Fontes et al. report a case study of a person with recurrent glioblastoma for whom patient-derived zebrafish xenografts (zAvatars) were used to test 13 off-label therapies with radiotherapy. zAvatars identified pemetrexed and doxorubicin as effective, guiding treatment that stabilized the patient.

Using SLAC’s X-ray laser, the method revealed atomic motions in a simple catalyst, opening the door to study more complex molecules key to chemical processes in industry and nature.