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jonykipnis.bsky.social
Jonathan Kipnis
@jonykipnis.bsky.social
2.5K followers 93 following 58 posts
#TCellsMakeYouSmart
This is my personal account where I will likely talk mostly about science… produced by us and others.
Posts Replies Media Videos
Reposted by Jonathan Kipnis
focisimmunology.bsky.social
✨ Opening Keynote Spotlight at the FOCIS 2026 Annual Meeting

Join Jonathan Kipnis, PhD for the opening keynote, “What is CNS Immune Privilege (Not)?”

📅 June 9, 2026 | ⏰ 4:30–5:15 PM PST

See the full program here: zurl.co/9SGq2

#Immunology #FOCIS2026
May 6, 2026 at 4:29 PM
jonykipnis.bsky.social
Don’t be so obsessed about Israel!
Just go visit… and then get obsessed! 🤩
April 24, 2026 at 11:30 AM
Reposted by Jonathan Kipnis
cp-neuron.bsky.social
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties
Du et al. show that repeated microglia depletion allows peripheral monocytes to engraft the brain. Brain-engrafted macrophages acquire transcriptional and epigenetic identities distinct from microglia and adopt a border-associated macrophage-like phenotype. Monocytes from both blood and skull origins replenish the brain, revealing unexpected routes of brain macrophage renewal.
dlvr.it
March 11, 2026 at 3:24 PM
Reposted by Jonathan Kipnis
jem.org
Amyloidosis of bridging veins is a pathologic feature of #Alzheimers disease, from @leonsmyth.bsky.social, Rupal Mehta, @jonykipnis.bsky.social et al. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...
March 4, 2026 at 9:01 AM
Reposted by Jonathan Kipnis
theaacr.bsky.social
Brain Borders and CNS Trafficking:
Graeme F. Woodworth, Jonathan Kipnis, and Michael John Mitchel will address this topic in a plenary session at the AACR Special Conference on Brain Cancer (March 23-25, 2026; Philadelphia). Learn more:
buff.ly/CAwsGw8
#AACRbrain26 @jonykipnis.bsky.social
February 24, 2026 at 4:33 PM
Reposted by Jonathan Kipnis
scottrussophd.bsky.social
Join us Sep 5-12, 2026 in Venice at the Neuroscience School of Advanced Studies for a course on Integrated Brain-Body Neuroscience featuring world-class speakers @mcalpinelab.bsky.social @jonykipnis.bsky.social @scottrussophd.bsky.social Jessica Able, Jens Brüning, Ivan de Araujo & Kara Marshall.
Integrated Brain-Body Neuroscience - Neuroscience School of Advanced Studies
Integrated Brain-Body Neuroscience September 5-12, 2026   Director: Scott J. Russo Icahn School of Medicine at Mount Sinai, New York, USA   Faculty: Jonathan Kipnis, Washington University School of Me...
www.neurosas.org
February 24, 2026 at 4:07 PM
Reposted by Jonathan Kipnis
stemcellsciencenews.com
Researchers led by Drs. Pavle Boskovic, @jonykipnis.bsky.social, and Marco Colonna present amyloid-β-specific engineered CD4+ CAR-T as an approach to directly target sites of pathology for Alzheimer’s disease.

