Single-Cell Inference of Structural States Of Ribosomes www.biorxiv.org/content/10.6...
Single-Cell Inference of Structural States Of Ribosomes
Protein synthesis is dynamically regulated to control cell growth, differentiation, and stress responses. Recent single-cell sequencing methods can map ribosome positions on individual transcripts[1][...
www.biorxiv.org
October 31, 2026 at 9:00 PM
Single-Cell Inference of Structural States Of Ribosomes www.biorxiv.org/content/10.6...
Very happy to share that our work (beautifully led by @miemonti.bsky.social and #Hasan) is finally out! 😄We find that tRNAs engaged in actively translating ribosomes significantly differ from the 'total' pool available in the cell, specially upon stress! www.nature.com/articles/s41...
Selective profiling of translationally active tRNAs and their dynamics under stress - Nature Methods
tRIBO-seq distinguishes between ribosome-associated tRNAs and total tRNAs using nanopore sequencing, thus revealing their potentially distinct abundance, modification and fragmentation patterns in var...
www.nature.com
November 2, 2026 at 5:17 PM
Very happy to share that our work (beautifully led by @miemonti.bsky.social and #Hasan) is finally out! 😄We find that tRNAs engaged in actively translating ribosomes significantly differ from the 'total' pool available in the cell, specially upon stress! www.nature.com/articles/s41...
JCVI-syn3.0, the minimal bacterial cell built in 2016, runs on 473 genes. Its builders say 149 do jobs nobody can name. The cell posted this July still borrows its ribosomes. We read all three against Frankenstein: www.freeastroscience.com/can-scientis...
#Biology #FreeAstroScience #Halloween
#Biology #FreeAstroScience #Halloween
Can Scientists Create Life? What Frankenstein Asks
This Halloween, see how close labs are to building a living cell, why the 2026 SpudCell still borrows its ribosomes, and what Frankenstein warns us.
www.freeastroscience.com
October 31, 2026 at 5:26 PM
JCVI-syn3.0, the minimal bacterial cell built in 2016, runs on 473 genes. Its builders say 149 do jobs nobody can name. The cell posted this July still borrows its ribosomes. We read all three against Frankenstein: www.freeastroscience.com/can-scientis...
#Biology #FreeAstroScience #Halloween
#Biology #FreeAstroScience #Halloween
Ribosome assembly has been imaged inside intact human cells for the first time, capturing dozens of assembly stages—but the earliest intermediates remain too small to resolve. doi.org/hcqq3g
Detailed images reveal ribosome assembly inside human cells for the first time
For decades, ribosomes have been under the lens of many scientists. Ribosomes are highly sophisticated and complex molecular machines that allow cells to synthesize proteins.
phys.org
October 29, 2026 at 9:30 PM
Ribosome assembly has been imaged inside intact human cells for the first time, capturing dozens of assembly stages—but the earliest intermediates remain too small to resolve. doi.org/hcqq3g
A new Nature Methods paper from one of our #LongTREC supervisors, @evamarianovoa.bsky.social , and colleagues introduces #tRIBO-seq. It’s a nanopore-based method that reads tRNAs bound to ribosomes while they make protein.
Read the full paper in Nature Methods now to learn more.
#tRNA #Nanopore
Read the full paper in Nature Methods now to learn more.
#tRNA #Nanopore
Very happy to share that our work (beautifully led by @miemonti.bsky.social and #Hasan) is finally out! 😄We find that tRNAs engaged in actively translating ribosomes significantly differ from the 'total' pool available in the cell, specially upon stress! www.nature.com/articles/s41...
Selective profiling of translationally active tRNAs and their dynamics under stress - Nature Methods
tRIBO-seq distinguishes between ribosome-associated tRNAs and total tRNAs using nanopore sequencing, thus revealing their potentially distinct abundance, modification and fragmentation patterns in var...
www.nature.com
November 3, 2026 at 8:57 AM
A new Nature Methods paper from one of our #LongTREC supervisors, @evamarianovoa.bsky.social , and colleagues introduces #tRIBO-seq. It’s a nanopore-based method that reads tRNAs bound to ribosomes while they make protein.
