THIS IS HUGE! Researchers at Cornell University have developed a new thermostable, MULTI-TARGET vaccine platform that offers stronger, longer-lasting protection against SARS-CoV-2 AND influenza while providing broader immunity against VARIOUS flu strains. 🧪🧵⬇️
March 13, 2025 at 4:00 PM
THIS IS HUGE! Researchers at Cornell University have developed a new thermostable, MULTI-TARGET vaccine platform that offers stronger, longer-lasting protection against SARS-CoV-2 AND influenza while providing broader immunity against VARIOUS flu strains. 🧪🧵⬇️
Cornell University researchers have developed a new thermostable vaccine platform that offers stronger, longer-lasting protection against COVID-19 and influenza, potentially eliminating the need for annual boosters. The vaccine provided 100% SURVIVAL in mouse models, maintained immunity for EIGHT
March 13, 2025 at 4:02 PM
Cornell University researchers have developed a new thermostable vaccine platform that offers stronger, longer-lasting protection against COVID-19 and influenza, potentially eliminating the need for annual boosters. The vaccine provided 100% SURVIVAL in mouse models, maintained immunity for EIGHT
Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI - @mitkochinstitute.bsky.social www.nature.com/articles/s41...
Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI - Nature Biotechnology
The thermostability of RNA vaccines is improved with AI.
www.nature.com
September 28, 2026 at 2:48 PM
Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI - @mitkochinstitute.bsky.social www.nature.com/articles/s41...
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I...
www.rcsb.org/structure/7QVH
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I...
www.rcsb.org/structure/7QVH
RCSB PDB - 7QVH: The crystal structure of HotPETase, an evolved thermostable variant of IsPETase
The crystal structure of HotPETase, an evolved thermostable variant of IsPETase
www.rcsb.org
February 9, 2025 at 9:15 PM
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I...
www.rcsb.org/structure/7QVH
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I do not have bandwidth for another side project.
I...
www.rcsb.org/structure/7QVH
different viruses in a thermostable vaccine, making it possible to have dual, triple, or more viral targets in the same vaccines. Not only that, but having multiple viral targets in the same vaccine makes the vaccine manufacturing process easier and cheaper. In addition to prompting complete
March 13, 2025 at 4:03 PM
different viruses in a thermostable vaccine, making it possible to have dual, triple, or more viral targets in the same vaccines. Not only that, but having multiple viral targets in the same vaccine makes the vaccine manufacturing process easier and cheaper. In addition to prompting complete
Also, amatoxins are thermostable. You can't cook them out. You can't freeze them out. They laugh at drying, steaming, and smoking.
You cannot deactivate them in any way that matters, but they will deactivate you.
You cannot deactivate them in any way that matters, but they will deactivate you.
Fun fact—when you die a day or two after eating this, they will be able to pour your liver out of your body at the autopsy.
April 21, 2024 at 1:45 PM
Also, amatoxins are thermostable. You can't cook them out. You can't freeze them out. They laugh at drying, steaming, and smoking.
You cannot deactivate them in any way that matters, but they will deactivate you.
You cannot deactivate them in any way that matters, but they will deactivate you.
#UxbridgeEnglishDictionary THERMOSTABLE: A stand for flasks.
September 11, 2025 at 6:06 AM
#UxbridgeEnglishDictionary THERMOSTABLE: A stand for flasks.
🔥 New from our group in Protein Science!
We introduce CheMelt, a tool for analyzing thermal & chemical protein denaturation, integrated into the EMBL Hamburg eSPC platform.
📖 Read the paper:
onlinelibrary.wiley.com/doi/10.1002/...
@embl.org @cssbhamburg.bsky.social
@au.dk
#Biophysics #CheMelt
We introduce CheMelt, a tool for analyzing thermal & chemical protein denaturation, integrated into the EMBL Hamburg eSPC platform.
📖 Read the paper:
onlinelibrary.wiley.com/doi/10.1002/...
@embl.org @cssbhamburg.bsky.social
@au.dk
#Biophysics #CheMelt
Global analysis of thermal and chemical denaturation using <fc>CheMelt</fc>: Thermodynamic dissection of highly thermostable de novo designed proteins
De novo protein design often produces thermostable proteins that denature above 100°C, which complicates the analysis of their stability. Thermostable proteins can be unfolded by combined chemical an...
onlinelibrary.wiley.com
September 30, 2026 at 2:56 PM
🔥 New from our group in Protein Science!
We introduce CheMelt, a tool for analyzing thermal & chemical protein denaturation, integrated into the EMBL Hamburg eSPC platform.
📖 Read the paper:
onlinelibrary.wiley.com/doi/10.1002/...
@embl.org @cssbhamburg.bsky.social
@au.dk
#Biophysics #CheMelt
We introduce CheMelt, a tool for analyzing thermal & chemical protein denaturation, integrated into the EMBL Hamburg eSPC platform.
