Aksentijevic Lab
@dunjaaks.bsky.social
Cardiac metabolism research group 🫀⚡️
William Harvey Research Institute
Queen Mary University of London
William Harvey Research Institute
Queen Mary University of London
I couldn’t have thought of a more fitting room to discuss my research on metabolism in heart failure on World Heart Day, in a room with mitochondria literally on the roof! 🫀🧬
September 29, 2026 at 9:22 PM
I couldn’t have thought of a more fitting room to discuss my research on metabolism in heart failure on World Heart Day, in a room with mitochondria literally on the roof! 🫀🧬
Reposted by Aksentijevic Lab
🫀🔬 New research led by Prof @dunjaaks.bsky.social at @qmul.bsky.social finds excess sodium builds up in heart cells before structural heart disease appears in chronic kidney disease, and that the drug sotagliflozin can rapidly reverse it.
🔗 www.qmul.ac.uk/whri/latest-...
🔗 www.qmul.ac.uk/whri/latest-...
August 19, 2026 at 10:40 AM
🫀🔬 New research led by Prof @dunjaaks.bsky.social at @qmul.bsky.social finds excess sodium builds up in heart cells before structural heart disease appears in chronic kidney disease, and that the drug sotagliflozin can rapidly reverse it.
🔗 www.qmul.ac.uk/whri/latest-...
🔗 www.qmul.ac.uk/whri/latest-...
New in Cardiovascular Research: 🫀 Na⁺ overload is an early driver of uraemic cardiomyopathy. Dual #SGLT1/2 inhibition normalises Na⁺ and restores cardiac metabolic homeostasis revealing a shared mechanism of cardioprotection across #CKD and #T2D. academic.oup.com/cardiovascre...
Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy
AbstractAims. Chronic kidney disease (CKD) is associated with uraemic cardiomyopathy characterised by early metabolic dysfunction. Elevated myocardial intr
academic.oup.com
August 11, 2026 at 6:36 PM
New in Cardiovascular Research: 🫀 Na⁺ overload is an early driver of uraemic cardiomyopathy. Dual #SGLT1/2 inhibition normalises Na⁺ and restores cardiac metabolic homeostasis revealing a shared mechanism of cardioprotection across #CKD and #T2D. academic.oup.com/cardiovascre...
Can AI, omics, and organoids replace animal models in cardiovascular research? In our EU_METAHEART position paper in @Nature Reviews Cardiology we outline why animal models remain essential in cardiovascular research complementing emerging technologies. Read more:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In the era of AI, omics and organoids, animal models are still needed in cardiovascular research - Nature Reviews Cardiology
As artificial intelligence (AI), multiomics and human organoids reshape cardiovascular research, calls to replace animal models are accelerating. We argue that understanding complex, multiorgan cardio...
www.nature.com
August 5, 2026 at 10:23 PM
Can AI, omics, and organoids replace animal models in cardiovascular research? In our EU_METAHEART position paper in @Nature Reviews Cardiology we outline why animal models remain essential in cardiovascular research complementing emerging technologies. Read more:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our latest paper🫀
We show that dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and reshapes cardiac metabolism in type 2 diabetes.
Read it here 👉🏻 www.nature.com/articles/s44...
We show that dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and reshapes cardiac metabolism in type 2 diabetes.
Read it here 👉🏻 www.nature.com/articles/s44...
Dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and metabolism in type 2 diabetic mice - npj Metabolic Health and Disease
npj Metabolic Health and Disease - Dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and metabolism in type 2 diabetic mice
www.nature.com
August 5, 2026 at 10:14 PM
Excited to share our latest paper🫀
We show that dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and reshapes cardiac metabolism in type 2 diabetes.
Read it here 👉🏻 www.nature.com/articles/s44...
We show that dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and reshapes cardiac metabolism in type 2 diabetes.
Read it here 👉🏻 www.nature.com/articles/s44...
To the world its a game.
