Anton Goloborodko
@golobor.bsky.social
A bio-physicist turned phys-biologist,
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
Pinned
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
Reposted by Anton Goloborodko
What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6...
September 18, 2026 at 6:01 AM
What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6...
With all the chatter on unintended AI misalignment, I worry much more about intended misalignment, namely, in military and law enforcement. 1/
September 18, 2026 at 6:31 AM
With all the chatter on unintended AI misalignment, I worry much more about intended misalignment, namely, in military and law enforcement. 1/
Reposted by Anton Goloborodko
exactly, “gen AI” just means “bad AI” in order to avoid the charge of being against *all* AI. I am also against bad AI. by defintion, everyone is against bad AI!
Or to put it another way, "Generative AI = bad, ML = good" is just incoherent, but what folks mean by it is that the good categories of AI are mechanical replacement, and the bad categories of AI are labor replacement, but with the caveat that it usually misses that a lot of labor is also mechanical
August 2, 2026 at 12:33 PM
exactly, “gen AI” just means “bad AI” in order to avoid the charge of being against *all* AI. I am also against bad AI. by defintion, everyone is against bad AI!
Reposted by Anton Goloborodko
how about some good news: new cat just dropped!!!!
September 17, 2026 at 5:28 PM
how about some good news: new cat just dropped!!!!
Reposted by Anton Goloborodko
Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cohesin reshapes replication fork contacts to aid fork slowing and reversal - Nature
Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...
www.nature.com
September 16, 2026 at 4:04 PM
Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anton Goloborodko
Introducing highly experimental localfold.org
Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann.
WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann.
WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
September 17, 2026 at 3:12 AM
Introducing highly experimental localfold.org
Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann.
WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann.
WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
Reposted by Anton Goloborodko
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
September 15, 2026 at 1:53 PM
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
Reposted by Anton Goloborodko
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2026!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
September 15, 2026 at 10:39 AM
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2026!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
Reposted by Anton Goloborodko
Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)
A practical guide to studying genome function using single-molecule genomics
Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...
www.nature.com
September 14, 2026 at 12:33 PM
Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)
Reposted by Anton Goloborodko
My lab at the Center for Gene Expression (CGEN), University of Copenhagen is looking for a motivated Postdoc interested in cohesin biology, 3D chromatin, and super-resolution microscopy.
📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk.
📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk.
September 10, 2026 at 12:16 PM
My lab at the Center for Gene Expression (CGEN), University of Copenhagen is looking for a motivated Postdoc interested in cohesin biology, 3D chromatin, and super-resolution microscopy.
📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk.
📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk.
New preprint from our group (led solely by our student Vladimir Dmitriev):
a valency-bounding correction (VBC) for coarse-grained MD. It lets you cap how many neighbours a particle can bind, without introducing explicit patches or fixed bond directions. arxiv.org/abs/2609.07842 1/
a valency-bounding correction (VBC) for coarse-grained MD. It lets you cap how many neighbours a particle can bind, without introducing explicit patches or fixed bond directions. arxiv.org/abs/2609.07842 1/
Valency-bounding correction potential for coarse-grained molecular dynamics simulations
Many systems in soft and living matter bind through a limited number of bonds per particle: proteins associate via discrete surface patches, nucleic acids form one-to-one contacts, and the phase behav...
arxiv.org
September 10, 2026 at 11:44 AM
New preprint from our group (led solely by our student Vladimir Dmitriev):
a valency-bounding correction (VBC) for coarse-grained MD. It lets you cap how many neighbours a particle can bind, without introducing explicit patches or fixed bond directions. arxiv.org/abs/2609.07842 1/
a valency-bounding correction (VBC) for coarse-grained MD. It lets you cap how many neighbours a particle can bind, without introducing explicit patches or fixed bond directions. arxiv.org/abs/2609.07842 1/
Reposted by Anton Goloborodko
Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair.
A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌
doi.org/10.64898/202...
A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌
doi.org/10.64898/202...
September 9, 2026 at 5:08 AM
Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair.
A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌
doi.org/10.64898/202...
A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌
doi.org/10.64898/202...
Reposted by Anton Goloborodko
Five PhD programs. One extraordinary city. World's most livable.
