The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Kinoshita, J., ..., Inoue, Y. H. (2024). Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins in Drosophila Fat Body via the TNF-JNK Pathway. Int J Mol Sci, 25(23 www.mdpi.com/1422-0067/25...
September 16, 2026 at 7:13 PM
Kinoshita, J., ..., Inoue, Y. H. (2024). Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins in Drosophila Fat Body via the TNF-JNK Pathway. Int J Mol Sci, 25(23 www.mdpi.com/1422-0067/25...
Garcia-Alonso, L. (2024). Fasciclin 2 functions as an expression-level switch on EGFR to control organ shape and size in Drosophila. PLoS One, 19(12):e0309891 journals.plos.org/plosone/arti...
Fasciclin 2 functions as an expression-level switch on EGFR to control organ shape and size in Drosophila
Fasciclin 2 (Drosophila NCAM) is a homophilic Cell Adhesion Molecule expressed at moderate levels in the proliferating epithelial cells of imaginal discs, where it engages EGFR in a cell autonomous au...
journals.plos.org
September 16, 2026 at 7:11 PM
Garcia-Alonso, L. (2024). Fasciclin 2 functions as an expression-level switch on EGFR to control organ shape and size in Drosophila. PLoS One, 19(12):e0309891 journals.plos.org/plosone/arti...
Arias, R. A., Tomlinson, A. (2025). Decoding a Cell's Fate: How Notch and receptor tyrosine kinase signals specify the Drosophila R7 photoreceptor. Dev Biol, 519:21-29 www.sciencedirect.com/science/arti...
September 16, 2026 at 7:09 PM
Arias, R. A., Tomlinson, A. (2025). Decoding a Cell's Fate: How Notch and receptor tyrosine kinase signals specify the Drosophila R7 photoreceptor. Dev Biol, 519:21-29 www.sciencedirect.com/science/arti...
Nelson, J. O., Slicko, A., Raz, A. A., Yamashita, Y. M. (2025). Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance. Nature communications, 16(1):399 www.nature.com/articles/s41...
Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance - Nature Communications
The germline maintains unstable essential ribosomal DNA (rDNA) repeats to ensure each generation inherits a functional genome, yet it’s unclear how this activity is controlled. Here, the authors find ...
www.nature.com
September 16, 2026 at 7:06 PM
Nelson, J. O., Slicko, A., Raz, A. A., Yamashita, Y. M. (2025). Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance. Nature communications, 16(1):399 www.nature.com/articles/s41...
Nelson, K. A., Lenhart, K. F., Anllo, L., DiNardo, S. (2025). The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling. eLife, 13 elifesciences.org/articles/100...
September 16, 2026 at 7:05 PM
Nelson, K. A., Lenhart, K. F., Anllo, L., DiNardo, S. (2025). The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling. eLife, 13 elifesciences.org/articles/100...
Zhang, S., Li, K., Luo, Z., Xu, M., Zheng, S. (2025). A Bio-Inspired Visual Neural Model for Robustly and Steadily Detecting Motion Directions of Translating Objects Against Variable Contrast in the Figure-Ground. Biomimetics (Basel), 10(1) www.mdpi.com/2313-7673/10...
September 15, 2026 at 12:33 PM
Zhang, S., Li, K., Luo, Z., Xu, M., Zheng, S. (2025). A Bio-Inspired Visual Neural Model for Robustly and Steadily Detecting Motion Directions of Translating Objects Against Variable Contrast in the Figure-Ground. Biomimetics (Basel), 10(1) www.mdpi.com/2313-7673/10...
Neuman, S. D., Thakur, R. S., Gratz, S. J., O'Connor-Giles, K. M., Bashirullah, A. (2024). Neurodegenerative and neurodevelopmental roles for bulk lipid transporters VPS13A and BLTP2 in movement disorders. bioRxiv, www.biorxiv.org/content/10.1...
September 15, 2026 at 12:29 PM
Neuman, S. D., Thakur, R. S., Gratz, S. J., O'Connor-Giles, K. M., Bashirullah, A. (2024). Neurodegenerative and neurodevelopmental roles for bulk lipid transporters VPS13A and BLTP2 in movement disorders. bioRxiv, www.biorxiv.org/content/10.1...