📖 Read the paper:
onlinelibrary.wiley.com/doi/10.1002/...
@embl.org @cssbhamburg.bsky.social
@au.dk
#Biophysics #CheMelt
"The immune responses to the spray-dried vaccines were unaffected by storage of the vaccines for 3 months at temperatures as high as 50 °C. ALD-coated rabies vaccine microparticles were also thermostable, with no changes in immunogenicity apparent after 3 months storage at 50 °C."
September 25, 2025 at 4:00 PM
"The immune responses to the spray-dried vaccines were unaffected by storage of the vaccines for 3 months at temperatures as high as 50 °C. ALD-coated rabies vaccine microparticles were also thermostable, with no changes in immunogenicity apparent after 3 months storage at 50 °C."
Research Briefing: AI-guided optimization for thermostable mRNA vaccines www.nature.com/articles/s41...
AI-guided optimization for thermostable mRNA vaccines - Nature Biotechnology
AGENT, an AI-driven framework integrating high-throughput experimentation with Bayesian optimization, enables the rapid engineering of thermostable, solid-state mRNA vaccines. These formulations retai...
www.nature.com
September 29, 2026 at 3:37 PM
Research Briefing: AI-guided optimization for thermostable mRNA vaccines www.nature.com/articles/s41...
PCR, the molecular biology technique? Where you use thermostable polymerase from a cool hot spring bacterium to rapidly amplify even traces of the target genetic material? For detection?
The thing done in a tube, far outside your body?
Are the swabs magic???
The thing done in a tube, far outside your body?
Are the swabs magic???
August 28, 2026 at 1:14 PM
PCR, the molecular biology technique? Where you use thermostable polymerase from a cool hot spring bacterium to rapidly amplify even traces of the target genetic material? For detection?
The thing done in a tube, far outside your body?
Are the swabs magic???
The thing done in a tube, far outside your body?
Are the swabs magic???
"We stabilized mRNA vaccines ....Moderna ...and Pfizer-BioNTech ....compositions into solid-state formulations that retained 100% bioactivity after storage at 37 °C for more than 2 months."
That sounds almost too good to be true.
#science
#immunology
buff.ly/LJrTlCo
That sounds almost too good to be true.
#science
#immunology
buff.ly/LJrTlCo
Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI - Nature Biotechnology
The thermostability of RNA vaccines is improved with AI.
buff.ly
September 28, 2026 at 7:29 PM
"We stabilized mRNA vaccines ....Moderna ...and Pfizer-BioNTech ....compositions into solid-state formulations that retained 100% bioactivity after storage at 37 °C for more than 2 months."
That sounds almost too good to be true.
#science
#immunology
buff.ly/LJrTlCo
That sounds almost too good to be true.
#science
#immunology
buff.ly/LJrTlCo
I love to hear thermostable 🎉
March 13, 2025 at 4:11 PM
I love to hear thermostable 🎉
#HyperMPNN - A general strategy to #design thermostable #proteins learned from hyperthermophiles.
Cool stuff! Use this approach to make your favourite protein into #thermostable version!
biorxiv.org/cgi/content/...
Cool stuff! Use this approach to make your favourite protein into #thermostable version!
biorxiv.org/cgi/content/...
HyperMPNN ‒ A general strategy to design thermostable proteins learned from hyperthermophiles
Stability is a key factor to enable the use of recombinant proteins in therapeutic or biotechnological applications. Deep learning protein design approaches like ProteinMPNN have shown strong performa...
biorxiv.org
December 3, 2024 at 4:52 AM
#HyperMPNN - A general strategy to #design thermostable #proteins learned from hyperthermophiles.
Cool stuff! Use this approach to make your favourite protein into #thermostable version!
biorxiv.org/cgi/content/...
Cool stuff! Use this approach to make your favourite protein into #thermostable version!
biorxiv.org/cgi/content/...
ProteinMPNN trained exclusively on proteins from thermophiles, with some experimental validation www.biorxiv.org/content/10.1...
HyperMPNN ‒ A general strategy to design thermostable proteins learned from hyperthermophiles
Stability is a key factor to enable the use of recombinant proteins in therapeutic or biotechnological applications. Deep learning protein design approaches like ProteinMPNN have shown strong performa...
www.biorxiv.org
December 2, 2024 at 11:26 AM
ProteinMPNN trained exclusively on proteins from thermophiles, with some experimental validation www.biorxiv.org/content/10.1...
Norovirus is a major cause of global gastroenteritis outbreaks. This thermostable tablet vaccine is easy to deliver, and could prevent illness and limit spread in settings like schools, nursing homes, and hospitals. A game-changer for public health.
May 14, 2025 at 8:16 PM
Norovirus is a major cause of global gastroenteritis outbreaks. This thermostable tablet vaccine is easy to deliver, and could prevent illness and limit spread in settings like schools, nursing homes, and hospitals. A game-changer for public health.