CeMM, ISTA, VBC, VDS-mes, Aithyra — molecular medicine to AI to microbial ecology.
Vienna has a PhD for every curiosity.
Symposium Sept 10 → doctoralinsights.at
#DocInsights
CeMM, ISTA, VBC, VDS-mes, Aithyra — molecular medicine to AI to microbial ecology.
Vienna has a PhD for every curiosity.
Symposium Sept 10 → doctoralinsights.at
#DocInsights
September 5, 2026 at 9:40 AM
Five PhD programs. One extraordinary city. World's most livable.
CeMM, ISTA, VBC, VDS-mes, Aithyra — molecular medicine to AI to microbial ecology.
Vienna has a PhD for every curiosity.
Symposium Sept 10 → doctoralinsights.at
#DocInsights
CeMM, ISTA, VBC, VDS-mes, Aithyra — molecular medicine to AI to microbial ecology.
Vienna has a PhD for every curiosity.
Symposium Sept 10 → doctoralinsights.at
#DocInsights
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
September 3, 2026 at 8:09 PM
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
Reposted by Anton Goloborodko
We often picture replicated chromosomes as perfectly symmetrical Xs. But scientists in the Goloborodko and Gerlich labs at IMBA have discovered that their two copies are consistently offset. The finding could reshape how we understand DNA repair and genome stability: https://bit.ly/4iLa7Yv
September 3, 2026 at 6:45 PM
We often picture replicated chromosomes as perfectly symmetrical Xs. But scientists in the Goloborodko and Gerlich labs at IMBA have discovered that their two copies are consistently offset. The finding could reshape how we understand DNA repair and genome stability: https://bit.ly/4iLa7Yv
Reposted by Anton Goloborodko
If you're looking for a PhD position, or know someone looking checkout our interdisciplinary PhD Fellowship program!
We are always looking for talented students with a physics or computational background to join our group to work on the physics of living systems!
We are always looking for talented students with a physics or computational background to join our group to work on the physics of living systems!
Ready for the next step in your scientific career?
Apply now for a fully funded Biozentrum PhD Fellowship and explore a wide range of research fields before choosing your PhD lab. 🧪 Applications for the current call are open until October 18, 2026. More information 👇
Apply now for a fully funded Biozentrum PhD Fellowship and explore a wide range of research fields before choosing your PhD lab. 🧪 Applications for the current call are open until October 18, 2026. More information 👇
Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
www.biozentrum.unibas.ch
August 10, 2026 at 10:50 AM
If you're looking for a PhD position, or know someone looking checkout our interdisciplinary PhD Fellowship program!
We are always looking for talented students with a physics or computational background to join our group to work on the physics of living systems!
We are always looking for talented students with a physics or computational background to join our group to work on the physics of living systems!
Reposted by Anton Goloborodko
We are hiring a new phd student.
The Vienna BioCenter PhD program in Molecular BioSciences will offer 25+ fully-funded positions in the Autumn Call which is now open. Check the vacancies in this call: www.vbcphd.at
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
September 1, 2026 at 5:20 PM
We are hiring a new phd student.
Reposted by Anton Goloborodko
Last call: registration for the 9th Austrian Cryo-EM (ACE) Symposium closes tomorrow, 1 September.
24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session.
events.vbc.ac.at/imp_events/c...
#cryoEM #cryoET
24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session.
events.vbc.ac.at/imp_events/c...
#cryoEM #cryoET
Cryo-EM Symposium 2026
Register here for the Cryo-EM Symposium 2026, 24-25 September at the IMP, Campus-Vienna-Biocenter 1, 1030 Vienna.Please select the applicable registration fee and add it to the cart. Please click on t...
events.vbc.ac.at
August 31, 2026 at 11:01 AM
Last call: registration for the 9th Austrian Cryo-EM (ACE) Symposium closes tomorrow, 1 September.
24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session.
events.vbc.ac.at/imp_events/c...
#cryoEM #cryoET
24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session.
events.vbc.ac.at/imp_events/c...
#cryoEM #cryoET
Reposted by Anton Goloborodko
We watched piRNAs and transposons across development, saw them dance tightly and wrote a paper about it.
