Read the full paper: Synthesis of Zwitterionic Tris(pyrazolyl) Ligands and Their Mn(II) Bis-Chelates Exhibiting Charge–Transfer-Induced Spin Crossover

Extended Data Fig. 1 Screening and optimization of zwitterionic polymer structure. a, Chemical structure of OP(DEA)Cy5. b, Flow cytometry analysis of the internalization of OP(DEA)Cy5 with different monomer number in MDA-MB-231 cells with or without wortmannin for 2 h (n = 3 biologically independent samples). c, Western blot analysis of PD-L1 degradation in MDA-MB-231 cells treated with McR-TACsPD-L1 (monomer number, n = 25) under indicated concentrations. d, Dose-response of PD-L1 degradation by McR-TACsPD-L1 (monomer number, n = 25) with indicated concentrations in MDA-MB-231 cells for 24 h (n = 3 biologically independent samples). e, Chemical structure of OP(DEA)APC (molar ratio of polymer to antibody = 3:1). f, Flow cytometry analysis of the internalization of OP(DEA)APC with different monomer number in MDA-MB-231 cells with or without wortmannin for 2 h (n = 3 biologically independent samples). g, Dose-response of PD-L1 degradation by AbnR-TACsPD-L1 (monomer number, n = 40) with indicated concentrations in MDA-MB-231 cells for 24 h (n = 3 biologically independent samples). h, Dose-response of PD-L1 degradation by AbnR-TACsPD-L1 (monomer number, n = 60) with indicated concentrations in MDA-MB-231 cells for 24 h (n = 3 biologically independent samples). i, Dose-response of PD-L1 degradation by AbnR-TACsPD-L1 (molar ratio of antibody...

AbstractEngineering the electrode–electrolyte interface has emerged as a critical strategy to overcome sluggish kinetics of alkaline hydrogen evolution reaction (HER). However, the dynamic and complex nature of the double electric layer makes mechanistic understanding at the molecular level and rational interfacial regulation highly challenging. Herein, we demonstrate that molecular modification of Ni-doped MoS2 catalyst with a zwitterionic molecule (z-Ni-MoS2) markedly enhances alkaline HER kinetics. In-situ Raman spectroscopy combined with ab initio molecular dynamics (AIMD) simulations reveals that the quaternary ammonium cation reconstructs interfacial water into linear hydrogen-bond chains via electrostatic repulsion of potassium ions from the z-Ni-MoS2 surface. This distinctive interfacial microenvironment enables water molecules within hydrogen-bond chains to directly relay protons to sulfur sites via a Grotthuss-associated mechanism. In contrast to the conventional diffusion-dominated, non-Grotthuss-associated mechanism, this mechanism lowers the water-dissociation barrier and promotes interfacial proton transport, thereby accelerating alkaline HER kinetics. To evaluate device-level applicability, z-Ni-MoS2 was incorporated into an anion exchange membrane water electrolyzer (AEM-WE). The system delivers outstanding performance of 5.21 A cm–2 at 1.8 V and 9.57 A cm–2 at 2 V, 80 °C, surpassing the United States Department of Energy (DOE) 2026 target (3 A cm–2 at 1.8 V). This work provides molecular-level insight for interfacial water restructuring as a design principle for high-performance alkaline HER catalysts.

Solution blending of zwitterionic polymers with PEDOT:PSS provides a simple route to OECT materials with enhanced threshold voltage stability in biologically relevant environments. The polymer sequen...

Researchers at Ludwig-Maximilians-Universität München, the University of Augsburg and the University of Innsbruck, have developed a rapid, room-temperature synthesis route for strongly confined CsPbBr 3 perovskite quantum dots (QDs), using a zwitterionic ligand to achieve high photoluminescence quantum yields and long-term stability in air. (a) Schematic representation of the PeLED device architecture. (b) Photograph of the PeLED under operation. Image credit: Advanced Functional Materials Cesium lead halide perovskite nanocrystals are attractive for LED applications thanks to their high photoluminescence quantum yields, narrow emission linewidths and compositional tunability. Pushing these nanocrystals into the strongly quantum-confined regime shifts their emission from green into the cyan and blue range, which is useful for display and lighting applications, but synthesizing such small, uniform crystals under simple ambient conditions has remained difficult. Existing approaches to strongly confined CsPbBr 3 QDs typically require inert atmospheres, multistep procedures or other complex conditions that limit rapid, reproducible production. The team's method uses 2-ammonioethyl 2-octyl-1-dodecyl phosphate (OD-PEA), a zwitterionic ligand with strong binding affinity to the QD surface, added to a PbBr 2 precursor solution alongside oleylamine and oleic acid.

N-heterocyclic carbenes (NHCs) function as “molecular scissors,” cleaving otherwise inert Sb═Sb bonds in distibenes to generate monomeric, zwitterionic stibinide species. These intermediates act as e...