Holly Sullivan-Toole
@hollysully.bsky.social
Dev Affective Neuro, Reward, Reinforcement Learning, Anhedonia, Dopaminergic Circuitry, Brain Iron
she/her
she/her
Seconded! Congrats @mattmattoni.bsky.social on the Flux Dissertation Award and an excellent talk!!!
An outstanding Dissertation Award talk by Matt Mattoni @mattmattoni.bsky.social on heterogeneity and idiographic (vs. nomothetic) approaches in developmental cognitive neuroscience. He made his case very well - and bonus: increased everyone's vocabulary! 👏 See more @ 1/ doi.org/10.1162/IMAG...
Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report
Abstract. Functional connectivity is frequently used to assess dynamic brain functioning and predict individual differences in behavioral outcomes, such as psychopathology. Inferences from functional ...
doi.org
September 10, 2026 at 7:42 AM
Seconded! Congrats @mattmattoni.bsky.social on the Flux Dissertation Award and an excellent talk!!!
Reposted by Holly Sullivan-Toole
An outstanding Dissertation Award talk by Matt Mattoni @mattmattoni.bsky.social on heterogeneity and idiographic (vs. nomothetic) approaches in developmental cognitive neuroscience. He made his case very well - and bonus: increased everyone's vocabulary! 👏 See more @ 1/ doi.org/10.1162/IMAG...
Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report
Abstract. Functional connectivity is frequently used to assess dynamic brain functioning and predict individual differences in behavioral outcomes, such as psychopathology. Inferences from functional ...
doi.org
September 10, 2026 at 12:04 AM
An outstanding Dissertation Award talk by Matt Mattoni @mattmattoni.bsky.social on heterogeneity and idiographic (vs. nomothetic) approaches in developmental cognitive neuroscience. He made his case very well - and bonus: increased everyone's vocabulary! 👏 See more @ 1/ doi.org/10.1162/IMAG...
Reposted by Holly Sullivan-Toole
ICE has fallen out of the headlines but July marked the largest number of migrant detentions ever on record. Five migrants have died in ICE custody in the last two months. It's also currently impossible to legally migrate to this country, as 100% of visa applications have been paused.
A man and woman embrace as ICE and FHP detain her during an immigration stop in Fort Myers this morning.
August 27, 2026 at 12:02 PM
ICE has fallen out of the headlines but July marked the largest number of migrant detentions ever on record. Five migrants have died in ICE custody in the last two months. It's also currently impossible to legally migrate to this country, as 100% of visa applications have been paused.
When I was little *both* my grandmothers *each* explained to me that Dolly was a queen. Her voice. Her style. Her heart. Lots of comments about her philanthropy (which was gold) but she was an artist first—so authentically herself.
Loving this deep cut.
www.youtube.com/watch?v=D1TX...
Loving this deep cut.
www.youtube.com/watch?v=D1TX...
Dolly Parton - The Bargain Store (Official Audio)
YouTube video by DollyPartonVEVO
www.youtube.com
August 26, 2026 at 4:15 AM
When I was little *both* my grandmothers *each* explained to me that Dolly was a queen. Her voice. Her style. Her heart. Lots of comments about her philanthropy (which was gold) but she was an artist first—so authentically herself.
Loving this deep cut.
www.youtube.com/watch?v=D1TX...
Loving this deep cut.
www.youtube.com/watch?v=D1TX...
Reposted by Holly Sullivan-Toole
Impressive network neuroscience work by Bene Ramirez @benediktramirez.bsky.social ! This allows the field to start discussing the nuances of discrete parcellation. It's gonna have big implications for precision interventions.
Excited to share our new preprint introducing Precision Confidence Mapping (PCM), a framework for estimating how confident we should be in individualized functional network assignments from resting-state fMRI.
Why does this matter for precision neuromodulation? 🧵👇
www.biorxiv.org/content/10.6...
Why does this matter for precision neuromodulation? 🧵👇
www.biorxiv.org/content/10.6...
www.biorxiv.org
August 23, 2026 at 8:24 PM
Impressive network neuroscience work by Bene Ramirez @benediktramirez.bsky.social ! This allows the field to start discussing the nuances of discrete parcellation. It's gonna have big implications for precision interventions.
