[astro-ph.GA] This study focuses on propanethiol (or propyl mercaptan, C3H7SH), a sulfur analogue of propanol and a key target for investigating interstellar sulfur chemistry. We report the laboratory...

Communications Chemistry, Published online: 22 September 2026; doi:10.1038/s42004-026-02216-yPersulfide dioxygenases (PDOs) protect against hydrogen sulfide and reactive sulfur species (RSS) poisoning. The bacterial PDO from Staphylococcus aureus CstB is unique in its oxidative metabolism of organic thiol persulfides to thiosulfate and the free thiol, without the release of toxic sulfite. Here, the authors reveal that a dynamic loop in CstB facilitates three distinct chemical transformations, enabling efficient clearance of RSS that is independent of the specific thiol persulfide.

Alt: a small black and white skunk is standing on a dirt ground. It stamps on the dirt, looking slightly nervous or annoyed.

Due to its efficiency, selectivity and biocompatibility, the thiol–ene coupling has demonstrated its potential for protein labelling. Here, we report the electrochemical thiol–ene activation to captur...

Here we report the use of a tetrabutylammonium decatungstate (TBADT)/thiol photocatalytic system for selective addition of acetone and other simple ketone, nitrile, and chlorocarbon functionalities to terminal olefins. This system avoids the use of energetic reagents such as peroxides and proceeds under mild conditions using Earth-abundant element catalysts, providing a sustainable approach to C–C bond formation using activated olefins. Initial exploration reveals that hydroalkylation of unactivated olefins is also possible, though in lower efficiency, and preliminary mechanistic experiments are consistent with a radical mechanism.

The thiol-ene coupling between an alkene and a thiol can be exploited for selective labelling of cysteine residues in protein profiling applications, however, the labelling of complex cell lysate mixt...

Peptide macrocyclization offers a versatile method for enhancing peptide stability, cell permeability, and biological activity. Herein, we report a radical-mediated, thiol–yne process for peptide macr...

Abstract. Cellular redox homeostasis depends on a finely tuned balance between oxidizing and reducing conditions, and disturbances in this balance lead to

The 2026 Gordon Research Conference on Thiol-Based Redox Regulation and Signaling will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

The 2026 Gordon Research Seminar on Thiol-Based Redox Regulation and Signaling (GRS) will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.