To all of us its coming together after unimaginable loss ..& still standing. #inat
Thank you 🇧🇦🫶⚽️ #proudBosnian #dreambigdreamBiH FIFA World Cup 2026™ - Canada, Mexico and the United States
To all of us its coming together after unimaginable loss ..& still standing. #inat
Thank you 🇧🇦🫶⚽️ #proudBosnian #dreambigdreamBiH FIFA World Cup 2026™ - Canada, Mexico and the United States
July 2, 2026 at 8:47 AM
To the world its a game.
To all of us its coming together after unimaginable loss ..& still standing. #inat
Thank you 🇧🇦🫶⚽️ #proudBosnian #dreambigdreamBiH FIFA World Cup 2026™ - Canada, Mexico and the United States
To all of us its coming together after unimaginable loss ..& still standing. #inat
Thank you 🇧🇦🫶⚽️ #proudBosnian #dreambigdreamBiH FIFA World Cup 2026™ - Canada, Mexico and the United States
The ISHR European Section Meeting is currently underway in Birmingham.It is always a pleasure to reconnect with colleagues from across Europe and beyond. A fantastic start to the day watching Mike Murphy deliver the Keith Reimer Distinguished Lecture. @mitoredox.bsky.social
June 24, 2026 at 3:59 PM
The ISHR European Section Meeting is currently underway in Birmingham.It is always a pleasure to reconnect with colleagues from across Europe and beyond. A fantastic start to the day watching Mike Murphy deliver the Keith Reimer Distinguished Lecture. @mitoredox.bsky.social
Idemo Bosno! 🇧🇦🫀🫶🍀⚽️ @fifaclubworldcup.bsky.social
June 12, 2026 at 11:16 AM
Idemo Bosno! 🇧🇦🫀🫶🍀⚽️ @fifaclubworldcup.bsky.social
Honoured to be invited by the Rector of the University of Sarajevo to speak in my homeland alongside Luke O’Neill.Looking forward to discussions on science, research, and innovation with students and colleagues in🇧🇦
June 4, 2026 at 10:59 AM
Honoured to be invited by the Rector of the University of Sarajevo to speak in my homeland alongside Luke O’Neill.Looking forward to discussions on science, research, and innovation with students and colleagues in🇧🇦
Nature’s extremes can teach us so much about human biology. By studying bats, animals with extraordinary metabolic demands, we can gain new insights into cardiovascular health and disease. Our latest paper is out👉🏻🦇 journals.plos.org/plosone/arti...
Metabolomics-constrained modelling reveals dominant oxidative metabolism in the Egyptian fruit bat myocardium
Aim The present study aimed to elucidate which pathways contribute to cardiometabolic adaptation in Egyptian fruit bats. Methods Utilising cardiac tissues from Egyptian fruit bats (Rousettus aegypti...
journals.plos.org
June 2, 2026 at 8:51 PM
Nature’s extremes can teach us so much about human biology. By studying bats, animals with extraordinary metabolic demands, we can gain new insights into cardiovascular health and disease. Our latest paper is out👉🏻🦇 journals.plos.org/plosone/arti...
Two fantastic days in Manchester at #BSCR and #BCS meetings, combining science, networking, and Trustee duties. So proud of my group: Dr Ivana Iveljic (cardiooncology), Sanushe Dambure (CKD HFpEF genetics) Megan Young (NLRP3 inflammasome in HFpEF). Outstanding work from all! 👏🔬❤️
June 2, 2026 at 8:43 PM
Join us for @EU_METAHEART WG4 Webinar! 🫀
Tomorrow 13.00 London Time, 14.00 Berlin Time
Link 👉🏻 ukw-de.zoom.us/j/9107037780...
Tomorrow 13.00 London Time, 14.00 Berlin Time
Link 👉🏻 ukw-de.zoom.us/j/9107037780...
