February 12, 2025 at 9:08 AM
TTF2 promotes replisome eviction from stalled forks in mitosis https://www.biorxiv.org/content/10.1101/2024.11.30.626186v1
TTF2 promotes replisome eviction from stalled forks in mitosis https://www.biorxiv.org/content/10.1101/2024.11.30.626186v1
When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, wh
www.biorxiv.org
December 1, 2024 at 5:46 AM
TTF2 promotes replisome eviction from stalled forks in mitosis https://www.biorxiv.org/content/10.1101/2024.11.30.626186v1
A new paper from Karim Labib's lab shows how TTF2 couples phosphorylated TRAIP to Pol ε, leading TRAIP to ubiquitylate the CMG helicase and triggering mitotic replisome disassembly at sites of incomplete DNA replication | Science www.science.org/doi/10.1126/...
July 4, 2026 at 5:18 PM
A new paper from Karim Labib's lab shows how TTF2 couples phosphorylated TRAIP to Pol ε, leading TRAIP to ubiquitylate the CMG helicase and triggering mitotic replisome disassembly at sites of incomplete DNA replication | Science www.science.org/doi/10.1126/...
A huge thanks to Ryo Fujisawa for joining our JC this week!
Ryo's formidable work on TTF2 from his recent article "TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε" was enlightening. Great scientific discussion!
Ryo's work doi.org/10.1101/2024...
Ryo's formidable work on TTF2 from his recent article "TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε" was enlightening. Great scientific discussion!
Ryo's work doi.org/10.1101/2024...
TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε
Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of replication forks to facilitate chromosome segregation. The TRAIP ubiquitin ligase i...
doi.org
January 16, 2025 at 1:57 PM
A huge thanks to Ryo Fujisawa for joining our JC this week!
Ryo's formidable work on TTF2 from his recent article "TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε" was enlightening. Great scientific discussion!
Ryo's work doi.org/10.1101/2024...
Ryo's formidable work on TTF2 from his recent article "TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε" was enlightening. Great scientific discussion!
Ryo's work doi.org/10.1101/2024...
got my ass beat in ttf2 so were making rice abt it
March 27, 2025 at 8:04 PM
got my ass beat in ttf2 so were making rice abt it
2/ Using TTF2 depletion to force nascent transcripts to persist on mitotic chromatin, we found that this abnormal retention leads to mitotic errors including abnormal chromosomes and bridges.
February 17, 2026 at 11:06 AM
2/ Using TTF2 depletion to force nascent transcripts to persist on mitotic chromatin, we found that this abnormal retention leads to mitotic errors including abnormal chromosomes and bridges.
🧵1/
Excited to share our new preprint!
We uncover a new layer of control in how cells restart transcription after mitosis.
👉 TTF2 prevents premature rRNA transcription during mitotic exit
(www.biorxiv.org/content/10.6...)
Excited to share our new preprint!
We uncover a new layer of control in how cells restart transcription after mitosis.
👉 TTF2 prevents premature rRNA transcription during mitotic exit
(www.biorxiv.org/content/10.6...)
March 27, 2026 at 10:18 AM
🧵1/
Excited to share our new preprint!
We uncover a new layer of control in how cells restart transcription after mitosis.
👉 TTF2 prevents premature rRNA transcription during mitotic exit
(www.biorxiv.org/content/10.6...)
Excited to share our new preprint!
We uncover a new layer of control in how cells restart transcription after mitosis.
👉 TTF2 prevents premature rRNA transcription during mitotic exit
(www.biorxiv.org/content/10.6...)
"What music do you vibe to bro?"
Literally me: www.youtube.com/watch?v=TTf2...
Literally me: www.youtube.com/watch?v=TTf2...
High Energy Protons
YouTube video by Juno Reactor - Topic
www.youtube.com
June 11, 2025 at 6:33 PM
"What music do you vibe to bro?"
Literally me: www.youtube.com/watch?v=TTf2...
Literally me: www.youtube.com/watch?v=TTf2...
no this is an unfair bet she has 400h on ttf2
March 20, 2025 at 9:16 AM
no this is an unfair bet she has 400h on ttf2
翻到這兩張🐯，，機性戀大爆發呃啊來玩ttf2吧，，
May 6, 2026 at 7:51 AM
翻到這兩張🐯，，機性戀大爆發呃啊來玩ttf2吧，，
Another interesting bit on TTF2 function in mitosis 🔍: www.biorxiv.org/content/10.6...
March 27, 2026 at 5:06 PM
Another interesting bit on TTF2 function in mitosis 🔍: www.biorxiv.org/content/10.6...
lets play ttf2!!
March 18, 2025 at 5:20 PM
lets play ttf2!!
I still think this is the most glorious of Ducati racers. In a time when they were true underdogs in Endurance and TTF1. Rutter staved the strokers off in TTF2, but awaiting the weeklies to see how Villa, Grau and co went in endurance was almost an obsession for a pursuit.
November 22, 2024 at 12:21 PM
I still think this is the most glorious of Ducati racers. In a time when they were true underdogs in Endurance and TTF1. Rutter staved the strokers off in TTF2, but awaiting the weeklies to see how Villa, Grau and co went in endurance was almost an obsession for a pursuit.
TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Pol epsilon https://www.biorxiv.org/content/10.1101/2024.12.01.626218v1
TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Pol epsilon https://www.biorxiv.org/content/10.1101/2024.12.01.626218v1
Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapi
www.biorxiv.org
December 2, 2024 at 4:30 PM
TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Pol epsilon https://www.biorxiv.org/content/10.1101/2024.12.01.626218v1
Hey there, if you are reading this and are transgender or a ally and also a tf2 fan you should join this discord I run!
Trying to grow this server so we can have more members for events!
#TF2 #valve #TeamFortress2
discord.gg/GvvT2CRwmr
Trying to grow this server so we can have more members for events!
#TF2 #valve #TeamFortress2
discord.gg/GvvT2CRwmr
Join the tTF2: Transgender Team fortress 2 Community Discord Server!
Welcome to tTF2! We are a little community of transgender tf2 players and fans! | 43 members
discord.gg
October 2, 2025 at 3:38 PM
Hey there, if you are reading this and are transgender or a ally and also a tf2 fan you should join this discord I run!
Trying to grow this server so we can have more members for events!
#TF2 #valve #TeamFortress2
discord.gg/GvvT2CRwmr
Trying to grow this server so we can have more members for events!
#TF2 #valve #TeamFortress2
discord.gg/GvvT2CRwmr
modern cod "movement" players are giving actual movement game players (TTF2, Quake, bhop / surf communities, etc )a bad name and making us look stupid
August 20, 2023 at 8:01 PM
modern cod "movement" players are giving actual movement game players (TTF2, Quake, bhop / surf communities, etc )a bad name and making us look stupid
the screams of a creature that genuinely furgot ttf2 was owned by ea
March 18, 2025 at 11:11 PM
the screams of a creature that genuinely furgot ttf2 was owned by ea
the universe is so cruel, we have to go to band practice right as ttf2 finishes downloading..
March 18, 2025 at 9:01 PM
the universe is so cruel, we have to go to band practice right as ttf2 finishes downloading..
ttf2也不错(˵¯͒〰¯͒˵)
不过都是重生工作室底下的
感觉工作室没想往好了整😠
不过都是重生工作室底下的
感觉工作室没想往好了整😠
May 16, 2025 at 4:22 PM
ttf2也不错(˵¯͒〰¯͒˵)
不过都是重生工作室底下的
感觉工作室没想往好了整😠
不过都是重生工作室底下的
感觉工作室没想往好了整😠
We also appreciated the insights from the back-to-back paper "TTF2 promotes replisome eviction from stalled forks in mitosis" from the Johannes Walter and David Pellman labs: doi.org/10.1101/2024...
TTF2 promotes replisome eviction from stalled forks in mitosis
When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitig...
doi.org
January 16, 2025 at 1:57 PM
We also appreciated the insights from the back-to-back paper "TTF2 promotes replisome eviction from stalled forks in mitosis" from the Johannes Walter and David Pellman labs: doi.org/10.1101/2024...
A Mitotic Architectural Switch Safeguards the Genome
A phospho-regulated switch reprograms TRAIP in mitosis to ubiquitylate the replisome, enabling fork breakage and chromosome arm joining. TTF2 tethers Cyclin B–CDK1-phosphorylated TRAIP to Pol ε, safeguarding genome integrity before segregation.
A phospho-regulated switch reprograms TRAIP in mitosis to ubiquitylate the replisome, enabling fork breakage and chromosome arm joining. TTF2 tethers Cyclin B–CDK1-phosphorylated TRAIP to Pol ε, safeguarding genome integrity before segregation.
July 10, 2026 at 2:00 PM
A Mitotic Architectural Switch Safeguards the Genome
A phospho-regulated switch reprograms TRAIP in mitosis to ubiquitylate the replisome, enabling fork breakage and chromosome arm joining. TTF2 tethers Cyclin B–CDK1-phosphorylated TRAIP to Pol ε, safeguarding genome integrity before segregation.
A phospho-regulated switch reprograms TRAIP in mitosis to ubiquitylate the replisome, enabling fork breakage and chromosome arm joining. TTF2 tethers Cyclin B–CDK1-phosphorylated TRAIP to Pol ε, safeguarding genome integrity before segregation.
A preprint using: PB-TA-ERN (RRID:Addgene_80474) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
Removal of nascent transcripts by TTF2 is required for efficient sister chromatid resolution in human cells
www.biorxiv.org
January 31, 2026 at 1:00 PM
A preprint using: PB-TA-ERN (RRID:Addgene_80474) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
Authors used HeLa from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
TTF2 prevents premature rRNA synthesis during mitotic exit
www.biorxiv.org
March 26, 2026 at 12:00 PM
Authors used HeLa from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
Gosh, with X-Men '97 on the horizon, I'm looking at the fanfics I've attempted over the years.
NONE OF THIS IS DONE.
If I ever manage to fix them up and post them online (not sure how likely this would be) I'd definitely do some retitling for these fanfics.
NONE OF THIS IS DONE.
If I ever manage to fix them up and post them online (not sure how likely this would be) I'd definitely do some retitling for these fanfics.
March 19, 2024 at 12:52 AM
Gosh, with X-Men '97 on the horizon, I'm looking at the fanfics I've attempted over the years.
NONE OF THIS IS DONE.
If I ever manage to fix them up and post them online (not sure how likely this would be) I'd definitely do some retitling for these fanfics.
NONE OF THIS IS DONE.
If I ever manage to fix them up and post them online (not sure how likely this would be) I'd definitely do some retitling for these fanfics.