TimsTOF ultra 2 cookies for the group.🍪😋🎄🎄🎄 #teammassspec @brukercorporation.bsky.social
December 15, 2024 at 12:32 PM
TimsTOF ultra 2 cookies for the group.🍪😋🎄🎄🎄 #teammassspec @brukercorporation.bsky.social
Let the fun begin! A Bruker timsTOF HT was just installed in our lab as part of the GreenTE Gravitation project!!!
March 12, 2025 at 11:56 PM
Let the fun begin! A Bruker timsTOF HT was just installed in our lab as part of the GreenTE Gravitation project!!!
Uh oh… TimsTOF disappeared
February 11, 2026 at 11:23 AM
Uh oh… TimsTOF disappeared
I hadn't fully realised how much slower searching timsTOF data was
November 29, 2024 at 3:09 PM
I hadn't fully realised how much slower searching timsTOF data was
Exciting news: We have released #FragPipe 23, and it's one of our biggest updates ever. Windows installer, support for TMT on Astral and timsTOF, TMT35, PTM site reports for DIA, improved Astral data handling in #MSFragger, improved diaTracer for diaPASEF data, better Skyline integration, and more!
May 5, 2025 at 4:06 AM
Exciting news: We have released #FragPipe 23, and it's one of our biggest updates ever. Windows installer, support for TMT on Astral and timsTOF, TMT35, PTM site reports for DIA, improved Astral data handling in #MSFragger, improved diaTracer for diaPASEF data, better Skyline integration, and more!
Astral & TimsTOF Ultra are challenging @pride-ebi.bsky.social infrastructure.
September 13, 2026 at 10:03 AM
Astral & TimsTOF Ultra are challenging @pride-ebi.bsky.social infrastructure.
timsTOF over the years
June 1, 2025 at 12:51 PM
timsTOF over the years
News in Proteomics Research | Astral vs TIMSTOF Ultra on real single cells? Just about evenly unreal numbers! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
November 17, 2024 at 10:00 PM
News in Proteomics Research | Astral vs TIMSTOF Ultra on real single cells? Just about evenly unreal numbers! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
Thanks to everyone that attended our #proteomics Short course last week ! We generated over 150 GB of timsTOF HT data comparing different proteomics sample
Prep methods .
Prep methods .
September 4, 2025 at 9:01 PM
Thanks to everyone that attended our #proteomics Short course last week ! We generated over 150 GB of timsTOF HT data comparing different proteomics sample
Prep methods .
Prep methods .
Master thread for Lego analytical instrument designs. First up: Updated Bruker MALDI-timsTOF fleX with reference image attached. 76 parts total.
November 6, 2024 at 11:30 PM
Master thread for Lego analytical instrument designs. First up: Updated Bruker MALDI-timsTOF fleX with reference image attached. 76 parts total.
Introducing our new timsTOF Ultra2 to fellow Bluesky colleagues #teammassspec #proteomics
November 18, 2024 at 10:05 PM
Introducing our new timsTOF Ultra2 to fellow Bluesky colleagues #teammassspec #proteomics
Heck Yeah, I just searched over 300 timsTOF HT diaPASEF files with DIA-NN 2.0 on my cluster in under 2 hours. I'll try and make a video of how I did it tomorrow. It's not that terribly hard
February 21, 2025 at 12:21 AM
Heck Yeah, I just searched over 300 timsTOF HT diaPASEF files with DIA-NN 2.0 on my cluster in under 2 hours. I'll try and make a video of how I did it tomorrow. It's not that terribly hard
Want to watch our timsTOF HT and Evosep acquire 100 bat plasma samples in real time? I know you do!! Will the column clog or things break? Tune in to find out!! I'm obviously procrastinating btw 😉
www.youtube.com/live/Mb2pJpQ...
www.youtube.com/live/Mb2pJpQ...
Watch out timsTOF HT acquire proteomics data in real time!!
YouTube video by Brett Phinney
www.youtube.com
July 9, 2025 at 9:15 PM
Want to watch our timsTOF HT and Evosep acquire 100 bat plasma samples in real time? I know you do!! Will the column clog or things break? Tune in to find out!! I'm obviously procrastinating btw 😉
www.youtube.com/live/Mb2pJpQ...
www.youtube.com/live/Mb2pJpQ...
I have a 3-year postdoc position available at University of Manchester for a mass spec expert in proteomics. The person will be involved in exciting projects in single cell proteomics, drug discovery and innate immunity - on timsTOF Ultra AIP & HF & Astral Zoom.
www.jobs.ac.uk/job/DQJ093/r...
www.jobs.ac.uk/job/DQJ093/r...
Home - Trost Lab
www.trostlab.org
February 2, 2026 at 7:53 PM
I have a 3-year postdoc position available at University of Manchester for a mass spec expert in proteomics. The person will be involved in exciting projects in single cell proteomics, drug discovery and innate immunity - on timsTOF Ultra AIP & HF & Astral Zoom.
www.jobs.ac.uk/job/DQJ093/r...
www.jobs.ac.uk/job/DQJ093/r...
🧪If you join our lab you will be able to use our three timsTOF mass spectrometers….and we also got a new microwave oven for our lab kitchen today!😜
#ChemSky
#AcademicSky
#ChemSky
#AcademicSky
February 13, 2025 at 4:41 PM
🧪If you join our lab you will be able to use our three timsTOF mass spectrometers….and we also got a new microwave oven for our lab kitchen today!😜
#ChemSky
#AcademicSky
#ChemSky
#AcademicSky
New preprint out!
We benchmarked five plasma enrichment methods and developed an automated, cost-effective MagNet workflow.
Up to 4,200 proteins/sample identified using DIA on timsTOF Pro 2 with, at just a few dollars/sample.
doi.org/10.1101/2025...
