Rémi Fronzes
@fronzeslab.bsky.social
🔬 CNRS Research Director, Bordeaux
Structural biologist & microbiologist
🏃♂️ Runner & 🚴 Cyclist (mostly Velotaf)
⛰️ Mountain & nature lover
🏛️ Formerly at UCL/Birkbeck & Institut Pasteur
🦠 Trying to figure out how bacteria fight, defend & adapt
Structural biologist & microbiologist
🏃♂️ Runner & 🚴 Cyclist (mostly Velotaf)
⛰️ Mountain & nature lover
🏛️ Formerly at UCL/Birkbeck & Institut Pasteur
🦠 Trying to figure out how bacteria fight, defend & adapt
Pinned
Rémi Fronzes
@fronzeslab.bsky.social
· May 26
New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold.
Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social
www.biorxiv.org/content/10.6...
Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social
www.biorxiv.org/content/10.6...
@cnrs banned Claude from our labs. We are not allowed to use it and cannot pay access to these ressources with research grants.
This is a NONSENSE.
We are wasting time and money. And above all undermine our competitiveness
This is a NONSENSE.
We are wasting time and money. And above all undermine our competitiveness
Anthropic has used Claude to optimise structure prediction and design code to improve speed and memory efficiency. 2-3X speed improvements on AF3, 5X on OF3, 5X on BindCraft low memory modes to model large assemblies. All released as open source
www.anthropic.com/research/cla...
www.anthropic.com/research/cla...
How Claude is uplifting biomolecular modeling
Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.
www.anthropic.com
September 18, 2026 at 11:10 AM
@cnrs banned Claude from our labs. We are not allowed to use it and cannot pay access to these ressources with research grants.
This is a NONSENSE.
We are wasting time and money. And above all undermine our competitiveness
This is a NONSENSE.
We are wasting time and money. And above all undermine our competitiveness
Using Claude science for a « in silico » structural biology project.
Definitely very useful to automate processing pipelines and data processing.
But makes a lot of errors and is going in the wrong direction if not carefully guided and monitored. To be handled with great care
Definitely very useful to automate processing pipelines and data processing.
But makes a lot of errors and is going in the wrong direction if not carefully guided and monitored. To be handled with great care
September 15, 2026 at 6:02 AM
Using Claude science for a « in silico » structural biology project.
Definitely very useful to automate processing pipelines and data processing.
But makes a lot of errors and is going in the wrong direction if not carefully guided and monitored. To be handled with great care
Definitely very useful to automate processing pipelines and data processing.
But makes a lot of errors and is going in the wrong direction if not carefully guided and monitored. To be handled with great care
Reposted by Rémi Fronzes
Finally a more intuitaive way to learn pLDDT/pAE? 😎
sokrypton.github.io/protein_figh...
(Character idea from @hannes-stark.bsky.social & Alex Waldherr)
sokrypton.github.io/protein_figh...
(Character idea from @hannes-stark.bsky.social & Alex Waldherr)
September 14, 2026 at 1:47 PM
Finally a more intuitaive way to learn pLDDT/pAE? 😎
sokrypton.github.io/protein_figh...
(Character idea from @hannes-stark.bsky.social & Alex Waldherr)
sokrypton.github.io/protein_figh...
(Character idea from @hannes-stark.bsky.social & Alex Waldherr)
Here is the problem with IA leadership. One day they say something that seems reasonable (regulation, safeguards), and the next something completely nuts…
It shows that these people cannot be trusted to manage such a sensitive technology.
It shows that these people cannot be trusted to manage such a sensitive technology.
‘Virtual employees’ could join workforce as soon as this year, OpenAI boss says
‘Virtual employees’ could join workforce as soon as this year, OpenAI boss says
Sam Altman says tools that carry out jobs anonymously, known as AI agents, could transform business output
Virtual employees could join workforces this year and transform how companies work, according to the chief executive of OpenAI.
The first…
www.theguardian.com
September 13, 2026 at 2:30 PM
Here is the problem with IA leadership. One day they say something that seems reasonable (regulation, safeguards), and the next something completely nuts…
It shows that these people cannot be trusted to manage such a sensitive technology.
It shows that these people cannot be trusted to manage such a sensitive technology.
