A multimeric pore complex in the poxvirus core revealed by integrative structural analysis pubmed.ncbi.nlm.nih.gov/42963376/ #cryoem
November 2, 2026 at 2:34 AM
A multimeric pore complex in the poxvirus core revealed by integrative structural analysis pubmed.ncbi.nlm.nih.gov/42963376/ #cryoem
Agentic cryo-EM structure determination with CryoPilot www.biorxiv.org/content/10.64898/2026.10.29.762908v1 #cryoem
October 31, 2026 at 11:46 AM
Agentic cryo-EM structure determination with CryoPilot www.biorxiv.org/content/10.64898/2026.10.29.762908v1 #cryoem
Low-pass filtering revisited: ramped phase randomization for cryo-EM map comparison and data augmentation www.biorxiv.org/content/10.64898/2026.10.30.763149v1 #cryoem
November 2, 2026 at 8:10 AM
Low-pass filtering revisited: ramped phase randomization for cryo-EM map comparison and data augmentation www.biorxiv.org/content/10.64898/2026.10.30.763149v1 #cryoem
"Frozen" chromatin: insights on its structuring from cryo-EM tomography pubmed.ncbi.nlm.nih.gov/42963474/ #cryoem
November 1, 2026 at 12:46 PM
"Frozen" chromatin: insights on its structuring from cryo-EM tomography pubmed.ncbi.nlm.nih.gov/42963474/ #cryoem
EMC chaperone activity is required for cotranslational calcium channel assembly pubmed.ncbi.nlm.nih.gov/42963453/ #cryoem
November 1, 2026 at 5:22 PM
EMC chaperone activity is required for cotranslational calcium channel assembly pubmed.ncbi.nlm.nih.gov/42963453/ #cryoem
Structural basis of voltage gating in a partially activated K+ channel pubmed.ncbi.nlm.nih.gov/42957739/ #cryoem
November 1, 2026 at 4:38 AM
Structural basis of voltage gating in a partially activated K+ channel pubmed.ncbi.nlm.nih.gov/42957739/ #cryoem
Femtosecond pulsed laser ablation for in-tissue electron cryo-tomography www.biorxiv.org/content/10.64898/2026.10.28.761815v1 #cryoem
October 29, 2026 at 7:10 AM
Femtosecond pulsed laser ablation for in-tissue electron cryo-tomography www.biorxiv.org/content/10.64898/2026.10.28.761815v1 #cryoem
A learning-to-rank framework for large-scale identification of unknown proteins from cryo-EM and cryo-ET maps pubmed.ncbi.nlm.nih.gov/42959064/ #cryoem
November 1, 2026 at 1:34 AM
A learning-to-rank framework for large-scale identification of unknown proteins from cryo-EM and cryo-ET maps pubmed.ncbi.nlm.nih.gov/42959064/ #cryoem
Single-particle cryo-electron microscopy (cryoEM) has transformed our ability to capture detailed 3D structures of biomedical molecules.
But how close are today’s cryoEM experiments to what is theoretically possible?
www.cambridge.org/core/journal...
But how close are today’s cryoEM experiments to what is theoretically possible?
www.cambridge.org/core/journal...
October 29, 2026 at 10:47 AM
Single-particle cryo-electron microscopy (cryoEM) has transformed our ability to capture detailed 3D structures of biomedical molecules.
But how close are today’s cryoEM experiments to what is theoretically possible?
www.cambridge.org/core/journal...
But how close are today’s cryoEM experiments to what is theoretically possible?
www.cambridge.org/core/journal...
Preserving information and integrity in Cryo-EM: Toward a Fourier-space deposition approach pubmed.ncbi.nlm.nih.gov/42956948/ #cryoem
October 30, 2026 at 2:50 PM
Preserving information and integrity in Cryo-EM: Toward a Fourier-space deposition approach pubmed.ncbi.nlm.nih.gov/42956948/ #cryoem
Cholesterol binding stabilizes the activated state of THIK-1 and promotes atherosclerosis pubmed.ncbi.nlm.nih.gov/42963430/ #cryoem
November 1, 2026 at 9:58 PM
Cholesterol binding stabilizes the activated state of THIK-1 and promotes atherosclerosis pubmed.ncbi.nlm.nih.gov/42963430/ #cryoem
Cryo-EM structure of a protein nanopore reveals lipid acyl chains as integral components pubmed.ncbi.nlm.nih.gov/42962025/ #cryoem
October 31, 2026 at 8:58 PM
Cryo-EM structure of a protein nanopore reveals lipid acyl chains as integral components pubmed.ncbi.nlm.nih.gov/42962025/ #cryoem
Age-dependent structural evolution of a functional amyloid contributes to memory impairment in Drosophila pubmed.ncbi.nlm.nih.gov/42962658/ #cryoem
October 31, 2026 at 7:26 PM
Age-dependent structural evolution of a functional amyloid contributes to memory impairment in Drosophila pubmed.ncbi.nlm.nih.gov/42962658/ #cryoem
Cryo-EM structure of the Arabidopsis thaliana V-type ATPase pubmed.ncbi.nlm.nih.gov/42950819/ #cryoem
October 29, 2026 at 5:37 PM
Cryo-EM structure of the Arabidopsis thaliana V-type ATPase pubmed.ncbi.nlm.nih.gov/42950819/ #cryoem
Here you can see a recent cryoEM structure of human Dicer with pre-mir-517a in pre-dicing state (PDB code: 21CB)
3D view: 3dproteinimaging.com/protein-imag...
Rendering by Francisco Enguita made with #ProteinImager
#SciArt #molecularart #mirna #dicer #endonuclease #precursor #regulation #cryoem
3D view: 3dproteinimaging.com/protein-imag...
