Peter Carlton
@carltonlab.org
From Seattle USA, now in Hieidaira, Japan. Researching meiosis @ Kyoto University. he/him. シアトル生まれ、比叡平（滋賀県大津市）に住む。京都大学・生命科学研究科の准教授。研究テーマは線虫の減数分裂
Orcid: 0000-0002-5320-6024
HP: https://www.carltonlab.org
Orcid: 0000-0002-5320-6024
HP: https://www.carltonlab.org
Reposted by Peter Carlton
Want to enhance your image analysis skills with napari?
We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data.
🕒 Applications close on 15 September.
Learn more and apply 👇
www.crick.ac.uk/whats-on/cbi...
We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data.
🕒 Applications close on 15 September.
Learn more and apply 👇
www.crick.ac.uk/whats-on/cbi...
www.crick.ac.uk
September 28, 2026 at 11:12 AM
Want to enhance your image analysis skills with napari?
We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data.
🕒 Applications close on 15 September.
Learn more and apply 👇
www.crick.ac.uk/whats-on/cbi...
We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data.
🕒 Applications close on 15 September.
Learn more and apply 👇
www.crick.ac.uk/whats-on/cbi...
Not real data here in this example but I am really enjoying interactive #terminal plotting… 2 tmux panes with ssh replicating ~90% of what I usually do with jupyter.
September 28, 2026 at 6:37 AM
Not real data here in this example but I am really enjoying interactive #terminal plotting… 2 tmux panes with ssh replicating ~90% of what I usually do with jupyter.
Reposted by Peter Carlton
Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers)
www.the-scientist.com/allegations-...
www.the-scientist.com/allegations-...
Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist
Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.
www.the-scientist.com
September 25, 2026 at 5:36 PM
Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers)
www.the-scientist.com/allegations-...
www.the-scientist.com/allegations-...
Here is an amazing 1960's video from a company that once cared deeply about quality, starting with making their own glass
www.youtube.com/watch?v=qwej...
www.youtube.com/watch?v=qwej...
科学の眼－ニコン－
YouTube video by NPO法人科学映像館
www.youtube.com
September 25, 2026 at 4:06 PM
Here is an amazing 1960's video from a company that once cared deeply about quality, starting with making their own glass
www.youtube.com/watch?v=qwej...
www.youtube.com/watch?v=qwej...
Reposted by Peter Carlton
The response from Nikon makes me wonder whether tools marketed by Nikon were used: www.microscope.healthcare.nikon.com/en_EU/produc...
NIS-Elements | NIS.ai
The optional NIS.ai module allows users to utilize pretrained AI networks for image processing, as well as create, annotate, and train custom AI networks for segmentation and analysis. Advanced image ...
www.microscope.healthcare.nikon.com
September 22, 2026 at 9:09 PM
The response from Nikon makes me wonder whether tools marketed by Nikon were used: www.microscope.healthcare.nikon.com/en_EU/produc...
Reposted by Peter Carlton
From the new info my bet is fluo labeling inference pushed to 11. Hallucinating nonsensical DAPI nuclei, mitochondria stain, membrane labeling from a kind of phase contrast image: wrong localization, wrong scale, wrong movement. Keeping this movie as SWiM winner is a disgrace to the competition
The might have also added a scale bar (not sure if that was there before?). This would make the blue structures very small.
September 22, 2026 at 8:48 PM
From the new info my bet is fluo labeling inference pushed to 11. Hallucinating nonsensical DAPI nuclei, mitochondria stain, membrane labeling from a kind of phase contrast image: wrong localization, wrong scale, wrong movement. Keeping this movie as SWiM winner is a disgrace to the competition
Reposted by Peter Carlton
Human cilia disease specialist on the Small World in Motion winning movie
You guys really need to do something about this...My advice would be to retract 1st prize and give it to the runner up...othewise it sends a cruel message that PCD patients cilia look like this....which they do not. It is a biologically impossible movie....
September 19, 2026 at 11:19 PM
Human cilia disease specialist on the Small World in Motion winning movie
Reposted by Peter Carlton
Out today in Nature: sex without crossovers.
Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones.
doi.org/10.1038/s415...
Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones.
doi.org/10.1038/s415...
September 16, 2026 at 4:19 PM
Out today in Nature: sex without crossovers.
Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones.
doi.org/10.1038/s415...
Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones.
doi.org/10.1038/s415...
Reposted by Peter Carlton
Happy to share that this paper is now published in Nature Genetics!
Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out!
www.nature.com/articles/s41...
Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out!
www.nature.com/articles/s41...
September 8, 2026 at 10:13 AM
Happy to share that this paper is now published in Nature Genetics!
Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out!
www.nature.com/articles/s41...
Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out!
www.nature.com/articles/s41...
Reposted by Peter Carlton
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗
www.nature.com/articles/s41... (1/2)
www.nature.com/articles/s41... (1/2)
September 8, 2026 at 10:22 AM
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗
www.nature.com/articles/s41... (1/2)
www.nature.com/articles/s41... (1/2)
Reposted by Peter Carlton
Our paper on euchromatin and cohesin is now published!!🙌
Euchromatin forms condensed domains, and cohesin constrains their local mixing.
This organization maintains transcriptional insulation.
This work was truly a team effort, and I’m grateful to everyone who contributed to it.
Euchromatin forms condensed domains, and cohesin constrains their local mixing.
This organization maintains transcriptional insulation.
This work was truly a team effort, and I’m grateful to everyone who contributed to it.
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗
www.nature.com/articles/s41... (1/2)
www.nature.com/articles/s41... (1/2)
September 9, 2026 at 8:07 AM
Our paper on euchromatin and cohesin is now published!!🙌
Euchromatin forms condensed domains, and cohesin constrains their local mixing.
This organization maintains transcriptional insulation.
This work was truly a team effort, and I’m grateful to everyone who contributed to it.
Euchromatin forms condensed domains, and cohesin constrains their local mixing.
This organization maintains transcriptional insulation.
This work was truly a team effort, and I’m grateful to everyone who contributed to it.
Back from an unforgettable trip to Indonesia!
First, a weekend of discussing study opportunities with highly motivated students.
Then, a few days waiting for a volcano to let us fly home.
Glad to have spent 5 days in Jakarta, but have really just scratched the surface of an amazing city and country.
First, a weekend of discussing study opportunities with highly motivated students.
Then, a few days waiting for a volcano to let us fly home.
Glad to have spent 5 days in Jakarta, but have really just scratched the surface of an amazing city and country.
September 9, 2026 at 1:12 PM
Back from an unforgettable trip to Indonesia!
First, a weekend of discussing study opportunities with highly motivated students.
Then, a few days waiting for a volcano to let us fly home.
Glad to have spent 5 days in Jakarta, but have really just scratched the surface of an amazing city and country.
First, a weekend of discussing study opportunities with highly motivated students.
Then, a few days waiting for a volcano to let us fly home.
Glad to have spent 5 days in Jakarta, but have really just scratched the surface of an amazing city and country.
Anak Krakatau has calmed down enough to let us slip out of Jakarta tonight; hopefully it will stay that way for a long time.
September 8, 2026 at 7:41 AM
Anak Krakatau has calmed down enough to let us slip out of Jakarta tonight; hopefully it will stay that way for a long time.
Reposted by Peter Carlton
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
September 3, 2026 at 8:09 PM
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
modern terminals are amazing, it hasn't been this good since Tektronix emulation in xterm.
September 3, 2026 at 1:18 AM
modern terminals are amazing, it hasn't been this good since Tektronix emulation in xterm.
I spent 16 years in the SF Bay Area, and have lived 16 more in Kansai, Japan where I'll most likely stay for the rest of my life, but this picture depicts one uniquely representative frame from my permanently imprinted birthplace (Seattle/Salish Sea)
💦🌧️💦 Sat, Aug 29
Entirely lovely to awaken to the sound of lively pouring rain & report of a big guy orca in Central Puget Sound (looks like Jack). Wonder if T36s stayed too.
📷 Sweetly lined up photo w/WS ferry & a human fishing as the T36/36Bs went by the Edmonds pier. By Jason Luc 8/28.
#psws
Entirely lovely to awaken to the sound of lively pouring rain & report of a big guy orca in Central Puget Sound (looks like Jack). Wonder if T36s stayed too.
📷 Sweetly lined up photo w/WS ferry & a human fishing as the T36/36Bs went by the Edmonds pier. By Jason Luc 8/28.
#psws
August 29, 2026 at 3:36 PM
I spent 16 years in the SF Bay Area, and have lived 16 more in Kansai, Japan where I'll most likely stay for the rest of my life, but this picture depicts one uniquely representative frame from my permanently imprinted birthplace (Seattle/Salish Sea)
🇦🇺↔🇯🇵 for undergrad/masters students studying in Australia and interested in short-term research opportunities this summer (Jan 7 – Feb 18 2027) - please check out Kyoto University's KU-STAR program: www.kugd.k.kyoto-u.ac.jp/en/ku-star-p... !
