Striatum stimulation made choices more sensitive to both rewards and mental effort than sham stimulation did, as people weighed taking on a demanding memory task for money. doi.org/hcmfgv
Stimulating the striatum changes how people weigh mental effort against rewards
Choosing whether to tackle or complete a difficult task often entails weighing the rewards that we could gain from this task against the mental effort it will require.
medicalxpress.com
October 2, 2026 at 1:40 PM
Striatum stimulation made choices more sensitive to both rewards and mental effort than sham stimulation did, as people weighed taking on a demanding memory task for money. doi.org/hcmfgv
@thermofishersci.bsky.social's resource, RRID:AB_2535792, was just reported to be used in the paper. We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #BetterScience
A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior
Read the full paper: A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior
doi.org
October 2, 2026 at 7:01 AM
@thermofishersci.bsky.social's resource, RRID:AB_2535792, was just reported to be used in the paper. We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #BetterScience
#openscience in action/
Using the Allen Brain Cell Atlas, Sora Mitamur is uncovering new insights into the cellular organization and gene expression patterns of the ventral striatum through computational analysis.
Explore the ABC Atlas: https://brain-map.org/bkp/explore/abc-atlas
Using the Allen Brain Cell Atlas, Sora Mitamur is uncovering new insights into the cellular organization and gene expression patterns of the ventral striatum through computational analysis.
Explore the ABC Atlas: https://brain-map.org/bkp/explore/abc-atlas
October 1, 2026 at 11:39 PM
#openscience in action/
Using the Allen Brain Cell Atlas, Sora Mitamur is uncovering new insights into the cellular organization and gene expression patterns of the ventral striatum through computational analysis.
Explore the ABC Atlas: https://brain-map.org/bkp/explore/abc-atlas
Using the Allen Brain Cell Atlas, Sora Mitamur is uncovering new insights into the cellular organization and gene expression patterns of the ventral striatum through computational analysis.
Explore the ABC Atlas: https://brain-map.org/bkp/explore/abc-atlas
A Striated Earthstar (Geastrum striatum) poking up from the conifer and leaf debris behind my garden shed. #Fungi #Mushrooms #Mycology #Nature #Photography #Nikon #Edinburgh #Scotland
September 30, 2026 at 1:47 PM
A Striated Earthstar (Geastrum striatum) poking up from the conifer and leaf debris behind my garden shed. #Fungi #Mushrooms #Mycology #Nature #Photography #Nikon #Edinburgh #Scotland
source: pmc.ncbi.nlm.nih.gov/articles/PMC...
@salma-shaban.bsky.social @bwdionne.bsky.social @jeffpears0n.bsky.social
@salma-shaban.bsky.social @bwdionne.bsky.social @jeffpears0n.bsky.social
Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum
Antimicrobial resistance threatens the efficacy of antimicrobial treatment options, including last-line-of-defense drugs. Understanding how this resistance develops can help direct antimicrobial stewa...
pmc.ncbi.nlm.nih.gov
September 29, 2026 at 6:01 PM
#OTILT Corynebacterium striatum can develop high-level daptomycin resistance through drug target removal of phosphatidylglycerol (PG) from the cell membrane. Specifically, one loss-of-function mutation in the pgsA2 gene results in loss of membrane PG and replacement by phosphatidylinositol.
September 29, 2026 at 6:00 PM
#OTILT Corynebacterium striatum can develop high-level daptomycin resistance through drug target removal of phosphatidylglycerol (PG) from the cell membrane. Specifically, one loss-of-function mutation in the pgsA2 gene results in loss of membrane PG and replacement by phosphatidylinositol.
So why is local gene editing useful? For example to treat Huntington's Disease, we'd prefer to disrupt HTT in just the striatum if possible, in case it has essential functions elsewhere.
Also caging Cas12f by default reduces off-target toxicity that would otherwise accumulate.
Also caging Cas12f by default reduces off-target toxicity that would otherwise accumulate.
September 29, 2026 at 5:33 PM
So why is local gene editing useful? For example to treat Huntington's Disease, we'd prefer to disrupt HTT in just the striatum if possible, in case it has essential functions elsewhere.
Also caging Cas12f by default reduces off-target toxicity that would otherwise accumulate.
Also caging Cas12f by default reduces off-target toxicity that would otherwise accumulate.
#wordweavers 29 Sep: Is your character more likely to enjoy a sunrise or sunset, and why?