It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
A developmental switch in the piRNA pathway ensures stage-specific transposon silencing https://www.biorxiv.org/content/10.64898/2026.08.28.747770v1
August 29, 2026 at 5:09 PM
We watched piRNAs and transposons across development, saw them dance tightly and wrote a paper about it.
It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)
Reposted by Anton Goloborodko
How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!
Formation of an RNA-mediated nuclear compartment https://www.biorxiv.org/content/10.64898/2026.08.20.746005v1
August 24, 2026 at 3:41 PM
How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!
Reposted by Anton Goloborodko
Really fascinating talk today at #EMBLTranscript from Bienko lab! THE INTROSOMES!
Today’s session recurring question: do regulatory functions emerge from the act of transcription, or from the RNA product itself?
www.biorxiv.org/content/10.1...
Today’s session recurring question: do regulatory functions emerge from the act of transcription, or from the RNA product itself?
www.biorxiv.org/content/10.1...
Chromatin-associated intronic RNAs from long genes form introsomes that shape nuclear architecture in neuronal cells
Cell differentiation towards neurons is accompanied by widespread changes in three-dimensional (3D) genome organization and gene expression. Chromatin-associated RNAs have been proposed to be importan...
www.biorxiv.org
August 27, 2026 at 1:31 PM
Really fascinating talk today at #EMBLTranscript from Bienko lab! THE INTROSOMES!
Today’s session recurring question: do regulatory functions emerge from the act of transcription, or from the RNA product itself?
www.biorxiv.org/content/10.1...
Today’s session recurring question: do regulatory functions emerge from the act of transcription, or from the RNA product itself?
www.biorxiv.org/content/10.1...
Reposted by Anton Goloborodko
Excited to share our paper in @natgenet.nature.com on the de novo design of tissue-specific mammalian enhancers that function in vivo in mouse embryos. 🧬🐭
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 25, 2026 at 9:18 AM
Excited to share our paper in @natgenet.nature.com on the de novo design of tissue-specific mammalian enhancers that function in vivo in mouse embryos. 🧬🐭
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anton Goloborodko
Did I miss the open letters supporting academic freedom when professors were being fired for being insufficiently worshipful about Charlie Kirk?
August 24, 2026 at 10:22 PM
Did I miss the open letters supporting academic freedom when professors were being fired for being insufficiently worshipful about Charlie Kirk?
Reposted by Anton Goloborodko
Deadly tick-borne virus gains ground in Europe as climate warms | Science | AAAS
Hyalomma marginatum ticks, the main vector for Crimean-Congo hemorrhagic fever, have been spotted in 40 European countries.
www.science.org/content/arti...
#MicroSky
Hyalomma marginatum ticks, the main vector for Crimean-Congo hemorrhagic fever, have been spotted in 40 European countries.
www.science.org/content/arti...
#MicroSky
Deadly tick-borne virus gains ground in Europe as climate warms
Kosovo shows how surveillance can uncover hidden circulation—and help countries prepare before human cases appear
www.science.org
August 24, 2026 at 5:19 PM
Deadly tick-borne virus gains ground in Europe as climate warms | Science | AAAS
Hyalomma marginatum ticks, the main vector for Crimean-Congo hemorrhagic fever, have been spotted in 40 European countries.
www.science.org/content/arti...
#MicroSky
Hyalomma marginatum ticks, the main vector for Crimean-Congo hemorrhagic fever, have been spotted in 40 European countries.
www.science.org/content/arti...
#MicroSky
Reposted by Anton Goloborodko
The newly established Department of Systems Biology (systems.bio.uci.edu) @UCIrvine is hiring a tenure-track Assistant Professor in Systems Biology. Great science, incredible faculty support, and beautiful, sunny SoCal weather! ☀️🌴 Details: recruit.ap.uci.edu/JPF10377. Please share.
recruit.ap.uci.edu
August 24, 2026 at 4:41 PM
The newly established Department of Systems Biology (systems.bio.uci.edu) @UCIrvine is hiring a tenure-track Assistant Professor in Systems Biology. Great science, incredible faculty support, and beautiful, sunny SoCal weather! ☀️🌴 Details: recruit.ap.uci.edu/JPF10377. Please share.