May 18, 2026 at 8:44 PM
Join us for @EU_METAHEART WG4 Webinar! 🫀
Tomorrow 13.00 London Time, 14.00 Berlin Time
Link 👉🏻 ukw-de.zoom.us/j/9107037780...
Tomorrow 13.00 London Time, 14.00 Berlin Time
Link 👉🏻 ukw-de.zoom.us/j/9107037780...
Join us for the EU_METAHEART WG4 Webinar! “From Omics to Mechanisms: Mechano-Energetic Uncoupling in Heart Failure”📆22 April 🕚12:00 (London) / 13:00 (Berlin) Hear from leading experts in cardiovascular research on proteomics, redox biology & cardiometabolic disease
April 21, 2026 at 7:06 PM
Join us for the EU_METAHEART WG4 Webinar! “From Omics to Mechanisms: Mechano-Energetic Uncoupling in Heart Failure”📆22 April 🕚12:00 (London) / 13:00 (Berlin) Hear from leading experts in cardiovascular research on proteomics, redox biology & cardiometabolic disease
Some mornings in the lab are just better than others. 💙💛🇧🇦 🥼👩🏻🔬🧪
April 1, 2026 at 10:22 AM
Some mornings in the lab are just better than others. 💙💛🇧🇦 🥼👩🏻🔬🧪
Grateful for the opportunity to contribute to the new scientific statement from the European Society of Cardiology on metabolic dysfunction and cardiovascular disease.A great collaborative effort across ESC Basic Science Council and Working Groups. #ESC
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities: A scientific statement of the ESC Council on Basic Cardiovascular Science, the ESC Working Group on Atherosclerosis...
Abstract. Metabolic disorders such as obesity, type 2 diabetes, and dyslipidaemia are major drivers of cardiovascular risk and have reached epidemic levels
academic.oup.com
March 9, 2026 at 7:46 PM
Grateful for the opportunity to contribute to the new scientific statement from the European Society of Cardiology on metabolic dysfunction and cardiovascular disease.A great collaborative effort across ESC Basic Science Council and Working Groups. #ESC
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Thank you @qmulfmd.bsky.social for focus on our #immunometabolism study published earlier this week in @natureportfolio.nature.com Nature Cardiovascular Research 🫀
www.qmul.ac.uk/media/news/2...
www.qmul.ac.uk/media/news/2...
Drug that targets immune cells shows potential as new treatment for diabetic heart disease
www.qmul.ac.uk
February 27, 2026 at 6:29 PM
Thank you @qmulfmd.bsky.social for focus on our #immunometabolism study published earlier this week in @natureportfolio.nature.com Nature Cardiovascular Research 🫀
www.qmul.ac.uk/media/news/2...
www.qmul.ac.uk/media/news/2...
Excited to share our latest paper in Nature Cardiovascular Research showing #diabetic #cardiomyopathy is driven by aberrant #immunometabolism Enhancing Treg migratory capacity restores immune balance and improves🫀dysfunction a promising new therapeutic direction in T2D
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research
Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.
www.nature.com
February 24, 2026 at 1:54 PM
Excited to share our latest paper in Nature Cardiovascular Research showing #diabetic #cardiomyopathy is driven by aberrant #immunometabolism Enhancing Treg migratory capacity restores immune balance and improves🫀dysfunction a promising new therapeutic direction in T2D
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Aksentijevic Lab
Congrats to Dunja on her latest paper just out in Nature Cardiovascular Research!
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research
Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.
doi.org
February 23, 2026 at 3:20 PM
Congrats to Dunja on her latest paper just out in Nature Cardiovascular Research!
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Honoured to be invited by French national TV to discuss our latest discoveries on naked mole rat cardiac metabolic and physiological resilience. Proud to see our published work featured alongside international leaders in the field.
www.tf1.fr/tf1/jt-20h/v...
www.tf1.fr/tf1/jt-20h/v...
