Frédéric Blanc
@fredericblanc.bsky.social
Professor of Geriatrics, Geriatrician and Neurologist
Disease with Lewy bodies
Alzheimer's disease
Lewy body disease
University of Strasbourg
University Hospital of Strasbourg
Disease with Lewy bodies
Alzheimer's disease
Lewy body disease
University of Strasbourg
University Hospital of Strasbourg
α-synuclein clearance and propagation are mediated by glymphatic function and aquaporin-4 mis-localization observed in the presence of human synucleinopathy may contribute to the development and propagation of Lewy body pathology
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation
Braun et al. report that human synucleinopathy is associated with mislocalization of the astroglial water channel aquaporin-4 and glymphatic clearance of a
academic.oup.com
September 10, 2026 at 2:21 PM
α-synuclein clearance and propagation are mediated by glymphatic function and aquaporin-4 mis-localization observed in the presence of human synucleinopathy may contribute to the development and propagation of Lewy body pathology
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
25% of malnutrition in dementia with Lewy bodies.
High-risk malnutration if greater cognitive, depressive, autonomic, and sleep-related burden.
aspenjournals.onlinelibrary.wiley.com/doi/10.1002/...
High-risk malnutration if greater cognitive, depressive, autonomic, and sleep-related burden.
aspenjournals.onlinelibrary.wiley.com/doi/10.1002/...
Malnutrition and clinical correlates in dementia with Lewy bodies: A retrospective cross‐sectional study
Graphical summary of clinical correlates of malnutrition in patients with dementia with Lewy bodies (DLB). Sleeping brain (with cap): represents sleep-related symptoms, including REM sleep behavior ...
aspenjournals.onlinelibrary.wiley.com
August 13, 2026 at 8:27 AM
25% of malnutrition in dementia with Lewy bodies.
High-risk malnutration if greater cognitive, depressive, autonomic, and sleep-related burden.
aspenjournals.onlinelibrary.wiley.com/doi/10.1002/...
High-risk malnutration if greater cognitive, depressive, autonomic, and sleep-related burden.
aspenjournals.onlinelibrary.wiley.com/doi/10.1002/...
1. Si troubles cognitifs legers, la glucosamine augmenterait le risque de maladie d'Alzheimer de 25%
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
Glucosamine supplements may speed memory loss from Alzheimer’s, new research shows
Animal experiments and analysis of patient records suggest that taking glucosamine is safe for a healthy brain but is associated with further decline in diseased brains.
theconversation.com
August 11, 2026 at 8:47 AM
1. Si troubles cognitifs legers, la glucosamine augmenterait le risque de maladie d'Alzheimer de 25%
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
1. Si troubles cognitifs legers, la glucosamine augmenterait le risque de maladie d'Alzheimer de 25%
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
Glucosamine supplements may speed memory loss from Alzheimer’s, new research shows
Animal experiments and analysis of patient records suggest that taking glucosamine is safe for a healthy brain but is associated with further decline in diseased brains.
theconversation.com
August 11, 2026 at 8:45 AM
1. Si troubles cognitifs legers, la glucosamine augmenterait le risque de maladie d'Alzheimer de 25%
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
2. Si maladie d'Alzheimer, la glucosamine augmenterait le risque de décès de 25%
Donc si troubles cognitifs, pas de glucosamine = Structoflex, Flexea Dolenio, etc
theconversation.com/glucosamine-...
Reposted by Frédéric Blanc
Exciting news in the progress of neflamapimod, a potential treatment for Lewy body dementia.
The Innovation Passport award is designed to accelerate time to market and expedite patient access to potentially transformative new investigational medicines.
The Innovation Passport award is designed to accelerate time to market and expedite patient access to potentially transformative new investigational medicines.
CervoMed Announces Neflamapimod Awarded Innovation Passport Designation Under the UK Innovative Licensing and Access Pathway (ILAP) for Treatment of Dementia with Lewy Bodies (DLB) | CervoMed
Innovation Passport award designed to support accelerated time to market and help expedite patient access to potentially transformative new investigational medicines Neflamapimod selected for the ILAP...
ir.cervomed.com
August 4, 2026 at 12:24 PM
Exciting news in the progress of neflamapimod, a potential treatment for Lewy body dementia.
The Innovation Passport award is designed to accelerate time to market and expedite patient access to potentially transformative new investigational medicines.
The Innovation Passport award is designed to accelerate time to market and expedite patient access to potentially transformative new investigational medicines.
