Abstract. Microbial communities frequently encounter recurrent antibiotic disturbance, yet how ecological, evolutionary, and environmental processes jointl

Professor in Medical Bacteriology, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology, Uppsala University

Previous research in microbes successfully predicted biculture growth based on monoculture growth curves. Still, the usual model-based approach does not seem to extend to communities involving more th...

In this Review, Iredell and colleagues examine key aspects of phage biology and their relevance to phage therapy, and outline current approaches for clinical application of phages, along with their associated challenges.

Abstract. Even though complex microbial communities are ubiquitous and provide essential services for natural and human-associated ecosystems, our knowledg

Arbitrium phages belonging to different species and genera can influence each other’s infection dynamics by secreting chemically similar, non-cognate signal peptides. These findings indicate that arbi...

Nedanstående förteckning visar beviljade bidrag i alfabetisk ordning efter den sökandes namn. Förteckningen är endast en orientering; samtliga sökande har fått ett...

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On Thursday the 4th of June 2026, M.Sc. Teemu Kuosmanen defends his PhD thesis On Stochasticity and Control of Evolving Populations. The thesis is related to research done in the Department of Compute...

Biological communities are complex, dynamic systems that underpin ecosystem functionality, yet their long-term dynamics and predictability remain p...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

He helped develop the technique of whole-genome shotgun sequencing, still widely used today

Abstract. Recent studies have revealed bacterial genome-wide evolution to be complex and dynamic even in a constant environment, characterized by the emerg

Even though complex microbial communities are ubiquitous and provide essential services for natural and human-associated ecosystems, our knowledge about their assembly and dynamics is incomplete. There is an ongoing debate whether the behavior of complex communities can be predicted from the outcome of pairwise competition of species, and whether communities reach alternative stable states depending on the level and complexity of resource provided for growth. To estimate the effect of two resource gradients, total carbon availability and resource complexity, on the compositional dynamics of a complex microbial community, we conducted a 16-day serial passage experiment, transferring a 16-species synthetic community in 96 different resource environments. We observed that although both resource dimensions influenced community composition, total carbon exerted a considerably larger effect. Additionally, we saw the emergence of a tristable pattern along the total carbon gradient, a feature not observed for the resource complexity gradient. Using monoculture assays, we identified lag phase duration as the dominant predictor of competitive success at carbon extremes, with maximum growth rate increasing in importance as lag times converged. Total carbon availability thus structured community state transitions and regulated which growth trait governed competitive sorting. These results suggest the importance of total carbon level over resource complexity and identifying dominant species for the quest to successfully manage, maintain and manipulate complex microbial communities. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, https://ror.org/00yjd3n13, P500PB_214345 Knut and Alice Wallenberg Foundation, KAW 2024.0159 Jenny ja Antti Wihurin Rahasto, 00250005 Finnish Cultural Foundation, 85241664 Research Council of Finland, 346126, 364232

Postdoctoral Researcher in discovering the benefits of plant growth-promoting bacteriophages

On Friday the 24th of October 2025, M.Sc. Florian Borse his PhD thesis on Modelling Microbial Population Growth Across Spatial, Strain and Environmental Diversity. The thesis is related to research do...