Very interested in trying… just before our advanced cryosparc course!
Agentic cryo-EM structure determination with CryoPilot www.biorxiv.org/content/10.64898/2026.10.29.762908v1 #cryoem
November 2, 2026 at 7:54 AM
Very interested in trying… just before our advanced cryosparc course!
🔬 Preferred orientation is a familiar challenge in #cryoEM, but can smarter data processing help overcome it?
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
October 29, 2026 at 12:02 PM
🔬 Preferred orientation is a familiar challenge in #cryoEM, but can smarter data processing help overcome it?
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
While developing Automated Workflow v2 in #CryoSPARC, we explored how different particle picking and curation strategies could help address this challenge. 👉 cryosparc.com/blog/automat...
In the latest CryoSPARC Blog we walk through the key processing strategies to handle preferred orientation in the tested #EMPIAR datasets. These steps resulted in a smaller, more balanced particle stack, showing that retaining more particles doesn't necessarily translate into a better reconstruction
October 29, 2026 at 12:03 PM
In the latest CryoSPARC Blog we walk through the key processing strategies to handle preferred orientation in the tested #EMPIAR datasets. These steps resulted in a smaller, more balanced particle stack, showing that retaining more particles doesn't necessarily translate into a better reconstruction
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
www.biorxiv.org
October 31, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
Are you using a software for one particular part of your pipeline and jumping through hoops to port it into #Relion or #CryoSparc? Let me know! Let's wrap it into a streamlined Relion based pipeline. #IsoNet2 and #DeepETPicker already integrated so end-to-end tomography is ready. Picking and all
#TeamTomo, if you're not using #Relion for #cryoET aka #tomography maybe you should be
AND! if you want more flexibility in your pipeline and a way to schedule jobs so you can work faster, now you can
#opensource
github.com/schiracha/RE...
AND! if you want more flexibility in your pipeline and a way to schedule jobs so you can work faster, now you can
#opensource
github.com/schiracha/RE...
October 26, 2026 at 10:55 PM
Are you using a software for one particular part of your pipeline and jumping through hoops to port it into #Relion or #CryoSparc? Let me know! Let's wrap it into a streamlined Relion based pipeline. #IsoNet2 and #DeepETPicker already integrated so end-to-end tomography is ready. Picking and all
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
www.biorxiv.org
October 26, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #OpenScience
💡 When working with terabytes of #cryoEM data, on-the-fly processing can be a game changer!
Beyond saving time, #CryoSPARC Live helps researchers make informed decisions throughout data collection and processing 👉 www.youtube.com/watch?v=iKfv...
Beyond saving time, #CryoSPARC Live helps researchers make informed decisions throughout data collection and processing 👉 www.youtube.com/watch?v=iKfv...
CryoSPARC Live™: The advantages of on-the-fly processing in cryo-EM
YouTube video by Structura Biotechnology Inc.
www.youtube.com
October 21, 2026 at 11:59 AM
💡 When working with terabytes of #cryoEM data, on-the-fly processing can be a game changer!
Beyond saving time, #CryoSPARC Live helps researchers make informed decisions throughout data collection and processing 👉 www.youtube.com/watch?v=iKfv...
Beyond saving time, #CryoSPARC Live helps researchers make informed decisions throughout data collection and processing 👉 www.youtube.com/watch?v=iKfv...
By processing data as it is collected, CryoSPARC Live can help you:
🔹 Evaluate data quality and adjust acquisition parameters when needed.
🔹 Estimate how much #cryo-EM data to collect.
🔹 Run preprocessing alongside data transfer, while starting particle picking and curation on the fly.
🔹 Evaluate data quality and adjust acquisition parameters when needed.
🔹 Estimate how much #cryo-EM data to collect.
🔹 Run preprocessing alongside data transfer, while starting particle picking and curation on the fly.
October 21, 2026 at 11:59 AM
By processing data as it is collected, CryoSPARC Live can help you:
🔹 Evaluate data quality and adjust acquisition parameters when needed.
🔹 Estimate how much #cryo-EM data to collect.
🔹 Run preprocessing alongside data transfer, while starting particle picking and curation on the fly.
🔹 Evaluate data quality and adjust acquisition parameters when needed.
🔹 Estimate how much #cryo-EM data to collect.
🔹 Run preprocessing alongside data transfer, while starting particle picking and curation on the fly.
🎥 In this video, we compare conventional batch-based processing with the streamlined approach offered by CryoSPARC Live, explore its advantages, and walk through setting up a Live session, from preprocessing, particle picking, 2D classification and particle curation.
October 21, 2026 at 11:59 AM
🎥 In this video, we compare conventional batch-based processing with the streamlined approach offered by CryoSPARC Live, explore its advantages, and walk through setting up a Live session, from preprocessing, particle picking, 2D classification and particle curation.