#PlasmaProteomics #DIA #timsTOF #Evosep
We benchmarked five plasma enrichment methods and developed an automated, cost-effective MagNet workflow.
Up to 4,200 proteins/sample identified using DIA on timsTOF Pro 2 with, at just a few dollars/sample.
doi.org/10.1101/2025...
#PlasmaProteomics #DIA #timsTOF #Evosep
Automated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states, and its compatibility with minimally invasive sampling. Deep proteomic p...
doi.org
May 11, 2025 at 1:21 PM
New preprint out!
We benchmarked five plasma enrichment methods and developed an automated, cost-effective MagNet workflow.
Up to 4,200 proteins/sample identified using DIA on timsTOF Pro 2 with, at just a few dollars/sample.
doi.org/10.1101/2025...
#PlasmaProteomics #DIA #timsTOF #Evosep
We benchmarked five plasma enrichment methods and developed an automated, cost-effective MagNet workflow.
Up to 4,200 proteins/sample identified using DIA on timsTOF Pro 2 with, at just a few dollars/sample.
doi.org/10.1101/2025...
#PlasmaProteomics #DIA #timsTOF #Evosep
Struggling to compare Bruker timsTOF methods or extract window schemes from raw .d files? I developed a free desktop tool to solve this: timsCompare! 🚀
It automates the manual work of extracting method parameters, presenting them in a structured and comparable view.
(A thread 🧵)
It automates the manual work of extracting method parameters, presenting them in a structured and comparable view.
(A thread 🧵)
October 15, 2025 at 11:01 AM
Struggling to compare Bruker timsTOF methods or extract window schemes from raw .d files? I developed a free desktop tool to solve this: timsCompare! 🚀
It automates the manual work of extracting method parameters, presenting them in a structured and comparable view.
(A thread 🧵)
It automates the manual work of extracting method parameters, presenting them in a structured and comparable view.
(A thread 🧵)
My MS predictions for 2025:
- ⬆️Single cell applications and extending linearity over a wide dynamic range (Bruker - new timsTOF, Thermo - new Exploris)
- TMT32 and 35-plex better showcased
- Thermo OptiSpray dual column-emitter source
- Thermo isotope ratio Exploris release
#ASMS2025 #TeamMassSpec
- ⬆️Single cell applications and extending linearity over a wide dynamic range (Bruker - new timsTOF, Thermo - new Exploris)
- TMT32 and 35-plex better showcased
- Thermo OptiSpray dual column-emitter source
- Thermo isotope ratio Exploris release
#ASMS2025 #TeamMassSpec
December 11, 2024 at 12:45 PM
My MS predictions for 2025:
- ⬆️Single cell applications and extending linearity over a wide dynamic range (Bruker - new timsTOF, Thermo - new Exploris)
- TMT32 and 35-plex better showcased
- Thermo OptiSpray dual column-emitter source
- Thermo isotope ratio Exploris release
#ASMS2025 #TeamMassSpec
- ⬆️Single cell applications and extending linearity over a wide dynamic range (Bruker - new timsTOF, Thermo - new Exploris)
- TMT32 and 35-plex better showcased
- Thermo OptiSpray dual column-emitter source
- Thermo isotope ratio Exploris release
#ASMS2025 #TeamMassSpec
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
October 31, 2025 at 7:07 PM
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
Getting the ol' grad school gang back together with Carafe2 -- Bo Wen (@maccoss.bsky.social and Bill Noble) and @jspaezp.bsky.social (@willfondrie.com at @talusbio.bsky.social) teamed up for essentially some late night hackathons to build out Carafe for @brukercorporation.bsky.social timsTOF data.
Carafe2 enables high quality in silico spectral library generation for timsTOF data-independent acquisition proteomics www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
March 31, 2026 at 6:00 PM
Getting the ol' grad school gang back together with Carafe2 -- Bo Wen (@maccoss.bsky.social and Bill Noble) and @jspaezp.bsky.social (@willfondrie.com at @talusbio.bsky.social) teamed up for essentially some late night hackathons to build out Carafe for @brukercorporation.bsky.social timsTOF data.
Carafe2 enables high quality in silico spectral library generation for timsTOF data-independent acquisition proteomics www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
March 31, 2026 at 3:40 PM
Carafe2 enables high quality in silico spectral library generation for timsTOF data-independent acquisition proteomics www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Bruker has released a new timsTOF, the timsOmni Sigma (no comment on rizz):
www.bruker.com/en/products-...
Biggest difference looks to be the pre-TIMS ion guide, which is an SCP version for the Sigma.
www.bruker.com/en/products-...
Biggest difference looks to be the pre-TIMS ion guide, which is an SCP version for the Sigma.
April 8, 2026 at 2:17 PM
Bruker has released a new timsTOF, the timsOmni Sigma (no comment on rizz):
www.bruker.com/en/products-...
Biggest difference looks to be the pre-TIMS ion guide, which is an SCP version for the Sigma.
www.bruker.com/en/products-...
Biggest difference looks to be the pre-TIMS ion guide, which is an SCP version for the Sigma.
timsCompare is free, open-source, and available now on GitHub! All feedback, bug reports, and feature ideas are welcome.
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
GitHub - kronigert/timsCompare: A desktop application for mass spectrometry users to load, view, compare timsTOF methods and export isolation schemes and method reports from Bruker's .d method directo...
A desktop application for mass spectrometry users to load, view, compare timsTOF methods and export isolation schemes and method reports from Bruker's .d method directories. - kronigert/timsCom...
github.com
October 15, 2025 at 11:01 AM
timsCompare is free, open-source, and available now on GitHub! All feedback, bug reports, and feature ideas are welcome.
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
December 15, 2024 at 5:59 PM