Lars-Anders Carlson
@lacarlson.bsky.social
Structural virology group leader at Umeå University, Sweden. www.carlsonlab.se
Pinned
Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
www.nature.com
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...
#virology #teamtomo
www.nature.com/articles/s41...
Reposted by Lars-Anders Carlson
What in the world am I looking at here? @Nikon? www.nikonsmallworld.com/galleries/20...
Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD) | 2026 Small World in Motion Competition
Ning Xu - Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD), a genetic disorder affecting respiratory function.
www.nikonsmallworld.com
September 18, 2026 at 5:55 AM
What in the world am I looking at here? @Nikon? www.nikonsmallworld.com/galleries/20...
“Ethanol is a privilege, not a right,”
September 16, 2026 at 7:49 PM
“Ethanol is a privilege, not a right,”
Reposted by Lars-Anders Carlson
Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells.
www.biorxiv.org/content/10.6...
🧵1/8
www.biorxiv.org/content/10.6...
🧵1/8
September 14, 2026 at 8:35 AM
Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells.
www.biorxiv.org/content/10.6...
🧵1/8
www.biorxiv.org/content/10.6...
🧵1/8
It was a great meeing and a nice venue in central Umeå[email protected]
Last week, @nordicembl.bsky.social held its annual meeting, opening with EMBL Director General Tony Hyman’s keynote.
The Partnership brings together DANDRITE, FIMM, MIMS, and NCMBM and is a major strategic player in Europe's molecular understanding of disease mechanisms.
The Partnership brings together DANDRITE, FIMM, MIMS, and NCMBM and is a major strategic player in Europe's molecular understanding of disease mechanisms.
September 16, 2026 at 7:40 PM
It was a great meeing and a nice venue in central Umeå[email protected]
Reposted by Lars-Anders Carlson
Tempted to use AI to write your cover letter or email to a potential employer? RESIST! It is simultaneously obvious, insulting, and renders you totally undifferentiated from the other 80 people being considered t the same time. There has never been a better time to write concisely in your own voice!
September 15, 2026 at 4:24 PM
Tempted to use AI to write your cover letter or email to a potential employer? RESIST! It is simultaneously obvious, insulting, and renders you totally undifferentiated from the other 80 people being considered t the same time. There has never been a better time to write concisely in your own voice!
Reposted by Lars-Anders Carlson
Reposted by Lars-Anders Carlson
Huge kudos to JCB. Not only was the review process super constructive, they enthusiastically embraced the underutilized #GolgiTime hashtag 😀
Avl9 defines a family of DENN domain GTPase-activating proteins. New study from Ryan C. Vignogna (@rvig.bsky.social) & J. Christopher Fromme (@fromme-lab.bsky.social) @cornelluniversity.bsky.social:
rupress.org/jcb/article/...
#GolgiTime #GTPases #Migration #Biochemistry #StructuralBiology #Golgi
rupress.org/jcb/article/...
#GolgiTime #GTPases #Migration #Biochemistry #StructuralBiology #Golgi
September 16, 2026 at 3:04 PM
Huge kudos to JCB. Not only was the review process super constructive, they enthusiastically embraced the underutilized #GolgiTime hashtag 😀
Reposted by Lars-Anders Carlson
But if you gain fulfillment from the doing & the teaching, from the achievements of others, including your competitors, from those that came before you, & those that will follow, you are somewhat insulated.
Ultimately, this is a good moment to reflect on what brings YOU joy & act accordingly.
Ultimately, this is a good moment to reflect on what brings YOU joy & act accordingly.
September 13, 2026 at 6:04 PM
But if you gain fulfillment from the doing & the teaching, from the achievements of others, including your competitors, from those that came before you, & those that will follow, you are somewhat insulated.
Ultimately, this is a good moment to reflect on what brings YOU joy & act accordingly.
Ultimately, this is a good moment to reflect on what brings YOU joy & act accordingly.
Reposted by Lars-Anders Carlson
The fastest way to learn is to try, fail, and write down why you failed.
September 14, 2026 at 2:28 AM
The fastest way to learn is to try, fail, and write down why you failed.
Reposted by Lars-Anders Carlson
Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism!
Work led by graduate student @paulafprado.bsky.social in our group.
www.biorxiv.org/content/10.6...