Glaçant…
IA : le patron d’Anthropic, Dario Amodei, appelle à ralentir la vitesse de développement de l’intelligence artificielle avant que des agents soient « capables de prendre le contrôle d’internet »
Le message publié samedi par Dario Amodei survient quelques jours après qu’un chercheur d’Anthropic, Jacob Coxon, a annoncé quitter la start-up californienne, l’accusant de minimiser le risque existen...
www.lemonde.fr
September 12, 2026 at 7:30 PM
Glaçant…
Reposted by Rémi Fronzes
Can you tell how an antibiotic kills bacteria just by watching them under a regular microscope — without any dyes ? Yes, it turns out, at least if you are a deep neural net.
September 10, 2026 at 6:18 PM
Can you tell how an antibiotic kills bacteria just by watching them under a regular microscope — without any dyes ? Yes, it turns out, at least if you are a deep neural net.
Reposted by Rémi Fronzes
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
September 8, 2026 at 11:10 AM
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
Met some locals during my trail run this weekend. They were not impressed by my pace.
September 7, 2026 at 6:11 AM
Met some locals during my trail run this weekend. They were not impressed by my pace.
Reposted by Rémi Fronzes
September 5, 2026 at 11:11 AM
François Jacob and Jacques Monod.
September 4, 2026 at 11:30 AM
François Jacob and Jacques Monod.
@krastevalab.bsky.social and @remaut-lab.bsky.social will probably enjoy this one.
Molecule of the Month: Biofilms
Bacterial communities glued together and protected by biological polymers
More at PDB-101:
Bacterial communities glued together and protected by biological polymers
More at PDB-101:
PDB101: Molecule of the Month: Biofilms
Bacterial communities glued together and protected by biological polymers
pdb101.rcsb.org
September 1, 2026 at 5:06 PM
@krastevalab.bsky.social and @remaut-lab.bsky.social will probably enjoy this one.
Reposted by Rémi Fronzes
Our new paper with @ckellison.bsky.social. is finally out!
We identify an ancient and widely conserved mechanism that promotes initiation of fiber polymerization in type IV pili and type II secretion systems.
We identify an ancient and widely conserved mechanism that promotes initiation of fiber polymerization in type IV pili and type II secretion systems.
β-strand addition within tip initiation complexes licenses assembly of diverse type IV filaments | PNAS
PilC/PilY1 proteins are tip-located adhesins of type IV pili (T4P) that are critical
for T4P function in diverse behaviors including twitching moti...
www.pnas.org
August 31, 2026 at 7:47 PM
Our new paper with @ckellison.bsky.social. is finally out!
We identify an ancient and widely conserved mechanism that promotes initiation of fiber polymerization in type IV pili and type II secretion systems.
We identify an ancient and widely conserved mechanism that promotes initiation of fiber polymerization in type IV pili and type II secretion systems.
Or me, if I were still at the bench in the lab 😬
Making biscuits this morning like...
Swedish Chef's Floury Bread Making
Alt: Swedish Chef's Floury Bread Making
static.klipy.com
August 30, 2026 at 2:52 PM
Or me, if I were still at the bench in the lab 😬
My kids cooking…
😂
😂
Making biscuits this morning like...
Swedish Chef's Floury Bread Making
Alt: Swedish Chef's Floury Bread Making
static.klipy.com
August 30, 2026 at 2:50 PM
My kids cooking…
😂
😂
Reposted by Rémi Fronzes
🧬 Happy to share our new preprint: ppigFinder, a desktop tool integrating bacterial genome analysis with large-scale AlphaFold 3 protein–protein interaction screening.
We showcase it by exploring the VirD4 interactome of Xanthomonas citri.
💻 github.com/leepusp/ppig...
We showcase it by exploring the VirD4 interactome of Xanthomonas citri.
💻 github.com/leepusp/ppig...
GitHub - leepusp/ppigfinder
Contribute to leepusp/ppigfinder development by creating an account on GitHub.
github.com
August 28, 2026 at 10:38 AM
🧬 Happy to share our new preprint: ppigFinder, a desktop tool integrating bacterial genome analysis with large-scale AlphaFold 3 protein–protein interaction screening.
We showcase it by exploring the VirD4 interactome of Xanthomonas citri.
💻 github.com/leepusp/ppig...
We showcase it by exploring the VirD4 interactome of Xanthomonas citri.
💻 github.com/leepusp/ppig...
This is a massive scandal...
We should all check our antibody stocks and if the validation data appears faked/manipulated, we should ask for a refund. That's the least these companies could do.
We should all check our antibody stocks and if the validation data appears faked/manipulated, we should ask for a refund. That's the least these companies could do.
