilic or clear cytoplasm
➕ CK7, PAX8, HNF1β, p53, Napsin
➖ GATA3, p63, ER, PR, WT1
#slidearchiveseries seminoma with brisk lymphocytes, rete testis invasion, and GCNIS—classic 'fried egg' 🍳 appearance with a dash of pepper #gupath #testistumor #pathoutpic
February 22, 2025 at 2:50 AM
#slidearchiveseries seminoma with brisk lymphocytes, rete testis invasion, and GCNIS—classic 'fried egg' 🍳 appearance with a dash of pepper #gupath #testistumor #pathoutpic
#slidearchiveseries clear cell renal cell carcinoma with rhabdoid differentiation #gupath
🔬 large eccentric nuclei with prominent nucleoli, abundant eosinophilic cytoplasm, globular eosinophilic intracytoplasmic inclusions
🔬 large eccentric nuclei with prominent nucleoli, abundant eosinophilic cytoplasm, globular eosinophilic intracytoplasmic inclusions
May 26, 2025 at 10:09 PM
#slidearchiveseries clear cell renal cell carcinoma with rhabdoid differentiation #gupath
🔬 large eccentric nuclei with prominent nucleoli, abundant eosinophilic cytoplasm, globular eosinophilic intracytoplasmic inclusions
🔬 large eccentric nuclei with prominent nucleoli, abundant eosinophilic cytoplasm, globular eosinophilic intracytoplasmic inclusions
#slidearchiveseries nephrogenic adenoma #gupath #pathsky #pathoutpic
🏥 prior urothelial injury (surgery, calculi, trauma)
sites: bladder > urethra > ureter
🔬 metaplastic lesion, multiple morphological patterns
🎨 PAX8, AMACR, GATA3 (40%), PSA (weak) (+)
⚠️ exclude prostate & bladder ca
🏥 prior urothelial injury (surgery, calculi, trauma)
sites: bladder > urethra > ureter
🔬 metaplastic lesion, multiple morphological patterns
🎨 PAX8, AMACR, GATA3 (40%), PSA (weak) (+)
⚠️ exclude prostate & bladder ca
December 12, 2024 at 3:20 AM
#slidearchiveseries nephrogenic adenoma #gupath #pathsky #pathoutpic
🏥 prior urothelial injury (surgery, calculi, trauma)
sites: bladder > urethra > ureter
🔬 metaplastic lesion, multiple morphological patterns
🎨 PAX8, AMACR, GATA3 (40%), PSA (weak) (+)
⚠️ exclude prostate & bladder ca
🏥 prior urothelial injury (surgery, calculi, trauma)
sites: bladder > urethra > ureter
🔬 metaplastic lesion, multiple morphological patterns
🎨 PAX8, AMACR, GATA3 (40%), PSA (weak) (+)
⚠️ exclude prostate & bladder ca
#slidearchiveseries mixed germ cell tumor, predominantly embryonal carcinoma with smaller components of yolk sac tumor and teratoma, LVI present (additionally confirmed with ERG immunostain) #gupath #pathsky #pathoutpic
December 12, 2024 at 11:31 PM
#slidearchiveseries mixed germ cell tumor, predominantly embryonal carcinoma with smaller components of yolk sac tumor and teratoma, LVI present (additionally confirmed with ERG immunostain) #gupath #pathsky #pathoutpic
#slidearchiveseries paratesticular embryonal rhabdomyosarcoma #gupath #BSTpath #pathsky #pathoutpic
🔬 moderately cellular with loose, myxoid stroma
✨focal areas of diffuse anaplasia, atypical mitotic figures
🎨 MyoD1, myogenin, desmin
🧬 FOXO1 gene rearrangement negative
🔬 moderately cellular with loose, myxoid stroma
✨focal areas of diffuse anaplasia, atypical mitotic figures
🎨 MyoD1, myogenin, desmin
🧬 FOXO1 gene rearrangement negative
December 12, 2024 at 3:24 AM
#slidearchiveseries paratesticular embryonal rhabdomyosarcoma #gupath #BSTpath #pathsky #pathoutpic
🔬 moderately cellular with loose, myxoid stroma
✨focal areas of diffuse anaplasia, atypical mitotic figures
🎨 MyoD1, myogenin, desmin
🧬 FOXO1 gene rearrangement negative
🔬 moderately cellular with loose, myxoid stroma
✨focal areas of diffuse anaplasia, atypical mitotic figures
🎨 MyoD1, myogenin, desmin
🧬 FOXO1 gene rearrangement negative