Protein design tools may be getting increasingly sophisticated, but you still need a sophisticated understanding of protein structure for them to work. This can include knowing enzyme mechanisms down...

A protein language model called Pinal designs working enzymes from plain-English prompts. What the Nature paper proves, and what it does not.

Codon-free models learn protein biology straight from raw DNA, with no translation table supplied. Here is what the evidence actually shows, and where these models still fall short.

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation...

Mol-1: Molence Bio's open all-atom structure prediction model, derived from Protenix, for protein, nucleic acid, ligand and ion complexes, tuned for antibody–antigen, protein–ligand and peptide accura...

ESMFold2 & ESMC (Biohub): Biohub's protein 'world model': ESMC language model (~2.8B sequences), ESMFold2 complex structure prediction/design, and ESM Atlas (6.8B sequences). Commercial use: Permissiv...

Explore RFD4-Proteina, the open-source AI model co-developed by NVIDIA and the UW Institute for Protein Design to accelerate drug discovery and sustainable biot

This Article introduces a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity.

Citrini Research spent three months and $200K using Anthropic's AI to design proteins targeting scorpion toxins, and 17 of them actually bound to their targets. The firm is now betting that AI-driven biology will supercharge demand for the tools and services that make wet-lab science happen.

De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.

RFdiffusion3 AI System Transforms Protein Design at the Atomic Level Researchers recently unveiled the detailed design scheme for RFdiffusion3. This generative artificial intelligence system constructs proteins and nucleic acids atom by atom. Moreover, proteins crafted through this new system successfully perform intended functions during actual chemical reactions. An international research team built this precise atomic modeling tool. Members include scientists from the University of Washington, Oxford University, and Nvidia.

Here, the authors show that protein design is a generalizable strategy to generate new antimicrobials by neutralizing the function of bacterial adhesins to combat two causative agents of urinary tract...

Google gives European researchers access to AlphaFold 3    Techzine Global