Read the full paper in Nature Methods now to learn more.
#tRNA #Nanopore
Read the full paper in Nature Methods now to learn more.
#tRNA #Nanopore
A surprising finding was Nsp1-mediated mRNA loss could be significantly reduced in cells that lacked the ribosome quality control sensor ZNF598, suggesting ribosomes that initiate in a cap-dependent manner in the presence of Nsp1 are compromised in some way during elongation.
October 30, 2026 at 10:28 PM
A surprising finding was Nsp1-mediated mRNA loss could be significantly reduced in cells that lacked the ribosome quality control sensor ZNF598, suggesting ribosomes that initiate in a cap-dependent manner in the presence of Nsp1 are compromised in some way during elongation.
✨ New paper: Altering the E. coli Ribosome Exit Tunnel to Improve Consecutive Incorporation of Challenging Monomers, ACS Central Science doi.org/10.1021/acsc...
@alexandra-kent.bsky.social @c-majumdar.bsky.social Katie @alexsolivan.bsky.social Martina Jessica Alanna @jhdcate.bsky.social #NSFFunded
@alexandra-kent.bsky.social @c-majumdar.bsky.social Katie @alexsolivan.bsky.social Martina Jessica Alanna @jhdcate.bsky.social #NSFFunded
Altering the E. coli Ribosome Exit Tunnel to Improve Consecutive Incorporation of Challenging Monomers
Abstract. Ribosomes are capable
of incorporating a wide array of
natural
and unnatural monomers into growing polymer chains, but can be stalled
by monomers
pubs.acs.org
November 2, 2026 at 10:09 PM
✨ New paper: Altering the E. coli Ribosome Exit Tunnel to Improve Consecutive Incorporation of Challenging Monomers, ACS Central Science doi.org/10.1021/acsc...
@alexandra-kent.bsky.social @c-majumdar.bsky.social Katie @alexsolivan.bsky.social Martina Jessica Alanna @jhdcate.bsky.social #NSFFunded
@alexandra-kent.bsky.social @c-majumdar.bsky.social Katie @alexsolivan.bsky.social Martina Jessica Alanna @jhdcate.bsky.social #NSFFunded
My early prototypes were basically slower ribosomes with delusions of grandeur; retention uncovers more compromises than design.
October 31, 2026 at 9:57 PM
My early prototypes were basically slower ribosomes with delusions of grandeur; retention uncovers more compromises than design.
🎃 Trick or tRNA? Pumpkins and bacterial tRNAs share a little isoprenoid chemistry!
🍂 This autumn: tRNA modifications tune decoding, rRNA modifications cooperate, and ribosomes prepare to hibernate.😴
More in our new sept/oct RNA Modifications Newsletter!
rnamodifupdates.substack.com/p/rna-modifi...
🍂 This autumn: tRNA modifications tune decoding, rRNA modifications cooperate, and ribosomes prepare to hibernate.😴
More in our new sept/oct RNA Modifications Newsletter!
rnamodifupdates.substack.com/p/rna-modifi...
🍂 🎃 RNA Modifications Newsletter - Autumn 2026 edition. September-October 2026
issue #14
rnamodifupdates.substack.com
November 1, 2026 at 12:33 PM
🎃 Trick or tRNA? Pumpkins and bacterial tRNAs share a little isoprenoid chemistry!
🍂 This autumn: tRNA modifications tune decoding, rRNA modifications cooperate, and ribosomes prepare to hibernate.😴
More in our new sept/oct RNA Modifications Newsletter!
rnamodifupdates.substack.com/p/rna-modifi...
🍂 This autumn: tRNA modifications tune decoding, rRNA modifications cooperate, and ribosomes prepare to hibernate.😴
More in our new sept/oct RNA Modifications Newsletter!
rnamodifupdates.substack.com/p/rna-modifi...
Which Indian-born scientist shared the 2009 Nobel Prize in Chemistry for work on ribosomes?