Jamais malade : les secrets du rat-taupe nu - Journal de 20 heures | TF1+
[VIDÉO] Extrait en streaming sur TF1+ ▶️ 5m38s - Le rat-taupe nu passionne les biologistes. Originaire de la corne de l'Afrique, ce rongeur sans poils est l'un des animaux les plus étrangers au monde....
www.tf1.fr
February 22, 2026 at 8:55 PM
Honoured to be invited by French national TV to discuss our latest discoveries on naked mole rat cardiac metabolic and physiological resilience. Proud to see our published work featured alongside international leaders in the field.
www.tf1.fr/tf1/jt-20h/v...
www.tf1.fr/tf1/jt-20h/v...
If we want a more equitable and informed world, we must continue to promote literacy, champion education, and actively support women and girls in science not as an option, but as a responsibility.👩🏻🔬 #WomenInScienceDay
February 12, 2026 at 9:12 AM
If we want a more equitable and informed world, we must continue to promote literacy, champion education, and actively support women and girls in science not as an option, but as a responsibility.👩🏻🔬 #WomenInScienceDay
An incredible morning at the @bloomberglp.bsky.social HQ in the heart of the City of London with Natasha Davidov
Interviewed for the @bloomberglp.bsky.social _adria Leaders Programme-from women in research to naked mole-rat longevity and mending broken hearts.
Interviewed for the @bloomberglp.bsky.social _adria Leaders Programme-from women in research to naked mole-rat longevity and mending broken hearts.
December 18, 2025 at 6:21 PM
An incredible morning at the @bloomberglp.bsky.social HQ in the heart of the City of London with Natasha Davidov
Interviewed for the @bloomberglp.bsky.social _adria Leaders Programme-from women in research to naked mole-rat longevity and mending broken hearts.
Interviewed for the @bloomberglp.bsky.social _adria Leaders Programme-from women in research to naked mole-rat longevity and mending broken hearts.
The best part of being an academic, Director of Education, and Programme Lead? Watching my students and mentees cross the stage and graduate. Their success is the real reward. 🎓
December 17, 2025 at 10:48 PM
The best part of being an academic, Director of Education, and Programme Lead? Watching my students and mentees cross the stage and graduate. Their success is the real reward. 🎓
Grateful for the opportunity to contribute to this international study🇦🇺🇬🇧: “Liraglutide-Driven Weight Loss Modulates Placental Remodeling in Obese Pregnancies in Mice”. Despite pre-conception weight loss with liraglutide, controlled diet led to better placental health. www.mdpi.com/3639816
www.mdpi.com
December 17, 2025 at 10:14 PM
Grateful for the opportunity to contribute to this international study🇦🇺🇬🇧: “Liraglutide-Driven Weight Loss Modulates Placental Remodeling in Obese Pregnancies in Mice”. Despite pre-conception weight loss with liraglutide, controlled diet led to better placental health. www.mdpi.com/3639816
Huge congratulations, Jan Miljkovic and Mike Murphy @mitoredox.bsky.social on your Nature Communications study out today! @natcomms.nature.com
Grateful for the opportunity to collaborate and contribute to the team behind this important work. @qmulwhri.bsky.social
www.nature.com/articles/s41...
Grateful for the opportunity to collaborate and contribute to the team behind this important work. @qmulwhri.bsky.social
www.nature.com/articles/s41...
Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples - Nature Communications
Hydrogen sulfide (H2S) reversibly modifies low molecular weight and protein thiols to form persulfides (RSS−) and polysulfides (RS(S)nS−) for antioxidant defence and regulation of activity. Here, the ...
www.nature.com
December 10, 2025 at 5:42 PM
Huge congratulations, Jan Miljkovic and Mike Murphy @mitoredox.bsky.social on your Nature Communications study out today! @natcomms.nature.com
Grateful for the opportunity to collaborate and contribute to the team behind this important work. @qmulwhri.bsky.social
www.nature.com/articles/s41...
Grateful for the opportunity to collaborate and contribute to the team behind this important work. @qmulwhri.bsky.social
www.nature.com/articles/s41...