🧵 1/9
Work led by graduate student @paulafprado.bsky.social in our group.
www.biorxiv.org/content/10.6...
🧵 1/9
September 11, 2026 at 10:06 PM
Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism!
Work led by graduate student @paulafprado.bsky.social in our group.
www.biorxiv.org/content/10.6...
🧵 1/9
Work led by graduate student @paulafprado.bsky.social in our group.
www.biorxiv.org/content/10.6...
🧵 1/9
Great read about a Nobel laureate I admittedly knew nothing about. Accompanied by very nice photos!
Irène Joliot-Curie was a battlefield radiologist, activist, politician, and daughter of two of the most famous scientists in the world: Marie Skłodowska and Pierre Curie.
Discover her journey to her own Nobel Prize: https://bit.ly/2D7FAzk
Discover her journey to her own Nobel Prize: https://bit.ly/2D7FAzk
September 12, 2026 at 1:31 PM
Great read about a Nobel laureate I admittedly knew nothing about. Accompanied by very nice photos!
Reposted by Lars-Anders Carlson
Even highly antibiotic-resistant bacteria become more vulnerable when their cell wall transport system is disrupted, according to a new study from @umeauniversitet.bsky.social
September 11, 2026 at 7:23 AM
Even highly antibiotic-resistant bacteria become more vulnerable when their cell wall transport system is disrupted, according to a new study from @umeauniversitet.bsky.social
Cool new infection biology from Umeå!
The discovery reveals a previously overlooked weakness that could help researchers develop new strategies to combat #antibioticresistance.
#research supported by Knut and Alice Wallenberg Foundation tinyurl.com/4c83v338
#research supported by Knut and Alice Wallenberg Foundation tinyurl.com/4c83v338
Researchers discover Achilles' heel of antibiotic-resistant bacteria
Highly antibiotic-resistant bacteria become more susceptible when transport to the cell wall is disrupted.
tinyurl.com
September 11, 2026 at 10:48 AM
Cool new infection biology from Umeå!
Reposted by Lars-Anders Carlson
Reposted by Lars-Anders Carlson
Reposted by Lars-Anders Carlson
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome
Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.
Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome
Nature - Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.
www.nature.com
September 10, 2026 at 7:08 PM
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome
Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.
Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.
After ~2 years of having a dormant X account for my lab, I got an email today about a login from abroad, and decided to finally pull the plug on the account. With some nostalgia to early days of #cryoEM twitter, but life has long since moved on...
September 10, 2026 at 2:32 PM
After ~2 years of having a dormant X account for my lab, I got an email today about a login from abroad, and decided to finally pull the plug on the account. With some nostalgia to early days of #cryoEM twitter, but life has long since moved on...
Reposted by Lars-Anders Carlson
Congratulations, Julia Mahamid!
The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology.
Learn more: www.embl.org/news/awards-...
The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology.
Learn more: www.embl.org/news/awards-...
September 9, 2026 at 9:10 AM
Congratulations, Julia Mahamid!
The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology.
Learn more: www.embl.org/news/awards-...
The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology.
Learn more: www.embl.org/news/awards-...
Reposted by Lars-Anders Carlson
So (if I understand this correctly), the way AI (companies) will "solve" all the major problems in maths, biology, and medicine in the next 5 years will be by stealing and building on the ideas of researchers naive enough to think their chats with AI companies would be private.
September 8, 2026 at 2:30 PM
So (if I understand this correctly), the way AI (companies) will "solve" all the major problems in maths, biology, and medicine in the next 5 years will be by stealing and building on the ideas of researchers naive enough to think their chats with AI companies would be private.
Reposted by Lars-Anders Carlson
I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky
📢 We’re hiring!
Join Caitlyn McCafferty’s (@computingcaitie.bsky.social) new group as Lab Manager and help shape lab operations, develop protocols and support research on the structure and dynamics of motile cilia. Apply by October 9: www.fmi.ch/education-ca...
Join Caitlyn McCafferty’s (@computingcaitie.bsky.social) new group as Lab Manager and help shape lab operations, develop protocols and support research on the structure and dynamics of motile cilia. Apply by October 9: www.fmi.ch/education-ca...