Reposted by Holly Sullivan-Toole
Excited to share our new preprint introducing Precision Confidence Mapping (PCM), a framework for estimating how confident we should be in individualized functional network assignments from resting-state fMRI.
Why does this matter for precision neuromodulation? 🧵👇
www.biorxiv.org/content/10.6...
Why does this matter for precision neuromodulation? 🧵👇
www.biorxiv.org/content/10.6...
www.biorxiv.org
August 23, 2026 at 7:29 PM
Excited to share our new preprint introducing Precision Confidence Mapping (PCM), a framework for estimating how confident we should be in individualized functional network assignments from resting-state fMRI.
Why does this matter for precision neuromodulation? 🧵👇
www.biorxiv.org/content/10.6...
Why does this matter for precision neuromodulation? 🧵👇
www.biorxiv.org/content/10.6...
Reposted by Holly Sullivan-Toole
Psychology has been riding the intensive longitudinal train for a bit, but what about immunology?
Now live @brainbehavimm.bsky.social, our physiometric report on the stability of inflammatory proteins collected every 3 days for 22 days during a natural stressor 1/X
Now live @brainbehavimm.bsky.social, our physiometric report on the stability of inflammatory proteins collected every 3 days for 22 days during a natural stressor 1/X
Inflammatory Proteins are Highly Variable During a Natural Stressor: A Call for Intensive Longitudinal Blood Microsampling
Although research into how inflammation mediates the effects of stress on disorders such as heart disease and depression has grown rapidly, standard l…
www.sciencedirect.com
August 18, 2026 at 1:02 PM
Psychology has been riding the intensive longitudinal train for a bit, but what about immunology?
Now live @brainbehavimm.bsky.social, our physiometric report on the stability of inflammatory proteins collected every 3 days for 22 days during a natural stressor 1/X
Now live @brainbehavimm.bsky.social, our physiometric report on the stability of inflammatory proteins collected every 3 days for 22 days during a natural stressor 1/X
Loving my husband’s new viola style. Modern, distinct, butterscotch-y.
www.givensviolins.com/product/viol...
www.givensviolins.com/product/viol...
Viola: 15 1/2" Patrick Toole, Philadelphia, PA 2024 | Claire Givens Violins, Inc
The Makers: Patrick studied violin making at the Newark School of Violin Making in England, where he developed a deep appreciation for craftsmanship and the beauty of natural materials. After spendin...
www.givensviolins.com
August 9, 2026 at 9:57 PM
Loving my husband’s new viola style. Modern, distinct, butterscotch-y.
www.givensviolins.com/product/viol...
www.givensviolins.com/product/viol...
Reposted by Holly Sullivan-Toole
Study in 30,000 kids shows that unpredictable early-life experience is a potent Adverse Childhood Event www.nature.com/articles/s44.... Just dropped in Nature MH, with an amazing team. 🧪🧠 And unpredictability is actionable! would love your thoughts. @cate-cholamine.bsky.social @drkoraly.bsky.social
Unpredictability is a childhood adversity that contributes to mental health problems - Nature Mental Health
In this population-based cohort study, Glynn et al. tested the contribution of childhood unpredictability to mental health outcomes in ~30,000 participants, examining the relative and additive roles o...
www.nature.com
July 21, 2026 at 4:08 PM
Study in 30,000 kids shows that unpredictable early-life experience is a potent Adverse Childhood Event www.nature.com/articles/s44.... Just dropped in Nature MH, with an amazing team. 🧪🧠 And unpredictability is actionable! would love your thoughts. @cate-cholamine.bsky.social @drkoraly.bsky.social
Brunch of champions
August 1, 2026 at 5:46 PM
Brunch of champions
Reposted by Holly Sullivan-Toole
𝗕𝗥𝗘𝗔𝗞𝗜𝗡𝗚🚨
Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody.
He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital.
This thread is one you must spend time on. We cannot ignore the atrocities!
Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody.
He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital.
This thread is one you must spend time on. We cannot ignore the atrocities!
July 31, 2026 at 3:04 PM
𝗕𝗥𝗘𝗔𝗞𝗜𝗡𝗚🚨
Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody.
He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital.
This thread is one you must spend time on. We cannot ignore the atrocities!
Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody.
He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital.
This thread is one you must spend time on. We cannot ignore the atrocities!
