Comparative genomics has traditionally relied on sequence-based markers, yet the global evolutionary landscape of protein architecture remains largely unexplored. We present the Structural History of ...

Klose et al. provide structural insights into a supercomplex between the EMC and Spf1 that brings together cellular machines for membrane protein insertion and extraction into a single entity, providing a framework for integrated membrane protein quality control.

Mol-1: Molence Bio's open all-atom structure prediction model, derived from Protenix, for protein, nucleic acid, ligand and ion complexes, tuned for antibody–antigen, protein–ligand and peptide accura...

EMBL researchers have visualised the human nucleolus, the ‘factory’ for ribosome production, by combining cryo-electron tomography (cryo-ET) with correlative light and electron microscopy (CLEM). The in-cell snapshots provided secondary structural detail for the two key ribosomal subunit precursors, the SSU processome and the pre-60S, and revealed new assembly configurations. The team found that a protein factor long thought to bind late in assembly actually binds much earlier, and that ribosomes do not mature in a linear assembly line from the centre of the nucleolus to its edge. The approach offers new ways to study large molecular complexes in the crowded environment of the nucleus.

ESMFold2 & ESMC (Biohub): Biohub's protein 'world model': ESMC language model (~2.8B sequences), ESMFold2 complex structure prediction/design, and ESM Atlas (6.8B sequences). Commercial use: Permissiv...

Code for running PottsMPNN to generate sequences and predict energies - KeatingLab/PottsMPNN

Analyze and model biomembranes from 3D structural data. - KosinskiLab/mosaic