Glucosamine and Alzheimer's disease
theconversation.com/glucosamine-...
www.nature.com/articles/s42...
theconversation.com/glucosamine-...
www.nature.com/articles/s42...
Hyperglycosylation is a metabolic driver of Alzheimer’s disease - Nature Metabolism
Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic ta...
www.nature.com
August 5, 2026 at 7:32 AM
Glucosamine and Alzheimer's disease
theconversation.com/glucosamine-...
www.nature.com/articles/s42...
theconversation.com/glucosamine-...
www.nature.com/articles/s42...
Une étude dévoile un lien entre la prise de glucosamine contre l'arthrose et le déclin cognitif share.google/zInr5KBbTwuW...
Alzheimer: une étude met en garde contre un complément alimentaire répandu
Une étude américaine dresse un lien entre la prise d'un complément alimentaire nommé glucosamine et l'accélération de troubles cognitifs chez des personnes déjà diagnostiquées avec la maladie d'Alzhei...
share.google
August 5, 2026 at 7:28 AM
Une étude dévoile un lien entre la prise de glucosamine contre l'arthrose et le déclin cognitif share.google/zInr5KBbTwuW...
Reposted by Frédéric Blanc
#CRVO CervoMed Announces New Clinical, Plasma Biomarker and Imaging Data at AAIC 2026 for Neflamapimod in the Treatment of Dementia with Lewy Bodies (DLB)
https://www.stocktitan.net/news/CRVO/cervo-med-announces-new-clinical-plasma-biomarker-and-imaging-data-339o5rlgdw9v.html
https://www.stocktitan.net/news/CRVO/cervo-med-announces-new-clinical-plasma-biomarker-and-imaging-data-339o5rlgdw9v.html
CervoMed Announces New Clinical, Plasma Biomarker and Imaging Data at AAIC 2026 for Neflamapimod in the Treatment of Dementia with Lewy Bodies (DLB)
CervoMed Announces New Clinical, Plasma Biomarker and Imaging Data at AAIC 2026 for Neflamapimod in the Treatment of Dementia with Lewy Bodies (DLB) New analyses of Phase 2b clinical trial reinforce treatment effect of neflamapimod observed relative to
www.stocktitan.net
July 14, 2026 at 11:30 AM
#CRVO CervoMed Announces New Clinical, Plasma Biomarker and Imaging Data at AAIC 2026 for Neflamapimod in the Treatment of Dementia with Lewy Bodies (DLB)
https://www.stocktitan.net/news/CRVO/cervo-med-announces-new-clinical-plasma-biomarker-and-imaging-data-339o5rlgdw9v.html
https://www.stocktitan.net/news/CRVO/cervo-med-announces-new-clinical-plasma-biomarker-and-imaging-data-339o5rlgdw9v.html
Reposted by Frédéric Blanc
New research does not support an association between Lewy Body density & neuronal or synaptic loss in Dementia with Lewy Bodies, even in regions with particularly high LB burden (eg cingulate gyrus)
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
July 25, 2026 at 12:39 PM
New research does not support an association between Lewy Body density & neuronal or synaptic loss in Dementia with Lewy Bodies, even in regions with particularly high LB burden (eg cingulate gyrus)
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Frédéric Blanc
We know this is a particular emotive subject for Lewy body families.
Delusions (false beliefs) which may include delusions of ‘misidentification’ i.e. not recognising someone or something are more common in Lewy body dementia than in other dementias.
#Lewybodydementia #Capgrassyndrome
Delusions (false beliefs) which may include delusions of ‘misidentification’ i.e. not recognising someone or something are more common in Lewy body dementia than in other dementias.
#Lewybodydementia #Capgrassyndrome
The Real Imposter Syndrome: When Lewy Body Dementia Makes Family Strangers | Lewy Body
Capgras syndrome is a delusion of misidentification in which a person believes that someone close to them has been replaced by a double or imposter. In Lewy
www.lewybody.org
July 28, 2026 at 10:15 AM
We know this is a particular emotive subject for Lewy body families.
Delusions (false beliefs) which may include delusions of ‘misidentification’ i.e. not recognising someone or something are more common in Lewy body dementia than in other dementias.
#Lewybodydementia #Capgrassyndrome
Delusions (false beliefs) which may include delusions of ‘misidentification’ i.e. not recognising someone or something are more common in Lewy body dementia than in other dementias.
