Is this anything? Send skeet.
January 11, 2025 at 5:31 PM
Is this anything? Send skeet.
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
El xist penòs del dia
December 6, 2024 at 1:33 PM
El xist penòs del dia
Happy to share the 2nd part of my PhD @natsmb.nature.com!
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 5:04 PM
Happy to share the 2nd part of my PhD @natsmb.nature.com!
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
És un xist, en @hquinto.eurosky.social segur que se'l sap!
September 28, 2026 at 7:35 AM
És un xist, en @hquinto.eurosky.social segur que se'l sap!
New paper: Remodeling of XIST regulatory landscape during primate evolution
We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells.
urlr.me/eyG38M
@manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social
We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells.
urlr.me/eyG38M
@manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social
January 19, 2026 at 8:42 AM
New paper: Remodeling of XIST regulatory landscape during primate evolution
We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells.
urlr.me/eyG38M
@manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social
We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells.
urlr.me/eyG38M
@manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social
Sometimes life drawing means just capturing a stressed foot. Model, Xist. #lifedrawing #graphitedrawing #drawing #art #figuredrawing
January 26, 2025 at 7:52 AM
Sometimes life drawing means just capturing a stressed foot. Model, Xist. #lifedrawing #graphitedrawing #drawing #art #figuredrawing
June 11, 2025 at 2:41 AM
🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today:
www.nature.com/articles/s41...
What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
www.nature.com/articles/s41...
What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation - Nature Communications
Regulation of X chromosome inactivation in mammals requires precise control of the levels of the non-coding RNA Xist. Almeida et al. describe an autoregulatory mechanism in which nascent Xist transcri...
www.nature.com
June 8, 2026 at 8:54 PM
🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today:
www.nature.com/articles/s41...
What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
www.nature.com/articles/s41...
What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
scopOphilic_micromessaging_1437 - scopOphilic1997-MicroMessaging series. (2025)
Presenting: Morgan Avenue Walls 06
#scopOphilic #micromessaging #streetart #brooklyn #nyc #photography #ArtistsOnBlueSky #MorganAvenue #AKS #XIST #AONES #MEKO #DAKS #TK5 #WIT #TerminallyChill #POLO #SDX #REUP #GFLS
Presenting: Morgan Avenue Walls 06
#scopOphilic #micromessaging #streetart #brooklyn #nyc #photography #ArtistsOnBlueSky #MorganAvenue #AKS #XIST #AONES #MEKO #DAKS #TK5 #WIT #TerminallyChill #POLO #SDX #REUP #GFLS
December 8, 2025 at 8:13 PM
scopOphilic_micromessaging_1437 - scopOphilic1997-MicroMessaging series. (2025)
Presenting: Morgan Avenue Walls 06
#scopOphilic #micromessaging #streetart #brooklyn #nyc #photography #ArtistsOnBlueSky #MorganAvenue #AKS #XIST #AONES #MEKO #DAKS #TK5 #WIT #TerminallyChill #POLO #SDX #REUP #GFLS
Presenting: Morgan Avenue Walls 06
#scopOphilic #micromessaging #streetart #brooklyn #nyc #photography #ArtistsOnBlueSky #MorganAvenue #AKS #XIST #AONES #MEKO #DAKS #TK5 #WIT #TerminallyChill #POLO #SDX #REUP #GFLS
What would you trade for a peanut-butter sandwich?
#kidlit #illustration #picturebooks #childrensbooks #kidlitart #illtrademypeanutbuttersandwich #xist #xistpublishing #read #drawing #cartoonillustration #digitalart
#kidlit #illustration #picturebooks #childrensbooks #kidlitart #illtrademypeanutbuttersandwich #xist #xistpublishing #read #drawing #cartoonillustration #digitalart
February 23, 2025 at 4:35 AM
What would you trade for a peanut-butter sandwich?