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
www.biorxiv.org
October 18, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
Our paper on the #CsMT workflow to reconstruct microtubules in #Cryosparc is now online. Fantastic work from several undergrads in the lab and Asuva Arin, and fantastic collaboration with the Cianfrocco lab.
Please try it out; it is simple and quick. #OpenScience
doi.org/10.1107/S205...
Please try it out; it is simple and quick. #OpenScience
doi.org/10.1107/S205...
CsMT: a robust and streamlined CryoSPARC workflow for cryo-EM reconstruction of microtubules
CsMT is a robust and streamlined CryoSPARC-based workflow to reconstruct undecorated and decorated microtubule maps. By unifying the processing pipeline into a single user-friendly tool, it makes high...
doi.org
October 14, 2026 at 5:30 PM
Our paper on the #CsMT workflow to reconstruct microtubules in #Cryosparc is now online. Fantastic work from several undergrads in the lab and Asuva Arin, and fantastic collaboration with the Cianfrocco lab.
Please try it out; it is simple and quick. #OpenScience
doi.org/10.1107/S205...
Please try it out; it is simple and quick. #OpenScience
doi.org/10.1107/S205...
Connecting image formation to data processing provides valuable context for interpreting your data, identifying potential artifacts, and understanding the principles behind downstream processing. All this and more, in the #CryoSPARC Guide 👉 guide.cryosparc.com/cryo-em-foun...
Image Formation | CryoSPARC Guide
guide.cryosparc.com
October 14, 2026 at 12:01 PM
Connecting image formation to data processing provides valuable context for interpreting your data, identifying potential artifacts, and understanding the principles behind downstream processing. All this and more, in the #CryoSPARC Guide 👉 guide.cryosparc.com/cryo-em-foun...
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
www.biorxiv.org
October 9, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
🧬 In honor of Breast Cancer Awareness Month, we’re sharing a structural biology story about NBCn1, a plasma membrane transporter that helps breast cancer cells regulate their intracellular pH and survive in an acidic tumor microenvironment.
Read more on the #CryoSPARC Blog! 👉 bit.ly/4jbfn88
Read more on the #CryoSPARC Blog! 👉 bit.ly/4jbfn88
October 8, 2026 at 12:10 PM
🧬 In honor of Breast Cancer Awareness Month, we’re sharing a structural biology story about NBCn1, a plasma membrane transporter that helps breast cancer cells regulate their intracellular pH and survive in an acidic tumor microenvironment.
Read more on the #CryoSPARC Blog! 👉 bit.ly/4jbfn88
Read more on the #CryoSPARC Blog! 👉 bit.ly/4jbfn88
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
Cryo-tides: synthetic peptides for cryo-EM grid preparation of multi-subunit protein complexes sensitive to the air-water interface
www.biorxiv.org
October 8, 2026 at 12:00 PM
Authors published a paper in Biorxiv, they used cryoSPARC in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
🇨🇦 Last week, we wrapped up “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with #CryoSPARC” in Toronto!
Thank you to all the #cryoEM scientists who joined us, and to @sickkidsto.bsky.social for another great collaboration!
We already look forward to the next workshop! Stay tuned!
Thank you to all the #cryoEM scientists who joined us, and to @sickkidsto.bsky.social for another great collaboration!
We already look forward to the next workshop! Stay tuned!
September 29, 2026 at 12:05 PM
🇨🇦 Last week, we wrapped up “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with #CryoSPARC” in Toronto!
Thank you to all the #cryoEM scientists who joined us, and to @sickkidsto.bsky.social for another great collaboration!
We already look forward to the next workshop! Stay tuned!
Thank you to all the #cryoEM scientists who joined us, and to @sickkidsto.bsky.social for another great collaboration!
We already look forward to the next workshop! Stay tuned!
🇨🇦 Today we kicked off our hands-on workshop, “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with CryoSPARC,” in collaboration with The Hospital for Sick Children @sickkidsto.bsky.social!
Excited for two days of diving deeper into advanced #cryoEM data processing with #CryoSPARC. 🔬
Excited for two days of diving deeper into advanced #cryoEM data processing with #CryoSPARC. 🔬
September 24, 2026 at 4:09 PM
🇨🇦 Today we kicked off our hands-on workshop, “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with CryoSPARC,” in collaboration with The Hospital for Sick Children @sickkidsto.bsky.social!
Excited for two days of diving deeper into advanced #cryoEM data processing with #CryoSPARC. 🔬
Excited for two days of diving deeper into advanced #cryoEM data processing with #CryoSPARC. 🔬
The @structurabio.bsky.social @sickkidsto.bsky.social CryoSPARC workshop is underway!
