Egoviruses: distant relatives of poxviruses abundant in the gut microbiome of humans and animals worldwide
Novel dsDNA viruses related to poxviruses in the gut - host unclear, but could be either the mammals themselves or a unicellular eukaryote in the gut
www.biorxiv.org/content/10.1...
Novel dsDNA viruses related to poxviruses in the gut - host unclear, but could be either the mammals themselves or a unicellular eukaryote in the gut
www.biorxiv.org/content/10.1...
June 29, 2024 at 11:03 PM
Egoviruses: distant relatives of poxviruses abundant in the gut microbiome of humans and animals worldwide
Novel dsDNA viruses related to poxviruses in the gut - host unclear, but could be either the mammals themselves or a unicellular eukaryote in the gut
www.biorxiv.org/content/10.1...
Novel dsDNA viruses related to poxviruses in the gut - host unclear, but could be either the mammals themselves or a unicellular eukaryote in the gut
www.biorxiv.org/content/10.1...
conducting work with poxviruses. And we do maintain a stockpile of smallpox vaccine, so ring vaccination or, if needed, community-wide vaccination campaigns can be quickly implemented in the event of an exposure.
August 15, 2024 at 5:09 PM
conducting work with poxviruses. And we do maintain a stockpile of smallpox vaccine, so ring vaccination or, if needed, community-wide vaccination campaigns can be quickly implemented in the event of an exposure.
““Poxviruses love to mess with translation,” he said.
Cells infected by viruses sometimes try to shut down their protein factories to halt the production of new viruses. The poxviruses can use host proteins to restart them.”
Cells infected by viruses sometimes try to shut down their protein factories to halt the production of new viruses. The poxviruses can use host proteins to restart them.”
September 28, 2026 at 8:59 PM
““Poxviruses love to mess with translation,” he said.
Cells infected by viruses sometimes try to shut down their protein factories to halt the production of new viruses. The poxviruses can use host proteins to restart them.”
Cells infected by viruses sometimes try to shut down their protein factories to halt the production of new viruses. The poxviruses can use host proteins to restart them.”
As mpox surges, will it become endemic, or can its spread be beaten back? Declining immunity to poxviruses poses long-term challenges as cases rise in previously unaffected regions.
December 26, 2024 at 12:35 PM
As mpox surges, will it become endemic, or can its spread be beaten back? Declining immunity to poxviruses poses long-term challenges as cases rise in previously unaffected regions.
Really interesting preprint. There are lots of poxviruses out there that have zoonotic potential.
Also, the spillback risk of mpox into animals is a bit of a headache, too.
Also, the spillback risk of mpox into animals is a bit of a headache, too.
New preprint up! Really happy to have this study come together. We delve into predicting reservoirs of orthopoxviruses, including mpox virus, using ML models that integrate ecology and viral genomics 🦠🧬🐭
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 1, 2023 at 1:14 PM
Really interesting preprint. There are lots of poxviruses out there that have zoonotic potential.
Also, the spillback risk of mpox into animals is a bit of a headache, too.
Also, the spillback risk of mpox into animals is a bit of a headache, too.
if you want to know why poxviruses are emerging suddenly, up until the 1980s, everyone on Earth was vaccinated for smallpox, and the poxvirus family is conservative. immunity to smallpox grants you immunity to other family members. its been 2 generations of vulnerable people now
February 10, 2024 at 2:00 AM
if you want to know why poxviruses are emerging suddenly, up until the 1980s, everyone on Earth was vaccinated for smallpox, and the poxvirus family is conservative. immunity to smallpox grants you immunity to other family members. its been 2 generations of vulnerable people now
A recombinant strain of mpox virus has been isolated from a patient in the UK containing fragments of clade I and clade II virus. Recombination occurs when two strains of virus infect a cell. These events tend to be rare but are well described in poxviruses.
www.theguardian.com/world/2025/d...
www.theguardian.com/world/2025/d...
England health officials identify newly evolved variant of mpox
Virus caught by person who travelled to Asia combines more severe form of mpox with less virulent type
www.theguardian.com
December 8, 2025 at 5:47 PM
A recombinant strain of mpox virus has been isolated from a patient in the UK containing fragments of clade I and clade II virus. Recombination occurs when two strains of virus infect a cell. These events tend to be rare but are well described in poxviruses.
www.theguardian.com/world/2025/d...
www.theguardian.com/world/2025/d...