Which one of them? Because this question could start a fight in The Mansion: Hippocampus stands by the sunrise and Ventral Striatum by the sunset, and Herr Cingulate, Anterior Division, has enough conflict […]
Which one of them? Because this question could start a fight in The Mansion: Hippocampus stands by the sunrise and Ventral Striatum by the sunset, and Herr Cingulate, Anterior Division, has enough conflict […]
Original post on mastodon.nu
mastodon.nu
September 29, 2026 at 9:45 AM
#wordweavers 29 Sep: Is your character more likely to enjoy a sunrise or sunset, and why?
Which one of them? Because this question could start a fight in The Mansion: Hippocampus stands by the sunrise and Ventral Striatum by the sunset, and Herr Cingulate, Anterior Division, has enough conflict […]
Which one of them? Because this question could start a fight in The Mansion: Hippocampus stands by the sunrise and Ventral Striatum by the sunset, and Herr Cingulate, Anterior Division, has enough conflict […]
#pennedpossibilities 1142: Does your MC care about vanity and their image?
Nope, they're all about procedure and regulation, and image and vanity aren't measurable metrics on their clipboard.
My side character Ventral Striatum, the Goddess of Desire, on the other hand, cares a great deal. She […]
Nope, they're all about procedure and regulation, and image and vanity aren't measurable metrics on their clipboard.
My side character Ventral Striatum, the Goddess of Desire, on the other hand, cares a great deal. She […]
Original post on mastodon.nu
mastodon.nu
September 29, 2026 at 9:40 AM
#pennedpossibilities 1142: Does your MC care about vanity and their image?
Nope, they're all about procedure and regulation, and image and vanity aren't measurable metrics on their clipboard.
My side character Ventral Striatum, the Goddess of Desire, on the other hand, cares a great deal. She […]
Nope, they're all about procedure and regulation, and image and vanity aren't measurable metrics on their clipboard.
My side character Ventral Striatum, the Goddess of Desire, on the other hand, cares a great deal. She […]
Picture a coach that just says "do that again"… this dopamine signal functioned a bit like that.
The study:
Greenstreet et al. (2025). "Dopaminergic action prediction errors serve as a value-free teaching signal." Nature.
The study:
Greenstreet et al. (2025). "Dopaminergic action prediction errors serve as a value-free teaching signal." Nature.
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
doi.org
September 28, 2026 at 4:02 PM
Picture a coach that just says "do that again"… this dopamine signal functioned a bit like that.
The study:
Greenstreet et al. (2025). "Dopaminergic action prediction errors serve as a value-free teaching signal." Nature.
The study:
Greenstreet et al. (2025). "Dopaminergic action prediction errors serve as a value-free teaching signal." Nature.
Today, we had the pleasure of hosting Dr. Iakovos Lazaridis @iaklaz.bsky.social from @mitpress.bsky.social for a special seminar with his talk: “The striatum across timescales: dopamine, astrocytes and behavioral context”👏
A fantastic lecture, thank you!
#SeminarsIN
@csic.es @dicv.csic.es @umh.es
A fantastic lecture, thank you!
#SeminarsIN
@csic.es @dicv.csic.es @umh.es
September 28, 2026 at 2:30 PM
Today, we had the pleasure of hosting Dr. Iakovos Lazaridis @iaklaz.bsky.social from @mitpress.bsky.social for a special seminar with his talk: “The striatum across timescales: dopamine, astrocytes and behavioral context”👏
A fantastic lecture, thank you!
#SeminarsIN
@csic.es @dicv.csic.es @umh.es
A fantastic lecture, thank you!
#SeminarsIN
@csic.es @dicv.csic.es @umh.es
One of these populations is highly enriched for OPRM1, raising intriguing questions about how these cells may relate to the opioid-sensitive “hotspots” described historically in the ventral striatum.
September 28, 2026 at 12:28 PM
One of these populations is highly enriched for OPRM1, raising intriguing questions about how these cells may relate to the opioid-sensitive “hotspots” described historically in the ventral striatum.
When something good happens after what you just did, your brain has to link that result back to the action. In slices of mouse striatum (think reward learning) dopamine enlarged dendritic spines (input points on neurons) that had just been activated, but only if it came 0.3 to 2 seconds after.