Zheng, T., Long, K., Wang, S., Rui, M. (2025). Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting. Cell Mol Life Sci, 82(1):47 link.springer.com/article/10.1...
Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting - Cellular and Molecular Life Sciences
The selective elimination of inappropriate projections is essential for sculpting neural circuits during development. The class IV dendritic arborization (C4da) sensory neurons of Drosophila remodel t...
link.springer.com
September 15, 2026 at 12:28 PM
Zheng, T., Long, K., Wang, S., Rui, M. (2025). Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting. Cell Mol Life Sci, 82(1):47 link.springer.com/article/10.1...
Rabah, Y., Berwick, J. P., Sagar, N., Pasquer, L., PlaCais, P. Y., Preat, T. (2025). Astrocyte-to-neuron H(2)O(2) signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer's disease model. Nature metabolism, 7(2):321-335 www.nature.com/articles/s42...
Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model - Nature Metabolism
Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...
www.nature.com
September 15, 2026 at 12:27 PM
Rabah, Y., Berwick, J. P., Sagar, N., Pasquer, L., PlaCais, P. Y., Preat, T. (2025). Astrocyte-to-neuron H(2)O(2) signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer's disease model. Nature metabolism, 7(2):321-335 www.nature.com/articles/s42...
Wint, R., Cleary, M. D. (2024). Transfer RNA Levels Are Tuned to Support Differentiation During Drosophila Neurogenesis. Genes, 15(12) www.mdpi.com/2073-4425/15...
September 15, 2026 at 12:26 PM
Wint, R., Cleary, M. D. (2024). Transfer RNA Levels Are Tuned to Support Differentiation During Drosophila Neurogenesis. Genes, 15(12) www.mdpi.com/2073-4425/15...
Wang, Q., Miles, L., Wang, S., Noristani, H. N., Monahan Vargas, E. J., Powell, J., O'Rourke-Ibach, S. J., Li, S., Song, Y. (2024). Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration. bioRxiv www.biorxiv.org/content/10.1...
September 15, 2026 at 12:24 PM
Wang, Q., Miles, L., Wang, S., Noristani, H. N., Monahan Vargas, E. J., Powell, J., O'Rourke-Ibach, S. J., Li, S., Song, Y. (2024). Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration. bioRxiv www.biorxiv.org/content/10.1...
Reposted by The Interactive Fly
Hey #Drosophila folks - the #flycross #mentee survey is open for #grad students, #postdoc and #pretenure faculty. ~95 mentors from across the world, with diverse expertise. The co-chairs @shyama13.bsky.social and @jocmcdonald.bsky.social have done a phenomenal work in taking the program forward 🎉
September 11, 2026 at 12:33 PM
Hey #Drosophila folks - the #flycross #mentee survey is open for #grad students, #postdoc and #pretenure faculty. ~95 mentors from across the world, with diverse expertise. The co-chairs @shyama13.bsky.social and @jocmcdonald.bsky.social have done a phenomenal work in taking the program forward 🎉
Zakerzade, R., Chang, C. H., Chatla, K., Krishnapura, A., Appiah, S. P., Zhang, J., Unckless, R. L., Blumenstiel, J. P., Bachtrog, D., Wei, K. H. (2025). Diversification and recurrent adaptation of the synaptonemal complex in Drosophila PLoS genetics, 21(1):e1011549 journals.plos.org/plosgenetics...
Diversification and recurrent adaptation of the synaptonemal complex in Drosophila
Author summary The synaptonemal complex (SC) is essential for meiotic recombination and faithful chromosome segregation across eukaryotes, yet components of the SC are often poorly conserved. Here, we...
journals.plos.org
September 11, 2026 at 2:05 AM
Zakerzade, R., Chang, C. H., Chatla, K., Krishnapura, A., Appiah, S. P., Zhang, J., Unckless, R. L., Blumenstiel, J. P., Bachtrog, D., Wei, K. H. (2025). Diversification and recurrent adaptation of the synaptonemal complex in Drosophila PLoS genetics, 21(1):e1011549 journals.plos.org/plosgenetics...