📘 @pnas.org
🔖 https://bit.ly/4aGMCv8
February 19, 2026 at 12:10 AM
Reposted by Jonathan Kipnis
labwaggoner.bsky.social
@biorxivpreprint.bsky.social A framework for reparative CAR T engineering in the CNS @idoamitlab.bsky.social @weizmanninstitute.bsky.social @jonykipnis.bsky.social @washumedicine.bsky.social
www.biorxiv.org/content/10.6...
February 12, 2026 at 2:41 AM
Reposted by Jonathan Kipnis
labwaggoner.bsky.social
Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease @pnas.org @jonykipnis.bsky.social
www.pnas.org/doi/10.1073/...
February 11, 2026 at 10:20 PM
Reposted by Jonathan Kipnis
erictopol.bsky.social
First proof-of-concept for engineered T cells as a potential treatment for Alzheimer's disease
pnas.org/doi/10.1073/...
February 10, 2026 at 3:23 PM
Reposted by Jonathan Kipnis
natmed.nature.com
A new trial provides direct human evidence that the #placeboeffect can shape humoral #immunity and vaccine responses, opening new avenues for biomedical research. News & Views from Jonathan Kipnis & colleagues
https://www.nature.com/articles/s41591-025-04168-7
Placebo effect influences vaccine responses - Nature Medicine
A randomized trial provides direct human evidence that the placebo effect can shape humoral immunity, showing that reward-related brain activity correlates with vaccine-induced antibody production and opening new avenues for treating many medical conditions.
www.nature.com
January 21, 2026 at 12:01 PM
Reposted by Jonathan Kipnis
erictopol.bsky.social
Brain food on our brain drainage system to help keep you healthy, with @jonykipnis.bsky.social
erictopol.substack.com/p/how-our-br...
December 23, 2025 at 6:09 PM
Reposted by Jonathan Kipnis
davalos.bsky.social
Great podcast on the state of the science on brain fluid clearance and immune surveillance, by @jonykipnis.bsky.social discussing with @erictopol.bsky.social. They break down how sleep and our immune cells influence cognitive function and risk for dementia for 🧠 geek and lay audiences alike!👏
erictopol.bsky.social Eric Topol @erictopol.bsky.social · Dec 21
How Our Brain Drains Its Waste Products
and its relevance to our sleep quality and risk of neurodegenerative diseases
A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles
erictopol.substack.com/p/how-our-br...
How Our Brain Drains Its Waste Products
Particular Relevance to Sleep, Alzheimer's Disease and Immune Surveillance
erictopol.substack.com
December 22, 2025 at 10:10 PM
Reposted by Jonathan Kipnis
erictopol.bsky.social
How Our Brain Drains Its Waste Products
and its relevance to our sleep quality and risk of neurodegenerative diseases
A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles
erictopol.substack.com/p/how-our-br...
How Our Brain Drains Its Waste Products
Particular Relevance to Sleep, Alzheimer's Disease and Immune Surveillance
erictopol.substack.com
December 21, 2025 at 4:52 PM
Reposted by Jonathan Kipnis
jem.org
Smyth, Mehta, @jonykipnis.bsky.social et al. show that bridging veins accumulate amyloid in mouse models of #Alzheimers disease and human Alzheimer’s disease specimens, associated with impaired cerebrospinal fluid efflux. rupress.org/jem/article/...

🎥 See video summary: youtu.be/FsM6ontxHEI
December 16, 2025 at 3:45 PM
Reposted by Jonathan Kipnis
erictopol.bsky.social
My top 10 books for 2025
December 15, 2025 at 4:39 PM
Reposted by Jonathan Kipnis
erictopol.bsky.social
How do the metabolic waste products get cleared from our brain? And how does this process intersect with the brain's immune system?
An exceptional review by
@jonykipnis.bsky.social
and colleagues
cell.com/neuron/fullt...
Resolving the mysteries of brain clearance and immune surveillance
This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems, and neuroimmune interacti...
cell.com
December 5, 2025 at 4:30 PM
Reposted by Jonathan Kipnis
rupress.org
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...

#Neuroinflammation #Alzheimers
December 2, 2025 at 5:45 PM
Reposted by Jonathan Kipnis
jem.org
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...

#Neuroinflammation #Alzheimers
December 2, 2025 at 5:00 PM
Reposted by Jonathan Kipnis
cp-neuron.bsky.social
Resolving the mysteries of brain clearance and immune surveillance
This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems, and neuroimmune interactions, with implications for neurodegenerative and neuroimmune disorders.
dlvr.it
November 24, 2025 at 7:37 PM
Reposted by Jonathan Kipnis
washu.edu
Look Up! ✨

The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao!

#WashU #northernlights #AuroraBorealis
November 13, 2025 at 11:46 PM
Reposted by Jonathan Kipnis
curealzheimersfund.bsky.social
We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
October 15, 2025 at 3:34 PM
Reposted by Jonathan Kipnis
npr.org
The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.
The Booker shortlist honors authors 'in total command' of their craft
The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.
n.pr
September 23, 2025 at 8:50 PM
Reposted by Jonathan Kipnis
adeczkowska.bsky.social
Some thoughts on meningeal mast cells inspired by Xinzhong Dong and @jonykipnis.bsky.social recent (and AWESOME) papers. Lead: @fakesamir.bsky.social

www.cell.com/trends/immun...
www.cell.com
September 18, 2025 at 8:28 PM
Reposted by Jonathan Kipnis
glymphaticrnet.bsky.social
📅 Save the Date: Oxford 2026 Glymphatic Research Symposium!

• Dates: March 30th, March 31st, April 1st 2026.
• Keynote speakers: Maiken Nedergaard & Jonathan Kipnis.
• Venue: Keble College, Oxford, UK.
• Registration link to follow

Looking forward to seeing you there! 🧠
September 12, 2025 at 2:59 PM