Rendering by Francisco Enguita made with #ProteinImager
#SciArt #molecularart #mirna #dicer #endonuclease #precursor #regulation #cryoem
October 29, 2026 at 10:57 AM
Here you can see a recent cryoEM structure of human Dicer with pre-mir-517a in pre-dicing state (PDB code: 21CB)
3D view: 3dproteinimaging.com/protein-imag...
Rendering by Francisco Enguita made with #ProteinImager
#SciArt #molecularart #mirna #dicer #endonuclease #precursor #regulation #cryoem
3D view: 3dproteinimaging.com/protein-imag...
Rendering by Francisco Enguita made with #ProteinImager
#SciArt #molecularart #mirna #dicer #endonuclease #precursor #regulation #cryoem
A tale of two states: AlphaFold binding pockets on the apo-holo continuum www.biorxiv.org/content/10.64898/2026.10.26.762003v1 #cryoem
October 31, 2026 at 10:14 AM
A tale of two states: AlphaFold binding pockets on the apo-holo continuum www.biorxiv.org/content/10.64898/2026.10.26.762003v1 #cryoem
PHENOMS: Open-Source Software for Rust-Accelerated Hydrogen-Bond Analysis in Molecular Dynamics Simulations www.biorxiv.org/content/10.64898/2026.10.26.761768v1 #cryoem
October 31, 2026 at 1:18 PM
PHENOMS: Open-Source Software for Rust-Accelerated Hydrogen-Bond Analysis in Molecular Dynamics Simulations www.biorxiv.org/content/10.64898/2026.10.26.761768v1 #cryoem
The dynamics of large biomolecular assemblies pubmed.ncbi.nlm.nih.gov/42956544/ #cryoem
October 30, 2026 at 4:22 PM
The dynamics of large biomolecular assemblies pubmed.ncbi.nlm.nih.gov/42956544/ #cryoem
Deep Learning for Protein Secondary-Structure Segmentation in Intermediate-Resolution Cryo-EM Maps: A Resolution-Stratified Benchmark Dataset and Controlled Evaluation pubmed.ncbi.nlm.nih.gov/42959586/ #cryoem
November 1, 2026 at 12:02 AM
Deep Learning for Protein Secondary-Structure Segmentation in Intermediate-Resolution Cryo-EM Maps: A Resolution-Stratified Benchmark Dataset and Controlled Evaluation pubmed.ncbi.nlm.nih.gov/42959586/ #cryoem
Structural basis of glycoprotein recognition by the human folding sensor UDP-glucose:glycoprotein glucosyltransferase pubmed.ncbi.nlm.nih.gov/42961939/ #cryoem
October 31, 2026 at 10:30 PM
Structural basis of glycoprotein recognition by the human folding sensor UDP-glucose:glycoprotein glucosyltransferase pubmed.ncbi.nlm.nih.gov/42961939/ #cryoem
🔬 Preferred orientation is a familiar challenge in #cryoEM, but can smarter data processing help overcome it?
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
October 29, 2026 at 12:02 PM
🔬 Preferred orientation is a familiar challenge in #cryoEM, but can smarter data processing help overcome it?
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
🧬 𝗡𝗲𝘄 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁!
We identify 𝗟𝘂𝗱𝗣, a bacterial ribosome arrest peptide that monitors Sec-dependent protein secretion. Cryo-EM reveals how LudP remodels the ribosomal A-site to stall translation.
📄 doi.org/10.64898/202...
#CryoEM #StructuralBiology
We identify 𝗟𝘂𝗱𝗣, a bacterial ribosome arrest peptide that monitors Sec-dependent protein secretion. Cryo-EM reveals how LudP remodels the ribosomal A-site to stall translation.
📄 doi.org/10.64898/202...
#CryoEM #StructuralBiology
doi.org
October 30, 2026 at 3:17 AM
🧬 𝗡𝗲𝘄 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁!
We identify 𝗟𝘂𝗱𝗣, a bacterial ribosome arrest peptide that monitors Sec-dependent protein secretion. Cryo-EM reveals how LudP remodels the ribosomal A-site to stall translation.
📄 doi.org/10.64898/202...
#CryoEM #StructuralBiology
We identify 𝗟𝘂𝗱𝗣, a bacterial ribosome arrest peptide that monitors Sec-dependent protein secretion. Cryo-EM reveals how LudP remodels the ribosomal A-site to stall translation.
📄 doi.org/10.64898/202...
#CryoEM #StructuralBiology
Disruption of R2TP-mediated PIKK maturation with de novo designed binders www.biorxiv.org/content/10.64898/2026.10.26.761954v1 #cryoem
October 29, 2026 at 1:26 PM
Disruption of R2TP-mediated PIKK maturation with de novo designed binders www.biorxiv.org/content/10.64898/2026.10.26.761954v1 #cryoem
The multidrug transporter Pdr5 from Saccharomyces cerevisiae is an ergosterol-modulated efflux pump www.biorxiv.org/content/10.64898/2026.10.29.762749v1 #cryoem
October 31, 2026 at 8:42 AM
The multidrug transporter Pdr5 from Saccharomyces cerevisiae is an ergosterol-modulated efflux pump www.biorxiv.org/content/10.64898/2026.10.29.762749v1 #cryoem
Structural mechanism of programmable gene integration by the R2 retrotransposon coupled with CRISPR-Cas9 pubmed.ncbi.nlm.nih.gov/42951937/ #cryoem
October 31, 2026 at 1:34 AM
Structural mechanism of programmable gene integration by the R2 retrotransposon coupled with CRISPR-Cas9 pubmed.ncbi.nlm.nih.gov/42951937/ #cryoem