September 24, 2026 at 3:01 PM
The @structurabio.bsky.social @sickkidsto.bsky.social CryoSPARC workshop is underway!
It heavily integrates with @globusorg.bsky.social and #CryoSPARC @structurabio.bsky.social to allow for a streamlined user/facility experience.
September 24, 2026 at 1:55 AM
It heavily integrates with @globusorg.bsky.social and #CryoSPARC @structurabio.bsky.social to allow for a streamlined user/facility experience.
🔎 A classic #cryoEM particle curation conundrum: 2D or 3D classification?
"Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views.
Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0
"Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views.
Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0
September 23, 2026 at 12:04 PM
🔎 A classic #cryoEM particle curation conundrum: 2D or 3D classification?
"Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views.
Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0
"Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views.
Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0
🚀 Register now for the 2026 Stanford-SLAC CryoEM Center (S2C2) Data Processing Workshop, December 9-11!
We’re excited to contribute as #CryoSPARC instructors to this hybrid workshop, together with instructors from CryoDRGN, EMAN2 and AreTomo!
More info and registration 👉 bit.ly/4gXbnXd
We’re excited to contribute as #CryoSPARC instructors to this hybrid workshop, together with instructors from CryoDRGN, EMAN2 and AreTomo!
More info and registration 👉 bit.ly/4gXbnXd
September 16, 2026 at 12:03 PM
🚀 Register now for the 2026 Stanford-SLAC CryoEM Center (S2C2) Data Processing Workshop, December 9-11!
We’re excited to contribute as #CryoSPARC instructors to this hybrid workshop, together with instructors from CryoDRGN, EMAN2 and AreTomo!
More info and registration 👉 bit.ly/4gXbnXd
We’re excited to contribute as #CryoSPARC instructors to this hybrid workshop, together with instructors from CryoDRGN, EMAN2 and AreTomo!
More info and registration 👉 bit.ly/4gXbnXd
💡 The idea is simple: getting to know your data is often the shortcut to more efficient particle picking. In our latest #CryoSPARC blog post, we cover how to speed up #cryoEM data processing through efficient early curation of your dataset. 👉 cryosparc.com/blog/curatio...
September 10, 2026 at 12:00 PM
💡 The idea is simple: getting to know your data is often the shortcut to more efficient particle picking. In our latest #CryoSPARC blog post, we cover how to speed up #cryoEM data processing through efficient early curation of your dataset. 👉 cryosparc.com/blog/curatio...
🚀 Next week we will be at the 2026 New England #Cryo-EM Symposium at MIT, showcasing recent #CryoSPARC developments.
If you're attending, we'd love to connect! cryoem.mit.edu/2026-ne-cryo...
If you're attending, we'd love to connect! cryoem.mit.edu/2026-ne-cryo...
September 3, 2026 at 12:01 PM
🚀 Next week we will be at the 2026 New England #Cryo-EM Symposium at MIT, showcasing recent #CryoSPARC developments.
If you're attending, we'd love to connect! cryoem.mit.edu/2026-ne-cryo...
If you're attending, we'd love to connect! cryoem.mit.edu/2026-ne-cryo...
💊 The Pain Paradox: Activating TRPV1 to Silence Its Response - Researchers leveraged rational drug design, functional experiments, and #cryoEM to characterize a new capsaicin-inspired TRPV1 agonist with prolonged analgesic effects.
Read more in the #CryoSPARC Blog 👉 cryosparc.com/blog/trpv1-m...
Read more in the #CryoSPARC Blog 👉 cryosparc.com/blog/trpv1-m...
September 1, 2026 at 12:00 PM
💊 The Pain Paradox: Activating TRPV1 to Silence Its Response - Researchers leveraged rational drug design, functional experiments, and #cryoEM to characterize a new capsaicin-inspired TRPV1 agonist with prolonged analgesic effects.
Read more in the #CryoSPARC Blog 👉 cryosparc.com/blog/trpv1-m...
Read more in the #CryoSPARC Blog 👉 cryosparc.com/blog/trpv1-m...
Here is a highlight of our work on TRPV1 agonist MSP20, which binds to the vanilloid site, desensitizes TRPV1, and shows the potential of a long-lasting analgesic with neuroprotective effects. cryosparc.com/blog/trpv1-m...
The Pain Paradox: Activating TRPV1 to Silence Its Response | CryoSPARC
Combining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.
cryosparc.com
September 1, 2026 at 4:12 PM
Here is a highlight of our work on TRPV1 agonist MSP20, which binds to the vanilloid site, desensitizes TRPV1, and shows the potential of a long-lasting analgesic with neuroprotective effects. cryosparc.com/blog/trpv1-m...