#Lewybodydementia #Capgrassyndrome
Reposted by Frédéric Blanc
Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias www.nature.com/articles/s43...
#Alzheimers #dementia #biomarkers #proteomics #science #neuroscience #NeuroSkyence
#Alzheimers #dementia #biomarkers #proteomics #science #neuroscience #NeuroSkyence
Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias - Nature Aging
A large multicenter proteomics study identified blood biomarkers that distinguish Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, supporting biomarker-based differential di...
www.nature.com
July 28, 2026 at 8:55 PM
Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias www.nature.com/articles/s43...
#Alzheimers #dementia #biomarkers #proteomics #science #neuroscience #NeuroSkyence
#Alzheimers #dementia #biomarkers #proteomics #science #neuroscience #NeuroSkyence
Significant reduction in the proportion of CD3+ cells in patients with Dementia with Lewy bodies
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 2, 2026 at 2:29 PM
Significant reduction in the proportion of CD3+ cells in patients with Dementia with Lewy bodies
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Et la première instagrammeuse, grâce à la photographie, la Comtesse Virginia de Castiglione?
www.pol-editeur.com/index.php?sp...
www.pol-editeur.com/index.php?sp...
August 1, 2026 at 7:22 AM
Et la première instagrammeuse, grâce à la photographie, la Comtesse Virginia de Castiglione?
www.pol-editeur.com/index.php?sp...
www.pol-editeur.com/index.php?sp...
Dementia with Lewy bodies and peripheral inflammation: more cognitive decline with IL-15, IL-6, YKL-40, Eotaxin-3, IL12p70, and less with MDC, TNFR1, M-CSF1, IL16, GM-CSF, IL-12, MIP-3α, TNF-beta and IP10.
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Peripheral and central inflammation associated with progressive cognitive decline in dementia with Lewy bodies
Swann et al. report patterns of peripheral and neuroinflammation associated with different rates of cognitive decline in dementia with Lewy bodies. The aut
academic.oup.com
August 1, 2026 at 7:16 AM
Dementia with Lewy bodies and peripheral inflammation: more cognitive decline with IL-15, IL-6, YKL-40, Eotaxin-3, IL12p70, and less with MDC, TNFR1, M-CSF1, IL16, GM-CSF, IL-12, MIP-3α, TNF-beta and IP10.
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Dementia with Lewy bodies is not only diagnosed less frequently, but is also less likely to be timely diagnosed 😒 for the major neurocognitive disorders (dementia) compared with Alzheimer’s disease or limbic age-related TDP43 encephalopathy (LATE).
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Neurology® Journals
www.neurology.org
July 29, 2026 at 2:23 PM
Dementia with Lewy bodies is not only diagnosed less frequently, but is also less likely to be timely diagnosed 😒 for the major neurocognitive disorders (dementia) compared with Alzheimer’s disease or limbic age-related TDP43 encephalopathy (LATE).
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
La maladie à corps de Lewy, non seulement moins bien diagnostiquée, mais aussi moins probablement diagnostiquée à temps pour les troubles neurocognitifs majeurs (démence), quand comparée à la maladie d'Alzheimer ou au LATE (TDP43 liée à l' âge).
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Associations of Alzheimer Disease and Related Dementia Neuropathologies With Timely Diagnosis of Dementia in Healthcare Settings | Neurology
Background and ObjectivesA timely diagnosis of dementia may provide valuable time for treatment and planning,
yet underdiagnosis is common. This study investigated the relationship between presence
of...
www.neurology.org
July 29, 2026 at 2:18 PM
La maladie à corps de Lewy, non seulement moins bien diagnostiquée, mais aussi moins probablement diagnostiquée à temps pour les troubles neurocognitifs majeurs (démence), quand comparée à la maladie d'Alzheimer ou au LATE (TDP43 liée à l' âge).
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Reposted by Frédéric Blanc
Ces organismes privés qui n’ont qu’une hâte : rentabiliser notre santé
30 euros de plus pour avoir accès à un médecin en moins de 48 heures : ce centre de santé privé fait polémique
Un troisième centre médical Celsius Santé ouvrira ses portes à Paris en septembre. L'établissement promet des rendez-vous en moins de 48 heures moyennant un supplément de 30 euros en plus des honorair...
www.egora.fr
July 25, 2026 at 5:42 AM
Ces organismes privés qui n’ont qu’une hâte : rentabiliser notre santé
Reposted by Frédéric Blanc
Avons-nous par nature une aversion à l’effort ? Ne serait-ce pas plutôt son gaspillage que nous fuyons ?