September 9, 2026 at 9:33 AM
I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky
Reposted by Lars-Anders Carlson
NEW: The NIH is quietly restricting funding for research that evaluates how public policy impacts human health.
According to internal documents I obtained, the agency no longer considers policymakers "mission relevant" — a massive shift for the biomedical funder.
My latest for @nature.com:
According to internal documents I obtained, the agency no longer considers policymakers "mission relevant" — a massive shift for the biomedical funder.
My latest for @nature.com:
NIH limits funding for research on the health effects of public policy
US biomedical agency no longer considers policymakers as ‘mission relevant’, leaving dozens of grants in limbo.
www.nature.com
August 11, 2026 at 4:16 PM
NEW: The NIH is quietly restricting funding for research that evaluates how public policy impacts human health.
According to internal documents I obtained, the agency no longer considers policymakers "mission relevant" — a massive shift for the biomedical funder.
My latest for @nature.com:
According to internal documents I obtained, the agency no longer considers policymakers "mission relevant" — a massive shift for the biomedical funder.
My latest for @nature.com:
Reposted by Lars-Anders Carlson
A wild publishing ride to get here... but finally!
(first bioRxiv: January 5th, 2024 🙃)
Amazing work from @lorenzlamm.bsky.social and colleagues 🤗
Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
(first bioRxiv: January 5th, 2024 🙃)
Amazing work from @lorenzlamm.bsky.social and colleagues 🤗
Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
www.nature.com
September 8, 2026 at 9:48 AM
A wild publishing ride to get here... but finally!
(first bioRxiv: January 5th, 2024 🙃)
Amazing work from @lorenzlamm.bsky.social and colleagues 🤗
Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
(first bioRxiv: January 5th, 2024 🙃)
Amazing work from @lorenzlamm.bsky.social and colleagues 🤗
Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
Reposted by Lars-Anders Carlson
Excited to share our new work!!
We’ve solved the 3.1 Å cryo-EM structure of African horse sickness virus VP2 - and used it to guide the design of nanoparticle vaccine candidates.🎯
Fantastic TEAMWORK!
Structure-guided vaccine design in action!
www.nature.com/articles/s41...
We’ve solved the 3.1 Å cryo-EM structure of African horse sickness virus VP2 - and used it to guide the design of nanoparticle vaccine candidates.🎯
Fantastic TEAMWORK!
Structure-guided vaccine design in action!
www.nature.com/articles/s41...
Cryo-EM structure of African horse sickness virus VP2 receptor-binding protein enables nanoparticle vaccine design - Nature Communications
A high-resolution structure of African horse sickness virus viral attachment protein reveals a functional domain and neutralizing target, enabling a nanoparticle vaccine that protects in mice and indu...
www.nature.com
September 7, 2026 at 12:11 PM
Excited to share our new work!!
We’ve solved the 3.1 Å cryo-EM structure of African horse sickness virus VP2 - and used it to guide the design of nanoparticle vaccine candidates.🎯
Fantastic TEAMWORK!
Structure-guided vaccine design in action!
www.nature.com/articles/s41...
We’ve solved the 3.1 Å cryo-EM structure of African horse sickness virus VP2 - and used it to guide the design of nanoparticle vaccine candidates.🎯
Fantastic TEAMWORK!
Structure-guided vaccine design in action!
www.nature.com/articles/s41...
Reposted by Lars-Anders Carlson
Bunsen burners’ reputation for sterilizing workplaces flames out www.nature.com/articles/d41...
Bunsen burners’ reputation for sterilizing workplaces flames out
Study shows that the venerable device does not waft bacteria away from workbenches, as is often assumed.
www.nature.com
September 7, 2026 at 3:22 PM
Bunsen burners’ reputation for sterilizing workplaces flames out www.nature.com/articles/d41...
Reposted by Lars-Anders Carlson
Professor Lewis E Kay FRS is awarded the Royal Medal (Biological) 2026 for his remarkable contribution to understand and quantify protein dynamics and their relevance to protein function. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/
August 27, 2026 at 1:09 PM
Professor Lewis E Kay FRS is awarded the Royal Medal (Biological) 2026 for his remarkable contribution to understand and quantify protein dynamics and their relevance to protein function. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/