Had the pleasure of joining ACAMH @acamh.bsky.social to discuss my research on how reinforcement learning changes across adolescence — and how it is altered by risk factors for psychopathology
What is #Anhedonia? What drives changes in reward responsiveness during adolescence? In this #MindtheKids podcast, we explore how adolescents learn from rewards and what this means for #depression risk and #mentalhealth outcomes with Holly Sullivan-Toole. https://bit.ly/4hcqSLk
July 27, 2026 at 4:41 PM
Had the pleasure of joining ACAMH @acamh.bsky.social to discuss my research on how reinforcement learning changes across adolescence — and how it is altered by risk factors for psychopathology
the Cranberries EEiDI,SWCW is prob my #1 but this is on the list too!
July 26, 2026 at 11:10 PM
the Cranberries EEiDI,SWCW is prob my #1 but this is on the list too!
Reposted by Holly Sullivan-Toole
Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty?
Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention
Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention
July 21, 2026 at 7:08 PM
Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty?
Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention
Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention
Come see this work and more at the Computational Psychiatry Conference tuesday morning poster session!!
July 12, 2026 at 4:49 PM
Come see this work and more at the Computational Psychiatry Conference tuesday morning poster session!!
🚨 preprint alert !!!
Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence
osf.io/preprints/ps...
Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence
osf.io/preprints/ps...
July 12, 2026 at 4:32 PM
🚨 preprint alert !!!
Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence
osf.io/preprints/ps...
Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence
osf.io/preprints/ps...
Reposted by Holly Sullivan-Toole
Excited to share a paper recently accepted at Nature Mental Health! 😄
For decades, we've assumed that covariance among psychopathology informs comorbidity. What if we’ve been wrong?
For decades, we've assumed that covariance among psychopathology informs comorbidity. What if we’ve been wrong?
Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm
July 9, 2026 at 12:21 AM
Excited to share a paper recently accepted at Nature Mental Health! 😄
For decades, we've assumed that covariance among psychopathology informs comorbidity. What if we’ve been wrong?
For decades, we've assumed that covariance among psychopathology informs comorbidity. What if we’ve been wrong?
Reposted by Holly Sullivan-Toole
Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm
July 8, 2026 at 7:08 PM
Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm
Reposted by Holly Sullivan-Toole
Hi all! I’m looking for a full-time RA / lab manager (start date: late Aug or Sept, 1 year of funding guaranteed). Ideal candidate is a recent grad w/ relevant research experience. App review has begun, so if you’re interested, please apply here ASAP, by 7/12! Thx! phf.tbe.taleo.net/phf02/ats/ca...
Hiring Research Assistant, - Garden City, N.Y.
View job details and apply now
phf.tbe.taleo.net
July 6, 2026 at 7:16 PM
Hi all! I’m looking for a full-time RA / lab manager (start date: late Aug or Sept, 1 year of funding guaranteed). Ideal candidate is a recent grad w/ relevant research experience. App review has begun, so if you’re interested, please apply here ASAP, by 7/12! Thx! phf.tbe.taleo.net/phf02/ats/ca...
Reposted by Holly Sullivan-Toole
Very happy to see this Review with @diegopizzagalli.bsky.social out in @cp-trendsneuro.bsky.social
www.cell.com/trends/neuro...
This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG.
Many thanks for the support from @sfb-trr-289.bsky.social
www.cell.com/trends/neuro...
This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG.
Many thanks for the support from @sfb-trr-289.bsky.social
Brain rhythms of depression: A predictive processing perspective
Depression is marked by anhedonia, social withdrawal, and a diminished capacity to
learn from positive experiences—features that can be framed within predictive processing.
Here, we review findings fr...
www.cell.com
July 6, 2026 at 2:44 PM
Very happy to see this Review with @diegopizzagalli.bsky.social out in @cp-trendsneuro.bsky.social
www.cell.com/trends/neuro...
This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG.
Many thanks for the support from @sfb-trr-289.bsky.social
www.cell.com/trends/neuro...
This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG.
Many thanks for the support from @sfb-trr-289.bsky.social
Reposted by Holly Sullivan-Toole
People with depression and anxiety symptoms are surprisingly better at overriding gut-instinct motivational biases, while those with compulsions and intrusive thoughts showed the opposite pattern, suggesting distinct motivational disruptions across psychiatric dimensions.