Progress on understanding membrane fusion in Poxviruses!
Congrats to the authors on this important work.
Congrats to the authors on this important work.
Now online! Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection
Since 2022, several strains of the monkeypox virus adapted to human-to-human transmission have emerged and raised international alarm, highlighting the need for new treatments. We studied A16/G9, a conserved complex involved in viral entry, and found that antibodies targeting this complex block fusion and neutralize MPXV. Mice immunized with the protein elicit a protective immune response. These findings pave the way to develop better vaccines and antivirals. Structural analysis of the poxvirus A16/G9 fusion complex reveals how antibodies block viral entry, providing a new target for vaccines and antivirals against mpox and related viruses.
dlvr.it
August 26, 2025 at 3:20 PM
Progress on understanding membrane fusion in Poxviruses!
Congrats to the authors on this important work.
Congrats to the authors on this important work.
A Structural Atlas of TAP Inhibition by Herpesviruses and Poxviruses pubmed.ncbi.nlm.nih.gov/40611894/ #cryoem
July 6, 2025 at 3:37 AM
A Structural Atlas of TAP Inhibition by Herpesviruses and Poxviruses pubmed.ncbi.nlm.nih.gov/40611894/ #cryoem
Now with the correct link:
We reviewed the "Molecular Mechanisms of Poxvirus Evolution"
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
journals.asm.org/doi/10.1128/...
We reviewed the "Molecular Mechanisms of Poxvirus Evolution"
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
journals.asm.org/doi/10.1128/...
October 16, 2025 at 7:20 PM
Now with the correct link:
We reviewed the "Molecular Mechanisms of Poxvirus Evolution"
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
journals.asm.org/doi/10.1128/...
We reviewed the "Molecular Mechanisms of Poxvirus Evolution"
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
journals.asm.org/doi/10.1128/...
Everything is a zoonosis! drawing challenge
#7- Dolphin
a/w:
Brucella ceti
Erysipelothrix rusiopathiae
Mycobacterium cheloneae
Influenza viruses
Poxviruses
Blastomycosis
Lobomycosis
Bonus: not a zoonosis but research on 🐬 ifx w C gattii in the PNW and on C gatti dispersal is fascinating! 🔗👇
#IDSky
#7- Dolphin
a/w:
Brucella ceti
Erysipelothrix rusiopathiae
Mycobacterium cheloneae
Influenza viruses
Poxviruses
Blastomycosis
Lobomycosis
Bonus: not a zoonosis but research on 🐬 ifx w C gattii in the PNW and on C gatti dispersal is fascinating! 🔗👇
#IDSky
July 15, 2025 at 10:31 PM
Everything is a zoonosis! drawing challenge
#7- Dolphin
a/w:
Brucella ceti
Erysipelothrix rusiopathiae
Mycobacterium cheloneae
Influenza viruses
Poxviruses
Blastomycosis
Lobomycosis
Bonus: not a zoonosis but research on 🐬 ifx w C gattii in the PNW and on C gatti dispersal is fascinating! 🔗👇
#IDSky
#7- Dolphin
a/w:
Brucella ceti
Erysipelothrix rusiopathiae
Mycobacterium cheloneae
Influenza viruses
Poxviruses
Blastomycosis
Lobomycosis
Bonus: not a zoonosis but research on 🐬 ifx w C gattii in the PNW and on C gatti dispersal is fascinating! 🔗👇
#IDSky
Congrats Dr Annika Binder for a fantastic thesis and defense on microtubule binding proteins of #malaria #parasites exactly 25 years after I got my Dr for something with #actin and poxviruses and almost failed a question on, well, microtubule binding proteins.
March 31, 2025 at 6:08 PM
Congrats Dr Annika Binder for a fantastic thesis and defense on microtubule binding proteins of #malaria #parasites exactly 25 years after I got my Dr for something with #actin and poxviruses and almost failed a question on, well, microtubule binding proteins.
