Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...
Truncated TrkB: The predominant TrkB isoform in nociceptors
Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral…
www.sciencedirect.com
May 17, 2025 at 10:49 PM
Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine | Science Advances www.science.org/doi/10.1126/...
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine
TrkB and mGluR5 undergo signaling and trafficking cross-talk to control the antidepressant-like effects of ketamine.
www.science.org
May 5, 2026 at 10:06 AM
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine | Science Advances www.science.org/doi/10.1126/...
BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...
Truncated TrkB: The predominant TrkB Isoform in Nociceptors
Truncated form of the tropomyosin receptor kinase B isoform (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sens...
www.biorxiv.org
December 27, 2024 at 11:54 PM
BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum - Translational Psychiatry
Translational Psychiatry - Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
www.nature.com
March 22, 2025 at 5:43 PM
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Some kind of partial 5-HT2A/TrkB receptor modulator that costs nothing we can just sprinkle on everything like salt
September 24, 2026 at 2:01 AM
Some kind of partial 5-HT2A/TrkB receptor modulator that costs nothing we can just sprinkle on everything like salt
Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles https://www.biorxiv.org/content/10.64898/2026.08.06.743248v1
August 12, 2026 at 8:18 PM
Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles https://www.biorxiv.org/content/10.64898/2026.08.06.743248v1
MDGA2 mutations are associated with #Autism spectrum disorder (ASD) but why? This study shows that MDGA2 competes with BDNF & constrains TrkB signaling; aberrant TrkB activation caused by MDGA2-deficiency is crucial for ASD-related phenotypes @plosbiology.org 🧪 plos.io/42amhjK
April 2, 2025 at 5:04 PM
MDGA2 mutations are associated with #Autism spectrum disorder (ASD) but why? This study shows that MDGA2 competes with BDNF & constrains TrkB signaling; aberrant TrkB activation caused by MDGA2-deficiency is crucial for ASD-related phenotypes @plosbiology.org 🧪 plos.io/42amhjK
Key Refs: 🧪💉💊
📰 Antidepressants act via TRKB: pubmed.ncbi.nlm.nih.gov/33606976/
📰 Psychedelics act via TrkB:
www.nature.com/articles/s41...
📰 BDNF receptor TrkB as the mediator of the antidepressant drug action:
www.frontiersin.org/journals/mol...
📰 Antidepressants act via TRKB: pubmed.ncbi.nlm.nih.gov/33606976/
📰 Psychedelics act via TrkB:
www.nature.com/articles/s41...
📰 BDNF receptor TrkB as the mediator of the antidepressant drug action:
www.frontiersin.org/journals/mol...
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors - PubMed
It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), t...
pubmed.ncbi.nlm.nih.gov
June 23, 2025 at 1:43 PM
Key Refs: 🧪💉💊
📰 Antidepressants act via TRKB: pubmed.ncbi.nlm.nih.gov/33606976/
📰 Psychedelics act via TrkB:
www.nature.com/articles/s41...
📰 BDNF receptor TrkB as the mediator of the antidepressant drug action:
www.frontiersin.org/journals/mol...
📰 Antidepressants act via TRKB: pubmed.ncbi.nlm.nih.gov/33606976/
📰 Psychedelics act via TrkB:
www.nature.com/articles/s41...
📰 BDNF receptor TrkB as the mediator of the antidepressant drug action:
www.frontiersin.org/journals/mol...
Truncated TrkB: The predominant TrkB Isoform in Nociceptors https://www.biorxiv.org/content/10.1101/2024.12.27.630513v1
December 27, 2024 at 11:17 PM
Truncated TrkB: The predominant TrkB Isoform in Nociceptors https://www.biorxiv.org/content/10.1101/2024.12.27.630513v1
Catching up on blog posts! Here’s one on the idea that antidepressants have a common mechanism in promoting new neural connections. More and more work on this is showing up:
TrkB, BDNF, and Depression
www.science.org
November 18, 2025 at 5:59 PM
Catching up on blog posts! Here’s one on the idea that antidepressants have a common mechanism in promoting new neural connections. More and more work on this is showing up:
🆕Lab study shows that ayahuasca enhances fear extinction, including under stress-induced deficits, and reduces fear generalization; cortical BDNF-TrkB receptor signaling contributes to these effects @isabel-werle.bsky.social @ecnp.eu
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 18, 2025 at 9:19 AM
🆕Lab study shows that ayahuasca enhances fear extinction, including under stress-induced deficits, and reduces fear generalization; cortical BDNF-TrkB receptor signaling contributes to these effects @isabel-werle.bsky.social @ecnp.eu
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.nature.com/articles/s41... We recently described the mechanism of TrkB receptor activation by antidepressants. Transmembrane domain plays a critical role. 🧪
Structural basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB - Nature Communications
Neurotrophin receptor TrkB regulates neuronal growth and neuroplasticity. Here, the authors present the NMR structure of the intramembrane region of TrkB activated by antidepressant drugs, yielding in...