Play free: https://brainfart.prasadkhake.com/q?id=nobel72&source=bs
#NobelPrize #Trivia
Play free: https://brainfart.prasadkhake.com/q?id=nobel72&source=bs
#NobelPrize #Trivia
October 30, 2026 at 11:01 PM
Which Indian-born scientist shared the 2009 Nobel Prize in Chemistry for work on ribosomes?
Play free: https://brainfart.prasadkhake.com/q?id=nobel72&source=bs
#NobelPrize #Trivia
Play free: https://brainfart.prasadkhake.com/q?id=nobel72&source=bs
#NobelPrize #Trivia
How does a ribosome get built inside a human cell?
EMBL scientists have now visualised its assembly pathway in intact cells for the first time. Here's how they did it👇 www.embl.org/news/science...
EMBL scientists have now visualised its assembly pathway in intact cells for the first time. Here's how they did it👇 www.embl.org/news/science...
Watching ribosomes in the making all at once | EMBL
A combination of cryogenic light and electron tomography visualises ribosome assembly pathways inside intact human cells, providing subnanometer-resolution pre-ribosome structures, while also revealin...
www.embl.org
October 30, 2026 at 9:45 AM
How does a ribosome get built inside a human cell?
EMBL scientists have now visualised its assembly pathway in intact cells for the first time. Here's how they did it👇 www.embl.org/news/science...
EMBL scientists have now visualised its assembly pathway in intact cells for the first time. Here's how they did it👇 www.embl.org/news/science...
Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming https://www.biorxiv.org/content/10.64898/2026.10.28.762373v1
October 29, 2026 at 9:49 PM
Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming https://www.biorxiv.org/content/10.64898/2026.10.28.762373v1
Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming https://www.biorxiv.org/content/10.64898/2026.10.28.762373v1
October 29, 2026 at 9:49 PM
Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming https://www.biorxiv.org/content/10.64898/2026.10.28.762373v1
Check out the paper for more details! Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1 www.biorxiv.org/content/10.6...
Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1
SARS-CoV-2 nonstructural protein 1 (Nsp1) is a conserved viral factor that potently silences host transcripts by binding ribosomes. Yet how it acts at the level of individual mRNAs remains unclear, wi...
www.biorxiv.org
October 30, 2026 at 10:28 PM
Check out the paper for more details! Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1 www.biorxiv.org/content/10.6...
Take a look at the most recent issues with articles on #diabetes #mitochondria #cancer #ribosomes #muscle. You can see the full list at biomed.news/reports.
If you don’t see you research topic comment below with your topic to find out how to get your this on our platform
If you don’t see you research topic comment below with your topic to find out how to get your this on our platform
October 29, 2026 at 11:48 AM
Take a look at the most recent issues with articles on #diabetes #mitochondria #cancer #ribosomes #muscle. You can see the full list at biomed.news/reports.
If you don’t see you research topic comment below with your topic to find out how to get your this on our platform
If you don’t see you research topic comment below with your topic to find out how to get your this on our platform
JCVI-syn3.0, the minimal bacterial cell built in 2016, runs on 473 genes. Its builders say 149 of them do jobs nobody can name. The synthetic cell posted this July still borrows its ribosomes. We read all three against Frankenstein: www.freeastroscience.com/can-scientis...
Can Scientists Create Life? What Frankenstein Asks
This Halloween, see how close labs are to building a living cell, why the 2026 SpudCell still borrows its ribosomes, and what Frankenstein warns us.
www.freeastroscience.com
October 31, 2026 at 5:05 PM
JCVI-syn3.0, the minimal bacterial cell built in 2016, runs on 473 genes. Its builders say 149 of them do jobs nobody can name. The synthetic cell posted this July still borrows its ribosomes. We read all three against Frankenstein: www.freeastroscience.com/can-scientis...
I'd call them and tell them their ribosomes suck. Is this what passes for amino acids on your planet?
October 26, 2026 at 8:39 PM
I'd call them and tell them their ribosomes suck. Is this what passes for amino acids on your planet?