Adaptive suppression of motivational biases increases with mood/anxiety traits
Changes in motivational biases appear central to many psychiatric disorders including depression, anxiety, and substance abuse. Motivational biases, theorized to embody default response strategies…
www.biologicalpsychiatrycnni.org
July 6, 2026 at 12:02 PM
People with depression and anxiety symptoms are surprisingly better at overriding gut-instinct motivational biases, while those with compulsions and intrusive thoughts showed the opposite pattern, suggesting distinct motivational disruptions across psychiatric dimensions.
Reposted by Holly Sullivan-Toole
“Every dollar invested in NIH-funded research returned about $2.50 to the broader economy — a 250% return on investment.”
“…sustained NIH funding has generated more than $822 billion in economic activity, supported more than 3.7 million jobs”
academicmedicine.aamc.org/stories/how-...
“…sustained NIH funding has generated more than $822 billion in economic activity, supported more than 3.7 million jobs”
academicmedicine.aamc.org/stories/how-...
Client Challenge
academicmedicine.aamc.org
July 3, 2026 at 3:59 PM
“Every dollar invested in NIH-funded research returned about $2.50 to the broader economy — a 250% return on investment.”
“…sustained NIH funding has generated more than $822 billion in economic activity, supported more than 3.7 million jobs”
academicmedicine.aamc.org/stories/how-...
“…sustained NIH funding has generated more than $822 billion in economic activity, supported more than 3.7 million jobs”
academicmedicine.aamc.org/stories/how-...
Reposted by Holly Sullivan-Toole
I'm really excited to share a new preprint! Lab studies have consistently shown that stress and negative emotions make people drink alcohol, but studies of daily life (EMA) keep failing to find it. What does that mean for the shared theoretical prediction both designs test? osf.io/preprints/ps...
June 14, 2026 at 12:05 PM
I'm really excited to share a new preprint! Lab studies have consistently shown that stress and negative emotions make people drink alcohol, but studies of daily life (EMA) keep failing to find it. What does that mean for the shared theoretical prediction both designs test? osf.io/preprints/ps...
Reposted by Holly Sullivan-Toole
We've known that socioeconomics (SES) matters for the 🧠. New & 🤯 is that SES drowns out all other brain associations, incl. IQ. If you train an algorithm to predict IQ from brain data, it's still way better at predicting SES. Science Mag: www.science.org/doi/10.1126/...
@smarek0502.bsky.social 👀🧵👇
@smarek0502.bsky.social 👀🧵👇
June 14, 2026 at 4:03 AM
We've known that socioeconomics (SES) matters for the 🧠. New & 🤯 is that SES drowns out all other brain associations, incl. IQ. If you train an algorithm to predict IQ from brain data, it's still way better at predicting SES. Science Mag: www.science.org/doi/10.1126/...
@smarek0502.bsky.social 👀🧵👇
@smarek0502.bsky.social 👀🧵👇
Reposted by Holly Sullivan-Toole
How do we predict what’s going to happen next?
In a new paper, we @arikahn.bsky.social @licezhang.bsky.social @nathanieldaw.bsky.social @catehartley.bsky.social ask how kids, teens, and adults solve this problem.
onlinelibrary.wiley.com/doi/10.1111/...
In a new paper, we @arikahn.bsky.social @licezhang.bsky.social @nathanieldaw.bsky.social @catehartley.bsky.social ask how kids, teens, and adults solve this problem.
onlinelibrary.wiley.com/doi/10.1111/...
Developmental Change in Structure Learning Reflects a Shift From Recency‐Based to Relational Prediction
Children are adept statistical learners, capable of parsing streams of structured input into meaningful units, but the cognitive processes they engage during learning may differ from those of adults...
onlinelibrary.wiley.com
June 3, 2026 at 12:36 PM
How do we predict what’s going to happen next?
In a new paper, we @arikahn.bsky.social @licezhang.bsky.social @nathanieldaw.bsky.social @catehartley.bsky.social ask how kids, teens, and adults solve this problem.
onlinelibrary.wiley.com/doi/10.1111/...
In a new paper, we @arikahn.bsky.social @licezhang.bsky.social @nathanieldaw.bsky.social @catehartley.bsky.social ask how kids, teens, and adults solve this problem.
onlinelibrary.wiley.com/doi/10.1111/...