Application deadline is Sep. 25, happy to take questions.
Application deadline is Sep. 25, happy to take questions.
KU-STAR Program AUS
What’s the KU-STAR Program? KU-STAR Program, Kyoto University Short-Term Academic Research Pro
www.kugd.k.kyoto-u.ac.jp
August 28, 2026 at 5:36 AM
🇦🇺↔🇯🇵 for undergrad/masters students studying in Australia and interested in short-term research opportunities this summer (Jan 7 – Feb 18 2027) - please check out Kyoto University's KU-STAR program: www.kugd.k.kyoto-u.ac.jp/en/ku-star-p... !
Application deadline is Sep. 25, happy to take questions.
Application deadline is Sep. 25, happy to take questions.
My brain entertaining me this morning
August 26, 2026 at 5:04 AM
My brain entertaining me this morning
Reposted by Peter Carlton
Is Claude, let alone his pal Jimmy "Trust me bro" the Feckless, out there deciphering hundreds of pages of unconventionally-spelled scrawl and vanished words across a dozen text variants that require chemistry experiments to fully settle?
August 13, 2026 at 11:07 AM
Is Claude, let alone his pal Jimmy "Trust me bro" the Feckless, out there deciphering hundreds of pages of unconventionally-spelled scrawl and vanished words across a dozen text variants that require chemistry experiments to fully settle?
Reposted by Peter Carlton
The Sasaki lab at the National Institute of Genetics in Japan are seeking for highly motivated PhD students to work on extrachromosomal circular DNA, gene amplification, genome stability, and cancer genome dynamics, starting in October 2027. Please see below and apply by August 31.
August 6, 2026 at 7:42 PM
The Sasaki lab at the National Institute of Genetics in Japan are seeking for highly motivated PhD students to work on extrachromosomal circular DNA, gene amplification, genome stability, and cancer genome dynamics, starting in October 2027. Please see below and apply by August 31.
Reposted by Peter Carlton
Really nice article laying out the semantics of sex/sexes that causes persistent confusion and arguing in our community. It lays out the undisputed patterns in biology and makes clear any "lack of consensus" on sex/sexes is arguing across different levels. academic.oup.com/icb/article/...
Evolution, Development, and the Incoherence of Sex: A Framework for Multiple Sex Concepts
Synopsis. The word sex can refer to at least seven distinct, evolutionarily related biological phenomena (0–6 below). Bacteria and archaea use mechanisms f
academic.oup.com
August 11, 2026 at 3:47 PM
Really nice article laying out the semantics of sex/sexes that causes persistent confusion and arguing in our community. It lays out the undisputed patterns in biology and makes clear any "lack of consensus" on sex/sexes is arguing across different levels. academic.oup.com/icb/article/...
Our latest publication is on bioRχiv! — a study of the meiotic double-strand break machinery, focused on C. elegans but using the extensive genomic resources available for the whole genus to learn more about how SPO-11 and its cofactors work together to break DNA
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks
DNA double-strand breaks (DSBs) generated during meiotic prophase by the topoisomerase-like protein SPO11 are essential to create crossovers between homologous chromosomes. Since crossovers are requir...
www.biorxiv.org
August 3, 2026 at 12:52 PM
Our latest publication is on bioRχiv! — a study of the meiotic double-strand break machinery, focused on C. elegans but using the extensive genomic resources available for the whole genus to learn more about how SPO-11 and its cofactors work together to break DNA
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Peter Carlton
ZHP-2/HEI10 generates CO precursors and triggers procrossover factor coarsening and CO formation through Polo kinase recruitment https://www.biorxiv.org/content/10.64898/2026.07.26.740636v1
July 27, 2026 at 9:31 PM
ZHP-2/HEI10 generates CO precursors and triggers procrossover factor coarsening and CO formation through Polo kinase recruitment https://www.biorxiv.org/content/10.64898/2026.07.26.740636v1
Since it's entered the zeitgeist again, I will take a moment to thank Carolyn Dewald who taught me the Odýsseia at USC and inspired me to memorize its first stanzas in Greek, which I still remember. That class continued into the modern age and pretty much established my tastes as a reader.
July 27, 2026 at 4:47 PM
Since it's entered the zeitgeist again, I will take a moment to thank Carolyn Dewald who taught me the Odýsseia at USC and inspired me to memorize its first stanzas in Greek, which I still remember. That class continued into the modern age and pretty much established my tastes as a reader.
July 22, 2026 at 2:07 PM