Shapiro, J. G., Changela, N., Jang, J. K., Joshi, J. N., McKim, K. S. (2025). Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes. PLoS genetics, 21(1):e1011400 journals.plos.org/plosgenetics...
Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes
Author summary The spindle assembly checkpoint (SAC) is known to delay cell cycle progression until chromosomes are properly attached to microtubules. Meiotic cells often have modified cell cycle phas...
journals.plos.org
September 11, 2026 at 1:39 AM
Shapiro, J. G., Changela, N., Jang, J. K., Joshi, J. N., McKim, K. S. (2025). Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes. PLoS genetics, 21(1):e1011400 journals.plos.org/plosgenetics...
Xu, Y., Chao, A., Rinaldin, M., Kickuth, A., Brugues, J., Di Talia, S. (2025). The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos. Current biology : CB, 35(3):655-664.e653 www.cell.com/current-biol...
The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos
Xu et al. investigate how the speed of chromosome separation is regulated during the
cleavage divisions of the Drosophila blastoderm. They find that spindle length and
the cell cycle oscillator jointl...
www.cell.com
September 11, 2026 at 1:38 AM
Xu, Y., Chao, A., Rinaldin, M., Kickuth, A., Brugues, J., Di Talia, S. (2025). The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos. Current biology : CB, 35(3):655-664.e653 www.cell.com/current-biol...
Rombouts, J., Tavella, F., Vandervelde, A., Phong, C., Ferrell, J. E., Jr., Yang, Q., Gelens, L. (2025). Mechanistic origins of temperature scaling in the early embryonic cell cycle. Journa;, bioRxiv www.biorxiv.org/content/10.1...
September 11, 2026 at 1:37 AM
Rombouts, J., Tavella, F., Vandervelde, A., Phong, C., Ferrell, J. E., Jr., Yang, Q., Gelens, L. (2025). Mechanistic origins of temperature scaling in the early embryonic cell cycle. Journa;, bioRxiv www.biorxiv.org/content/10.1...
Wong, S. S., Monteiro, J. M., Chang, C. C., ...., Saurya, S., Wainman, A., Raff, J. W. (2025). Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes. Science advances, 11(6):eadq9549 www.science.org/doi/10.1126/...
Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.
www.science.org
September 11, 2026 at 1:36 AM
Wong, S. S., Monteiro, J. M., Chang, C. C., ...., Saurya, S., Wainman, A., Raff, J. W. (2025). Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes. Science advances, 11(6):eadq9549 www.science.org/doi/10.1126/...
Kemp, J. P., Jr., Geisler, M. S., Hoover, M., Cho, C. Y., O'Farrell, P. H., Marzluff, W. F., Duronio, R. J. (2024). Cell cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes. bioRxiv www.biorxiv.org/content/10.1...
September 11, 2026 at 1:34 AM
Kemp, J. P., Jr., Geisler, M. S., Hoover, M., Cho, C. Y., O'Farrell, P. H., Marzluff, W. F., Duronio, R. J. (2024). Cell cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes. bioRxiv www.biorxiv.org/content/10.1...
Fujioka, M., Ke, W., Schedl, P., Jaynes, J. B. (2025). The homie insulator has sub-elements with different insulating and long-range pairing properties. bioRxiv, www.biorxiv.org/content/10.1...
September 8, 2026 at 8:29 PM
Fujioka, M., Ke, W., Schedl, P., Jaynes, J. B. (2025). The homie insulator has sub-elements with different insulating and long-range pairing properties. bioRxiv, www.biorxiv.org/content/10.1...
Wood, J. L., Nepal, S., Jones, B. W. (2025). Autoregulation of the glial gene reversed polarity in Drosophila. Scientific reports, 15(1):1238 www.nature.com/articles/s41...
Autoregulation of the glial gene reversed polarity in Drosophila - Scientific Reports
Scientific Reports - Autoregulation of the glial gene reversed polarity in Drosophila
www.nature.com
September 8, 2026 at 8:28 PM
Wood, J. L., Nepal, S., Jones, B. W. (2025). Autoregulation of the glial gene reversed polarity in Drosophila. Scientific reports, 15(1):1238 www.nature.com/articles/s41...
