Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
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aesposito1975.bsky.social
Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
@aesposito1975.bsky.social
#Physicist and cancer #biologist studying how molecular networks encode cell decisions and how mutations hijack cells, leading to #cancer.
Centre for Genome Engineering and Maintenance
Brunel University of London
Pinned
How many photons do you need to measure a fluorescence lifetime?
We are proud to release HILIGTHer, a #FLIM #DigitalTwin designed to simulate most features of time-domain FLIM systems, just announced at #FOM2026 and incredibly well-received.
Beta release now available: github.com/HiLIGHT-HORI...
They are here! :) #ChatGPT #sol #terra #luna
July 10, 2026 at 8:09 AM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
I am pleased to share a link to the latest paper from the Cook lab. www.biorxiv.org/content/10.6...
The DYRK protein kinases, near neighbours to the MAPKs in the CMGC arm of the human kinome, control critical cell fate decisions and are deregulated in disease, much like the MAPKs and CDKs.
www.biorxiv.org
May 1, 2026 at 11:35 AM
Confused about Fisher Information and optimisation of Fluorescence Microscopy, #FLIM specifically? I have just completed a tutorial for you

hilight-horizon.github.io/HILIGTHer_FL...

@hilighthorizon.bsky.social
April 7, 2026 at 10:31 AM
How many photons do you need to measure a fluorescence lifetime?
We are proud to release HILIGTHer, a #FLIM #DigitalTwin designed to simulate most features of time-domain FLIM systems, just announced at #FOM2026 and incredibly well-received.
Beta release now available: github.com/HiLIGHT-HORI...
April 2, 2026 at 5:43 PM
What is Focus on Microscopy for me? A scientific family, friends and amazing innovation. We often see, even 10 years in advance, the techniques that will eventually disrupt biology, biomedical research, and healthcare. Industry and academia, together.

#FOM2026 #Microscopy #HILIGHT
April 2, 2026 at 4:51 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
We’re open! Today’s your chance to get hands on with world-leading science 🔬

🧪⚙️🌱🔋

#CamFest
March 21, 2026 at 10:16 AM
After four months of happy usage of Google Antigravity with Gemini, sadly, #Gemini became unusable. It was an opportunity to explore #CODEX after a while and discover how CODEX (GPT5.4) is extraordinarily good and fast.

Preparing two major releases of software for #FLIM :)
March 20, 2026 at 5:47 PM
A scientist's view on #war

youtu.be/XI9NG068TwI?...
A Scientist's View of War
YouTube video by StarTalk
youtu.be
March 14, 2026 at 7:18 AM
I am honoured to be appointed as new Director for @cengem.bsky.social. With massive thanks for Prof Jo Bridger with whom I worked as deputy over the past few years, CHMLS senior leadership for entrusting me with CenGEM and my amazing colleagues for their support.
🚀 Big news! Meet the new leadership team at #CenGEM!🧬🔬

We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance.

#GenomeMaintenance #BrunelUniversity #BioScience
cengem.org
January 10, 2026 at 2:48 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
We are excited to announce HILIGHT 2026: FLIM & Photonics, a free two day technical meeting at Brunel University London on 4th–5th March 2026.

The programme will include talks from leading experts, posters, flash talks, and dedicated industry exhibition.

Register here: shorturl.at/AwEOv
December 1, 2025 at 4:55 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
This December we’re revealing speakers for HILIGHT 2026: FLIM & Photonics
Day 1: Prof Ruslan Dmitriev on using FLIM to track nanoplastics in organoids.

Free Event: lnkd.in/eGUXXzNe

LinkedIn Event page: lnkd.in/eBTRJRhq

HILIGHT website Event page : lnkd.in/ewRw4G4j
December 10, 2025 at 12:10 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
Here’s the next speaker in our HILIGHT 2026: FLIM & Photonics

Day 3: Dr Conor Treacy @c-trass.bsky.social on multiphoton FLIM and DNA signatures in Pancreatic Cancer Spheroids .

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 15, 2025 at 10:02 AM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.

Day 8: Dr Sylvain Boust, from III-V Lab, on versatile laser diode for 2ph FLIM at 8 Mpx/s in HILIGHT project.

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 19, 2025 at 6:47 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.

Day 9: Prof Gail Mcconnell @gailmcconnell.bsky.social on Multiphoton mesoscale imaging with the Mesolens.

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 20, 2025 at 1:15 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.

Day 4: Professor Edoardo Charbon on Picosecond Image Sensors: From FLIM to Quantum Imaging.

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 17, 2025 at 10:40 AM
exciting developments for fast FLIM... I have great expectations for 2026 :)
🚀Two steps forward. One clear direction for the #HILIGHTProject.

⚡Sub-nanosecond gating (<1 ns) now fully characterised at #FBK, and the HILIGHT detector has been coupled to a microscope for first photon-count images of Convallaria majalis 🌿.

📸 FLIM images coming next.

hilighthorizon.eu/blog/
December 19, 2025 at 4:47 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.

Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM.

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 18, 2025 at 4:12 PM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.

Day 7: Dr Gunnar Blume on short-pulse semiconductor lasers for fluorescence lifetime imaging and spectroscopy at FBH.

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 19, 2025 at 11:14 AM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.

Day 6: Dr Sara Pellegrini on Pixels for FLIM: SPADs in monolithic and 3D stacked technology.

Free Event: lnkd.in/eGUXXzNe

LinkedIn: lnkd.in/eBTRJRhq

HILIGHT: lnkd.in/ewRw4G4j
December 19, 2025 at 11:17 AM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
🎄 FLIM Advent Calendar 🎄
Here’s the next speaker in our HILIGHT 2026: FLIM & Photonics

Day 2: Prof Marina Kuimova on measuring cellular viscosity with molecular rotors and FLIM.

Free Event: lnkd.in/eGUXXzNe

LinkedIn Event page: lnkd.in/eBTRJRhq

HILIGHT website Event page : lnkd.in/ewRw4G4j
December 10, 2025 at 6:07 PM
If you want to know why all biological models are wrong, you will be interested in our latest virtual debate.

open.spotify.com/episode/6Usp...

#biology #model #science
December 1, 2025 at 7:50 AM
Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph
rudolphlab.com/blog/on-narr...
Rudolph BLOG
Pages of the Rudolph laboratory at Brunel University London.
rudolphlab.com
November 28, 2025 at 2:21 PM
The audio overview of our latest paper is now available on Spotify: open.spotify.com/episode/6ej9...

#KRAS #metabolism
EMBO Reports - FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
open.spotify.com
November 28, 2025 at 12:03 PM
I use #NotebookLM quite a bit for work. Useful for converting your content (in this case, our latest paper) into different formats. Here a #mindmap of "FOXO1 links #KRAS G12D and G12V alleles to glutamine and nitrogen #metabolism in #colorectalcancer" doi.org/10.1038/s443...
November 26, 2025 at 8:02 PM