Journal of Experimental Medicine
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jem.org
Journal of Experimental Medicine
@jem.org
4.9K followers 710 following 1.5K posts
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
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jem.org
New study from Danping Wei, Guangzhe Ge, Chih-Yuan Chiang, Yaqiang Cao et al. from the Jinfang Zhu lab identifies key transcriptional regulators of Th2 #cytokines through a CRISPR-based screen. rupress.org/jem/article/...

#LymphocyteBiology
October 28, 2026 at 4:00 PM
jem.org
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues @ccii-kyoto.bsky.social: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 28, 2026 at 5:00 AM
jem.org
#Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @czechacademy.bsky.social: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 28, 2026 at 1:02 AM
jem.org
CASS4 is a genetic risk factor for #Alzheimers disease but remains understudied in the brain. Walsh, @lukensjohnr.bsky.social et al. identify CASS4 as a critical regulator of amyloid β plaque compaction, microglial mobilization to damage, and focal adhesion signaling. rupress.org/jem/article/...
October 27, 2026 at 5:30 PM
jem.org
Ai-Ping Cao, Jun-Cheng Li, Rui Wang et al. reveal that the Vanin-pantethine-cholesterol axis acts as a metabolic checkpoint controlling #DendriticCell activation in autoimmune #inflammation. rupress.org/jem/article/...

#Autoimmunity #Psoriasis
October 27, 2026 at 5:01 PM
jem.org
A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration. New study from Mara Cetty Spinella, Gioacchino Natoli (European Institute of Oncology), Silvia Monticelli @usi.ch et al:
rupress.org/jem/article/...

#LymphocyteBiology #Tcells #Crohns #IBD #Autoimmunity
October 27, 2026 at 3:15 PM
jem.org
📰 #PressRelease: Researchers have discovered that the vitamin derivative pantethine prevents the development of #psoriasis in mice and helps alleviate patient symptoms in a small-scale human trial. www.eurekalert.org/news-release...

See the original JEM study: rupress.org/jem/article-...
October 27, 2026 at 2:30 PM
jem.org
Dysregulated AKT signaling reprograms #osteosarcoma to drive selective reliance on EP300. New study from Ian M. Delahunty, Stephanie Nance, Yang Zhang, Francois Lamoureux, Qi Liu, Benjamin Ory Jun Qi, Brian J. Abraham, Adam D. Durbin and colleagues:
rupress.org/jem/article/...
October 27, 2026 at 2:03 PM
jem.org
Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in #Parkinsons disease. New study from Taylor J. Stevenson, Justin Rustenhoven and colleagues @aucklanduni.bsky.social:
rupress.org/jem/article/...

#Neuroinflammation #Neuroscience #InnateImmunity #inflammation
October 27, 2026 at 1:31 PM
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DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. From Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth, Uthaman Gowthaman and colleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 27, 2026 at 5:00 AM
jem.org
Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. From Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li, and colleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 27, 2026 at 1:01 AM
jem.org
Disarming FcR-dependent neutrophil activation in MPO-ANCA #glomerulonephritis. Anne Davidson @northwellhealth.bsky.social discusses new study from Nishide et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#InnateImmunity #inflammation #Autoimmunity
October 26, 2026 at 8:30 PM
jem.org
Marwa Saad, Angelina Bilate, @danmucida.bsky.social et al. show that colorectal tumors with distinct metastatic potential trigger divergent early T cell responses. rupress.org/jem/article/...

#SolidTumors #MucosalImmunology #TumorImmunology #ColonCancer #TCells
October 26, 2026 at 4:01 PM
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Epitope-diverse #autoantibodies induce #neutrophil-epithelial niches driving kidney injury in ANCA-associated #glomerulonephritis. New study from Masayuki Nishide, Atsushi Kumanogoh (University of Osaka) and colleagues:
rupress.org/jem/article/...

#InnateImmunity #inflammation #Autoimmunity
October 26, 2026 at 1:31 PM
jem.org
Inhibitory receptor agonists: Emerging strategies in immune modulation. Review from Kieran R. Adam, Aamir Suhail, @vignalilab.bsky.social and @kuchroolab.bsky.social: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 26, 2026 at 5:00 AM
jem.org
B7 costimulation antagonizes RORγt+ regulatory #Tcells and immune #tolerance in the intestine. From Mengze Lyu @mengzelyu.bsky.social and Gregory F. Sonnenberg: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 26, 2026 at 1:00 AM
jem.org
IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @rosertp.bsky.social, Bashour, Filipska, @victorgreiff.bsky.social, Cerutti & colleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 25, 2026 at 5:00 AM
jem.org
PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity. From Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Peng R. Chen, Meng Michelle Xu and clleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 25, 2026 at 1:00 AM
jem.org
Regulatory T cells sabotage anti-tumor γδ #Tcells by creating IL-2–deficient environments. From @rafaelblancodom.bsky.social, @bsilvasantos.bsky.social, Sofia Mensurado and colleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 24, 2026 at 5:00 AM
jem.org
eIF3e-mediated translational checkpoint maintains immune #tolerance and prevents lymphoid malignancy. From Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchun Xiao and colleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 24, 2026 at 1:01 AM
jem.org
This collection covers genetic susceptibility to infectious disease, environmental & evolutionary tuning of innate immune responses, neuroimmune regulation of tissue function, metabolic & transcriptional cell-fate control, & #cytokine-mediated tissue protection & repair 👉 rupress.org/jem/collecti...
October 23, 2026 at 8:03 PM
jem.org
Are you attending the @cshasia.bsky.social meeting on Immune Tolerance in Suzhou? Get in touch with our Senior Scientific Editor, Zhijuan Qiu @zhijuanjexpmed.bsky.social, who will be there in person!

✉️ Email Zhijuan: rupress.org/jem/pages/ed...

Read our collection 👉 rupress.org/jem/collecti...
October 23, 2026 at 2:00 PM
jem.org
#Macrophages as programmable integrators of disease tolerance across lifespan. New Viewpoint from Dmitry V. Bulavin @ircan.bsky.social @univcotedazur.bsky.social:
rupress.org/jem/article/...

#InnateImmunity #inflammation
Macrophages as programmable integrators of disease tolerance across lifespan
Dmitry Bulavin discusses the role of macrophages as programmable integrators of multicellular tolerance networks. These networks are reconfigured with age,
rupress.org
October 23, 2026 at 1:31 PM
jem.org
Scientists co-led by @stjuderesearch.bsky.social have identified a potential therapeutic vulnerability in some forms of #osteosarcoma.: www.stjude.org/media-resour...

See the original study by @adurbinlab.bsky.social @junqilab.bsky.social and colleagues here: rupress.org/jem/article/...
Combination therapy reveals potential vulnerability in aggressive osteosarcoma
Explore new St. Jude research uncovering that degrading EP300 and inhibiting AKT in combination may synergize to treat sensitive metastatic osteosarcomas.
www.stjude.org
October 23, 2026 at 1:02 PM
jem.org
Chimeric allergen receptor regulatory #Tcells suppress birch pollen allergic airway #inflammation. From Ana Alcaraz-Serna, Yannick Muller and colleagues: rupress.org/jem/article/...

📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 23, 2026 at 5:00 AM