Kudryashova, K. S., Deriglazova, I. O., Osadchiy, I. S., Georgiev, P., Maksimenko, O. (2024). Construction of Promoter Elements for Strong, Moderate, and Weak Gene Expression in Drosophila melanogaster. Genes, 16(1) www.mdpi.com/2073-4425/16...
September 8, 2026 at 8:26 PM
Kudryashova, K. S., Deriglazova, I. O., Osadchiy, I. S., Georgiev, P., Maksimenko, O. (2024). Construction of Promoter Elements for Strong, Moderate, and Weak Gene Expression in Drosophila melanogaster. Genes, 16(1) www.mdpi.com/2073-4425/16...
Pimmett, V. L., McGehee, J., Trullo, A., Douaihy, M., Radulescu, O., Stathopoulos, A., Lagha, M. (2025). Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription. Development, 152(6) journals.biologists.com/dev/article/...
September 8, 2026 at 8:25 PM
Pimmett, V. L., McGehee, J., Trullo, A., Douaihy, M., Radulescu, O., Stathopoulos, A., Lagha, M. (2025). Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription. Development, 152(6) journals.biologists.com/dev/article/...
Soldatova, I. V., Shepelev, M. V., Georgiev, P., Tikhonov, M. (2024). A Novel Mechanism for Transcription Termination in the mod(mdg4) Locus of Drosophila melanogaster. Biology, 13(12) www.mdpi.com/2079-7737/13...
September 8, 2026 at 8:21 PM
Soldatova, I. V., Shepelev, M. V., Georgiev, P., Tikhonov, M. (2024). A Novel Mechanism for Transcription Termination in the mod(mdg4) Locus of Drosophila melanogaster. Biology, 13(12) www.mdpi.com/2079-7737/13...
Reposted by The Interactive Fly
🌍 How does biodiversity genomics scale?
Not just by sequencing more species—but by developing & sharing the methods and standards that make high-quality genomes possible.
Read the latest from Tvedte et al. in Genetics:
tinyurl.com/insect-genomes
#EarthBioGenomeProject #BiodiversityGenomics
Not just by sequencing more species—but by developing & sharing the methods and standards that make high-quality genomes possible.
Read the latest from Tvedte et al. in Genetics:
tinyurl.com/insect-genomes
#EarthBioGenomeProject #BiodiversityGenomics
September 8, 2026 at 7:30 PM
🌍 How does biodiversity genomics scale?
Not just by sequencing more species—but by developing & sharing the methods and standards that make high-quality genomes possible.
Read the latest from Tvedte et al. in Genetics:
tinyurl.com/insect-genomes
#EarthBioGenomeProject #BiodiversityGenomics
Not just by sequencing more species—but by developing & sharing the methods and standards that make high-quality genomes possible.
Read the latest from Tvedte et al. in Genetics:
tinyurl.com/insect-genomes
#EarthBioGenomeProject #BiodiversityGenomics
Reposted by The Interactive Fly
🧬 There is no one-size-fits-all pipeline for insect genomes.
Tiny bodies can mean very little DNA. Genome size, repetitive DNA, high heterozygosity & complex microbiomes can all create challenges.
Researchers are developing new approaches to unlock genomes across the Tree of Life. 🌳
#TreeOfLife
Tiny bodies can mean very little DNA. Genome size, repetitive DNA, high heterozygosity & complex microbiomes can all create challenges.
Researchers are developing new approaches to unlock genomes across the Tree of Life. 🌳
#TreeOfLife
September 8, 2026 at 7:29 PM
🧬 There is no one-size-fits-all pipeline for insect genomes.
Tiny bodies can mean very little DNA. Genome size, repetitive DNA, high heterozygosity & complex microbiomes can all create challenges.
Researchers are developing new approaches to unlock genomes across the Tree of Life. 🌳
#TreeOfLife
Tiny bodies can mean very little DNA. Genome size, repetitive DNA, high heterozygosity & complex microbiomes can all create challenges.
Researchers are developing new approaches to unlock genomes across the Tree of Life. 🌳
#TreeOfLife