@jimj100.bsky.social
Tulane SoM faculty. Breast cancer, chemotherapy, immunotherapy, and the role of cellular senescence
Reposted
Excited to share the first published paper from my lab! Postdoc Helen Jordan led this study on 1) how metabolites change differently in inflammation in tissues versus in cells in a dish and 2) the role of one of the most-increased metabolites, soluble sialic acid
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite
During an immune response, metabolism changes dramatically. Metabolites are oxidized
to power immune cell functions, serve as building blocks for proliferation, and act
as effectors to regulate pathog...
www.jbc.org
September 10, 2026 at 9:24 PM
Excited to share the first published paper from my lab! Postdoc Helen Jordan led this study on 1) how metabolites change differently in inflammation in tissues versus in cells in a dish and 2) the role of one of the most-increased metabolites, soluble sialic acid
www.jbc.org/article/S002...
www.jbc.org/article/S002...
α-Satellite RNA maintains centromeric cohesion through R-loops: Molecular Cell www.cell.com/molecular-ce...
Cool study that came together really well! Congrats to the team!
Cool study that came together really well! Congrats to the team!
α-Satellite RNA maintains centromeric cohesion through R-loops
Yang et al. show that α-satellite RNA, derived from human centromeric satellite repeats,
forms R-loops at human centromeres to ensure faithful chromosome segregation by recruiting
Shugoshin 1. This me...
www.cell.com
August 14, 2026 at 4:39 PM
α-Satellite RNA maintains centromeric cohesion through R-loops: Molecular Cell www.cell.com/molecular-ce...
Cool study that came together really well! Congrats to the team!
Cool study that came together really well! Congrats to the team!
Reposted
Pumped to share our new preprint showing GLP-1R agonism directly improves lymphatic contractility!
Our new preprint led by @maryschulz.bsky.social is now up. We show that semaglutide enhances the pumping capacity of collecting lymphatics. Our results support recent case reports suggesting beneficial effects of GLP-1R agonists in secondary lymphedema patients.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels
Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesi...
www.biorxiv.org
December 27, 2025 at 11:25 PM
Pumped to share our new preprint showing GLP-1R agonism directly improves lymphatic contractility!
Reposted
Our new preprint led by @maryschulz.bsky.social is now up. We show that semaglutide enhances the pumping capacity of collecting lymphatics. Our results support recent case reports suggesting beneficial effects of GLP-1R agonists in secondary lymphedema patients.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels
Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesi...
www.biorxiv.org
December 27, 2025 at 11:06 PM
Our new preprint led by @maryschulz.bsky.social is now up. We show that semaglutide enhances the pumping capacity of collecting lymphatics. Our results support recent case reports suggesting beneficial effects of GLP-1R agonists in secondary lymphedema patients.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted
It looks like Epstein is occasionally showing up in the Trump files.
December 27, 2025 at 4:40 PM
It looks like Epstein is occasionally showing up in the Trump files.
Reposted
GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels https://www.biorxiv.org/content/10.64898/2025.12.26.696603v1
December 27, 2025 at 8:01 PM
GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels https://www.biorxiv.org/content/10.64898/2025.12.26.696603v1
Reposted
Here the authors make inferences about macrophage GLP-1R signaling linked to senescence and efferocytosis using a GLP-1R antibody that is not validated for detection of the GLP-1R. www.sciencedirect.com/science/arti...
GLP-1R activation restores Gas6-driven efferocytosis in senescent foamy macrophages to promote neural repair
Spinal cord injury (SCI) is a devastating condition characterized by the accumulation of myelin debris (MD), persistent neuroinflammation, and impaire…
www.sciencedirect.com
September 8, 2025 at 11:20 AM
Here the authors make inferences about macrophage GLP-1R signaling linked to senescence and efferocytosis using a GLP-1R antibody that is not validated for detection of the GLP-1R. www.sciencedirect.com/science/arti...
Reposted
IMPORTANT IMPORTANT IMPORTANT IMPORTANT
Please watch the workshop video and COMMENT by 5:00 Monday 7/14
This is the source of the "no more model organism only grants in NIH-funded research" decree.
Please watch the workshop video and COMMENT by 5:00 Monday 7/14
This is the source of the "no more model organism only grants in NIH-funded research" decree.
Dear all, PLEASE add comments on the importance of model organism research at this link:
July 12, 2025 at 12:11 AM
IMPORTANT IMPORTANT IMPORTANT IMPORTANT
Please watch the workshop video and COMMENT by 5:00 Monday 7/14
This is the source of the "no more model organism only grants in NIH-funded research" decree.
Please watch the workshop video and COMMENT by 5:00 Monday 7/14
This is the source of the "no more model organism only grants in NIH-funded research" decree.
Reposted
Dear all, PLEASE add comments on the importance of model organism research at this link:
July 11, 2025 at 4:34 PM
Dear all, PLEASE add comments on the importance of model organism research at this link:
Reposted
Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/...
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling
has been associated with inflammation and tissue fibrosis, both of which are key features
in the p...
www.ahajournals.org
June 2, 2025 at 7:48 PM
Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/...
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
Reposted
Really excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction
Two evolutionary strategies allow the antiviral protein MxA to evolve simultaneous super-restriction against multiple viruses.
www.science.org
May 5, 2025 at 9:48 PM
Really excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
Reposted
While you highlight it, please note is the product of local journalism, which has been carrying a lot of the burden in an environment where national outlets simply can't cover everything everywhere all at once. Support your local journalists!
Please highlight this story.