Can a country decide to exlude an RG-3 pathogen from its list? No SARS-CoV-2👇
Sweden's RG-3: Rabies, poxviruses (variola and vaccinia viruses, other poxviruses), MERS-CoV, SARS-CoV-1, Ebola, Crimean-Congo, Marburg, Lassa viruses, including RVF viruses, Nipah, Hendra viruses,unknown viruses
Sweden's RG-3: Rabies, poxviruses (variola and vaccinia viruses, other poxviruses), MERS-CoV, SARS-CoV-1, Ebola, Crimean-Congo, Marburg, Lassa viruses, including RVF viruses, Nipah, Hendra viruses,unknown viruses
March 19, 2026 at 7:46 AM
Can a country decide to exlude an RG-3 pathogen from its list? No SARS-CoV-2👇
Sweden's RG-3: Rabies, poxviruses (variola and vaccinia viruses, other poxviruses), MERS-CoV, SARS-CoV-1, Ebola, Crimean-Congo, Marburg, Lassa viruses, including RVF viruses, Nipah, Hendra viruses,unknown viruses
Sweden's RG-3: Rabies, poxviruses (variola and vaccinia viruses, other poxviruses), MERS-CoV, SARS-CoV-1, Ebola, Crimean-Congo, Marburg, Lassa viruses, including RVF viruses, Nipah, Hendra viruses,unknown viruses
and their work on poxviruses. I didn't feel too bad because my external examiner did not know who Luria and Bertani were either. Robin Weiss was a pioneer in virology and is most famous for his work on retroviruses and identifying CD4 on lymphocytes as the binding receptor for HIV.
March 3, 2026 at 5:45 PM
and their work on poxviruses. I didn't feel too bad because my external examiner did not know who Luria and Bertani were either. Robin Weiss was a pioneer in virology and is most famous for his work on retroviruses and identifying CD4 on lymphocytes as the binding receptor for HIV.
We reviewed the "Molecular Mechanisms of Poxvirus Evolution" | mBio journals.asm.org/doi/10.1128/...
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
October 16, 2025 at 7:04 PM
We reviewed the "Molecular Mechanisms of Poxvirus Evolution" | mBio journals.asm.org/doi/10.1128/...
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
I have a Ph.D. In Molecular Virology. I worked with poxviruses in my post doc.
This idiot is dangerous.
This idiot is dangerous.
1/3 John Knox, anti-vaccine activist, is now acting head of ASPR -- the agency that handles pandemic response.
He’s called COVID vaccine campaigns “nothing other than genocide.” 😶
Not exactly reassuring...
He’s called COVID vaccine campaigns “nothing other than genocide.” 😶
Not exactly reassuring...
Meet the anti-vaccine activist who could lead the response to the next pandemic
Former firefighter John Knox's ties to RFK Jr. have landed him atop the agency that helped bring Covid-19 under control. People in the know are worried.
www.msnbc.com
October 30, 2025 at 3:15 PM
I have a Ph.D. In Molecular Virology. I worked with poxviruses in my post doc.
This idiot is dangerous.
This idiot is dangerous.
The common name is because lesions of chickenpox looked as if a "Child had been picked by the Bills of chickens."
This has added to confusion, as smallpox and cowpox are taxonomically Poxviruses, but chickenpox is actually human herpesvirus 3, or varicella-zoster virus (VZV), and not a pox at all.
This has added to confusion, as smallpox and cowpox are taxonomically Poxviruses, but chickenpox is actually human herpesvirus 3, or varicella-zoster virus (VZV), and not a pox at all.
October 29, 2024 at 12:42 PM
The common name is because lesions of chickenpox looked as if a "Child had been picked by the Bills of chickens."
This has added to confusion, as smallpox and cowpox are taxonomically Poxviruses, but chickenpox is actually human herpesvirus 3, or varicella-zoster virus (VZV), and not a pox at all.
This has added to confusion, as smallpox and cowpox are taxonomically Poxviruses, but chickenpox is actually human herpesvirus 3, or varicella-zoster virus (VZV), and not a pox at all.
Back in 2010 we found transposable elements (TEs) can hop between widely diverged species, like bats and monkeys. We suspected large DNA viruses like poxviruses, which cross species boundaries, could act as vectors for transposons to hop into their genome.
September 24, 2026 at 7:00 PM
Back in 2010 we found transposable elements (TEs) can hop between widely diverged species, like bats and monkeys. We suspected large DNA viruses like poxviruses, which cross species boundaries, could act as vectors for transposons to hop into their genome.