www.nature.com
November 16, 2024 at 2:16 PM
www.nature.com/articles/s41... We recently described the mechanism of TrkB receptor activation by antidepressants. Transmembrane domain plays a critical role. 🧪
BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors https://www.biorxiv.org/content/10.64898/2026.04.08.717148v1
April 9, 2026 at 7:15 AM
BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors https://www.biorxiv.org/content/10.64898/2026.04.08.717148v1
Prior work by the @martinowk.bsky.social lab and others have shown that CST (along with other neuropeptides) are regulated by BDNF-TrkB signaling. Indeed, Aaron found that disrupting TrkB signaling in CST neurons is sufficient to reproduce the sex-specific effect of accelerated kindling rate.
February 2, 2026 at 5:22 PM
Prior work by the @martinowk.bsky.social lab and others have shown that CST (along with other neuropeptides) are regulated by BDNF-TrkB signaling. Indeed, Aaron found that disrupting TrkB signaling in CST neurons is sufficient to reproduce the sex-specific effect of accelerated kindling rate.
MDGA2 mutations are associated with #Autism spectrum disorder (ASD) but why? This study shows that MDGA2 competes with BDNF & constrains TrkB signaling; aberrant TrkB activation caused by MDGA2-deficiency is crucial for ASD-related phenotypes @plosbiology.org 🧪 plos.io/42amhjK
April 3, 2025 at 4:40 PM
MDGA2 mutations are associated with #Autism spectrum disorder (ASD) but why? This study shows that MDGA2 competes with BDNF & constrains TrkB signaling; aberrant TrkB activation caused by MDGA2-deficiency is crucial for ASD-related phenotypes @plosbiology.org 🧪 plos.io/42amhjK
Still remember not long ago we were newbies in the drug field, and asked a big shot at the seminar about ‘Turk B’ aka TrkB. 😬
May 22, 2026 at 4:14 PM
Still remember not long ago we were newbies in the drug field, and asked a big shot at the seminar about ‘Turk B’ aka TrkB. 😬
Why Are Researchers Stunned by Semax Recovery Rates in Stroke Subjects? #semax #stroke #adhd #frontalortex #trkb #neuroscience #peptides #biohacking #neuroplasticity #researchlabs #sciencetok #brainhealth #pharmacology #biochemistry #labtrials
September 25, 2026 at 4:05 PM
Why Are Researchers Stunned by Semax Recovery Rates in Stroke Subjects? #semax #stroke #adhd #frontalortex #trkb #neuroscience #peptides #biohacking #neuroplasticity #researchlabs #sciencetok #brainhealth #pharmacology #biochemistry #labtrials
BDNF-TrkB Signaling Maintains Alveolar Epithelial Type 2 Cell Survival and Is Blocked in Hyperoxia-induced Neonatal Lung Injury
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ham4nj5
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ham4nj5
October 7, 2025 at 3:23 PM
BDNF-TrkB Signaling Maintains Alveolar Epithelial Type 2 Cell Survival and Is Blocked in Hyperoxia-induced Neonatal Lung Injury
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ham4nj5
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ham4nj5
Our lab's latest looking at resilience of synaptic plasticity with A neurotrophin agonist. Notably in the presence of continued amyloid pathology. 🧪🧬🖥️🧠 doi.org/10.1002/alz....
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer's mouse model
INTRODUCTION
Tropomyosin related kinase B (TrkB) and C (TrkC) receptor signaling promotes synaptic plasticity and interacts with pathways affected by amyloid beta (Aβ) toxicity. Upregulating TrkB/C .....
doi.org
June 26, 2024 at 2:25 AM
Our lab's latest looking at resilience of synaptic plasticity with A neurotrophin agonist. Notably in the presence of continued amyloid pathology. 🧪🧬🖥️🧠 doi.org/10.1002/alz....
TrkB and nociception : "TrkBT1 as a functional modulator of nociceptor activity rather than a passive regulator of full-length TrkB. By uncovering its dual roles in nociceptor sensitization and survival, this study provides new insights into the molecular mechanisms of BDNF/TrkB signaling in pain"
BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...