July 29, 2026 at 6:01 AM
Avons-nous par nature une aversion à l’effort ? Ne serait-ce pas plutôt son gaspillage que nous fuyons ?
The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer’s disease.
Antiseizure treatment is good for cognition +++
Congratulations to Benjamin Cretin, team Strasbourg
www.frontiersin.org/journals/agi...
Antiseizure treatment is good for cognition +++
Congratulations to Benjamin Cretin, team Strasbourg
www.frontiersin.org/journals/agi...
Frontiers | The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer’s disease: an exploratory study
BackgroundThe well-documented bidirectional relationship between Alzheimer’s disease (AD) and epilepsy suggests that seizures are not merely a complication o...
www.frontiersin.org
July 23, 2026 at 4:44 PM
The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer’s disease.
Antiseizure treatment is good for cognition +++
Congratulations to Benjamin Cretin, team Strasbourg
www.frontiersin.org/journals/agi...
Antiseizure treatment is good for cognition +++
Congratulations to Benjamin Cretin, team Strasbourg
www.frontiersin.org/journals/agi...
Leasing social : la troisième vague de locations longue durée de voitures électriques débute ce jeudi
www.liberation.fr/economie/tra...
www.liberation.fr/economie/tra...
Leasing social : la troisième vague de locations longue durée de voitures électriques débute ce jeudi
Une vingtaine de modèles d’une douzaine de marques sont éligibles, l’aide de l’Etat étant désormais renforcée pour les véhicules fabriqués en Europe.
www.liberation.fr
July 16, 2026 at 1:23 PM
Leasing social : la troisième vague de locations longue durée de voitures électriques débute ce jeudi
www.liberation.fr/economie/tra...
www.liberation.fr/economie/tra...
AAIC 2026: Wonderful session on dementia with Lewy bodies, with many key messages.
One on cholinergic decrease in the brain, more than in Alzheimer's disease.
One on cholinergic decrease in the brain, more than in Alzheimer's disease.
July 15, 2026 at 5:41 PM
AAIC 2026: Wonderful session on dementia with Lewy bodies, with many key messages.
One on cholinergic decrease in the brain, more than in Alzheimer's disease.
One on cholinergic decrease in the brain, more than in Alzheimer's disease.
Synapses (la plupart des animaux) ou Syncytium = sans synapse (un animal, le Cténophore), tout est possible dans la Nature, et le départ se faisait peut-être sans synapse...
theconversation.com/avec-ou-sans...
theconversation.com/avec-ou-sans...
July 11, 2026 at 8:07 AM
Synapses (la plupart des animaux) ou Syncytium = sans synapse (un animal, le Cténophore), tout est possible dans la Nature, et le départ se faisait peut-être sans synapse...
theconversation.com/avec-ou-sans...
theconversation.com/avec-ou-sans...
Amyloid exacerbates tau and synuclein pathologies, behavioral impairments, neuroinflammation in a mixed dementia model
That is exactly what we see clinically in dementia with Lewy bodies + amyloid 👍 and also synuclein (DLB) + Alzheimer's disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
That is exactly what we see clinically in dementia with Lewy bodies + amyloid 👍 and also synuclein (DLB) + Alzheimer's disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Amyloid exacerbates tau and alpha‐synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model
INTRODUCTION Neurodegenerative diseases often involve overlapping alpha-synuclein (asyn), amyloid beta, and tau proteinopathies, yet the mechanisms, impact, and directionality of their interactions ...
alz-journals.onlinelibrary.wiley.com
July 4, 2026 at 2:13 PM
Amyloid exacerbates tau and synuclein pathologies, behavioral impairments, neuroinflammation in a mixed dementia model
That is exactly what we see clinically in dementia with Lewy bodies + amyloid 👍 and also synuclein (DLB) + Alzheimer's disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
That is exactly what we see clinically in dementia with Lewy bodies + amyloid 👍 and also synuclein (DLB) + Alzheimer's disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Frédéric Blanc
« Il voit un enfant dans le salon. » Neuroleptique prescrit. 48h après : jambes raides, regard absent. Ce n'était pas Alzheimer. 🧵 1/4
July 3, 2026 at 5:00 AM
« Il voit un enfant dans le salon. » Neuroleptique prescrit. 48h après : jambes raides, regard absent. Ce n'était pas Alzheimer. 🧵 1/4