September 28, 2026 at 3:42 AM
When something good happens after what you just did, your brain has to link that result back to the action. In slices of mouse striatum (think reward learning) dopamine enlarged dendritic spines (input points on neurons) that had just been activated, but only if it came 0.3 to 2 seconds after.
[3] Liu Y, Persaud D, Vieira E et al. Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms. @ebiomedicine.bsky.social, 2026; 130
www.thelancet.com/journals/ebi...
#LongCOVIDBrain
www.thelancet.com/journals/ebi...
#LongCOVIDBrain
Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms
Findings of reduced VMAT2 binding may reflect reduced dopaminergic terminal integrity
in long COVID. Loss of dopamine nerve terminals may be contributing to symptom correlates
of apathy, motor slowing...
www.thelancet.com
September 28, 2026 at 12:15 AM
[3] Liu Y, Persaud D, Vieira E et al. Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms. @ebiomedicine.bsky.social, 2026; 130
www.thelancet.com/journals/ebi...
#LongCOVIDBrain
www.thelancet.com/journals/ebi...
#LongCOVIDBrain
#pennedpossibilities 1140: MC POV: When was a time you felt like a hero?
Prefrontal Cortex: I'm just doing my job, and if you consider that heroic, well... that's on you, isn't it?
Ventral Striatum: Oh, come now. Every time you make the right call—
PFC: Oh, sock it.
Hippocampus: I remember—
PFC […]
Prefrontal Cortex: I'm just doing my job, and if you consider that heroic, well... that's on you, isn't it?
Ventral Striatum: Oh, come now. Every time you make the right call—
PFC: Oh, sock it.
Hippocampus: I remember—
PFC […]
Original post on mastodon.nu
mastodon.nu
September 27, 2026 at 7:57 AM
#pennedpossibilities 1140: MC POV: When was a time you felt like a hero?
Prefrontal Cortex: I'm just doing my job, and if you consider that heroic, well... that's on you, isn't it?
Ventral Striatum: Oh, come now. Every time you make the right call—
PFC: Oh, sock it.
Hippocampus: I remember—
PFC […]
Prefrontal Cortex: I'm just doing my job, and if you consider that heroic, well... that's on you, isn't it?
Ventral Striatum: Oh, come now. Every time you make the right call—
PFC: Oh, sock it.
Hippocampus: I remember—
PFC […]
Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female #mice HormBehav
Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female #mice
Publication date: October 2026
Source: Hormones and Behavior, Volume 185
Author(s): Christopher D. Hall, Linda Wilbrecht, Kristen Delevich
dlvr.it
September 27, 2026 at 1:29 AM
Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female #mice HormBehav
Core activation program and selective regional responsiveness of microglia during aging and parabiosis
Core activation program and selective regional responsiveness of microglia during aging and parabiosis
Naz et al. benchmark reproducible microglial states across adulthood, aging, and parabiosis to define a conserved activation program and both shared and region-specific transcriptomic remodeling. They further reveal regional differences in microglial sensitivity to parabiosis-mediated accelerated aging and rejuvenation, with the cerebellum the most sensitive and the striatum the least.
dlvr.it
September 26, 2026 at 11:23 PM
Core activation program and selective regional responsiveness of microglia during aging and parabiosis
Atlas of the brain’s striatum could guide researchers to new drug treatments.
#science #neuroscience #news
www.lifescience.net/news/7770/at...
#science #neuroscience #news
www.lifescience.net/news/7770/at...
Atlas of the brain’s striatum could guide researchers to new drug treatments
A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders.
www.lifescience.net
September 26, 2026 at 11:15 PM
Atlas of the brain’s striatum could guide researchers to new drug treatments.
#science #neuroscience #news
www.lifescience.net/news/7770/at...
#science #neuroscience #news
www.lifescience.net/news/7770/at...
Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female #mice HormBehav
Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female #mice
Publication date: October 2026
Source: Hormones and Behavior, Volume 185
Author(s): Christopher D. Hall, Linda Wilbrecht, Kristen Delevich
dlvr.it
September 25, 2026 at 6:28 PM
Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female #mice HormBehav
Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms - eBioMedicine www.thelancet.com/journals/ebi...
Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms
Findings of reduced VMAT2 binding may reflect reduced dopaminergic terminal integrity
in long COVID. Loss of dopamine nerve terminals may be contributing to symptom correlates
of apathy, motor slowing...
www.thelancet.com
September 25, 2026 at 11:48 AM
Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms - eBioMedicine www.thelancet.com/journals/ebi...