This is one of (the?) best papers of my career to date. The work in it wouldn't have been possible #WithoutNSF
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase
Protein tyrosine phosphatases (PTPs) are a family of enzymes that play important roles in regulating cellular signaling pathways. Due to the unusual role of loo
papers.ssrn.com
May 3, 2025 at 12:42 AM
This is one of (the?) best papers of my career to date. The work in it wouldn't have been possible #WithoutNSF
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
UTag, a cysteine-free thermostable tagging system for tracking single mRNA translation live
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 9, 2026 at 7:30 AM
UTag, a cysteine-free thermostable tagging system for tracking single mRNA translation live
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
AGENT, an AI-driven framework, enables rapid engineering of thermostable mRNA vaccines that maintain full bioactivity after two months at 37°C.
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
September 30, 2026 at 3:08 AM
AGENT, an AI-driven framework, enables rapid engineering of thermostable mRNA vaccines that maintain full bioactivity after two months at 37°C.
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
[#PhD] 👩🎓Félicitations à #Heloïse_Demont qui a brillamment soutenu sa thèse sur l'étude de la signalisation thermostable induite par les domaines #TIRs de récepteurs immunitaires végétaux et recherche de nouveaux régulateurs de leur fonction !
November 28, 2024 at 9:18 PM
[#PhD] 👩🎓Félicitations à #Heloïse_Demont qui a brillamment soutenu sa thèse sur l'étude de la signalisation thermostable induite par les domaines #TIRs de récepteurs immunitaires végétaux et recherche de nouveaux régulateurs de leur fonction !
An AI-driven framework called AGENT has enabled the rapid development of thermostable mRNA vaccines that maintain full bioactivity after storage at 37°C for two months.
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
September 29, 2026 at 3:54 AM
An AI-driven framework called AGENT has enabled the rapid development of thermostable mRNA vaccines that maintain full bioactivity after storage at 37°C for two months.
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
🔗 Source: https://www.nature.com/articles/s41587-026-03330-x
the surface of SARS-CoV-2 and a neuraminidase protein found on influenza A. The vaccine works by triggering the host immune system to produce antibodies in response to the two proteins. The vaccine platform is thermostable, potentially making administration easier and more accessible than the
March 13, 2025 at 4:07 PM
the surface of SARS-CoV-2 and a neuraminidase protein found on influenza A. The vaccine works by triggering the host immune system to produce antibodies in response to the two proteins. The vaccine platform is thermostable, potentially making administration easier and more accessible than the
(Source for that time/temp is the actual scientific paper the article links to: jpharmsci.org/article/S002... )
Superior immune responses from thermostable, single-administration rabies vaccines prepared using atomic layer deposition
Shortcomings of current rabies virus (RABV) vaccines include thermal instability and
the need for multiple injections to achieve protective immune responses. To overcome
these drawbacks we describe a ...
jpharmsci.org
September 25, 2025 at 4:00 PM
(Source for that time/temp is the actual scientific paper the article links to: jpharmsci.org/article/S002... )
What’s cooler than being cool? No dry ice.
We’ve teamed up with Genovis to develop SEQguard™ Dino Preserve, a thermostable RNA protection solution for Plasmidsaurus RNA-Seq.
Now you can ship purified RNA at room temp. No ice. No stress. Just fast, reliable RNA-seq.
plasmidsaurus.com/news/skip-th...
We’ve teamed up with Genovis to develop SEQguard™ Dino Preserve, a thermostable RNA protection solution for Plasmidsaurus RNA-Seq.
Now you can ship purified RNA at room temp. No ice. No stress. Just fast, reliable RNA-seq.
plasmidsaurus.com/news/skip-th...
April 2, 2026 at 4:04 PM
What’s cooler than being cool? No dry ice.
We’ve teamed up with Genovis to develop SEQguard™ Dino Preserve, a thermostable RNA protection solution for Plasmidsaurus RNA-Seq.
Now you can ship purified RNA at room temp. No ice. No stress. Just fast, reliable RNA-seq.
plasmidsaurus.com/news/skip-th...
We’ve teamed up with Genovis to develop SEQguard™ Dino Preserve, a thermostable RNA protection solution for Plasmidsaurus RNA-Seq.
Now you can ship purified RNA at room temp. No ice. No stress. Just fast, reliable RNA-seq.
plasmidsaurus.com/news/skip-th...
"This vaccine is formulated into thermostable enterically coated tablets designed to release the rAd5 vector in the intestinal ileum, where an adaptive immune response is activated by host cell expression of VP1."
March 6, 2025 at 7:07 PM
"This vaccine is formulated into thermostable enterically coated tablets designed to release the rAd5 vector in the intestinal ileum, where an adaptive immune response is activated by host cell expression of VP1."