ICE stormed into the wrong house, trashed the place, and made women/girls stand outside in the rain in their underwear. ICE also stole phones, laptops, and cash savings from the family, who moved to OKC two weeks ago.
kfor.com/news/local/w...
ICE stormed into the wrong house, trashed the place, and made women/girls stand outside in the rain in their underwear. ICE also stole phones, laptops, and cash savings from the family, who moved to OKC two weeks ago.
kfor.com/news/local/w...
'We're citizens!': Oklahoma City family traumatized after ICE raids home, but they weren't suspects
A woman says her family’s fresh start in Oklahoma turned into a nightmare after federal immigration agents raided their home, taking their phones, laptops, and life savings – even though they were …
kfor.com
April 29, 2025 at 4:26 PM
While you highlight it, please note is the product of local journalism, which has been carrying a lot of the burden in an environment where national outlets simply can't cover everything everywhere all at once. Support your local journalists!
Reposted
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Reposted
On a letter I signed
www.nytimes.com/2025/03/31/s...
www.nytimes.com/2025/03/31/s...
Trump Administration Has Begun a War on Science, Researchers Say (Gift Article)
Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.
www.nytimes.com
March 31, 2025 at 4:08 PM
On a letter I signed
www.nytimes.com/2025/03/31/s...
www.nytimes.com/2025/03/31/s...
Reposted
Did you know that science labs work like small business entrepreneurs? Faculty hired on strength of ideas, get some startup $ to last 3-4 yrs. After that is grants- grants pay all our + our trainees’ salaries + scientific work. Funding in this country is frozen. That means scientific work stops
March 15, 2025 at 11:05 PM
Did you know that science labs work like small business entrepreneurs? Faculty hired on strength of ideas, get some startup $ to last 3-4 yrs. After that is grants- grants pay all our + our trainees’ salaries + scientific work. Funding in this country is frozen. That means scientific work stops
Reposted
Huge march in New York today protesting the illegal DOGE cuts
March 15, 2025 at 8:02 PM
Huge march in New York today protesting the illegal DOGE cuts
Reposted
Too bad Uvalde Elementary didn’t sell Teslas.
March 11, 2025 at 9:54 AM
Too bad Uvalde Elementary didn’t sell Teslas.
Reposted
Thread on Jay Bhattacharya's weak scientific bona fides. Let's look at his CV.
Too many scientists are saying "Bhattacharya has NIH funding, he can't be that bad."
No. He wants revenge. He hasn't gotten an NIH grant since 2017, and the two grants then were only as a stats/econ consultant.
Too many scientists are saying "Bhattacharya has NIH funding, he can't be that bad."
No. He wants revenge. He hasn't gotten an NIH grant since 2017, and the two grants then were only as a stats/econ consultant.
March 5, 2025 at 6:45 AM
Thread on Jay Bhattacharya's weak scientific bona fides. Let's look at his CV.
Too many scientists are saying "Bhattacharya has NIH funding, he can't be that bad."
No. He wants revenge. He hasn't gotten an NIH grant since 2017, and the two grants then were only as a stats/econ consultant.
Too many scientists are saying "Bhattacharya has NIH funding, he can't be that bad."
No. He wants revenge. He hasn't gotten an NIH grant since 2017, and the two grants then were only as a stats/econ consultant.
Don't be a useful idiot puppet for the regime drugmonkey.wordpress.com/2025/02/25/d...
Don’t be a useful idiot puppet for the regime
I say this to myself regularly in the past weeks, mostly when it comes to sitting on my hands about my regular NIH-related and academic science career-related hobby horse issues as they arise. We h…
drugmonkey.wordpress.com
February 26, 2025 at 5:11 PM
Don't be a useful idiot puppet for the regime drugmonkey.wordpress.com/2025/02/25/d...
Reposted
A US Senator Joins the Fray. Thank you
@murray.senate.gov ! More of this, please!
www.murray.senate.gov/senator-murr...
@murray.senate.gov ! More of this, please!
www.murray.senate.gov/senator-murr...
Senator Murray Blasts Trump & Elon for Illegally Paralyzing Lifesaving Research Again, Threatening to Extinguish Ongoing and Groundbreaking Work - Senator Patty Murray
ICYMI: Murray Blasts Trump and Musk Decimating HHS, Risking Americans’ Health and Livelihoods Washington, D.C. — U.S. Senator Patty Murray (D-WA), Vice Chair of the Senate Appropriations Committee and...
www.murray.senate.gov
February 22, 2025 at 12:17 AM
A US Senator Joins the Fray. Thank you
@murray.senate.gov ! More of this, please!
www.murray.senate.gov/senator-murr...
@murray.senate.gov ! More of this, please!
www.murray.senate.gov/senator-murr...
Reposted
A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter.
By @avaskham.bsky.social
bit.ly/3X8ngz8
By @avaskham.bsky.social
bit.ly/3X8ngz8
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
www.thetransmitter.org
February 18, 2025 at 11:23 PM
A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter.
By @avaskham.bsky.social
bit.ly/3X8ngz8
By @avaskham.bsky.social
bit.ly/3X8ngz8
Reposted
Approximately 10% of the NIH staff were fired yesterday. Barely anyone outside of the scientific community noticed, and I'd wager a sizeable number of NIH funded PIs have no idea either.
February 15, 2025 at 2:15 PM
Approximately 10% of the NIH staff were fired yesterday. Barely anyone outside of the scientific community noticed, and I'd wager a sizeable number of NIH funded PIs have no idea either.
Reposted
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
February 8, 2025 at 11:16 PM
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.