Sortase enzymes are cysteine transpeptidases that anchor surface proteins to the cell wall of Gram-positive bacteria. These enzymes are widely used in protein engineering applications because they…

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Sortase ligation is a common method for chemical protein synthesis; however, the products often contain a reaction scar. Now a traceless sortase ligation method is reported in which cleavable sortase ...

The global rise of methicillin-resistant Staphylococcus aureus (MRSA) has highlighted the urgent need for alternative therapeutic strategies beyond co…

Integration of ubiquitin clippases with sortase-based labelling and mass spectrometry reveals that a wide range of non-peptide molecules are ubiquitinated in vivo, and points to a potential role for u...

Nature - Ubiquitination of glycogen and metabolites in cells and tissues

Antibiotic resistance is making it harder to treat bacterial infections, even with our strongest medicines. This study explores a new approach that does not aim to kill bacteria but instead disarms them...