Truncated TrkB: The predominant TrkB Isoform in Nociceptors
Truncated form of the tropomyosin receptor kinase B isoform (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sens...
www.biorxiv.org
December 28, 2024 at 9:24 AM
TrkB and nociception : "TrkBT1 as a functional modulator of nociceptor activity rather than a passive regulator of full-length TrkB. By uncovering its dual roles in nociceptor sensitization and survival, this study provides new insights into the molecular mechanisms of BDNF/TrkB signaling in pain"
Recent evidence suggest that both drugs also bind and activate an entirely different receptor, TrkB, the receptor for BDNF and a key driver of neuroplasticity.
When these drugs activate TrkB, they enhance the ability for neurons to form new connections, a very good thing for a depressed brain. 🧪
When these drugs activate TrkB, they enhance the ability for neurons to form new connections, a very good thing for a depressed brain. 🧪
June 23, 2025 at 1:43 PM
Recent evidence suggest that both drugs also bind and activate an entirely different receptor, TrkB, the receptor for BDNF and a key driver of neuroplasticity.
When these drugs activate TrkB, they enhance the ability for neurons to form new connections, a very good thing for a depressed brain. 🧪
When these drugs activate TrkB, they enhance the ability for neurons to form new connections, a very good thing for a depressed brain. 🧪
#helyes Kasvu Therapeutics Raises €30M Series A Financing Round led by Hadean Ventures to Advance its Novel TrkB Potentiator into Clinical Development Targeting Neuropsychiatric Disorders [Press-release]
https://www.kasvutx.com/news-series-a-funding-round #NordicMade #LifeScience #biotech
https://www.kasvutx.com/news-series-a-funding-round #NordicMade #LifeScience #biotech
News-series-a-funding-round | Discover Innovative Neuroplasticity Solutions -- Kasvu Therapeutics
Kasvu Therapeutics advances neuroplasticity treatments for mental health with €30M Series A funding. Focused on developing selective TrkB potentiators for depression and neuropsychiatric disorders.
www.kasvutx.com
September 25, 2026 at 11:33 AM
#helyes Kasvu Therapeutics Raises €30M Series A Financing Round led by Hadean Ventures to Advance its Novel TrkB Potentiator into Clinical Development Targeting Neuropsychiatric Disorders [Press-release]
https://www.kasvutx.com/news-series-a-funding-round #NordicMade #LifeScience #biotech
https://www.kasvutx.com/news-series-a-funding-round #NordicMade #LifeScience #biotech
A brain circuit that links hunger signals with the jaw movements of eating www.nature.com/articles/d41... Fasinating novel insights into BDNF's role in feeding regulation LOF Mutations in BDNF and its receptor TRKB cause severe early onset obesity in humans
A brain circuit that links hunger signals with the jaw movements of eating
In mice, silencing a set of neurons in the brain’s hypothalamus leads to chewing behaviours, even when food is unavailable.
www.nature.com
December 7, 2024 at 4:19 PM
A brain circuit that links hunger signals with the jaw movements of eating www.nature.com/articles/d41... Fasinating novel insights into BDNF's role in feeding regulation LOF Mutations in BDNF and its receptor TRKB cause severe early onset obesity in humans
#Butyrate improves abnormal #sleep architecture in a #Parkinson's disease mouse model via BDNF/TrkB signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Butyrate improves abnormal sleep architecture in a Parkinson’s disease mouse model via BDNF/TrkB signaling - npj Parkinson's Disease
npj Parkinson's Disease - Butyrate improves abnormal sleep architecture in a Parkinson’s disease mouse model via BDNF/TrkB signaling
www.nature.com
June 20, 2025 at 8:28 AM
#Butyrate improves abnormal #sleep architecture in a #Parkinson's disease mouse model via BDNF/TrkB signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Case study 2: a fragment model built for 3′ chemistry, cross-fitted across donors, reveals an 8-donor shift in NTRK2 (TrkB) terminal-isoform usage: full-length share 20% in astrocytes/NSCs → 78% in mature neurons. Matches known TrkB.T1 biology. No reprocessing.
September 21, 2026 at 3:52 PM
Case study 2: a fragment model built for 3′ chemistry, cross-fitted across donors, reveals an 8-donor shift in NTRK2 (TrkB) terminal-isoform usage: full-length share 20% in astrocytes/NSCs → 78% in mature neurons. Matches known TrkB.T1 biology. No reprocessing.