p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
The Breakthrough Blood Test for Alzheimer's Disease
The p-Tau217 Biomarker for Prediction and Prevention
erictopol.substack.com
April 13, 2025 at 2:27 PM
p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
The Breakthrough Blood Test for Alzheimer's Disease
open.substack.com/pub/erictopo...
open.substack.com/pub/erictopo...
The Breakthrough Blood Test for Alzheimer's Disease
The p-Tau217 Biomarker for Prediction and Prevention
open.substack.com
April 13, 2025 at 9:03 PM
The Breakthrough Blood Test for Alzheimer's Disease
open.substack.com/pub/erictopo...
open.substack.com/pub/erictopo...
p-tau217 has been available in the US for the past ~2 years (Quest and LabCorp)
the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems
gift link www.nytimes.com/2025/05/21/h...
the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems
gift link www.nytimes.com/2025/05/21/h...
May 25, 2025 at 4:44 PM
p-tau217 has been available in the US for the past ~2 years (Quest and LabCorp)
the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems
gift link www.nytimes.com/2025/05/21/h...
the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems
gift link www.nytimes.com/2025/05/21/h...
Predicting the risk of developing Alzheimer's disease in the next 10 years with blood biomarkers, such as p-Tau217
www.nature.com/articles/s41... @naturemedicine.bsky.social
www.nature.com/articles/s41... @naturemedicine.bsky.social
March 26, 2025 at 2:27 PM
Predicting the risk of developing Alzheimer's disease in the next 10 years with blood biomarkers, such as p-Tau217
www.nature.com/articles/s41... @naturemedicine.bsky.social
www.nature.com/articles/s41... @naturemedicine.bsky.social
Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance
@naturemedicine.bsky.social
nature.com/articles/s41...
@naturemedicine.bsky.social
nature.com/articles/s41...
February 19, 2026 at 2:43 PM
Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance
@naturemedicine.bsky.social
nature.com/articles/s41...
@naturemedicine.bsky.social
nature.com/articles/s41...
Predicting Alzheimer's in people who are cognitively unimpaired in middle-age via blood tests
p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid
new publication today
www.thelancet.com/journals/ebi...
p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid
new publication today
www.thelancet.com/journals/ebi...
May 25, 2025 at 4:44 PM
Predicting Alzheimer's in people who are cognitively unimpaired in middle-age via blood tests
p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid
new publication today
www.thelancet.com/journals/ebi...
p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid
new publication today
www.thelancet.com/journals/ebi...
Including the latest data for GLP-1 drug's effect on the brain and on the p-tau217 biomarker
June 1, 2025 at 3:18 PM
Including the latest data for GLP-1 drug's effect on the brain and on the p-tau217 biomarker
p-tau217, the breakthrough blood biomarker for Alzheimer's, picks up risk the earliest and its performance surpasses all other tau biomarkers, across ancestries
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer’s disease in a multicenter and multiethnic aging population - Nature Aging
Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese...
www.nature.com
June 23, 2025 at 1:33 PM
p-tau217, the breakthrough blood biomarker for Alzheimer's, picks up risk the earliest and its performance surpasses all other tau biomarkers, across ancestries
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
New @nature.com
Detection of Alzheimer's pathology from a dried blood spot derived from capillaries with capability of quantifying p-tau217 and other neuromarker levels
www.nature.com/articles/s41...
Detection of Alzheimer's pathology from a dried blood spot derived from capillaries with capability of quantifying p-tau217 and other neuromarker levels
www.nature.com/articles/s41...
January 5, 2026 at 4:09 PM
New @nature.com
Detection of Alzheimer's pathology from a dried blood spot derived from capillaries with capability of quantifying p-tau217 and other neuromarker levels
www.nature.com/articles/s41...
Detection of Alzheimer's pathology from a dried blood spot derived from capillaries with capability of quantifying p-tau217 and other neuromarker levels
www.nature.com/articles/s41...