Ribosomes link amino acids into a chain, but proteins headed out of the cell get finished inside the rough ER. The chain threads in as it grows, then gets folded, tagged with sugars and checked for mistakes. #biology
October 28, 2026 at 6:05 PM
Ribosomes link amino acids into a chain, but proteins headed out of the cell get finished inside the rough ER. The chain threads in as it grows, then gets folded, tagged with sugars and checked for mistakes. #biology
is ribosomes realistic for rainbow hair riverside florida?
October 28, 2026 at 12:54 AM
is ribosomes realistic for rainbow hair riverside florida?
Protein synthesis and folding in a cell run like an automated production line. Under stress it jams: ribosomes collide, splicing goes wrong, the ER chokes on unfolded protein. My lab at NTU asks what keeps protein homeostasis steady through the storm.
October 30, 2026 at 4:26 PM
Protein synthesis and folding in a cell run like an automated production line. Under stress it jams: ribosomes collide, splicing goes wrong, the ER chokes on unfolded protein. My lab at NTU asks what keeps protein homeostasis steady through the storm.
dspace.mit.edu/entities/pub... for example. You can find many examples searching for automated protein synthesis as just one use case
Synthesis of proteins by automated flow chemistry
Ribosomes can produce proteins in minutes and are largely constrained to proteinogenic amino acids. Here, we report highly efficient chemistry matched with an automated fast-flow instrument for the di...
dspace.mit.edu
October 28, 2026 at 1:02 PM
dspace.mit.edu/entities/pub... for example. You can find many examples searching for automated protein synthesis as just one use case
CRV Science Labs ⚗️
🧬 Exploratory Comparative Genomics of Asgard Archaea (Heimdallarchaeia): Eukaryotic Signature Proteins, Regulatory Markers, and Ribosomal Expansion Segments — How closely do the cellular machinery, transcription…
https://crvscience.com/labs/discoveries/asgard-esp-machinery-tier1
🧬 Exploratory Comparative Genomics of Asgard Archaea (Heimdallarchaeia): Eukaryotic Signature Proteins, Regulatory Markers, and Ribosomal Expansion Segments — How closely do the cellular machinery, transcription…
https://crvscience.com/labs/discoveries/asgard-esp-machinery-tier1
CRV Science Labs ⚗️
🧬 Exploratory Comparative Genomics of Asgard Archaea (Heimdallarchaeia): Eukaryotic Signature Proteins, Regulatory Markers, and Ribosomal Expansion Segments — How closely do the cellular machinery, transcriptional regulators, and ribosomes of Asgard archaea (Candidatus Heimdalla…
crvscience.com
November 3, 2026 at 5:10 AM
CRV Science Labs ⚗️
🧬 Exploratory Comparative Genomics of Asgard Archaea (Heimdallarchaeia): Eukaryotic Signature Proteins, Regulatory Markers, and Ribosomal Expansion Segments — How closely do the cellular machinery, transcription…
https://crvscience.com/labs/discoveries/asgard-esp-machinery-tier1
🧬 Exploratory Comparative Genomics of Asgard Archaea (Heimdallarchaeia): Eukaryotic Signature Proteins, Regulatory Markers, and Ribosomal Expansion Segments — How closely do the cellular machinery, transcription…
https://crvscience.com/labs/discoveries/asgard-esp-machinery-tier1
Moderna's mRNA Flu vaccine and ribosomes are having a party.
October 24, 2026 at 9:25 PM
Moderna's mRNA Flu vaccine and ribosomes are having a party.
Someone alive today will design the chip inside our first probe to another star
I think it will look more like a cell than a laptop
x.com/mruspace/sta...
I think it will look more like a cell than a laptop
x.com/mruspace/sta...
Mru Aerospace (@mruspace) on X
One cell holds millions of ribosomes, all running the same tiny program. Lose a few and nothing notices.
A probe's chip could work the same way: many copies of one small program, so losing part of th...
x.com
October 30, 2026 at 9:54 AM
Someone alive today will design the chip inside our first probe to another star
I think it will look more like a cell than a laptop
x.com/mruspace/sta...
I think it will look more like a cell than a laptop
x.com/mruspace/sta...