#kidlit #illustration #picturebooks #childrensbooks #kidlitart #illtrademypeanutbuttersandwich #xist #xistpublishing #read #drawing #cartoonillustration #digitalart
#kidlit #illustration #picturebooks #childrensbooks #kidlitart #illtrademypeanutbuttersandwich #xist #xistpublishing #read #drawing #cartoonillustration #digitalart
Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇
Remodeling of XIST regulatory landscape during primate evolution
How gene regulation strategies rapidly evolve across short evolutionary timescales is explored.
www.science.org
January 28, 2026 at 3:48 PM
Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇
Fa gràcia perquè és un xist xorra.
November 30, 2024 at 3:39 PM
Fa gràcia perquè és un xist xorra.
Vivim una època en què vas a un parc, crides “Max!” i vénen 8 nens i 3 gossos. #xist #humor #bonusdeltwitter
November 20, 2024 at 5:08 PM
Vivim una època en què vas a un parc, crides “Max!” i vénen 8 nens i 3 gossos. #xist #humor #bonusdeltwitter
Thrilled to share our new Brockdorff lab paper at NSMB: we show that the primary role of m6A RNA modification on Xist is to promote RNA degradation. Xist turnover is mediated by the NEXT complex, not PAXT, and is independent of the m6A reader YTHDC1. www.nature.com/articles/s41...
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics - Nature Structural & Molecular Biology
Wei et al. show that the primary function of m6A on the nuclear long noncoding RNA Xist, a master regulator of X inactivation, is to promote RNA degradation. Xist turnover is mediated by the nuclear e...
www.nature.com
September 9, 2025 at 10:49 AM
Thrilled to share our new Brockdorff lab paper at NSMB: we show that the primary role of m6A RNA modification on Xist is to promote RNA degradation. Xist turnover is mediated by the NEXT complex, not PAXT, and is independent of the m6A reader YTHDC1. www.nature.com/articles/s41...
El follonero encara no ha pillat el xist
November 5, 2025 at 8:42 AM
El follonero encara no ha pillat el xist
scopOphilic_micromessaging_1300 - scopOphilic1997 presents a new MicroMessaging series: small, subtle, & often unintentional messages we send & receive. (2011)
#scopOphilic #micromessaging #streetart #graffiti #brooklyn #nyc #photography #RASK #WOE #VE #ASP #XIST #ORO #FTR #RUSHLAE
#scopOphilic #micromessaging #streetart #graffiti #brooklyn #nyc #photography #RASK #WOE #VE #ASP #XIST #ORO #FTR #RUSHLAE
November 17, 2025 at 6:39 PM
scopOphilic_micromessaging_1300 - scopOphilic1997 presents a new MicroMessaging series: small, subtle, & often unintentional messages we send & receive. (2011)
#scopOphilic #micromessaging #streetart #graffiti #brooklyn #nyc #photography #RASK #WOE #VE #ASP #XIST #ORO #FTR #RUSHLAE
#scopOphilic #micromessaging #streetart #graffiti #brooklyn #nyc #photography #RASK #WOE #VE #ASP #XIST #ORO #FTR #RUSHLAE
Double celebration on our floor @oxfordbiochemistry.bsky.social with @guifengwei.bsky.social from the Brockdorff lab and Dounia and Sherry from Fisher lab having their papers published today! And I hear there is more to come...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics - Nature Structural & Molecular Biology
Wei et al. show that the primary function of m6A on the nuclear long noncoding RNA Xist, a master regulator of X inactivation, is to promote RNA degradation. Xist turnover is mediated by the nuclear e...
www.nature.com
September 9, 2025 at 12:22 PM
Double celebration on our floor @oxfordbiochemistry.bsky.social with @guifengwei.bsky.social from the Brockdorff lab and Dounia and Sherry from Fisher lab having their papers published today! And I hear there is more to come...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Catxis!
(Que estic amb tu, eh? Només volia fer el xist)
(Que estic amb tu, eh? Només volia fer el xist)
September 29, 2026 at 12:18 PM
Catxis!
(Que estic amb tu, eh? Només volia fer el xist)
(Que estic amb tu, eh? Només volia fer el xist)