I recently reviewed this impressive body of data for predicting Alzheimer's and why I consider it a breakthrough
erictopol.substack.com/p/the-breakt...
erictopol.substack.com/p/the-breakt...
The Breakthrough Blood Test for Alzheimer's Disease
The p-Tau217 Biomarker for Prediction and Prevention
erictopol.substack.com
May 25, 2025 at 4:44 PM
I recently reviewed this impressive body of data for predicting Alzheimer's and why I consider it a breakthrough
erictopol.substack.com/p/the-breakt...
erictopol.substack.com/p/the-breakt...
The p-tau217 biomarker by age and prevalence of Alzheimer's disease in the community of ~12,000 people in Norway
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 17, 2025 at 4:08 PM
The p-tau217 biomarker by age and prevalence of Alzheimer's disease in the community of ~12,000 people in Norway
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Overuse of the p-tau217 biomarker could push healthy people toward unnecessary drugs, scientists fear. https://scim.ag/4sZprTu
An Alzheimer’s blood test is getting popular. But who really needs it?
Overuse of the p-tau217 biomarker could push healthy people toward unnecessary drugs, scientists fear
scim.ag
April 5, 2026 at 6:15 PM
Overuse of the p-tau217 biomarker could push healthy people toward unnecessary drugs, scientists fear. https://scim.ag/4sZprTu
More data for why p-tau 217 is a breakthrough biomarker in healthy, cognitively intact people
—Prediction; guiding clinical trials of new drugs
www.nature.com/articles/s43...
—Exercise reduces the level
www.thelancet.com/journals/lan...
jamanetwork.com/journals/jam...
—Prediction; guiding clinical trials of new drugs
www.nature.com/articles/s43...
—Exercise reduces the level
www.thelancet.com/journals/lan...
jamanetwork.com/journals/jam...
Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials - Nature Aging
Ossenkoppele, Salvado et al. show that plasma p-tau217 and tau-PET predict cognitive decline equally well among cognitively unimpaired individuals. Their combined use further boosts prognostic accurac...
www.nature.com
March 28, 2025 at 2:56 PM
More data for why p-tau 217 is a breakthrough biomarker in healthy, cognitively intact people
—Prediction; guiding clinical trials of new drugs
www.nature.com/articles/s43...
—Exercise reduces the level
www.thelancet.com/journals/lan...
jamanetwork.com/journals/jam...
—Prediction; guiding clinical trials of new drugs
www.nature.com/articles/s43...
—Exercise reduces the level
www.thelancet.com/journals/lan...
jamanetwork.com/journals/jam...
When you can accurately predict risk of Alzheimer's from blood biomarkers (p-tau217) and do something about it.
www.cnn.com/2025/04/07/h...
www.cnn.com/2025/04/07/h...
‘Amazing’ reduction in Alzheimer’s risk verified by blood markers, study says | CNN
Alzheimer’s blood tests may one day allow patients and their doctors to track their individual progress in reducing risk, according to a new study.
www.cnn.com
April 8, 2025 at 3:13 PM
When you can accurately predict risk of Alzheimer's from blood biomarkers (p-tau217) and do something about it.
www.cnn.com/2025/04/07/h...
www.cnn.com/2025/04/07/h...
How a blood test (p-Tau217) and drugs that have little efficacy (and major side effects) are creating "Alzheimer's Stage 1" in healthy people with no symptoms or memory deficit
www.latimes.com/science/stor...
www.latimes.com/science/stor...
February 18, 2024 at 4:30 PM
How a blood test (p-Tau217) and drugs that have little efficacy (and major side effects) are creating "Alzheimer's Stage 1" in healthy people with no symptoms or memory deficit
www.latimes.com/science/stor...
www.latimes.com/science/stor...
p-tau217 predicts cognitive changes prior to any cognitive impairment (again)
"The era of disease-modifying therapy in Alzheimer's disease is just starting."
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
"The era of disease-modifying therapy in Alzheimer's disease is just starting."