Fortunately smallpox only exists in 2 places in the world (labs). Unfortunately one is the CDC & even more unfortunately this other is in Russia. Also it’s possible (but very, very difficult) to make poxviruses with synthetic biology. At least if smallpox does come back we’ll know it was a lab leak.
May 5, 2025 at 1:31 AM
Fortunately smallpox only exists in 2 places in the world (labs). Unfortunately one is the CDC & even more unfortunately this other is in Russia. Also it’s possible (but very, very difficult) to make poxviruses with synthetic biology. At least if smallpox does come back we’ll know it was a lab leak.
Pharmaceuticals that are needed to treat a wide range of viral infections may already exist in licensed drugs. Researchers need to study what’s already on pharmacy shelves to pinpoint them medicalxpress.com/news/2023-08...
Treatments for poxviruses—including those causing mpox and smallpox—may already exist in licensed drugs
Scientists studying how poxviruses evade natural defenses in human cells have identified a new approach to treatment that may be more durable than current treatments.
medicalxpress.com
April 25, 2025 at 10:43 PM
Pharmaceuticals that are needed to treat a wide range of viral infections may already exist in licensed drugs. Researchers need to study what’s already on pharmacy shelves to pinpoint them medicalxpress.com/news/2023-08...
This sounds interesting! Poxviruses do crazy things...
tRNA as an assembly chaperone for a macromolecular transcription-processing complex pubmed.ncbi.nlm.nih.gov/40908366/ #cryoem
September 5, 2025 at 12:03 PM
This sounds interesting! Poxviruses do crazy things...
What I particularly like about this is that I worked on Arp2/3 mediated actin based motility of poxviruses during my PhD with @drmichaelway.bsky.social @embl.org. So 25 years seem to have passed in a wink... Arp2/3 was supposedly absent in Plasmodium but a simple pulldown changed our view.
June 14, 2025 at 4:35 PM
What I particularly like about this is that I worked on Arp2/3 mediated actin based motility of poxviruses during my PhD with @drmichaelway.bsky.social @embl.org. So 25 years seem to have passed in a wink... Arp2/3 was supposedly absent in Plasmodium but a simple pulldown changed our view.
Another nice example of a host-acquired gene in poxviruses, which modulates the host immune response.
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses
Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...
dx.plos.org
April 22, 2025 at 4:19 PM
Another nice example of a host-acquired gene in poxviruses, which modulates the host immune response.
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
🎉New Special Issue in #PathogensMDPI
🖇️Poxviruses: Biology, Evolution, Surveillance, and Control
👥Guest Editors: Dr. Maurício Teixeira Lima and Dr. Giliane de Souza Trindade
📅31 January 2027
📍https://www.mdpi.com/journal/pathogens/special_issues/3M36TO4DK0
#SpecialIssue #OpenAccess #Poxviruses
🖇️Poxviruses: Biology, Evolution, Surveillance, and Control
👥Guest Editors: Dr. Maurício Teixeira Lima and Dr. Giliane de Souza Trindade
📅31 January 2027
📍https://www.mdpi.com/journal/pathogens/special_issues/3M36TO4DK0
#SpecialIssue #OpenAccess #Poxviruses
September 22, 2026 at 7:01 AM
🎉New Special Issue in #PathogensMDPI
🖇️Poxviruses: Biology, Evolution, Surveillance, and Control
👥Guest Editors: Dr. Maurício Teixeira Lima and Dr. Giliane de Souza Trindade
📅31 January 2027
📍https://www.mdpi.com/journal/pathogens/special_issues/3M36TO4DK0
#SpecialIssue #OpenAccess #Poxviruses
🖇️Poxviruses: Biology, Evolution, Surveillance, and Control
👥Guest Editors: Dr. Maurício Teixeira Lima and Dr. Giliane de Souza Trindade
📅31 January 2027
📍https://www.mdpi.com/journal/pathogens/special_issues/3M36TO4DK0
#SpecialIssue #OpenAccess #Poxviruses
Previously, KO and overexpression showed host RNA 5’ triphosphatase DUSP11 can reduce RIG-I sensitivity.
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses
Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...
journals.plos.org
April 22, 2025 at 1:22 PM
Previously, KO and overexpression showed host RNA 5’ triphosphatase DUSP11 can reduce RIG-I sensitivity.
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...