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne.
1/🧵
1/🧵
August 26, 2026 at 10:04 AM
This is a massive scandal...
We should all check our antibody stocks and if the validation data appears faked/manipulated, we should ask for a refund. That's the least these companies could do.
We should all check our antibody stocks and if the validation data appears faked/manipulated, we should ask for a refund. That's the least these companies could do.
Reposted by Rémi Fronzes
Happy to see this work preprinted! Only our second foray into the mycobacterial T7SS
Characterizing the interaction of a type VII-secreted antimycobacterial toxin with its small helical partner proteins https://www.biorxiv.org/content/10.64898/2026.08.24.746431v1
August 25, 2026 at 5:18 PM
Happy to see this work preprinted! Only our second foray into the mycobacterial T7SS
No cheating. Share the last photo of the sky from your photo roll
August 25, 2026 at 9:28 AM
No cheating. Share the last photo of the sky from your photo roll
August 23, 2026 at 8:51 AM
Reposted by Rémi Fronzes
Unprecedented... 70 days!
France has just ended yesterday the longest series above the norm (1991-2020) ever measured! 🥵
Four heat waves—and another one before that, in May…
That’s what our future will look like—only worse! 😱
📈 via Nicolas Berrod
France has just ended yesterday the longest series above the norm (1991-2020) ever measured! 🥵
Four heat waves—and another one before that, in May…
That’s what our future will look like—only worse! 😱
📈 via Nicolas Berrod
August 22, 2026 at 10:23 AM
Unprecedented... 70 days!
France has just ended yesterday the longest series above the norm (1991-2020) ever measured! 🥵
Four heat waves—and another one before that, in May…
That’s what our future will look like—only worse! 😱
📈 via Nicolas Berrod
France has just ended yesterday the longest series above the norm (1991-2020) ever measured! 🥵
Four heat waves—and another one before that, in May…
That’s what our future will look like—only worse! 😱
📈 via Nicolas Berrod
💯
Just had someone ask me why I was not on X.
It is an ethical decision.
It is a moral decision.
Elon Musk is a monster.
To give him or his products any traffic or business is an ethical and moral failing given the incredible amount of data that shows his abuses upon the world.
It is an ethical decision.
It is a moral decision.
Elon Musk is a monster.
To give him or his products any traffic or business is an ethical and moral failing given the incredible amount of data that shows his abuses upon the world.
August 21, 2026 at 6:12 PM
💯
Super série d’émissions ! Extrêmement intéressant. J’ai binge-écouté tous les podcasts.
📻 Pour cette fin d’été, je vous ai concocté une série d’émissions aux petits oignons :
« les rumeurs qui ont changé le monde »… tout un programme !
2 semaines, 10 emissions, 10 rumeurs.
Rdv dès demain 11h sur France Culture.
Une indice sur le 1er premier épisode :
🚶🌝
« les rumeurs qui ont changé le monde »… tout un programme !
2 semaines, 10 emissions, 10 rumeurs.
Rdv dès demain 11h sur France Culture.
Une indice sur le 1er premier épisode :
🚶🌝
Les rumeurs qui ont changé le monde : un podcast à écouter en ligne
Du canular lunaire au monstre du Loch Ness, des pyramides électriques aux vaccins qui rendent malades, comment naissent les rumeurs ?
www.radiofrance.fr
August 21, 2026 at 5:49 PM
Super série d’émissions ! Extrêmement intéressant. J’ai binge-écouté tous les podcasts.
Reposted by Rémi Fronzes
This is now published! For those interested in microbial mechanotransduction: www.cell.com/current-biol...
August 18, 2026 at 4:21 PM
This is now published! For those interested in microbial mechanotransduction: www.cell.com/current-biol...
Nice trail run to the pic du Sauvegarde near Luchon this morning. 1600 D+ 18km.
August 19, 2026 at 1:45 PM
Nice trail run to the pic du Sauvegarde near Luchon this morning. 1600 D+ 18km.
Reposted by Rémi Fronzes
Out Now! Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota #MicroSky
Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota
Nature Microbiology, Published online: 17 August 2026; doi:10.1038/s41564-026-02450-zBacillus subtilis Ncp and NADH dehydrogenase form tube-like filaments with phospholipid-lined chambers that associate with quinones, which can expand bioenergetic capacity and support respiratory electron transfer.
go.nature.com
August 17, 2026 at 10:37 AM
Out Now! Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota #MicroSky