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
p-Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease
This diagnostic/prognostic study examines longitudinal data from studies of older patients without cognitive impairment to consider whether plasma phosphorylated tau 217 and tau positron emission tomo...
jamanetwork.com
August 25, 2025 at 3:46 PM
p-tau217 predicts cognitive changes prior to any cognitive impairment (again)
"The era of disease-modifying therapy in Alzheimer's disease is just starting."
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
"The era of disease-modifying therapy in Alzheimer's disease is just starting."
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Higher levels of physical activity are linked to lower plasma p-Tau217 (blood biomarker for Alzheimer's disease) and better cognition
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
This cross-sectional study examines associations among physical activity, plasma biomarkers, and cognition in a multicenter cohort of patients with and without cognitive impairment.
jamanetwork.com
March 5, 2025 at 4:16 PM
Higher levels of physical activity are linked to lower plasma p-Tau217 (blood biomarker for Alzheimer's disease) and better cognition
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
p-tau 217 as a stand-alone blood marker establishes risk of Alzheimer's disease in cognitively unimpaired individuals (again)
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Plasma P-Tau217 to Identify Preclinical AD
This cohort study evaluates the use of plasma phosphorylated tau 217 in identifying preclinical Alzheimer disease in individuals with amyloid β pathology.
jamanetwork.com
September 15, 2025 at 4:28 PM
p-tau 217 as a stand-alone blood marker establishes risk of Alzheimer's disease in cognitively unimpaired individuals (again)
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
A proof-of-concept study published in Nature Medicine reports a method to predict when someone is likely to develop symptoms of Alzheimer's disease using a single blood test. 🧪 #alzheimers
Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks - Nature Medicine
Plasma p-tau217 tests used to develop clocks that predict when cognitively unimpaired individuals would develop symptoms of Alzheimerʼs disease.
go.nature.com
February 22, 2026 at 8:00 PM
A proof-of-concept study published in Nature Medicine reports a method to predict when someone is likely to develop symptoms of Alzheimer's disease using a single blood test. 🧪 #alzheimers
🩸 🧠 ⏱️ What if a blood test could predict WHEN an individual would develop symptoms of Alzheimer’s disease? High plasma p-tau217 predicts greater risk for Alzheimer’s symptoms—do the plasma p-tau217 levels provide insights into WHEN symptoms might begin?
nature.com/articles/s41...
nature.com/articles/s41...
February 19, 2026 at 11:26 PM
🩸 🧠 ⏱️ What if a blood test could predict WHEN an individual would develop symptoms of Alzheimer’s disease? High plasma p-tau217 predicts greater risk for Alzheimer’s symptoms—do the plasma p-tau217 levels provide insights into WHEN symptoms might begin?
nature.com/articles/s41...
nature.com/articles/s41...
Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Plasma Phosphorylated Tau 217 and Incident MCI and Dementia in Older Women
This cohort study examines associations of baseline plasma phosphorylated tau 217 with incident mild cognitive impairment (MCI) or dementia and whether associations vary by age, race, APOE ε4 carrier ...
jamanetwork.com
March 10, 2026 at 3:15 PM
Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
First paper from CHEN lab!🩸->🧠Can we use p-tau217 value to estimate PET-like map of AD pathology?🤔 We say YES!💡In two datasets (A4, ADNI), p-tau217 level can predict concurrent Ab (but NOT Ab change) and future tau accumulation almost everywhere!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
June 21, 2025 at 7:43 PM
First paper from CHEN lab!🩸->🧠Can we use p-tau217 value to estimate PET-like map of AD pathology?🤔 We say YES!💡In two datasets (A4, ADNI), p-tau217 level can predict concurrent Ab (but NOT Ab change) and future tau accumulation almost everywhere!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window
INTRODUCTION We assessed the prognostic accuracy of plasma p-tau217 in predicting the progression to mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals over a mean follow-up ...
alz-journals.onlinelibrary.wiley.com
February 27, 2025 at 2:43 PM
Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
